Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation by Ren-Shi Shyu, Themmila Khamrang, Joen-Rong Sheu, Chih-Wei Hsia, Marappan Velusamy, Chih-Hsuan Hsia, Duen-Suey Chou, Chao-Chien Chang

“…Recently, we developed a novel Ir(III)-based compound, [Ir(Cp∗)1-(2-pyridyl)-3-(4-dimethylaminophenyl)imidazo[1,5-a]pyridine Cl]BF4 or Ir-6 and assessed its effectiveness as an antiplatelet drug. Ir-6 exhibited higher potency against human platelet aggregation stimulated by collagen. …”
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Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice by Takefumi Kimura, Takero Nakajima, Yuji Kamijo, Naoki Tanaka, Lixuan Wang, Atsushi Hara, Eiko Sugiyama, Eiji Tanaka, Frank J. Gonzalez, Toshifumi Aoyama

“…In this study, sulfatide levels and the expression of enzymes related to sulfatide metabolism were examined using wild-type (+/+), Ppara-heterozygous (+/−), and Ppara-null (−/−) mice given a control diet or one containing 0.1% fenofibrate, a clinically used hypolipidemic drug and PPARα activator. Fenofibrate treatment increased serum and hepatic sulfatides in Ppara (+/+) and (+/−) mice through a marked induction of hepatic cerebroside sulfotransferase (CST), a key enzyme in sulfatide synthesis, in a PPARα-dependent manner. …”
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DNA-encoded dynamic hydrogels for 3D bioprinted cartilage organoids by Ziyu Chen, Hao Zhang, Jingtao Huang, Weizong Weng, Zhen Geng, Mengmeng Li, Jiacan Su

“…Constructing high-fidelity cartilage organoids through three-dimensional (3D) bioprinting to replicate the structure and physiological functions of cartilage is crucial for regenerative medicine, drug screening, and disease modeling. However, commonly used matrix bioinks lack reversible cross-linking and precise controllability, hindering dynamic cellular regulation. …”
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Synthesis, Antimalarial Activity and Molecular Dynamics Studies of Pipecolisporin: A Novel Cyclic Hexapeptide with Potent Therapeutic Potential by Nety Kurniaty, Taufik Muhammad Fakih, Rani Maharani, Unang Supratman, Ace Tatang Hidayat, Nurhidanatasha Abu Bakar, Xiaoshuang Wei

“…Pipecolisporin represents a promising lead for future antimalarial drug development, with its efficacy, stability, and binding characteristics laying a solid foundation for ongoing research.…”
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The research progress on effective connectivity in adolescent depression based on resting-state fMRI by Xuan Deng, Jiajing Cui, Jinyuan Zhao, Jinji Bai, Junfeng Li, Kefeng Li

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Protective Effect of Rosa roxburghii Compound Plant Beverage on Acute Alcohol-induced Liver Injury in Mice by Zhengfang QI, Donghai LI, Yichun SUN, Xiaosheng YANG, Juan YANG, Rongrong ZHANG, Yu WANG, Xiong PAN, Chaoju ZHANG, Lilang LI

“…To study the protective effect of Rosa roxburghii Tratt compound plant beverage (RTCPB) against the acute alcoholic liver injury in mice, alcoholic liver injury models were established with 53% alcohol in male ICR mice using oral gavage. The drug was administered continuously for 21 days, the liver index, the content of triglyceride (TG), the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) contents were determined to evaluate the potential protective effect of RTCPB on acute alcohol-induced liver injury in mice. …”
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Dual anti-CTLA-4 and anti-PD-1 blockade in metastatic basal cell carcinoma by Sandip P. Patel, Eleanor Cano-Linson, Young Kwang Chae, Shiruyeh Schokrpur, Christopher D. Lao, Benjamin C. Powers, Adrienne I. Victor, Adedayo A. Onitilo, Sarah Shin, Naoko Takebe, Sara Threlkel, Christine M. McLeod, Helen X. Chen, Elad Sharon, Megan Othus, Christopher W. Ryan, Charles D. Blanke, Razelle Kurzrock

