Principles of effective out-patient diagnostics of diffuse liver diseases by Komova A. G., M. V. Mayevskaya, V. T. Ivashkin

“…Prevalence of diffuse liver diseases in the studied sample (n=4768) was following: non-alcoholic fatty liver disease —7,4% (n=352), alcohol-induced liver disease — 6,9% (n=329), hepatitis C — 6,7% (n=322), hepatitis B — 1,9% (n=91), drug-induced liver disease — 0,82% (n=39), cholestatic liver diseases — 0,69 % (n=33), autoimmune hepatitis — 0,78% (n=37), others — 5,4% (n=258). …”
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Effect of non-pharmacological interventions for overweight/obese women with polycystic ovary syndrome on ovulation and pregnancy outcomes: a protocol for a systematic review and ne... by Juan Li, Jie Yang, Fan-rong Liang, Jun Zhou, Gui-Xing Xu, Han Yang, Yan-qun Xiao, Jia-jia Liu, Zhi-yong Xiao, Xiao-yan Zheng, Li-ying Liu, Zheng Yu

“…STATA software V.15.0 and Aggregate Data Drug Information System V.1.16.8 will be used to conduct pairwise meta-analysis and NMA. …”
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Trifluridine/tipiracil regimen in combination with bevacizumab for metastatic colorectal cancer in the third line: an expert opinion by Carmine Pinto, Sara Lonardi, Evaristo Maiello, Erika Martinelli, Michele Prisciandaro, Lisa Salvatore, Lisa Salvatore, Andrea Sartore-Bianchi, Andrea Sartore-Bianchi, Mario Scartozzi, Giuseppe Aprile, Chiara Cremolini, Alberto Sobrero

“…Several therapeutic options are now available, although some differences across countries in drug approval and the optimal therapeutic sequencing associated with each peculiar patient subgroup represent a clinical challenge for oncologists. …”
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Characterisation of Chemical Constitutes and Spermatogenic Activity of Ushir (Vetiveria Zizanioides Linn) versus Ikshu (Saccharum Officinarum Linn) in Male Wistar Rats: A Research... by Akshay Sudhir Pargaonkar, Jaymala Jadhav, Bhagyashree Ratan Jibkate, Minakshi Urkude

“…The outcomes of animal research have helped consider the drug’s benefits and drawbacks. Need of the study: There is a need to evaluate this fact. …”
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The Role of Pentacyclic Triterpenoids in Non-Small Cell Lung Cancer: The Mechanisms of Action and Therapeutic Potential by Young-Shin Lee, Ryuk Jun Kwon, Hye Sun Lee, Jae Heun Chung, Yun Seong Kim, Han-Sol Jeong, Su-Jung Park, Seung Yeon Lee, Taehwa Kim, Seong Hoon Yoon

“…Furthermore, advances in drug delivery technologies such as nanocarriers and targeted delivery systems have improved the bioavailability and therapeutic efficacy of triterpenoids. …”
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Ultrastructural Analysis of Leishmania infantum chagasi Promastigotes Forms Treated In Vitro with Usnic Acid by João S. B. da Luz, Erwelly B. de Oliveira, Monica C. B. Martins, Nicácio H. da Silva, Luiz C. Alves, Fábio A. B. dos Santos, Luiz L. S. da Silva, Eliete C. Silva, Paloma L. de Medeiros

“…The aim of this study was to evaluate the antileishmanial activity of usnic acid on Leishmania infantum chagasi promastigotes and the occurrence of drug-induced ultrastructural damage in the parasite. …”
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A Meta-Analysis of Statin Use and Risk of Hepatocellular Carcinoma by Yikai Wang, Wenjun Wang, Muqi Wang, Juanjuan Shi, Xiaoli Jia, Shuangsuo Dang

“…Lipophilic statins can prevent hepatocellular carcinoma (odds ratio, 0.51, 95% CI: 0.46–0.57), while hydrophilic statins cannot (odds ratio, 0.77, 95% CI: 0.58–1.02). The single-drug analyses showed that simvastatin (odds ratio, 0.53, 95% CI: 0.48–0.59), atorvastatin (odds ratio, 0.54, 95% CI: 0.45–0.64), rosuvastatin (odds ratio, 0.55, 95% CI: 0.37–0.83), lovastatin (odds ratio, 0.30, 95% CI: 0.15–0.62), and pitavastatin (odds ratio, 0.36, 95% CI: 0.17–0.75) had significant benefits. …”
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A multidisciplinary collaborative care model involving family members in the treatment of type 2 diabetes mellitus and associated diabetes distress in young and middle-aged patient... by Wang Yan-Ping, Peng Lu-Yao, Yuan Xian-Ming, Chen Ting-Ting, Li Lin, Deng Kai-Qin

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Evaluation of the antidiarrheal activity of the 80% hydromethanolic crude extract and solvent fractions of Terminalia brownii Fresen (Combretaceae) leaves in Swiss Albino mice by Khalid Ibrahim Kassaw, Dawit Zewdu Wondafrash, Jibril Seid Yesuf, Mestayet Geta Mengistie

