Combination effects of Pistachio hull and carfilzomib on NF-κB p65, MDR1, MRP1, and Caspase3 gene expression in breast cancer cell line by Zahra Mirzaei, Sadegh Zarei, Ahmadreza Sayadi, Reza Hosseiniara, Mojgan Noroozi Karimabad, Mehdi Mahmoodi

“…Abstract Objective This study aimed to investigate the synergistic effects of the chemotherapy drug Carfilzomib (CFZ) and Pistachio hull extract on the SK-BR3 breast cancer cell line. …”
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A truncated pre-F protein mRNA vaccine elicits an enhanced immune response and protection against respiratory syncytial virus by Min Lin, Yifan Yin, Xiaomeng Zhao, Chen Wang, Xueqing Zhu, Letao Zhan, Li Chen, Siling Wang, Xue Lin, Jun Zhang, Ningshao Xia, Zizheng Zheng

“…Abstract The Food and Drug Administration (FDA) has approved vaccines designed by GSK, Pfizer and Moderna to protect high-risk populations against respiratory syncytial virus (RSV). …”
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Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate by Huagui Huang, Kaizhong Wang, Xiangyan Liu, Xin Liu, Jinzuo Wang, Moran Suo, Hui Wang, Shuang Chen, Xin Chen, Zhonghai Li

“…Among them, Barium titanate (BaTiO3) is widely used in tumor therapy, tissue engineering, health detection and drug delivery because of its good biocompatibility, low cytotoxicity and good piezoelectric properties. …”
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A False Case of Clozapine-Resistant Schizophrenia by J. P. Maia-de-Oliveira, J. P. Pinto, V. Alexandre, J. P. Machado-de-Sousa, S. L. Morais, C. Chaves, A. C. Sakamoto, A. W. Zuardi, J. A. S. Crippa, J. E. Hallak

“…Clozapine has been the drug of choice in such cases. However, approximately 30% of them do not respond to clozapine either. …”
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Cresp®: transforming the landscape of chemotherapy-induced anemia - a comprehensive retrospective real-world analysis in 523 Indian patients by MV Chandrakanth, Vivek Agarwala, Pranav Sopory, Himadri Nayak, Purvish M. Parikh, Minakshi Roy, Rajib De, Pradeep Narayan, Anjuli Tuladhar Barai, Kaustav Mandal, Moinak Basu, Subhabrata Kumar, Rajdeep Singh Uppal, Syed Mujtaba Hussain Naqvi, Rohit Desai

“…Significant improvements were noted from baseline in fatigue, and dyspnea. Adverse drug reactions included hypertension (5.4%), deep vein thrombosis (2.9%), and arrhythmias (0.8%).DiscussionDA demonstrates impressive efficacy and safety in managing CIA, leading to substantial improvements in mean hemoglobin levels in palliative setting. …”
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Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials by Gofarana Wilar, Cecep Suhandi, Kohji Fukunaga, Masanori Shigeno, Ichiro Kawahata, Rizky Abdulah, Takuya Sasaki

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Merck Open Global Health Library in vitro screening against Schistosoma mansoni identified two new substances with antischistosomal activities for further development by Monique Evelyn Ueberall, Martina Berchthold, Cécile Häberli, Sven Lindemann, Thomas Spangenberg, Jennifer Keiser, Christoph G. Grevelding

“…The current treatment of schistosomiasis relies on a single drug, praziquantel (PZQ). However, there is increasing concern about emerging resistance to PZQ due to its frequent use. …”
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Molecular-genetic pathways of hepatitis C virus regulation of the expression of cellular factors PREB and PLA2G4C, which play an important role in virus replication by E. L. Mishchenko, A. A. Makarova, E. A. Antropova, A. S. Venzel, T. V. Ivanisenko, P. S. Demenkov, V. A. Ivanisenko