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Intravenous Oxycodone versus Intravenous Morphine in Cancer Pain: A Randomized, Open-Label, Parallel-Group, Active-Control Study by Kyung-Hee Lee, Jung-Hun Kang, Ho-Suk Oh, Moon-Ki Choi, Byoung-Yong Shim, Young-Jun Eum, Hye-Jeong Park, Jin-Hyong Kang

“…Patient satisfaction, adverse events, and adverse drug reactions were similar for both groups. Conclusions. …”
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Synthesis and kinetic evaluation of analogs of (E)-4-amino-3-methylbut-2-en-1-yl diphosphate, a potent inhibitor of the IspH metalloenzyme by Petit, Benoît Eric, Jobelius, Hannah, Bianchino, Gabriella Ines, Guérin, Mélina, Borel, Franck, Chaignon, Philippe, Seemann, Myriam

“…Our previous research revealed that (E)-4-amino-3-methylbut-2-en-1-yl diphosphate (AMBPP) is one of the best inhibitors of IspH, a [4Fe–4S]-dependent enzyme involved in the methylerythritol phosphate pathway that is a valuable target for the discovery of new antibacterial and antiparasitic drugs as it is absent in humans. AMBPP has substantial limitations for drug development due to its poor metabolic stability. …”
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Evaluation of mobile clinics by MSF in pastoralist community in Doolo Zone, Somali region, Ethiopia by Birhanu Sahelie, Luke Baertlein, Bashir AIi Dubad, Mohammed Osman, Nathan Post, Beverley Stringer, Turid Piening, Hanna Majanen, Istifanus Chindong Damulak, Elburg Van Boetzalaer, Anna Kuehne, Patrick Keating

“…However, MSF staff and community members expressed that its appropriateness and effectiveness are limited by mobile clinic opening hours, large patient volumes, referral policies, staffing, and drug supply issues. Conclusions Limited opening hours, large patient volumes, weak referral processes and supply issues impacted the appropriateness and effectiveness of healthcare provision by mobile clinics to this pastoralist population. …”
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AKR1D1*36 C>T (rs1872930) allelic variant is associated with variability of the CYP2C9 genotype predicted pharmacokinetics of ibuprofen enantiomers – a pilot study in healthy volun... by Kapedanovska Nestorovska Aleksandra, Jakjovski Krume, Naumovska Zorica, Sterjev Zoran, Geskovska Nadica Matevska, Mladenovska Kristina, Suturkova Ljubica, Dimovski Aleksandar

“…The role of AKR1D1*36C>T (rs 1872930) allelic variant in interindividual variability of CYP450 mediated drug metabolism was recently elucidated. A total of 27 healthy male subjects, volunteers in IBP single-dose two-way cross-over bioequivalence studies were genotyped for CYP2C9*2, CYP2C9*3 and AKR1D1*36 polymorphisms. …”
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Therapeutic potential of brentuximab vedotin in breast cancer and lymphoma via targeted apoptosis and gene regulation by Abeer Ezzat, Mohga Shafiek, Shimaa Shawki, Shaimaa Abdel-Ghany, Mahmoud Nazih, Hussein Sabit

“…Additionally, the study investigated the potential of repurposing this drug for new therapeutic reasons, beyond its original indications. …”
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2′-O-Methylperlatolic Acid Enhances Insulin-Regulated Blood Glucose-Lowering Effect through Insulin Receptor Signaling Pathway by Wang Yinghao, Guan Qiaoli, Liu Guanfu, Wu Xiaoyun, Wang Xuanjun, Sheng Jun

“…Insulin receptor (InsR) sensitizers represent a new type of therapeutic agent for the treatment of diabetes, with 2′-O-methylperlatolic acid (2-O-M) being a potential InsR targeting drug. The purpose of this study was to determine whether 2-O-M functions as an activator of the insulin signaling pathway, regulating glucose hemostasis through the InsR and exerting a glucose-lowering effect in an animal model of diabetes. …”
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Continuously relapsing (for two years) course of diarrheal variant of IBS (<i>Clinical case</i>) by Ye. A. Poluektova, S. Yu. Kuchumova, A. A. Kurbatova, A. A. Sheptulin, O. S. Shifrin, V. T. Ivashkin

