Age of Insomnia Onset Correlates with a Reversal of Default Mode Network and Supplementary Motor Cortex Connectivity by Emiliano Santarnecchi, Chiara Del Bianco, Isabella Sicilia, Davide Momi, Giorgio Di Lorenzo, Salvatore Ferrone, Giulia Sprugnoli, Simone Rossi, Alessandro Rossi

“…We investigated changes of voxel-wise connectivity patterns in a sample of 17 drug-naïve PI patients and 17 age-gender matched healthy controls, as well as the relationship between brain connectivity and age of onset, illness duration, and severity. …”
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Inhibition of tumour necrosis factor alpha by Etanercept attenuates Shiga toxin-induced brain pathology by Robin Christ, Devon Siemes, Shuo Zhao, Lars Widera, Philippa Spangenberg, Julia Lill, Stephanie Thiebes, Jenny Bottek, Lars Borgards, Andreia G. Pinho, Nuno A. Silva, Susana Monteiro, Selina K. Jorch, Matthias Gunzer, Bente Siebels, Hannah Voss, Hartmut Schlüter, Olga Shevchuk, Jianxu Chen, Daniel R. Engel

“…Inhibition of TNF-α by the drug Etanercept strongly mitigated these changes, particularly within the complement pathway, suggesting TNF-α-dependent vasodilation and endothelial injury. …”
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Design of Bacterial Cultures in Fermented Functional Maize Product Formulation by Zuzana Matejčeková, Anna Mikulajová, Eva Vlková, Denisa Liptáková, Silvia Mošovská, Eva Hybenová, Ľubomír Valík

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Enhancing PDAC therapy: Decitabine-olaparib synergy targets KRAS-dependent tumors by Giorgia Anastasio, Michela Felaco, Alessia Lamolinara, Francesco del Pizzo, Elisa Cacciagrano, Carla Mottini, Margherita Mutarelli, Francesca Di Modugno, Manuela Iezzi, Luca Cardone

“…Previous research indicates that dKRAS-PDAC cells are sensitive to decitabine (DEC), an FDA-approved drug for hematological cancers, though its use in solid tumors is limited by side effects. …”
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The Prevalence and Risk Factors Associated with the Presence of Antibiotic Residues in Milk from Peri-Urban Dairy Cattle Farms in Kathmandu, Nepal by Erda E. Rame Hau, Minu Sharma, Bal K. Sharma Khanal, Peter D. Sly, Deirdre Mikkelsen, Nicholas Clark, Ricardo J. Soares Magalhães

“…While samples taken from farms where staff administered antibiotics were less likely to have single drug residues and multidrug residues (two, three, and four drugs), farms with more workers were more likely to have single residues. …”
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Genes related to neural tube defects and glioblastoma by Rui Cao, Yurong Liu, Kaixin Wei, Ning Jin, Yuxiang Liang, Ruifang Ao, Weiwei Pan, Xiang Wang, Xiuwei Wang, Li Zhang, Jun Xie

“…To obtain genes related to both NTDs and GBM, as well as small molecule drugs with potential clinical application value. …”
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Association between sleep during pregnancy and birth outcomes: a prospective cohort study by Libing Huang, Huanjun Chen, Fuhui Yao, Zhonghan Sun, Shijiao Yan, Yuwei Lai, Chuanzhu Lv, Xiong-Fei Pan, Rixing Wang, Xingyue Song

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Ginkgo biloba extract EGb761 mitigates ischemic stroke via metabolic pathway modulation by Xiaoyao Liu, Yuan Tian, Wenhui Xu, Yuxi Wang, Zhen Liu, Yuncheng Ma, Weiling Wang, Jian Gao, Ting Wang

“…Neurological deficit scores, infarct volume, cerebral edema rate, and inflammatory factors served as the primary metrics for drug efficacy. Serum metabolites were analyzed using 1H-nuclear magnetic resonance to elucidate the operative mechanism. …”
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Evaluation of the Psychiatric Disorders among Amphetamine Addicts in Rehabilitation Centers: A Cross-Sectional Analysis by Saud D. AlOtaibi, Hossam A. Elsisi, Mohammed J. AlShammary, Saud A. AlQader, Hejab A. AlHarbi, Bayan R. AlOlaiyan, Ahmad O. Alanazi, Firas S. AlMendeel, Yazeed N. AlHarbi, Ibrahim AlKhalaf, Ahmad H. Alhowail, Abdelhamid Mohamed Elwy, Ashraf M. Emara

“…Among the addicts, the mean severity dependence scale value was 10.46 (±1.82), which denotes high dependency on the illicit drug. The prevalence of high levels of anxiety, depression, and bipolar disorder was significantly higher among addicts when they were compared to healthy people (control). …”
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Knowledge, attitude and practice of community pharmacy personnel in tuberculosis patient detection: a multicentre cross-sectional study in a high-burden tuberculosis setting by Rovina Ruslami, Rizky Abdulah, Rob E Aarnoutse, Ivan Surya Pradipta, Khairunnisa Khairunnisa, Muh Akbar Bahar, Mersa Nurain Kausar, Efi Fitriana