“…However, rapid mutation processes in the viral genome and acquisition of drug resistance to the existing drugs remain the main obstacles to fighting HCV. …”
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Diethylcarbamazine Reduces Chronic Inflammation and Fibrosis in Carbon Tetrachloride- (CCl4-) Induced Liver Injury in Mice by Sura Wanessa Santos Rocha, Maria Eduarda Rocha de França, Gabriel Barros Rodrigues, Karla Patrícia Sousa Barbosa, Ana Karolina Santana Nunes, André Filipe Pastor, Anne Gabrielle Vasconcelos Oliveira, Wilma Helena Oliveira, Rayana Leal Almeida Luna, Christina Alves Peixoto

“…Based on the results of the present study, DEC can be used as a potential anti-inflammatory drug for chronic hepatic inflammation.…”
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Machine learning and genetic algorithm-guided directed evolution for the development of antimicrobial peptides by Heqian Zhang, Yihan Wang, Yanran Zhu, Pengtao Huang, Qiandi Gao, Xiaojie Li, Zhaoying Chen, Yu Liu, Jiakun Jiang, Yuan Gao, Jiaquan Huang, Zhiwei Qin

“…Conclusions: The findings of this study pave the way for the rational drug design of activity-enhanced peptide antibiotics.…”
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Comparative effect of atorvastatin and risperidone on modulation of TLR4/NF-κB/NOX-2 in a rat model of valproic acid-induced autism by Eman A. E. Farrag, Mona H. Askar, Zienab Abdallah, Safinaz M. Mahmoud, Eman A. Abdulhai, Eman Abdelrazik, Eman Mohamad El Nashar, Faten Mohammed Alasiri, Asma Nasser Saeed Alqahtani, Mamdouh Eldesoqui, Ali M. Eldib, Alshimaa Magdy

“…Developing novel disease-modifying drugs is essential for the continuous improvement of ASD. …”
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Collection and Determination of Clinical Problems and Outcome Indicators of Expert Consensus on Clinical Application of Ethnic Medicine in the Treatment of Palpitation (Arrhythmia-... by ZHANG Wenjie, LI Jun, CHEN Hengwen, TAN Yuqing, XIE Zicong, WU Ji, MENG Chao, LI Zhaoling, ZHANG Lesong

“…However, there is a concerning trend of abuse of ethnic medicine, particularly in the absence of tailored clinical drug recommendations specifically designed for this purpose. …”
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Assembly of Genetically Engineered Ionizable Protein Nanocage-based Nanozymes for Intracellular Superoxide Scavenging by Qiqi Liu, Zhanxia Gao, Xiangyun Zhang, Qiannan Duan, Yue Zhang, Adam C. Midgley, Li Jiao, Ruming Liu, Mingsheng Zhu, Deling Kong, Jie Zhuang, Xinglu Huang

“…These genetically engineered ionizable protein nanocarriers provide opportunities for developing ionizable drug delivery systems.…”
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Pan-cancer and experimental analyses reveal the immunotherapeutic significance of CST2 and its association with stomach adenocarcinoma proliferation and metastasis by Dan Huang, Jing Li, Zhijun He, Wenjing Liang, Likun Zhong, Jun Huang, Yinteng Wu, Shijian Zhao