“…The effects of these extracts and solvent fractions on reducing/delaying diarrhea were compared with the impact of the solvent used for reconstitution and a standard drug (loperamide 3 mg/kg or atropine 5 mg/kg), as well as with each other.ResultsThe hydromethanolic crude extract and ethyl acetate fraction at all tested doses significantly reduced wet defecation (P < 0.05). …”
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Facilitation of Tumor Stroma-Targeted Therapy: Model Difficulty and Co-Culture Organoid Method by Qiu-Shi Feng, Xiao-Feng Shan, Vicky Yau, Zhi-Gang Cai, Shang Xie

“…PDTOs, derived from tumor tissues or cancer-specific stem cells, accurately mimic the tissue-specific and genetic features of primary tumors, making them valuable for drug screening. Co-culture models combining PDTOs with stromal elements effectively recreate the dynamic TME, showing promise in personalized anti-cancer therapy. …”
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Mechanism of action of Xipayimaizibizi oral liquid on outlet obstruction-induced overactive bladder: An integrated study by Menglu Wang, Yang Yang, Yuhang Du, Jiamei Xie, Yige Zhao, Yongcheng An, Ziyi Shan, Shenyujun Wang, Meng Hao, Baosheng Zhao

“…The rats underwent bladder outlet obstruction surgery and were administered the corresponding drug concentrations by gavage for 4 weeks. The study observed the body weight, water intake, bladder and kidney indices (to evaluate their general status), urination behavior pattern (to observe frequency and urgency), and urodynamics (to measure bladder parameters). …”
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Exogenous dsRNA triggers sequence-specific RNAi and fungal stress responses to control Magnaporthe oryzae in Brachypodium distachyon by Ying Zheng, Benjamin Moorlach, Desiree Jakobs-Schönwandt, Anant Patel, Chiara Pastacaldi, Stefan Jacob, Ana R. Sede, Manfred Heinlein, Minna M. Poranen, Karl-Heinz Kogel, Maria Ladera Carmona

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Carthamin yellow-loaded glycyrrhetinic acid liposomes alleviate interstitial fibrosis in diabetic nephropathy by Yifei Wang, Wenfang He, Peiyao Ren, Li Zhao, Danna Zheng, Juan Jin

“…The inhibitory effects were stronger than CY alone and were mediated by the inactivation of the TGFBR1/Smad2/Smad3 pathway, as confirmed by TGFBR1 overexpression studies.Conclusions CY-loaded GA liposomes demonstrated significant therapeutic efficacy in alleviating renal interstitial fibrosis in DN by targeting the TGFBR1/Smad2/Smad3 pathway. This novel drug delivery system provides a promising approach for the treatment of DN.…”
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MRTX1133 attenuates KRASG12D mutated-colorectal cancer progression through activating ferroptosis activity via METTL14/LINC02159/FOXC2 axis by Junwei Zou, Xiuhua Shi, Zhaoying Wu, Siyuan Zuo, Xiaolei Tang, Hailang Zhou, Yong Huang

“…Our study provides novel insights into the therapeutic potential of MRTX1133 in treating KRASG12D-mutated CRC by identifying a METTL14/LINC02159/FOXC2 signalling axis that mediates drug response. Our findings highlight the importance of understanding the molecular mechanisms of lncRNAs in cancer to develop effective targeted therapies.…”
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Preparation of curcumin submicron particles by supercritical antisolvent method with external adjustable annular gap nozzle by Yechen Wang, Zirui Li, Sun Fayu, Fei Li, Weiqiang Wang

“…Curcumin was used as a model drug, ethanol as the solvent, and supercritical carbon dioxide (SC-CO2) as the antisolvent. …”
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Rapid detection of carbapenem-resistant Escherichia coli and carbapenem-resistant Klebsiella pneumoniae in positive blood cultures via MALDI-TOF MS and tree-based machine learning... by Xiaobo Xu, Zhaofeng Wang, Erjie Lu, Tao Lin, Hengchao Du, Zhongfei Li, Jiahong Ma

“…Early identification of infectious agents and determination of drug-resistant phenotypes can help patients with BSI receive timely, effective, and targeted treatment and improve their survival. …”
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Identification of Immune-Related lncRNA Pairs and Construction and Validation of a New Prognostic Signature of Colon Cancer by Minxian Xu, Qing Li, Jianfang Zhang, Hui Xie

“…The expression of immune checkpoint-related genes and chemical drug sensitivity were related to different risk groups. …”
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Low-Intensity Transcranial Ultrasound Stimulation Inhibits Epileptic Seizures in Motor Cortex by Modulating Hippocampus Neural Activity by Na Pang, Qianqian Wang, Jiamin Pei, Hailin Zhang, Yi Yuan, Jiaqing Yan

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Bioinorganic Synthesis of Polyrhodanine Stabilized Fe3O4/Graphene Oxide in Microbial Supernatant Media for Anticancer and Antibacterial Applications by Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Ahmad Gholami, Navid Omidifar, Maryam Zarei, Sonia Bahrani, Khadije Yousefi, Wei-Hung Chiang, Aziz Babapoor

“…Consequently, based on the results, it can be concluded that this novel polyrhodanine-based nanocompound can act as drug carriers due to their low toxic effects and may open a new window on the antibacterial agents.…”
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Effects of early neonatal proinflammatory stress on the expression of BDNF transcripts in the brain regions of prepubertal male rats by D. I. Peregud, S. V. Freiman, A. O. Tishkina, L. S. Sokhranyaeva, N. A. Lazareva, M. V. Onufriev, M. Y. Stepanichev, N. V. Gulyaeva

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