“…Several factors significantly associated with performing the TBPD practice (p<0.05), such as TB training experience (p<0.001), provision of a drug consultation service (p<0.001), male gender (p<0.05), a positive attitude towards TBPD (p<0.001), short working hours (p<0.001) and central city location of the pharmacy (p<0.05).Conclusions Most participants had good knowledge and attitude, which did not translate into actual TBPD practice. …”
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Gambaran Pengetahuan Remaja Puteri Terhadap Nyeri Haid (Dismenore) dan Cara Penanggulangannya by Erlina Rustam

“…In Pharmacology female adolescents using traditional medicine is a betel leaf (67.00%). While choosing a drug is OJ-2 (40.00%). Side effects are felt sleepy (56.52%). …”
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Global prevalence of 4 neglected foodborne trematodes targeted for control by WHO: A scoping review to highlight the gaps. by Rachel Tidman, Kaushi S T Kanankege, Mathieu Bangert, Bernadette Abela-Ridder

“…Despite differing epidemiology, there were overlapping risk factors for all FBTs in all geographical areas, including proximity to rural and agricultural environments; consumption of raw contaminated food; and limited water, hygiene, and sanitation. Mass drug administration and increased awareness and health education were commonly reported preventive factors for all FBTs. …”
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Medication reconciliation: impact of an educational intervention on the knowledge, attitude and practices of healthcare professionals - a prospective quasi-experimental study in a... by Abubakar Siddique Mustafa Hussain, Siti Maisharah Sheikh Ghadzi, Syed Azhar Syed Sulaiman, Saud Mohammad Alsahali, Safiya Fatima Khan

“…The overall KAP scores showed a statistically significant enhancement after the education intervention with a mean score difference of 2.04 (SD = 4.76, p < 0.0001*).Our study upholds that MedRec is highly valued by the participants due to its significant role in reducing medication errors and enhancing patient safety, and that it has the ability to recognize medication discrepancies and reduce adverse drug events. Conclusion The education intervention effectively influenced the knowledge, attitude and practice of healthcare professionals regarding medication reconciliation. …”
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Oncolytic Viruses and Immunotherapy for the Treatment of Uveal Melanoma and Retinoblastoma: The Current Landscape and Novel Advances by Merve Kulbay, Nicolas Tuli, Massimo Mazza, Armaan Jaffer, Sarinee Juntipwong, Emily Marcotte, Stuti Misty Tanya, Anne Xuan-Lan Nguyen, Miguel N. Burnier, Hakan Demirci

“…The recent developments in virus-like drug conjugates (i.e., AU011), oncolytic viruses for metastatic UM, and targeted immunotherapies have shown great results in clinical trials for the future clinical application of these novel technologies in the treatment algorithm of certain intraocular tumors.…”
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Gambaran Angka Kejadian Gangguan Anxietas pada Warga Batu Busuk Kelurahan Padang Besi Kecamatan Lubuk Kilangan Kota Padang Akibat Banjir Bandang 24 Juli 2012 by Rigo Junaidi, Adnil Edwin Nurdin, Rosfita Rasyid

“…Anxiety due to psychological factors arising from emotional or psychological response to external threats are considered dangerous to themselves and physical factors could be the cause of anxiety such as illness and the drug using. The community survey shows about 2-5% of adults suffer from anxiety disorders, with a lifetime prevalence more than 25%. …”
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Seven Immune-Related Genes’ Prognostic Value and Correlation with Treatment Outcome in Head and Neck Squamous Cell Carcinoma by Rui Mu, Yuehong Shen, Chuanbin Guo, Xinyun Zhang, Hongyu Yang, Huijun Yang

“…Head and neck squamous cell carcinoma (HNSCC) is a growing concern worldwide, due to its poor prognosis, low responsiveness to treatment, and drug resistance. Since immunotherapy effectively improves HNSCC patients’ survival status, it is important to continuously explore new immune-related predictive factors to accurately predict the immune landscape and clinical outcomes of individuals suffering from HNSCC. …”
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Advances, challenges and future applications of liver organoids in experimental regenerative medicine by Da Gong, Jiaye Mo, Jiaye Mo, Mei Zhai, Fulin Zhou, Guocai Wang, Shaohua Ma, Xiaoyong Dai, Xiaoyong Dai, Xuesong Deng

“…The liver is a vital organ responsible for numerous metabolic processes in the human body, including the metabolism of drugs and nutrients. After liver damage, the organ can rapidly return to its original size if the causative factor is promptly eliminated. …”
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Tissue Distribution of Total Flavonoids Extracts of Drynariae Rhizoma in Young and Old Rats by UPLC–MS/MS Determination by Yue Zhang, Xia Lei, Hongdan Xu, Guoliang Liu, Yeqiu Wang, Huifeng Sun, Fang Geng, Ning Zhang

“…These results provide reliable data support for further study of the pharmacological mechanism of TFDR, formulation of drug delivery schemes, and development of new Chinese medicines in the treatment of AD.…”
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Exploratory analysis of potential toxic elements in Moroccan couscous and health risk evaluation utilizing ICP-OES by Othmane Hammani, Najlae El-Otmani, Omar Ben Lenda, Hamza El Azhari, Abderrazak Rfaki, Naima Lahlouhi, Youssef Mourad, Abdelaziz Abdallaoui

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Inequalities in physical comorbidity: a longitudinal comparative cohort study of people with severe mental illness in the UK by Tim Doran, Darren M Ashcroft, Evangelos Kontopantelis, David Reeves, Siobhan Reilly, Claire Planner, Ivan Olier, Linda Gask

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