Anti-Neuroinflammatory Effects of Prenylated Indole Alkaloids from the Antarctic Fungus <i>Aspergillus</i> sp. Strain SF-7367 by Zhiming Liu, Chi-Su Yoon, Thao Quyen Cao, Hwan Lee, Il-Chan Kim, Joung Han Yim, Jae Hak Sohn, Dong-Sung Lee, Hyuncheol Oh

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Принципы использования рекомбинантных аденоассоциированных вирусов в исследованиях и терапии by Марченко С.А., Ланшаков Д.А.

“…Все больше фармацевтических компаний запускают клинические испытания с использованием AAV в качестве доставки гено- терапии. В 2023 г. Food and Drug Administration (FDA – Управление по контролю качества пищевых продуктов и лекарственных средств, США) был одобрен препарат Roctavian для лечения гемофилии A на основе AAV. …”
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Development of High Dietary Fiber Cereal Bar as Emergency Food Product and The Chemical-Microbiological Properties and Nutritional Content by Ani Radiati, Sumarto Sumarto, Fahmi Hafid, Emma Kamelia, Lia Nurcahyani, Dini Mariani, Siti Badriah, Tjahja Muhandri

“…Chemical analysis included dietary fiber, carbohydrates, protein, fat, minerals, and vitamins while the microbiological analysis covered total plate count (TPC) and detection of pathogenic bacteria such as Escherichia coli, Salmonella, and Staphylococcus aureus in accordance with food safety standards from the Indonesian Food and Drug Authority (BPOM). The testing was conducted from November 3–15, 2023, at PT Saraswanti Indo Genetech laboratory, Indonesia. …”
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Development and Optimization of Nano-Hydroxyapatite Encapsulating Tocotrienol-Rich Fraction Formulation Using Response Surface Methodology by Anis Syauqina Mohd Zaffarin, Shiow-Fern Ng, Min Hwei Ng, Haniza Hassan, Ekram Alias

“…Recently, the nano-hydroxyapatite (nHA) has been investigated as a drug delivery vehicle for various drugs and active compounds owing to its excellent biocompatibility, biodegradability, and osteogenic properties. …”
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Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults by Mohammed Lamorde, Pauline Byakika-Kibwika, William S. Tamale, Francis Kiweewa, Mairin Ryan, Alieu Amara, John Tjia, David Back, Saye Khoo, Marta Boffito, Cissy Kityo, Concepta Merry

“…Blood sampling was repeated seven days later with TDF/emtricitabine/efavirenz administered with food (19 g fat). Drug concentrations in plasma were determined by liquid chromatography and tandem mass spectrometry. …”
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Regulation of adipocyte differentiation and lipid metabolism by novel synthetic chromenes exploring anti-obesity and broader therapeutic potential by Kewalin Inthanon, Natthawut Wong-a-nan, Srisulak Dheeranupattana, Andres Garcia Guerra, Neal M. Davies, Chatchai Kesornpun, Sasithorn Sangher, Prasat Kittakoop

“…This study presents several promising prospects for the development of synthetic chromenes as potential anti-obesity agents, opening new avenues for drug discovery and benefitting individuals worldwide in addressing obesity-related challenges to human health. …”
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Protocols for the application of human embryonic stem cell-derived neurons for aging modeling and gene manipulation by Hui Zhang, Shuhui Sun, Juan Carlos Izpisua Belmonte, Guang-Hui Liu, Si Wang, Weiqi Zhang, Jing Qu

“…Our protocol enables investigations of the molecular mechanism underlying neuronal aging and facilitates drug evaluation.For complete details on the use and execution of this protocol, please refer to Zhang et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.…”
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Computational analysis of Allium sativum compounds to identify thermolabile hemolysin inhibitors against Vibrio alginolyticus in shrimp by Sayed Mashequl Bari, Nafees Bin Reza, Meamaching Marma, Sk. Foisal Ahmed, Md Arif Hussain, Md Naimuddin Jabed, Md Alomgir Hossain, Maria Manzoor, Md Saiful Alam

“…Pharmacokinetic and toxicity analyses showed favorable drug-like properties for gibberellin A7 and gibberellic acid with no violations. …”
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Synergistic action between a synthetic cannabinoid compound and tramadol in neuropathic pain rats by Quiñonez-Bastidas Geovanna Nallely, Osuna-Martínez Ulises, Reda-Licea Ana Laura, López-Ortíz Manuel, Regla Ignacio, Navarrete Andrés

“…Furthermore, the effective dose 35 (as the 35 % of the anti allodynic effect) was calculated from the maximum effect of each drug. Moreover, the isobolographic analysis was performed to determine the type of interaction between the drugs. …”
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Assessing the Risk Factors of Violent and Non-violent Suicide Attempt Methods: A Population-based Cross-sectional Study by Amin Moradi, Ehsan Mosafarkhani, Fateme Nikbakht, Zahra Amiri, Ali Vafaee Najar

“…Predictive variables for suicide attempts included age, sex, education, marital status, occupation, place of residence, drug abuse, smoking, psychiatric diagnoses, and the intended outcome of violent and non-violent methods. …”
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Pretreatment With Fragments of Substance-P or With Cholecystokinin Differentially Affects Recovery From Sub-Total Nigrostriatal 6-Hydroxydopamine Lesion by S. Nikolaus, J. P. Huston, R. K. W. Schwarting

