Association of Side-Branch Treatment and Patient Factors in Left Anterior Descending Artery True Bifurcation Lesions: Analysis from the GRAND-DES Pooled Registry by Gyu Chul Oh, Kyung Woo Park, Jeehoon Kang, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon Kwon Koo, Hyo-Soo Kim

“…However, because of improvements with 2nd generation drug-eluting stents (DESs), it remains unknown whether treatment of the SB may improve outcomes in certain subgroups, especially when exclusively using 2nd generation DESs. …”
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Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities by Gouda Ahmed M., Abdelazeem Ahmed H., Abdalla Ashraf N., Ahmed Muhammad

“…New compounds showed promising drug-likeness scores while the docking study revealed high binding affinity to COX-2. …”
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hnRNPH1 Inhibits Influenza Virus Replication by Binding Viral RNA by Ruixue Xue, Danqi Bao, Tianxin Ma, Shiqi Niu, Zihua Wu, Xuehua Lv, Yunxiang Zhang, Guanlong Xu, Dawei Yan, Zhifei Zhang, Xue Pan, Minghao Yan, Qiaoyang Teng, Chunxiu Yuan, Zejun Li, Qinfang Liu

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Primary Prophylaxis to Prevent the Development of Hepatic Encephalopathy in Cirrhotic Patients with Acute Variceal Bleeding by Fátima Higuera-de-la-Tijera, Alfredo I. Servín-Caamaño, Francisco Salas-Gordillo, José L. Pérez-Hernández, Juan M. Abdo-Francis, Jaime Camacho-Aguilera, Sai N. Alla, Fiacro Jiménez-Ponce

“…There was no significant difference between the three groups receiving any antiammonium drug (P = 0.94). In the group receiving lactulose, 59.1% had diarrhea, and 45.5% had abdominal discomfort, bloating, and flatulence. …”
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Mechanism of triptolide regulating proliferation and apoptosis of hepatoma cells by inhibiting JAK/STAT pathway by Wang Guanglian, Zhu Zhenxin, Sun Zhengang, Yang Zhiqi

“…The control group did not receive any drug treatment, while the low, medium, and high-dose groups were treated with TPL at concentrations of 0.02, 0.05, and 0.10 μM, respectively. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide, flow cytometry, and western blot were used to detach the TPL effect and mechanism. …”
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Evaluation of the Knowledge, Attitudes and Practice of Veterinary Professionals and Senior Animal Health Students in Central Gondar Zone, Gondar, Ethiopia: Antimicrobial Use and Re... by Abibo Wondie Mekonen, Yesuneh Tefera Mekasha, Melaku Getahun Feleke, Atsede Getaneh, Meron Dereje, Misganew Bafe, Sete Nigussie, Achenef Melaku Beyene

“…The study found that 56% of the participants’ think the previous knowledge they acquired regarding AMU and AMR was not sufficient, and the internet was used as a source of drug information by the majority of participants. …”
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Phytocompounds from Indonesia Medicinal Herbs as Potential Apelin Receptor Agonist for Heart Failure Therapy: An In-silico Approach by Muhamad Rizqy Fadhillah, Wawaimuli Arozal, Muhammad Habiburrahman, Somasundaram Arumugam, Heri Wibowo, Suci Widya Primadhani, Aryo Tedjo, Surya Dwira, Nurul Gusti Khatimah

“…However, no clinically approved drugs target APR. Phytochemical compounds from Indonesian herbs have become readily available for discovering novel apelin agonists. …”
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Targeting Cutaneous Leishmaniasis with Thiadiazine Thione Derivatives: An In Vivo Study of Its Anti-Inflammatory, Anti-Pyretic, Anti-Nociceptive, and Anti-Sedative Properties by Sarah Sarwar, Nadia Sarwar, Haleema Ali, Rafiullah, Rasool Khan, Ajaz Ahmad, Amin Ullah, Ho Soonmin, Nazif Ullah

“…Furthermore, compounds C4, C2, and C1 showed high nociceptive activity, while C1 and C5 demonstrated the most notable antisedative effects (94 ± 2 and 92 ± 1, respectively), outperforming the standard drug diazepam (13 ± 1). <b>Conclusion:</b> These in vivo findings suggest that THTT derivatives have the potential to serve as a template for developing leishmanicidal drugs, with added anti-inflammatory and analgesic properties.…”
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HLA-DMB correlates with antitumor immunity and an improved prognosis in endometrial carcinoma tumors by Xiaoyu Xi, Xiaona Zhang, Jianxin Tang, Xiumei Fan, Jiexian Du

“…The protein interaction network of HLA-DMB was constructed using the STRING database, and the chemical drugs related to HLA-DMB were predicted through the CTD database. …”
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Familial Hypercholesterolemia: Genetics, Symptoms, Diagnosis and Treatment - A Literature Overview by Maciej Rutkiewicz, Sabina Przygodzka, Katarzyna Gadżała, Karolina Garbino, Katarzyna Brudniak, Antoni Szuścik, Magdalena Czyczerska

“…All individuals have statins implemented. In most cases, one drug isn't enough, so therapy containing ezetimib is common. …”
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Innovative MOF-enhanced electroanalytical approach for sensitive sunitinib malate detection in renal carcinoma patients using CuO/lanthanum MOF-modified carbon paste electrode by Azza H. Rageh, Mohamed I. Said, Asmaa Abdeltawab, Fatma A.M. Abdel-aal

