Combination of autoimmune hepatitis to non-alcoholic steatohepatitis (Clinical case) by A. A. Driga, M. V. Mayevskaya, V. T. Ivashkin

“…Presented clinical case shows a rare combination of high-activity asymptomatic autoimmune hepatitis of 1-st type of long duration with non-alcoholic steatohepatitis in a patient with morbid obesity. Drug effect was a trigger factor for clinical manifestation of disease. …”
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Compact Quantum Cascade Laser-Based Noninvasive Glucose Sensor Upgraded with Direct Comb Data-Mining by Liying Song, Zhiqiang Han, Hengyong Nie, Woon-Ming Lau

“…Mid-infrared spectral analysis has long been recognized as the most accurate noninvasive blood glucose measurement method, yet no practical compact mid-infrared blood glucose sensor has ever passed the accuracy benchmark set by the USA Food and Drug Administration (FDA): to substitute for the finger-pricking glucometers in the market, a new sensor must first show that 95% of their glucose measurements have errors below 15% of these glucometers. …”
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Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications by Colin D. Paul, Chris Yankaskas, Pradip Shahi Thakuri, Brittany Balhouse, Shyanne Salen, Amber Bullock, Sylvia Beam, Anthony Chatman, Sybelle Djikeng, Xiaoyu Jenny Yang, Garrett Wong, Isha Dey, Spencer Holmes, Abigail Dockey, Lindsay Bailey-Steinitz, Lina Zheng, Weizhong Li, Vivek Chandra, Jakhan Nguyen, Jason Sharp, Erik Willems, Mark Kennedy, Matthew R. Dallas, David Kuninger

“…We anticipate that the standardization and versatility of this approach will have important benefits for basic cancer research, drug discovery, and personalized medicine and help make tumoroid models more accessible to the cancer research community.…”
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Mortality and Its Predictors among Adult Human Immune-Deficiency Virus-Infected Patients Attending Their Antiretroviral Treatment at Health Centers, Addis Ababa, Ethiopia: Multicen... by Selam Tesfayohannes, Sisay Shine, Abinet Mekuria, Sisay Moges

“…Predictors of mortality were: age above 50 years (AHR = 4.90, 95% CI: 2.00, 11.98), tuberculosis comorbidity (AHR = 3.46, 95% CI: 1.23, 3.33), lack of drug adherence (AHR = 1.76, 95% CI: 1.23, 3.33), co-trimoxazole therapy (AHR = 2.59, 95% CI: 1.37, 4.90), and CD4 cell count less than 200/dl (AHR = 2.77, 95% CI: 1.30, 5.92). …”
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GP73-mediated secretion of PKM2 and GP73 promotes angiogenesis and M2-like macrophage polarization in hepatocellular carcinoma by Shujie Wang, Tongjia Zhang, Yue Zhou, Zitao Jiao, Kejia Lu, Xinyi Liu, Wei Jiang, Zhe Yang, Hui Li, Xiaowei Zhang

“…This study reveals the role of GP73 in enhancing PKM2 and GP73 secretion in promoting HCC progression, providing a theoretical basis and drug targets for HCC therapy.…”
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Integrated assessment of mucilage impact on human health using the One Health approach: Prevalence and antimicrobial resistance profiles of Escherichia coli and Clostridium perfrin... by Artun Yibar, Hilal Ay, Fuat Aydin, Secil Abay, Emre Karakaya, Tuba Kayman, Cem Dalyan, Fatih Dogan Koca, Duygu Aydogdu, Nihed Ajmi, Muhammed Duman, Izzet Burcin Saticioglu

“…The study identified 13 E. coli and one C. perfringens strain, harboring 244 and six AMR genes from 21 and eight drug classes, respectively, along with multiple virulence factors (VFs). …”
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Integrated multi-omics analysis reveals clinical significance of hepatocyte nuclear factor-1β in tumor immune microenvironment, immunotherapy and prognostic prediction for colon ad... by Fushan Gao, Wenlin Gong, Haihua He, Zhen Zhang, Hongcai Yang, Fei Shao, Yibo Gao, Jie He