“…In accordance with our previous work, drug treatment effects were observed when excluding animals with most severe dopamine lesions: In animals with partial lesions (residual neostriatal dopamine levels of more than 10%), lesion-dependent asymmetries in turning behavior were observed in animals that were pre-treated with vehicle-, substance P1−7 , or Boc-cholecysto-kinin–4,. whereas turning after pre-treatment with substance P5−11 was not significantly asymmetrical. …”
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Simultaneous Determination of Night Effective Constituents and Correlation Analysis of Multiconstituents and Antiplatelet Aggregation Bioactivity In Vitro in Chuanxiong Rhizoma Sub... by Peihua Zhang, Linming Chen, Xiaoxiao Wang, Jinpei Chen, Shungui Xu, Ling Ye, Yixin Yao

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Applying implementation science frameworks to understand why fisherfolk continue or discontinue pre-exposure prophylaxis for HIV prevention in Uganda: a qualitative analysis by Simon Mwima, Rhoda Kitti Wanyenze, Rose Naigino, Laura M Bogart, William Musoke, Semei C Mukama, Stella Allupo, Herbert Kadama, Barbara Mukasa

“…In the outer setting, high HIV prevalence motivated PrEP initiation, but stigma, particularly the misconception that PrEP is an antiretroviral drug used by people living with HIV, led to discontinuation.Conclusion Fisherfolk in Uganda encounter multiple barriers to PrEP continuation, with women facing more significant challenges. …”
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Assessment of different genotyping markers and algorithms for distinguishing Plasmodium falciparum recrudescence from reinfection in Uganda by Alex Mwesigwa, Monica Golumbeanu, Sam Jones, Sara L. Cantoreggi, Benson Musinguzi, Joaniter I. Nankabirwa, Everd Maniple Bikaitwoha, Joan N Kalyango, Charles Karamagi, Mateusz Plucinski, Samuel L. Nsobya, Christian Nsanzabana, Pauline Byakika-Kibwika

“…Abstract Antimalarial therapeutic efficacy studies are vital for monitoring drug efficacy in malaria-endemic regions. The WHO recommends genotyping polymorphic markers including msp-1, msp-2, and glurp for distinguishing recrudescences from reinfections. …”
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Gut Microbiome Modulation in Hepatocellular Carcinoma: Preventive Role in NAFLD/NASH Progression and Potential Applications in Immunotherapy-Based Strategies by Elisa Monti, Clara Vianello, Ilaria Leoni, Giuseppe Galvani, Annalisa Lippolis, Federica D’Amico, Sara Roggiani, Claudio Stefanelli, Silvia Turroni, Francesca Fornari

“…., probiotic supplementations or anti-hypercholesterolemic drug treatment), and ultimately delay NAFLD progression to HCC. …”
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Economic impact of medication non-adherence by disease groups: a systematic review by Victoria Garcia-Cardenas, Rachelle Louise Cutler, Fernando Fernandez-Llimos, Michael Frommer, Charlie Benrimoj

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EMA/CO Combination Chemotheraphy in Gestational Trophoblastic Neoplasia: Update of Our Results by Tolga Taşçı, Işın Üreyen, Günsu Kimyon, Alper Karalök, Sevgi Koç, M. Faruk Köse, Gökhan Tulunay, Taner Turan

“…Resistance to the EMA-CO treatment developed in 6 (15.3%) patients and 3 of the patients with drug resistance died. During the follow-up time disease recurred in 3 (7.7%) patients. …”
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In vitro and molecular docking evaluation of black sesame seeds' anti-prostate cancer and antioxidant activity processed by nine steaming nine drying by Glennielyn D. Magdamit, Cheng-Yang Hsieh, Mon-Juan Lee, Kathlia A. De Castro-Cruz, Samantha Franchette B. Austria, Beatrice D. Sipat, Steven Kuan-Hua Huang, Po-Wei Tsai

“…Additionally, molecular docking analyses revealed compelling interactions between sesamin and sesamolin and key proteins implicated in prostate cancer (FYN, ITGB3, PDGFRA, PDGFRB, and PIK3R1), demonstrating higher LibDock scores than the standard anti-cancer drug 5-fluorouracil. This research highlights the exceptional antioxidant and anti-cancer potential of black sesame seeds, particularly through the three-steaming and three-drying method, emphasizing the importance of the sesamin to sesamolin ratio in developing future anti-cancer therapeutics.…”
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Using verbal and social autopsy approaches to understand why neonates die in rural settings: a case study of a remote rural district in Uganda by Peter Waiswa, Rornald Muhumuza Kananura, Dinah Amongin, Joseph Akuze, Jacquellyn Nambi Ssanyu, Felix Kizito

“…Qualitative insights underscored inadequate awareness of neonatal danger signs, deficient referral systems, drug shortages, reliance on unskilled traditional birth attendants and insufficient neonatal care facilities as significant contributors.Conclusion Addressing delays in both home-based care (delay 1) and timely access to appropriate care in healthcare facilities (delays 2 and 3) is pivotal in mitigating neonatal mortality. …”
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Protocol of a parallel group Randomized Control Trial (RCT) for Mobile-assisted Medication Adherence Support (Ma-MAS) intervention among Tuberculosis patients. by Zekariyas Sahile, Lua Perimal-Lewis, Paul Arbon, Anthony John Maeder

“…Urine test for the presence of isoniazid (INH) drug metabolites in urine will be undertaken at the random point at the fourth and eighth weeks of intervention to measure medication adherence. …”
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