aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed... by Yi Tang, Qingling Shen, Peng Lin, Zhixin Chen, Denghui Fan, Minling Zhuo, Yajiao Gan, Yixi Su, Qingfu Qian, Liwu Lin, Ensheng Xue, Zhikui Chen

“…The unique PDAC tumor microenvironment (TME) is characterized by significant fibrous tissue growth, and high interstitial pressure hinders drug penetration into tumors. Additionally, hypoxia and immune suppression within the tumor contribute to poor responses to radiotherapy and chemotherapy, ultimately leading to an unfavorable prognosis. …”
Get full text

Acute oral toxicity study of novel polyherbal formulations by using wistar rats and Swiss albino mice as per OECD 425 TG by Ramkishan Jatoth, S.P Dhanabal, V. Senthil, T. Ganesh, Jubie Selvaraj, P.S. Venkatesan

“…Background: Hydaljss08 is a new semisolid fermented hydroalcoholic polyherbal formulation containing crude drug substances. Immunoboost Tab is a novel polyherbal dosage form that is incorporated isolated, and fractionated phytochemical substances. …”
Get full text

Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review by Andrada Pintea, Andrei Manea, Cezara Pintea, Robert-Alexandru Vlad, Magdalena Bîrsan, Paula Antonoaea, Emöke Margit Rédai, Adriana Ciurba

Get full text

Use of Tramadol or Other Analgesics in Patients Treated in the Emergency Department as a Risk Factor for Opioid Use by Jorge Enrique Machado-Alba, Laura Sofía Serna-Echeverri, Luis Fernando Valladales-Restrepo, Manuel Enrique Machado-Duque, Andrés Gaviria-Mendoza

“…Based on a medication dispensation database, patients over 18 years of age treated in different clinics in Colombia who for the first time received tramadol, dipyrone, or a nonsteroidal anti-inflammatory drug (NSAID) in the emergency room between January and December 2018 were identified. …”
Get full text

Characterization of the core microflora and nutrient composition in packaged pasteurized milk products during storage by Ruixue Ding, Shanshan Yang, Lijuan Geng, Yumeng Liu, Baoping He, Liyun Liu, Xiqing Yue, Rina Wu, Junrui Wu

Get full text

Internal connections between dietary intake and gut microbiota homeostasis in disease progression of ulcerative colitis: a review by Wen Zeng, Dong He, Yifan Xing, Junyu Liu, Nan Su, Chong Zhang, Yi Wang, Xinhui Xing

“…Ulcerative colitis (UC) is a chronic systematic inflammation disorder with increasing incidence, unknown pathogenesis, limited drug treatment, and abundant medical expenses. Dietary intake, as a daily indispensable environment factor, is closely related to UC pathogenesis and prevention. …”
Get full text

Development and Validation of a Bordetella pertussis Whole-Genome Screening Strategy by Ricardo da Silva Antunes, Lorenzo G. Quiambao, Aaron Sutherland, Ferran Soldevila, Sandeep Kumar Dhanda, Sandra K. Armstrong, Timothy J. Brickman, Tod Merkel, Bjoern Peters, Alessandro Sette

Get full text

Valproate Treatment in an ALS Patient Carrying a c.194G>A Spastin Mutation and SMN2 Homozygous Deletion by Lucio Tremolizzo, Gessica Sala, Elisa Conti, Virginia Rodriguez-Menendez, Antonella Fogli, Angela Michelucci, Paolo Simi, Silvana Penco, Christian Lunetta, Massimo Corbo, Carlo Ferrarese

“…The patient was started on valproic acid (VPA, 600 mg/die per os) considering the capacity of this drug of increasing survival motor neuron through an epigenetic mechanism. …”
Get full text

Serum KL-6 levels reflect the severity of interstitial lung disease caused by immune checkpoint inhibitors by Xiaoping Li, Dan Xue, Qiongying Wei, Xuexue Tan

“…The lack of clear correlations with dosage, duration, or drug efficacy, coupled with nonspecific clinical manifestations, poses challenges in timely diagnosis and effective management. …”
Get full text

Pectin‐decorated selenium nanoparticles as a nanocarrier of curcumin to achieve enhanced physicochemical and biological properties by Yan Wu, Hong Liu, Zhihua Li, Dongye Huang, Lizheng Nong, Zhengxing Ning, Zhizhong Hu, Chunping Xu, Jing‐Kun Yan

“…Cur was successfully encapsulated into pectin‐SeNPs through hydrogen bonding interactions with an encapsulation efficiency of ∼60.6%, a loading content of ∼7.4%, and a pH‐dependent and controlled drug release in vitro. After encapsulation was completed, pectin‐SeNPs@Cur showed enhanced water solubility (∼500‐fold), dispersibility, and storage stability compared with those of free Cur. …”
Get full text

Isoacteoside alleviates hepatocellular carcinoma progression by inhibiting PDHB-mediated reprogramming of glucose metabolism by Lijun Zhao, Haonan Qi, Weiting Liu, Huiying Lv, Peixian Li, Wenyue Liu, Ruili Sun, Qiongzi Wang, Xiangpeng Wang