“…CIBERSORT, TIME, and GSVA analyses revealed that HNF1B was associated with macrophage infiltration, immune checkpoints, and signaling pathways. Drug prediction suggested a negative relationship between HNF1B and EGFR-targeted therapies, implying potential resistance. …”
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Hepatobiliary organoid research: the progress and applications by Rui-Qi Zou, Rui-Qi Zou, Yu-Shi Dai, Yu-Shi Dai, Fei Liu, Fei Liu, Si-Qi Yang, Si-Qi Yang, Hai-Jie Hu, Hai-Jie Hu, Fu-Yu Li, Fu-Yu Li

“…We focus on applying hepatobiliary organoids in benign and malignant diseases of the liver and biliary tract, drug research, and regenerative medicine to provide valuable reference information for the application of hepatobiliary organoids. …”
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Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers by Junjun Li, Itsunari Minami, Leqian Yu, Kiyotaka Tsuji, Minako Nakajima, Jing Qiao, Masato Suzuki, Ken Shimono, Norio Nakatsuji, Hitetoshi Kotera, Li Liu, Yong Chen

“…Human induced pluripotent stem cell (hiPSC) derived cardiomyocytes (CMs) hold high potential for use in drug assessment and myocardial regeneration. To create tissue-like constructs of CMs for extracellular monitoring, we placed aligned fibers (AFs) on the surface of a microelectrode array and then seeded hiPSC-CMs for subsequent monitoring for 14 days. …”
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The Effects of Noncompliance to Prolia (Denosumab) on the Changes in Bone Mineral Density: A Retrospective Review by Matthew Wong-Pack, Aashish Kalani, Jacob Hordyk, George Ioannidis, Robert Bensen, William G. Bensen, Alexandra Papaioannou, Jonathan D. Adachi, Arthur N. Lau

“…The differences in LS and FN BMD have shown that the relationship between the timing of drug administration in these three groups and change in BMD over 1 year was not clinically or statistically significant (p>0.05). …”
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Ex vivo biotransformation of lady’s mantle extracts via the human gut microbiota: the formation of phenolic metabolites and their impact on human normal and colon cancer cell lines... by Katarzyna Jakimiuk, Aleksandra Kruk, Marta Kinga Lemieszek, Jakub W. Strawa, Sebastian Granica, Adrian Wiater, Michał Tomczyk

“…(Rosaceae) stands out as a promising herbal drug candidate due to its phytochemicals displaying anti-inflammatory and antioxidant properties.MethodsIn our study, we investigated the interaction between the human gut microbiota and lady’s mantle herb extract (AV) following the biotransformation of the extract’s constituents and their impact on colorectal cancer cells (HT-29) and normal CCD 841 CoN epithelial cells. …”
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Tacrolimus- and Mycophenolate-Mediated Toxicity: Clinical Considerations and Options in Management of Post-Transplant Patients by Alan D. Kaye, Shivam S. Shah, Coplen D. Johnson, Adalyn S. De Witt, Austin S. Thomassen, Charles P. Daniel, Shahab Ahmadzadeh, Sridhar Tirumala, Kristin Nicole Bembenick, Adam M. Kaye, Sahar Shekoohi

“…Despite their utility, the toxicity profiles of these drugs, including those of early immunosuppressants such as cyclosporine and azathioprine, necessitate further consideration of alternative immunosuppressants like sirolimus, everolimus, and belatacept. …”
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Examining the Role Played by Remand Homes Towards Curbing the Rate of Juvenile Delinquency in Kabale Municipality. by Ampurire, Evarine