“…In stomach adenocarcinoma (STAD), CST2-related risk models are associated with prognosis and demonstrate strong predictive capabilities, while also being closely linked to the immune microenvironment. Drug sensitivity analysis indicates the correlation between CST2 and 21 chemotherapy drugs. …”
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Chinese stroke association guidelines on reperfusion therapy for acute ischaemic stroke 2024 by Liping Liu, Anding Xu, Xin Wang, Yongjun Wang, Yilong Wang, Zhongrong Miao, Yuming Xu, Benyan Luo, Bin Peng, Yong Huo, Qiang Dong, Zixiao Li, Xingquan Zhao, Caiyun Wang, Hongqiu Gu, Chunjuan Wang, Zhengqi Lu, Yunyun Xiong, Shuo Wang, Lihua Wang, Linong Ji, Xiaoping Gao, Wenzhi Wang, Yi Yang, Kai Wang, Junbo Ge, Xunming Ji, Jun Pu, Tong Zhang, Bo Hu, Ning Wang, Yun Xu, Jinsheng Zeng, Gang Zhao, Zhong Chen, Aoming Jin, Xiaoyuan Niu, Jiong Shi, Shuya Li, Jianmin Zhang, Ling Yin, Dou Li, Dehong Lu, Chao Qin, Dapeng Sun, Kaifu Ke, Yanhui Du, Xiaoning Zhang, Fudong Shi, Jianxin Zhou, Lan Chu, Li Guo Li He, Shengnian Zhou, Weixin Cai, Xiaomu Wu, Zhiyi He

“…Each recommendation was graded using the CSA’s class of recommendation and level of evidence in the Guideline Development Manual of the CSA.Results This guideline, reviewed and approved by the CSA Guidelines Writing Group, outlines the criteria for patient selection for thrombolysis and thrombectomy and summarises the latest evidence on various thrombolytic drug options to support decision-making in reperfusion therapy. …”
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Case report: PD-L1-targeted high-affinity natural killer cells and IL-15 superagonist N-803-based therapy extend overall survival of advanced metastatic pancreatic cancer patients by Tara Seery, Lennie Sender, Omid Jafari, Frank Jones, Patricia Spilman, Sandeep B. Reddy, Patrick Soon-Shiong

“…Induction of immunogenic cell death (ICD) by use of relatively low-dose chemo- or radiation therapy, enhancement of immune responses by the IL-15 superagonist N-803 (Anktiva®), and targeting of programmed death receptor ligand 1 (PD-L1)-expressing cells may offer a therapeutic approach to refractory mPC with the potential to increase overall survival (OS).MethodsFrom late 2019 to 2021, single-patient Investigational New Drug (spIND) protocols for five mPC patients were designed and approved that generally comprised combined Abraxane (nab-paclitaxel) and gemcitabine therapy with experimental therapeutics N-803, PD-L1-targeted high-affinity natural killer (PD-L1 t-haNK) cells, and aldoxorubicin, a serum albumin-binding doxorubicin prodrug. …”
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The management and clinical outcome of paracetamol poisoning in South African adults: A single-centre retrospective review by C Kotze, J Swanepoel, E C Kruger, E Decloedt

“…Paracetamol is a commonly prescribed drug, and often implicated in pharmaceutical overdoses. …”
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Tripterygium Glycosides Tablet Ameliorates Renal Tubulointerstitial Fibrosis via the Toll-Like Receptor 4/Nuclear Factor Kappa B Signaling Pathway in High-Fat Diet Fed and Streptoz... by Ze-jun Ma, Xiao-na Zhang, Li Li, Wei Yang, Shan-shan Wang, Xin Guo, Pei Sun, Li-ming Chen

“…Rats were randomly divided into normal control rats (NC group), diabetic rats without drug treatment (DM group), and diabetic rats treated with TGT (1, 3, or 6 mg/kg/day, respectively) for 8 weeks. …”
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Role of YAP/TAZ in bone diseases: A transductor from mechanics to biology by Xin Chen, Xing Ji, Zhaobai Lao, Bin Pan, Yu Qian, Wanlei Yang

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Human Factors Studies to Assess the Usability of the Faricimab Prefilled Syringe by Barakat MR, Kwong Jr HM, Marcon G, O'Leary OE, Paris LP, Schneider P, Tang Y, Graff JM

“…One patient experienced one mild adverse event of eye irritation that resolved the same day and was deemed unrelated to the study drug.Conclusion: Participants were able to safely and correctly prepare and administer a faricimab 6 mg dose using the PFS in accordance with the instructions for use, under realistic conditions representing the real world. …”
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