Suppression of Proinflammatory Cytokines and Mediators in LPS-Induced RAW 264.7 Macrophages by Stem Extract of Alternanthera sessilis via the Inhibition of the NF-κB Pathway by Katyakyini Muniandy, Sivapragasam Gothai, Khaleel M. H. Badran, S. Suresh Kumar, Norhaizan Mohd Esa, Palanisamy Arulselvan

“…Alternanthera sessilis, an edible succulent herb, has been widely used as herbal drug in many regions around the globe. Inflammation is a natural process of the innate immune system, accompanied with the increase in the level of proinflammatory mediators, for example, nitric oxide (NO) and prostaglandin (PGE2); cytokines such as interleukin 6 (IL-6), interleukin 1β (IL-1β), and tumor necrosis factor alpha (TNFα); and enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) via the activation and nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit p65 due to the phosphorylation of inhibitory protein, IκBα. …”
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Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020 by Yanqing Liu, Jie Chen, Xiang Li, Yu Fan, Cheng Peng, Xiaochun Ye, Yingshuang Wang, Xin Xie

“…Strategies such as combination therapy, structural optimization, and drug delivery systems are anticipated to enhance efficacy and overcome these challenges.…”
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Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents by Lili Wen, Yang Huang, Xianbiao Xie, Wan Huang, Junqiang Yin, Wenqian Lin, Qiang Jia, Weian Zeng

“…Taken together, bufalin treatment resulted in in vivo anti-inflammatory and analgesic effects, and bufalin may be a novel, potential drug for the treatment of inflammatory diseases.…”
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Clinical Features, Treatment, and Outcome of HIV-Associated Immune Thrombocytopenia in the HAART Era by Kimberley L. S. Ambler, Linda M. Vickars, Chantal S. Leger, Lynda M. Foltz, Julio S. G. Montaner, Marianne Harris, Viviane Dias Lima, Heather A. Leitch

“…Platelet response was not significantly associated with treatment received, but complete response was lower in patients with a history of injection drug use. Complications of ITP treatment occurred in two patients and there were four unrelated deaths. …”
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Virological and Immunological Aspects of AIDS Pathogenesis by Brian Conway, Francisco J Diaz-Mitoma

“…To date. a number of studies has suggested an association between drug resistance and clinical deterioration. However. a precise causal relationship has yet to be demonstrated. …”
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Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax by Caroline A. Coughlin, Dhanvantri Chahar, Marianna Lekakis, Abdessamad A. Youssfi, Lingxiao Li, Evan Roberts, Natalia Campos Gallego, Claude-Henry Volmar, Ola Landgren, Shaun Brothers, Anthony J. Griswold, Catalina Amador, Daniel Bilbao, Francesco Maura, Jonathan H. Schatz

“…We show mutant BCL10-driven DLBCL is resistant to multiple additional drug classes, demonstrating urgency to derive mechanistically rooted strategies to overcome undruggable BCL10 mutants that stabilize BTK-independent signaling filaments upstream of NF-kB activation. …”
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Surgery and Medical Treatment in Microprolactinoma: A Systematic Review and Meta-Analysis by Jianglong Lu, Lin Cai, Zerui Wu, Weiwei Lin, Jiadong Xu, Zhangzhang Zhu, Chengde Wang, Qun Li, Zhipeng Su

“…Dopamine agonists (DAs) are recommended as the first-line treatment for prolactinomas; however, tumour recurrence after drug withdrawal remains a clinical problem. Recent studies have reported high remission rates via surgery in microprolactinomas. …”
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Stage-specific function of sphingolipid synthases in African trypanosomes by Norton Heise, Carolina M. Koeller, Mohamed Sharif, James D. Bangs

“…TbSLSs are indispensable for the viability of BSF and are, thus, potential drug targets. The relative stage-specific expression of each TbSLS paralog was compared, and the results match phosphosphingolipid content. …”
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Effects of orally administered clioquinol on the fecal microbiome of horses by Mikaila Z. Smith, Mary York, Kile S. Townsend, Lynn M. Martin, Tamara Gull, Lyndon M. Coghill, Aaron C. Ericsson, Philip J. Johnson

“…Main Limitations Limitations including lack of control group and modest sample size are obviated by robust longitudinal study design and strong effect size associated with drug exposure. Conclusions Clioquinol has broad‐spectrum antibacterial effects on the fecal microbiome of horses, but spares certain bacterial families including several pathogens and pathobionts. …”
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Endovascular Treatment and Outcomes for Femoropopliteal In-Stent Restenosis: Insights from the XLPAD Registry by Michael H. Vu, Glaiza-Mae Sande-Docor, Yulun Liu, Shirling Tsai, Mitul Patel, Chris Metzger, Mehdi H. Shishehbor, Emmanouil S. Brilakis, Nicolas W. Shammas, Peter Monteleone, Subhash Banerjee