“…The causes of juvenile delinquency in Southern Division Kabale Municipality included lack of parental guidance 13%, family breakages 06%, insecurity in families 10%, peer pressure 06%, drug abuse 09%, bad relationship with parents 10%, being orphaned 14%, poverty 12%, social media influence 07% and adolescence phase influence 13%. …”
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Factors Contributing to Retention in Care and Treatment Adherence Among People Living With HIV Returning to Care in South-Eastern Tanzania: A Qualitative Study by Matimbwa H, Lolo SA, Matoy LS, Ndaki R, Ngahyoma S, Mollel HA, Luoga E, Vanobberghen F, Vianney JM, Idindili B, Weisser M

“…Working obligations remain a challenge, that could be addressed by facilitated access to remote drug pickup.Keywords: attrition from care, retention in HIV care, treatment adherence, people living with HIV, South-Eastern Tanzania…”
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Transcriptome analysis of ovarian cancer uncovers association between tumor-related inflammation/immunity and patient outcome by Jingfang Wang, Wenrui Zhu, Xia Li, Yuanyuan Wu, Wenhui Ma, Yangzhou Wang, Weihong Zhao, Fang Wei, Wenhao Wang

“…Although more and more drugs have been approved, the therapeutic effect of PARPi is still very limited. …”
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34th Malaysian Association of Clinical Biochemists Annual Conference in collaboration with 2nd Malaysian Biomedical Science Association Symposium 2024 by Wan Amir Nizam Wan Ahmad, Seri Narti Edayu Sarchio, Nur Najmi Mohamad Anuar, Nor Fadilah Rajab, Suvik Assaw, Rhun Yian Koh, Chooi Ling Lim, Nur Aishah Sharudin, Norlida Harun, Nurulamin Abu Bakar, Mohd Arifin Kaderi

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Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation by Ai-Li Xu, Zheng Shen, Shi-Hao Wang, Hai-Yun Luan, Yong Xu, Ze-Chun Kang, Zi-Qi Liao, Jie Liu, Xiao-Lei Duan, Wei-Hua Bian, Hui Sun, Xin Xie

“…Doxorubicin (DOX) is a prevalent chemotherapeutic drug for treating several malignancies. However, the mechanisms of DOX induced cardiac toxicity is not fully understood. …”
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A Network Pharmacology-Based Approach for Exploring Key Active Compounds and Pharmacological Mechanisms of Tangshen Formula for Treatment of Diabetic Nephropathy by Weie Zhou, Xuefeng Zhou, Yuan Zhang, Yuyang Wang, Wenjie Wu, Haojun Zhang, Tingting Zhao, Liang Peng, Hailing Zhao, Ping Li

“…Furthermore, DN lacks effective drugs for treatment nowadays. Chinese herbal medicine (CHM) often shows the feature of multicomponents, multitargets, multipathways, and synergistic effects and shows a promising source of new therapeutic drugs for DN. …”
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Population Structure Based on Microsatellite Length Polymorphism, Antifungal Susceptibility Profile, and Enzymatic Activity of <i>Candida auris</i> Clinical Isolates in Russia by Ellina Oganesyan, Victoria Klimenteva, Irina Vybornova, Valentina Venchakova, Ekaterina Parshikova, Sergey Kovyrshin, Olga Orlova, Alexander Kruglov, Svetlana Gordeeva, Natalya Vasilyeva, Anastasiya Taraskina

“…This study aimed to investigate the genetic relationships, enzymatic activities, and drug-resistance profiles of <i>C. auris</i> isolates to evaluate the population and epidemiological diversity of candidiasis in Russia. …”
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Identification and Analysis of Key Immune- and Inflammation-Related Genes in Idiopathic Pulmonary Fibrosis by Tan Y, Qian B, Ma Q, Xiang K, Wang S

“…Based on these key genes, we carried out nomogram construction, enrichment and immune analyses, regulatory network mapping, drug prediction, and expression verification.Results: 27 DE-IFRGs were identified by intersecting 256 DEGs, 1793 immune-related genes, and 1019 inflammation-related genes. …”
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