“…Prescribed treatment included dioctaedric smectite, probiotic and antipsychotic drug, which had led to complete relief of all symptoms.Conclusion. …”
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Low-level auricular vagus nerve stimulation lowers blood pressure and heart rate in paroxysmal atrial fibrillation patients: a self-controlled study by Yu Jiang, Yu Jiang, Di Su, Jingwen Xiao, Jingwen Xiao, Wenbo Cheng, Yuemei Hou, Yan Zhang, Yan Zhang

“…ObjectiveTo investigate the effects of low-level auricular vagus nerve stimulation (LL-aVNS) on blood pressure and heart rate in patients with paroxysmal atrial fibrillation.MethodsA total of 22 patients with paroxysmal atrial fibrillation diagnosed in Fuzhou First General Hospital Affiliated with Fujian Medical University from September 2021 to December 2022 were selected and given LL-aVNS treatment based on the original unchanged drug treatment for 4 weeks. The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate maximum (HRmax), heart rate minimum (HRmin), left ventricular ejection fraction (LVEF), left atrial diameter (LAD), Atrial Fibrillation Severity Scale (AFSS) symptom subscale, and Memorial Symptom Assessment Scale-Heart Failure (MSAS-HF) before and after the treatment were observed and compared. …”
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Evaluation of the Synergistic Antimicrobial Activity of Essential Oils and Cecropin A Natural Peptide on Gram-Negative Bacteria by Filippo Fratini, Chiara Pecorini, Ilaria Resci, Emma Copelotti, Francesca Paola Nocera, Basma Najar, Simone Mancini

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Cardiovascular toxicity of tisagenlecleucel in children and adolescents: analysis of spontaneous reports submitted to FAERS by Ganggang Wang, Lin Su, Yanjun Liu, Xiaohan Yang, Yi Li, Qi Mei, Qi Mei, Wen Gao

“…However, further research is required to better define its safety profile.ObjectivesTo determine the cardiovascular toxicity of tisagenlecleucel in children and adolescents.MethodsThe US Food and Drug Administration’s Adverse Event Reporting System was searched to identify cardiovascular adverse events (CVAEs) related to tisagenlecleucel in pediatric patients up to the age of 18 years.ResultsThe median time to onset of tisagenlecleucel-associated CVAEs was shorter than that of tisagenlecleucel-associated non-CVAEs (3 days [interquartile range (IQR) 1, 6] vs. 7 days [IQR 2, 54]). …”
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Permeability-Enhancing and Protective Effect on Small Intestine of Punicic Acid in Different Forms and Their Nanoemulsions With Low Toxicity by Duan D, Xie H, Jiang J, Yang P, Guo Z, Guo X, Chen X, Yao Q

“…It provides a practical strategy to enhance the bioavailability of the drugs with poor biological membrane penetration. …”
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Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case report by Lulu Wang, Yahui Feng, Sisi Wang, Leyao Shi, Yong Ren, Zhiya Yang, Dongmei Shi

“…Photodynamic therapy (PDT) is a treatment that combines a photosensitive drug with light to induce phototoxic response in target cells, primarily through singlet oxygen.. …”
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Development and preclinical testing of a naloxone prodrug depot for extended protection against opioid overdose by Hala Aldawod, Arjun D. Patel, Rasha Emara, Dengpan Liang, Joshua S. Ho, Toufiq Ul Amin, Md Tariqul Haque Tuhin, Abdulmalek Balgoname, Avishan Kiani, Jumana M. Ajlouny, Melanie A. Felmlee, Miki S. Park, Bhaskara R. Jasti, William K. Chan, James A. Uchizono, Mamoun M. Alhamadsheh

“…This non-polymeric depot-forming approach is rare and employs carboxylesterase 2 for selective bioactivation, ensuring controlled drug release. In male rats and cynomolgus monkeys, a single subcutaneous dose provides steady naloxone release over several days, reducing blood-brain barrier diffusion, withdrawal symptoms, and CNS toxicity. …”
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