Plaque morphological changes after drug-coated balloon angioplasty according to underlying plaque components by Naoki Fujisawa, MD, Takenobu Shimada, MD, Kenichiro Otsuka, MD, PhD, Takanori Yamazaki, MD, PhD, Daiju Fukuda, MD, PhD

“…A 52-year-old man with a short chronic total occlusion in the left superficial femoral artery underwent drug-coated balloon (DCB) angioplasty. Evaluation using integrated backscatter intravascular ultrasound revealed that the plaque volume of fibrosis was compressed just after treatment (from 494.67 mm3 to 398.36 mm3) and was further decreased at 1 month after treatment (to 362.07 mm3). …”
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InceptionDTA: Predicting drug-target binding affinity with biological context features and inception networks by Mahmood Kalemati, Mojtaba Zamani Emani, Somayyeh Koohi

Subjects: “…Drug-target binding affinity prediction…”
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Development and Validation of a Reversed-Phase HPLC Method for the Estimation of Zolpidem in Bulk Drug and Tablets by E. Konoz, A. H. Mohsen Sarrafi, R. Abdolahnejad, M. Bahrami-Zonoz

“…In the present study an isocratic reversed-phase high-performance liquid chromatography method was developed for the estimation of zolpidem in bulk drug and pharmaceutical dosage forms. The quantification was carried out on C18 columns. …”
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Oral Antibacterial Drug Prescribing in Primary Care Out-of-Hours Services: A Scoping Review by Sarah Khalid Al Hussain, Rhian Deslandes, Deborah Edwards, Karen Louise Hodson

“…This review aims to identify the existing literature on oral antibacterial drug prescribing within primary care OOH services. …”
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Assessing patient risk, benefit and outcomes in drug development: an observational study of regorafenib clinical trials by Matt Vassar, Vinay Prasad, Ryan McIntire, Alyson Haslam, Brody Dennis, Chance Bratten, Griffin K Hughes, Andriana M Peña, Chase Ladd, Brooke Gardner, William Nowlin, Reagan Livingston, Jordan Tuia

“…Objective Our objective of this study was to analyse all oncological clinical trials using regorafenib to create a complete risk/benefit profile for the drug.Background Creating a novel chemotherapy is costly both in time and capital spent for drug manufacturers. …”
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Impact of HER2-targeting antibody drug conjugates in treatment strategies for patients with breast cancer by Hanghang Ma, Jianbin Li

Subjects: “…Antibody-drug conjugate…”
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Efficacy of short term non steroidal anti-inflammatory drugs in Indian patients with axial spondyloarthritis by Shubha Bhalla, Shallu Verma, Anand Narayan Malaviya

Subjects: “…nonsteroidal anti-inflammatory drugs…”
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In vitro and ex vivo models of the oral mucosa as platforms for the validation of novel drug delivery systems by Robyn A Macartney, Abijit Das, Atina G Imaniyyah, Annabelle TR Fricker, Andrew M Smith, Stefano Fedele, Ipsita Roy, Hae-Won Kim, Dongjoon Lee, Jonathan C Knowles

“…The benefit of complex 3D models to facilitate the robust testing of new drugs and drug delivery systems during the developmental stages of pharmaceutical manufacturing has recently become distinguished within the field. …”
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Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma by Jiannan Lin, Shuwen Lu, Xiaoyu Zhao

“…Finally, we conducted drug-targeted MR analysis to evaluate the potential of each mediator plasma proteins as a drug target gene. …”
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Evolution of Alzheimer’s Disease Therapeutics: From Conventional Drugs to Medicinal Plants, Immunotherapy, Microbiotherapy and Nanotherapy by Emma Ortiz-Islas, Pedro Montes, Citlali Ekaterina Rodríguez-Pérez, Elizabeth Ruiz-Sánchez, Talía Sánchez-Barbosa, Diego Pichardo-Rojas, Cecilia Zavala-Tecuapetla, Karla Carvajal-Aguilera, Victoria Campos-Peña

