Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery by Arda Halu, Sarvesh Chelvanambi, Julius L. Decano, Joan T. Matamalas, Mary Whelan, Takaharu Asano, Namitra Kalicharran, Sasha A. Singh, Joseph Loscalzo, Masanori Aikawa

“…Abstract Background Large-scale pharmacogenomic resources, such as the Connectivity Map (CMap), have greatly assisted computational drug discovery. However, despite their widespread use, CMap-based methods have thus far been agnostic to the biological activity of drugs as well as to the genomic effects of drugs in multiple disease contexts. …”
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Updated treatment guidelines for drug-resistant TB: how safe are clofazimine-based regimens? by E. Pontali, M. Raviglione

“…In June 2024, WHO released ‘Key updates to the treatment of drug-resistant tuberculosis: rapid communication’, after the preliminary publication of results from two clinical trials: ‘BEAT-Tuberculosis’ and ‘endTB’. …”
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CDPMF-DDA: contrastive deep probabilistic matrix factorization for drug-disease association prediction by Xianfang Tang, Yawen Hou, Yajie Meng, Zhaojing Wang, Changcheng Lu, Juan Lv, Xinrong Hu, Junlin Xu, Jialiang Yang

Subjects: “…Drug-disease association prediction…”
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Efficacy and Safety of Drug-Eluting Bead TACE in the Treatment of Primary or Secondary Liver Cancer by Jiabing Wang, Haoqian Xu, Ying Wang, Long Feng, Fengming Yi

“…Background. The drug-eluting beads transarterial chemoembolization (DEB-TACE) has already been used in hepatic malignancies. …”
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Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer by Liu‐Jing Wen, Yue‐Sheng Wang, Jie Zhang

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Sleep-related drugs utilization and suicide behaviors: a population-based study in China by Yunshu Zhang, Bo Liu, Keqing Li, Hailing Jia, Hemin Shi, Yongqiao Liu, Jianfeng Li, Long Sun

Subjects: “…Sleep-related drug utilization…”
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Risk Factors and Prevention of Upper Gastrointestinal Complications Associated with Nonsteroidal Anti-Inflammatory Drugs by N. V. Bakulina, S. V. Tikhonov, K. A. Nagornova

Subjects: “…nonsteroidal anti-inflammatory drugs…”
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Estimation of the Secondary Attack Rate for Delta Hepatitis Coinfection among Injection Drug Users by Christiane Poulin, Theresa Gyorkos, Lawrence Joseph

“…The secondary attack rate for delta hepatitis coinfection was estimated among a cluster of injection drug users (IDUs). The infections occurred during an epidemic of hepatitis B in a rural area of Nova Scotia in 1988 and 1989. …”
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Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma by Nassir Mokarram, Ayden Case, Nadia N. Hossainy, Johnathan G. Lyon, Tobey J. MacDonald, Ravi Bellamkonda

“…Abstract The blood-brain barrier, essential for protecting the central nervous system, also restricts drug delivery to this region. Thus, delivering drugs across the blood-brain barrier is an active research area in immunology, oncology, and neurology; moreover, novel methods are urgently needed to expand therapeutic options for central nervous system pathologies. …”
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Antituberculosis Drugs (Rifampicin and Isoniazid) Induce Liver Injury by Regulating NLRP3 Inflammasomes by Qiang Su, Wei Kuang, Weiyi Hao, Jing Liang, Liang Wu, Chunmei Tang, Yali Wang, Tao Liu

“…Patients being treated for pulmonary tuberculosis often suffer liver injury due to the effects of anti-TB drugs, and the underlying mechanisms for those injuries need to be clarified. …”
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Understanding Professional Discretion by Principals in Managing Drugs in Gauteng Province schools in South Africa by Kgwete Ephraim Matala

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Promising new drugs and therapeutic approaches for treatment of ovarian cancer—targeting the hallmarks of cancer by Julia Hillmann, Nicolai Maass, Dirk O. Bauerschlag, Inken Flörkemeier

“…Department of Health and Human Services, 2024)) for new drugs on the basis of their mechanisms of action and identified new target approaches. …”
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Antituberculosis Drug-Induced Liver Injury with Autoimmune Features: Facing Diagnostic and Treatment Challenges by Maria Adriana Rangel, Isabel Pinto Pais, Raquel Duarte, Isabel Carvalho

“…The authors present a case report of antituberculosis drug-induced liver injury that offered diagnostic challenges (namely, the possibility of drug-induced autoimmune hepatitis) and treatment difficulties.…”
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Dysfunctional large-scale brain networks in drug-naïve depersonalization-derealization disorder patients by Sisi Zheng, Mingkang Song, Nan Song, Hong Zhu, Xue Li, Dongqing Yin, Shanshan Liu, Yan Zhao, Meng Fang, Yanzhe Ning, Hongxiao Jia

“…Methods A total of 47 drug-naïve DPRD patients and 49 healthy controls (HCs) were recruited and underwent resting-state functional scanning. …”
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Ruthenium (Ru) complex conjugates drugs and targeted tumors by inhibiting oral cancer cells by Rethinam Senthil

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Formulation of new drug delivery systems for insulin from natural bioactive biocompatible polymers by Howida A. Fetouh, Engy E. A. Aleem, Najiyah H. Mohammed, Jihad M. Abd-Almajeed Aldesouky, Amel M. Ismail

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Noninsulin Antidiabetic Drugs for Patients with Type 2 Diabetes Mellitus: Are We Respecting Their Contraindications? by Irene Ruiz-Tamayo, Josep Franch-Nadal, Manel Mata-Cases, Dídac Mauricio, Xavier Cos, Antonio Rodriguez-Poncelas, Joan Barrot, Gabriel Coll-de-Tuero, Xavier Mundet-Tudurí

“…To assess prescribing practices of noninsulin antidiabetic drugs (NIADs) in T2DM with several major contraindications according to prescribing information or clinical guidelines: renal failure, heart failure, liver dysfunction, or history of bladder cancer. …”
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Depression and anxiety in glaucoma patients using mono drug therapy vs polydrug therapy by Aaiza Tahir, Muhammad Waqas Ahmed, Summaya Khan, Omar Zafar, Muhammad Haroon Sarfraz, Muhammad Shahid Tarar

“…The mean age in the mono-drug group (mean= 48.81±10.58 years) was slightly lower than the polydrug group (mean=53.67±11.16years) (p=0.000018). …”
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Exploring the impact of xenobiotic drugs on forensic entomology for accurate post-mortem interval estimation by Sapna Jain, Jonathan J. Parrott, Gulnaz T. Javan

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Clinical manifestation and laboratory data of illicit drugs versus other substances intoxication in children by Leila Barati, Mohammadali Vakili, Omid Mehrpour, Mehrdad Teimoorian

“…Children who were poisoned by illicit drugs presented with impaired level of consciousness (92.5%), unstable vital signs and abnormal laboratory results. …”
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