“…Moreover, the proposed methodology via modification of CPE with the synthesized MOFs tailors them to be applied for clinical analysis and therapeutic drug monitoring of SUN, providing a valuable tool for personalized medicine and improving the treatment outcomes for renal cancer patients.…”
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Mortality-related risk factors of carbapenem-resistant Enterobacteriaceae infection with focus on antimicrobial regimens optimization: a real-world retrospective study in China by Sheng Deng, Jinglan Chen, Pengxiang Zhou, Qin Hu

“…All patients received definitive therapy and 65.0% (78/120) received sensitive drug treatment. Among those 65.4% (51/78) received combination therapy and 34.6% (27/78) received monotherapy. …”
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Identification of a New Pentafluorosulfanyl-Substituted Chalcone with Activity Against Hepatoma and Human Parasites by Alessandra Viperino, Michael Höpfner, Nicole Edel, Ibrahim S. Al Nasr, Waleed S. Koko, Tariq A. Khan, Imen Ben Abdelmalek, Rainer Schobert, Bernhard Biersack, Bianca Nitzsche

“…Background/Objectives: New drugs are required for the treatment of liver cancers and protozoal parasite infections. …”
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Safety profiles of sevoflurane in pediatric patients: a real-world pharmacovigilance assessment based on the FAERS database by Chuang Yang, Bangjian Deng, Qiang Wen, Pei Guo, Xiang Liu, Chen Wang

“…ObjectiveThis study aimed to evaluate the safety profile of sevoflurane in pediatric populations using real-world data.MethodsData were extracted from the Food and Drug Administration Adverse Event Reporting System (FAERS) from the first quarter of 2004 to the third quarter of 2024. …”
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Repurposing brucine as a chemopreventive agent in mammary gland carcinoma: Regulating lactate transport through MCT-4 by Asma Khatoon Zaidi, Anurag Kumar, Rohit Kumar, Jyoti Singh, Sneha Yadav, Archana Bharti Sonkar, Dharmendra Kumar, Neeraj Kumar Shrivastava, Mohd Nazam Ansari, Abdulaziz S. Saeedan, Gaurav Kaithwas

“…In the present study, we aim to identify a potential drug candidate that targets the Monocarboxylate Transporter-4 (MCT-4) protein. …”
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In vitro study on the inhibitory effect of various essential oils against murine coronavirus mouse hepatitis virus A-59 replication by Karelle Contant, Shiv Shankar, Monique Lacroix

“…Tanacetum annuum at 10000 µg/ml inhibited 5.03-log MHV-A59. Beyond 4-log, the drug can be qualified as an antiviral according to the guidelines of ICH. …”
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Prognostic significance of neutrophil extracellular trap-related genes in childhood acute lymphoblastic leukemia: insights from multi-omics and in vitro experiment by Cheng Chen, Yu Ma, Yadai Gao, Huiqing Ge, Xiaochun Zhang

“…Additional analyses included immune profiling, drug sensitivity, functional differences, cell-type-specific expression, enrichment analysis and RT-qPCR.Results A total of 1,270 DEGs were identified in GSE26713, of which 74 overlapped with NETRGs. …”
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Vasoreactive testing prevalence and characteristics in patients with idiopathic pulmonary arterial hypertension by Goncharova Natalia, Kirill Lapshin, Aelita Berezina, Irina Zlobina, Anton Ryzhkov, Zhaneta Matakaeva, Elizaveta Andreeva, Olga Moiseeva

“…INTRODUCTION: The choice of treatment strategy in patients with idiopathic pulmonary arterial hypertension (IPAH)/HPAH/DPAH (Hereditary pulmonary arterial hypertension/ Drug-induced pulmonary arterial hypertension) II-III functional class (FC) (WHO) based on an acute vasoreactive testing result (VRT). …”
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Solid Right Ventricular Compression by Intraventricular Septum-Hematoma Induced after Percutaneous Coronary Intervention by Ibrahim El-Battrawy, Ibrahim Akin, Benedikt Münz, David Manuel Leistner, Michael Behnes, Thomas Henzler, Holger Haubenreisser, Theano Papavassiliu, Martin Borggrefe, Ralf Lehmann

“…Despite successful PCI with drug eluting stent implantation into the right coronary artery (RCA) the patient complained about recurrent angina pectoris according to Canadian Cardiovascular Society (CCS) class IV. …”
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Consistent Condom Use and Associated Factors among HIV-Positive Clients on Antiretroviral Therapy in North West Ethiopian Health Center, 2016 GC by Mohammed Seid Ali, Eleni Tesfaye Tegegne, Mekibib Kassa Tesemma, Kaleab Tesfaye Tegegne

“…Inconsistent use of condom by People Living with Human Immune Deficiency Virus or Acquired Immune Deficiency Syndrome on Antiretroviral Therapy will lead to further worsening the Human Immune Deficiency Virus infection epidemic and reinfection with new drug resistant viral strains. Objective. To assess magnitude of consistent condom use and associated factors among HIV-positive clients on Antiretroviral Therapy in North West Ethiopian health center, 2016 GC. …”
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