Repurposing Drugs for Synergistic Combination Therapies to Counteract Monkeypox Virus Tecovirimat Resistance by Haydar Witwit, Beatrice Cubitt, Roaa Khafaji, Esteban M. Castro, Miguel Goicoechea, Maria M. Lorenzo, Rafael Blasco, Luis Martinez-Sobrido, Juan C. de la Torre

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Identification of Mycobacterium tuberculosis and its Drug Resistance by Targeted Nanopore Sequencing Technology by Chen Tang, Feng Xu, Xiaoqun Zheng, Guangxin Xiang

“…Tuberculosis (TB) remains the leading cause of human mortality in infectious diseases. Drug-resistant TB, particularly multidrug-resistant TB and extensively drug-resistant TB, poses a pressing clinical and public health challenge. …”
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Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach by Siti Junaidah Ahmad, Mohd Badrin Hanizam Abdul Rahim, Syarul Nataqain Baharum, Mohd Shukri Baba, Noraziah Mohamad Zin

“…Metabolomics approach in malaria drug discovery is still new and needs to be initiated, especially for drug research in Malaysia.…”
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Repurposing Drugs in Controlling Recurrent Platinum-Resistant Clear-Cell Ovarian Cancer by Woraporn Sinsuwan, Phawit Norchai

“…Repurposed conventional drugs have recently been found to offer the ability to control cancer with few side effects and at a reasonable cost to healthcare organizations. …”
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Bridging the gap: From petri dish to patient - Advancements in translational drug discovery by Mohamed El-Tanani, Syed Arman Rabbani, Yahia El-Tanani, Ismail I. Matalka, Ikramy A. Khalil

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Local Drug Delivery Systems for Vital Pulp Therapy: A New Hope by Ardavan Parhizkar, Saeed Asgary

“…It can be assumed that if the employed biomaterial is transferred to the target site using a specially designed micro-/nanosized local drug delivery system (LDDS), the biomaterial would be placed in closer proximity to the connective tissue, may be released in a controlled and sustained pattern, could properly conserve the remaining dental pulp and might appropriately enhance hard-tissue formation. …”
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Editorial: Revealing the unconventional mechanisms of mitochondria-targeting drugs in heart-related diseases by Kaidi Ren, Yang Yang

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Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery by Fanda Meng, Xinyu Qiao, Chenglong Xin, Xiaoli Ju, Meilin He

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Side Effects of Steroidal And Non-Steroidal Anti-Inflammatory Drugs on The Oral Cavity. by Shayma Ghazi, Khalid Yasin Rasul, Aras Khidhir Hamad, Aso Abdulkhaliq Khidhir, Lozan Khalil Ahmed

“… Background and objectives: The steroidal and Non-Steroidal Anti-Inflammatory drugs (NSAIDs) are widely used classes of medications for their anti-Inflammatory and analgesic effects and are associated with the risk of many oral side effects and which might be presented with variable degrees of severity. …”
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Analgesia Evaluation of 2 NSAID Drugs as Adjuvant in Management of Chronic Temporomandibular Disorders by Fernando Kurita Varoli, Murillo Sucena Pita, Sandra Sato, João Paulo Mardegan Issa, Cássio do Nascimento, Vinícius Pedrazzi

“…The aim of this triple-blind full-randomized clinical trial was to quantify analgesia in masticatory muscles and temporomandibular joints after occlusal splint therapy associated with the adjuvant administration of nonsteroidal anti-inflammatory drugs (NSAID) isolated or associated with other therapeutic agents. …”
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Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release by Abdullah M. Alswieleh

“…Such materials allow control of the drug release from MSN pores. Multifunctional MSNs were loaded with doxycycline (Doxy) to study their capacities and uploading time. …”
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Mining the Information for Structure Based Drug Designing by Relational Database Management Notion by R. Balajee, M. S. Dhanarajan

“…Structure based drug design is a technique that is used in the initial stages of a drug discovery program. …”
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Limiting the development of anti-cancer drug resistance in a spatial model of micrometastases by Ami B. Shah, Katarzyna A. Rejniak, Jana L. Gevertz

“…While chemoresistance in primary tumors is well-studied, much less is known about the influence of systemic chemotherapy on the development of drug resistance at metastatic sites. In this work, we use a hybrid spatial model of tumor response to a DNA damaging drug to study how the development of chemoresistance in micrometastases depends on the drug dosing schedule. …”
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Research on detection methods of related substances and degradation products of the antitumor drug selpercatinib by Jingjing Xiang, Liangliang Cai, Qin Wang, Yonghong Zhu, Yong Han

“…It efficiently separated the impurities present in selpercatinib, thereby confirming the method’s efficacy in ensuring the purity and quality of the drug.ConclusionThe chromatographic method established in this study can be used for the detection of selpercatinib and its impurities, providing significant reference value for the quality research of selpercatinib bulk drug and its preparations, and ensuring the safety of medication for patients.…”
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Spectrophotometric Determination of Antidepressant Drug Duloxetine in Pharmaceutical Preparations using π-Acceptors by Sidika Ertürk Toker, Armagan Önal

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Leveraging AI to automate detection and quantification of extrachromosomal DNA to decode drug responses by Kohen Goble, Aarav Mehta, Damien Guilbaud, Jacob Fessler, Jingting Chen, William Nenad, William Nenad, Christina G. Ford, Oliver Cope, Darby Cheng, William Dennis, Nithya Gurumurthy, Yue Wang, Kriti Shukla, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk, Elizabeth Brunk

“…IntroductionTraditional drug discovery efforts primarily target rapid, reversible protein-mediated adaptations to counteract cancer cell resistance. …”
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Formulation and Evaluation of Galantamine Gel as Drug Reservoir in Transdermal Patch Delivery System by Woo Fong Yen, Mahiran Basri, Mansor Ahmad, Maznah Ismail

“…The in vitro drug release studies revealed that the drug release from the donor chamber to receptor chamber of Franz diffusion cell was affected by the amount of polymer, amount of neutralizer, amount of drug, types of permeation enhancer, and amount of permeation enhancer. …”
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Improving drug repositioning with negative data labeling using large language models by Milan Picard, Mickael Leclercq, Antoine Bodein, Marie Pier Scott-Boyer, Olivier Perin, Arnaud Droit

Subjects: “…AI-driven drug discovery…”
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Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets by Asrar Alam

“…Malaria is a major global parasitic disease and a cause of enormous mortality and morbidity. Widespread drug resistance against currently available antimalarials warrants the identification of novel drug targets and development of new drugs. …”
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Novel design of drug delivery in stented arteries:A numerical comparative study by Mario Grassi, Giuseppe Pontrelli, Luciano Teresi, Gabriele Grassi, Lorenzo Comel, Alessio Ferluga, Luigi Galasso

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