Cerebral Cavernous Malformation: From Genetics to Pharmacotherapy by Zhuangzhuang Zhang, Jianwen Deng, Weiping Sun, Zhaoxia Wang

“…Recent preclinical and clinical studies have shown that various drugs can effectively reduce the burden of CCM lesions. …”
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Cellular Senescence as a Target in Cancer Control by Mar Vergel, Juan J. Marin, Purificacion Estevez, Amancio Carnero

“…Cells displaying characteristics of senescent cells can also be observed in response to other stimuli, such as oncogenic stress, DNA damage, or cytotoxic drugs and have been reported to be found in vivo. …”
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Multifaceted functions of the Wilms tumor 1 protein: From its expression in various malignancies to targeted therapy by Qing Nian, Yan Lin, Jinhao Zeng, Yanna Zhang, Rongxing Liu

“…Substantial information is available on the pathogenesis of WT1 in various diseases, and several WT1-targeted therapies, including chemical drugs, natural products, and targeted vaccines, are available. …”
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Targeting TLR/IL-1R Signalling in Human Diseases by Maria Loiarro, Vito Ruggiero, Claudio Sette

“…Given their central role in innate and adaptive immune responses, it is foreseen that pharmaceutical modulation of TLR/IL-1R signalling pathways by these drugs might yield clinical benefits in the treatment of inflammatory and autoimmune diseases.…”
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Refractory IgD Multiple Myeloma Treated with Daratumumab: A Case Report and Literature Review by Muhammad Husnain, Sandra Kurtin, Nikki Barkett, Irbaz bin Riaz, Amit Agarwal

“…A recent analysis of patients with relapsed and refractory multiple myeloma who were refractory to both proteasome inhibitors and immunomodulatory drugs showed the median overall survival of 9 months only. …”
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Anticancer effect of curcumin on breast cancer and stem cells by Hui-Tien Liu, Yuan-Soon Ho

“…Therefore, curcumin is a potential anticancer compound, and its concurrent application with other anticancer drugs appears promising. Keywords: Curcumin, Breast cancer, Breast cancer stem cell…”
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Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects by M. Ivan Ariful Fathoni, Fajar Adi-Kusumo, Gunardi Gunardi, Susanna Hilda Hutajulu

“…The neutrophil is one of the cells that is influenced by chemotherapy drugs. Chemotherapy-induced neutropenia is one of the most common toxic effects experienced by patients and often threatens chemotherapy to use efficiency. …”
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SLC7A11 is a potential therapeutic target and prognostic biomarker correlated with immune cell infiltration in cervical cancer by Mutangala Muloye Guy, Tingting Bian, Longyun Sun, Yiping Hao, Xinlin Jiao, Wenjing Zhang, Teng Zhang, Baoxia Cui

“…We also explore 37 kinds of drugs that may benefit cervical cancer patients.…”
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Docosahexaenoic acid-rich fish oil prevented insulin resistance by modulating gut microbiome and promoting colonic peptide YY expression in diet-induced obesity mice by Wanxiu Cao, Fang Liu, Robert W. Li, Yaoxian Chin, Yuming Wang, Changhu Xue, Qingjuan Tang

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Pharmacovigilance imbalance analysis of VEGFR-TKI-related taste and smell disorders by Zhong-hua Fu, Chenglong Zhao, Yaqin Wang, Lei Zhang, Lei Wang

“…Previous research found that the main culprits of TSD development in cancer patients are cytotoxic drugs such as taxol, fluorouracil, cyclophosphamide, and anthracycline-based drugs. …”
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Characterization of a New Immunosuppressive and Antimicrobial Peptide, DRS-DA2, Isolated from the Mexican Frog, Pachymedusa dacnicolor by Claire Lacombe, Estefania Aleman-Navaro, Thierry Drujon, Veronica Martinez-Osorio, Emmanuelle Sachon, Erika Melchy-Pérez, Ludovic Carlier, Lorena Elizabeth Fajardo Brigido, Yannick Fleury, Christophe Piesse, Guadalupe Gutiérrez-Escobedo, Alejandro De las Peñas, Irene Castaño, Florie Desriac, Jose Luis Beristain-Hernandez, Christophe Combadiere, Yvonne Rosenstein, Constance Auvynet

“…In addition to suppressing undesired inflammation and reducing disease progression, these drugs lessen the immune system protective functions. …”
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NET formation-mediated in situ protein delivery to the inflamed central nervous system by Yina Wu, Jinwon Park, Quoc-Viet Le, Junho Byun, Jaehyun Choi, Enzhen Xu, Jaiwoo Lee, Yu-Kyoung Oh

“…Abstract Delivering protein drugs to the central nervous system (CNS) is challenging due to the blood-brain and blood-spinal cord barrier. …”
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Hepatic Disorders and COVID-19: From Pathophysiology to Treatment Strategy by Parisa Shiri Aghbash, Hamed Ebrahimzadeh Leylabadlo, Hamidreza Fathi, Mohaddeseh Bahmani, Rojin Chegini, Hossein Bannazadeh Baghi

“…Furthermore, antiviral medications, immunosuppressive drugs after liver transplantation, pre-existing hepatic diseases, and chronic liver diseases such as cirrhosis have also been implicated in SARS-CoV-2-induced liver injury. …”
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The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model: Theoretical and Epidemiological Considerations by M. G. W. van den Heuvel, A. Bast, A. W. Ambergen, R. R. W. J. van der Hulst

“…This paper contains a literature study on the antioxidant working mechanisms of these drugs. Methods. Medical information of 134 DIEP patients (173 flaps) was studied from their medical files. …”
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Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease by María José Pérez, Rodrigo A. Quintanilla

“…How TZDs may improve or reduce these pathologic signs of AD and what the mechanisms and the implicated pathways in which these drugs work are are questions that remain to be answered. …”
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PPAR-γ Agonists and Their Effects on IGF-I Receptor Signaling: Implications for Cancer by A. Belfiore, M. Genua, R. Malaguarnera

“…In this regard, promising drugs have been developed to target the IGF-I receptor or its ligands. …”
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Development and Validation of a Derivative Spectrophotometric Method for Simultaneous Determination of Simvastatin and Ezetimibe by Effat Souri, Masoud Amanlou

“…The within-day and between-day precision values for both drugs were less than 3% (CV). Also, good recoveries were obtained with both synthetic mixtures and commercial tablets. …”
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L’échec mondial de la lutte antidrogue : quelles leçonspour l’Afghanistan ? by Pierre-Arnaud Chouvy

“…The history of international drugs in Asia is rich in counternarcotics failures, despite a few successes. …”
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Polypharmacy behavior: an aspect to be taken into consideration. by Senén Rodríguez Fernández, Sahily García Ledo, Maritza Almeida Torregrosa

“…<strong>Fundament: </strong>While medications are more sophisticated, their actions are wider as well as their undesirable reactions. If we use two drugs we will be duplicating the possibilities of their effects desired to benefit the patients, but also the adverse reactions. …”
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Physiological Roles of DNA Double-Strand Breaks by Farhaan A. Khan, Syed O. Ali

“…Cells boast a considerable set of defences to both prevent and repair these breaks and drugs which derail these processes represent an important category of anticancer therapeutics. …”
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