“…Alzheimer’s disease (AD) represents an escalating global health crisis, constituting the leading cause of dementia among the elderly and profoundly impairing their quality of life. Current FDA-approved drugs, such as rivastigmine, donepezil, galantamine, and memantine, offer only modest symptomatic relief and are frequently associated with significant adverse effects. …”
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To describe the subsets of malignant epithelial cells in gastric cancer, their developmental trajectories and drug resistance characteristics by Tingting Xu, Tianying Zhang, Yan Sun, Sijia Wu

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Evaluation of Drug Use Pattern in Emergency Department of Dilchora Referral Hospital, Dire Dawa, Ethiopia by Kirubel M. Mishore, Nigatu A. Bekele, Tsegaab Y. Yirba, Tsion F. Abone

“…Background. Drug use evaluation is a system of continuous, systematic, criteria-based drug evaluation that ensures the appropriate use of drugs. …”
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Integrated bioinformatics analysis to explore potential therapeutic targets and drugs for small cell carcinoma of the esophagus by Maofei Zhu, Maofei Zhu, Yueming Chu, Yueming Chu, Qiang Yuan, Qiang Yuan, Junfeng Li, Silin Chen, Lin Li, Lin Li, Lin Li

“…Furthermore, a total of 38 drugs were searched and filtered in DGIdb and ConnectivityMAP, in the molecular docking results of drugs with hub genes, the docking score of AURKA, CDK1, and EZH2 with multiple drugs were low (<6). …”
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Treatment for Nontype 1 Retinopathy of Prematurity by Intravitreal Injection of Antivascular Endothelial Growth Factor Drugs by Haitao Zhang, Xin Yang, Fangfang Zheng, Xiangke Yin, Suhua Wan

“…To explore clinical characteristics and treatment reasons for intravitreal injection of antivascular endothelial growth factor (anti-VEGF) drugs in the treatment of nontype 1 retinopathy of prematurity (ROP). …”
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Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds by Jean Baptiste Niyibizi, Peter G. Kirira, Francis T. Kimani, Fiona Oyatsi, Joseph K. Ng’ang’a

“…In addition, although there are effective drugs for treatment of malaria, this could be lost to the drug resistance in different Plasmodium species. …”
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Talk About Crime Among Young People in Northern Mexico: The Impact of Drug Trafficking in the Neighborhood by Ariagor Manuel Almanza Avendaño, Martha Romero-Mendoza, Anel Hortensia Gómez San Luis

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Indicators of the Microbial Corrosion of Steel Induced by Sulfate-Reducing Bacteria Under the Influence of Certain Drugs by Nataliia Tkachuk, Liubov Zelena, Yaroslav Novikov

“…The aim of the work was to study in vitro the sensitivity of SRB <i>Desulfovibrio oryzae</i> NUChC SRB1 to different concentrations of dimethyl sulfoxide (DMSO), and evaluate the indicators of the microbial corrosion of steel induced by this bacterium in the presence of the pharmaceutical drugs DMSO and paracetamol. The sensitivity of SRB <i>D. oryzae</i> to 1–100% DMSO (<i>v</i>/<i>v</i>) was studied via the dilution method in Postgate’s “C” liquid medium. …”
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Solid Self-Microemulsifying Drug Delivery System for Improved Oral Bioavailability of Relugolix: Preparation and Evaluation by Li ZL, Deng GX, Fang CZ, Zhao YQ, Yuan J, Chen L, Zhong HJ, Guo F

Subjects: “…solid self-microemulsifying drug delivery system…”
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Involvement of HLADQA1*05 in Patients with Inflammatory Bowel Disease Treated with Anti-TNF Drugs by Anna Pau, Ilaria Galliano, Elisa Barnini, Maddalena Dini, Antonio Pizzol, Alice Ponte, Stefano Gambarino, Pier Luigi Calvo, Massimiliano Bergallo

“…However, immunogenicity—where anti-drug antibodies diminish effectiveness—remains an issue, often requiring dose changes or combination therapies. …”
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When herpes zoster is not herpes: A case of statin-induced myopathy complicated by drug allergies by Hira Khalid Kareem, Muhammad Fawad Ashraf, Muhammad Shehryar, Hafsa Fayyaz, Shreyas Patil

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