“…Atherectomy (63.5% vs. 45.0%, p<0.001) and drug-coated balloons (DCB; 4.7% vs. 1.7%, p<0.001) were more frequently used in ISR lesions. …”
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Pediatric Non-Alcoholic Fatty Liver Disease (NAFLD): Trends, Mortality, and Socioeconomic Disparities in the U.S., 1998–2020 by Paul Wasuwanich, Joshua M. So, Mustafa Sadek, Chaowapong Jarasvaraparn, Songyos Rajborirug, Ruben E. Quiros-Tejeira, Wikrom Karnsakul

“…Sex, race/ethnicity, hepatitis B, hepatitis C, HIV, and IV drug use were not significantly associated with mortality. …”
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The Effect of Zinc Supplementation on Glycemic, Weight, and Blood Pressure Control in Patients With Type 2 Diabetes Mellitus: A Double‐Blind Randomized Controlled Trial by Mehrab Sayadi, Sara Javadpour Nowbandegani, Fatemeh Balaghi Inalou, Bahman Nazemzadegan, Shirzad Javidi Alsaadi, Mohammadreza Eskandari, Matin Sepehrinia

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Community Malaria Knowledge, Experiences, Perceived Roles, and Acceptability of Community-Directed Distribution of Intermittent Preventive Therapy for Pregnancy in Rural Southeast... by Ijeoma Nkem Okedo-Alex, Ifeyinwa Chizoba Akamike, Johnbosco Ifunanya Nwafor, Chihurumnanya Alo, Adaoha Pearl Agu, Dejene Derseh Abateneh, Chigozie Jesse Uneke

“…Only 18.4% of the participants rated their knowledge of IPTp as adequate, and only 9.3% knew the common drug names used for IPTp. The major perceived roles in malaria prevention in pregnancy were referral of pregnant women to the health facility, encouragement of household ITN use, and sustaining malaria-related projects. …”
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A Case of Nasopharyngeal Mycobacteriosis with Bony Erosion of the External Skull Base by Kohei Matsuo, Satoshi Tanaka, Masayuki Sakata, Hiroki Takeda, Akihiro Nagata, Masashi Mori, Rie Ito, Yoshifumi Yamamoto, Kiyonobu Ueno, Atsuhiko Uno

“…Surgical intervention should also be considered for drug-resistant mycobacteriosis. We concluded that mycobacteriosis should also be considered apart from carcinoma even if CT shows a diffuse enhancing mucosal irregularity with bone destruction in the nasopharynx.…”
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Antibody Responses and the Vaccine Efficacy of Recombinant Glycosyltransferase and Nicastrin Against <i>Schistosoma japonicum</i> by Bowen Dong, Haoran Zhong, Danlin Zhu, Luobin Wu, Jinming Wang, Hao Li, Yamei Jin

“…While praziquantel remains the primary treatment, concerns about drug resistance highlight the urgent need for new drugs and effective vaccines to achieve sustainable control. …”
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Fitness costs of Mycobacterium tuberculosis resistant to rifampicin is compensated by rapid Th2 polarization mediated by early and high IL-4 production during mice infection by Ma. Fernanda Arce-Aceves, Roberto Espinosa-Neira, Dulce A. Mata-Espinosa, Jorge A. Barrios-Payan, Hugo G. Castelán-Sánchez, Sofía L. Alcaraz-Estrada, Mauricio Castañón-Arreola, Rogelio Hernández-Pando

“…Abstract It was a general belief that drug resistance in Mycobacterium tuberculosis (Mtb) was associated with lesser virulence, particularly rifampicin resistance, which is usually produced by mutations in the RNA polymerase Beta subunit (RpoB). …”
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Effect of partial oocyte maturation before ovum pick up on developmental competence of buffalo oocytes by Amjad Riaz, Muhammad K. Ashraf, Talha Ashraf, Ali Husnain, Muhammad Yaseen, Muhammad H. Mushtaq, Burhan E. Azam

“…On the last PGF2α, dominant follicle ablation and supplementation of progesterone by inserting intra- vaginal controlled internal drug release was performed to synchronize the follicle wave emergence and considered as Day 0 of the experiment. …”
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Network-wide effects of pallidal deep brain stimulation normalised abnormal cerebellar cortical activity in the dystonic animal model by Fabiana Santana Kragelund, Konstantinos Spiliotis, Marco Heerdegen, Tina Sellmann, Henning Bathel, Anika Lüttig, Angelika Richter, Jens Starke, Rüdiger Köhling, Denise Franz

“…Background: Deep brain stimulation (DBS) targeting globus pallidus internus (GPi) is a recognised therapy for drug-refractory dystonia. However, the mechanisms underlying this effect are not fully understood. …”
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Cardiovascular disease and its risk factors among people living with HIV: A systematic review and meta-analysis by Min Du, Shimo Zhang, Min Liu, Jue Liu

“…There is an urgent need for more high-quality research to better understand the effects of HIV progression and drug use.…”
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Final Analysis of Post‐Marketing Surveillance for Avelumab + Axitinib in Patients With Renal Cell Carcinoma in Japan by Norio Nonomura, Taito Ito, Masashi Sato, Makiko Morita, Mie Ogi, Masahiro Kajita, Mototsugu Oya

“…The primary objective was to evaluate safety, defined as adverse drug reactions (ADRs) of safety specifications occurring during an observation period of ≤ 52 weeks for each patient. …”
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