“…In summary, our study validates PDHB as an oncogenic drug resistance-related gene capable of predicting HCC tumor progression. …”
Get full text

Identification and Simultaneous Determination of the Main Toxical Pyrrolizidine Alkaloids in a Compound Prescription of Traditional Chinese Medicine: Qianbai Biyan Tablet by Mengting Yang, Daopeng Tan, Anjing Lu, Lin Qin, Changhong Wang, Hua Ling, Yanliu Lu, Yuqi He

“…Data of the present study may be used as a reference to make new drug quality regularity and recommendation guideline for the safety of QT.…”
Get full text

Clinical and Technical Characteristics of Coronary Angiography and Percutaneous Coronary Interventions Performed before and after Transcatheter Aortic Valve Replacement with a Ball... by Alfredo Nunes Ferreira-Neto, Rishi Puri, Lluis Asmarats, Victoria Vilalta, Leonardo Guimaraes, Robert Delarochellière, Jean-Michel Paradis, Siamak Mohammadi, Eric Dumont, Josep Rodés-Cabau

“…Lesion location and classification, as well as the preference of using a drug-eluting stent, remained unchanged. During post-TAVR CA, the amount of contrast delivered and the radiation dose area product were significantly lower compared with pre-TAVR CA values. …”
Get full text

Immortalized Mesenchymal Stem Cells: A Safe Cell Source for Cellular or Cell Membrane-Based Treatment of Glioma by Yuxuan Zhang, Jie Liu, Yunzhao Mo, Zetao Chen, Taoliang Chen, Yan Li, Yaofeng Zheng, Shaokang Deng, Xiangdong Xu, Huajian Chen, Haoqi He, Jiansheng Chen, Tao Jin, Xinlin Sun, Yiquan Ke, Jihui Wang

“…The cell membranes of im-MSCs were taken up by glioma cells and targeted in situ gliomas in vivo, suggesting that im-MSCs and their plasma membranes can be used as natural drug carriers for targeting gliomas, and providing a safe, adequate, quality-controlled, and continuous source for the treatment of gliomas based on whole-cell or cell membrane carriers.…”
Get full text

Optimising Palm Olein-Based Betamethasone 17-Valerate Emulsions for Scalable Manufacturing and Stability by Thazin Win, Mohd. Rushdi Abu Bakar, Farahidah Mohamed, Muhammad Taher, Md. Zaidul I. Sarker

“…Despite its potential as a topical drug delivery vehicle, the practical implementation of manufacturing 20% (w/w) palm olein-in-water emulsions for commercial purposes has not been explored extensively, and obtaining experimental data on scale-up studies would be helpful in facilitating this realisation. …”
Get full text

Investigating the production and synergistic antibacterial activity of bacteriocin-like substance from Brevibacillus laterosporus SA-14 (TISTR 2453) for enhanced wound healing by Husna Madoromae, Apichart Atipairin, Malatee Tayeh, Monthon Lertcanawanichakul

Get full text

GLP-1 Gene-Modified Human Umbilical Cord Mesenchymal Stem Cell Line Improves Blood Glucose Level in Type 2 Diabetic Mice by Ying Chang, Mingxin Dong, Yan Wang, Haotian Yu, Chengbiao Sun, Xin Jiang, Wei Chen, Xin Wang, Na Xu, Wensen Liu, Ningyi Jin

“…The results showed that after 3 weeks of intramuscular injection of the new cell line, the fasting blood glucose of type 2 diabetic mice returned to the normal range, and the hypoglycemic effect was maintained within 3 weeks after putting an end to the drug. At the same time, during the administration, the mice lost weight, the food intake decreased, the half-life of GLP-1 in the body prolonged, the IR reduced, and the pancreatic function recovered. …”
Get full text

Post-traumatic Growth in the Link with Resilience, Self-compassion, and the Personal and Clinical Characteristics in Adolescents with Life-threatening Disease: A Cross-sectional Co... by Zahra Ghasemi, Manijeh Nourian, Azam Shirinabadi Farahani, Amir Heidari, Maliheh Nasiri

“…Higher resilience total scores during chemotherapy and radiotherapy (B=0.74, P<0.001), surgery (B=1.08, P<0.001), and drug treatment phases (B=0.89, P<0.001), were associated with higher PTG scores. …”
Get full text

Functional Prediction of Hypothetical Proteins from and Validation of the Predicted Models by Using ROC Curve Analysis by Md. Amran Gazi, Sultan Mahmud, Shah Mohammad Fahim, Mohammad Golam Kibria, Parag Palit, Md. Rezaul Islam, Humaira Rashid, Subhasish Das, Mustafa Mahfuz, Tahmeed Ahmeed

“…Majority of these cases occur among the children of the developing nations and the emergence of multi-drug resistance Shigella strains in clinical isolates demands the development of better/new drugs against this pathogen. …”
Get full text

Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy by Cui-qin Huang, Wen-tao Xiao, Xiang-rong Yao, Zhi-min Li, Jun-yan He

“…A prognostic nomogram integrating POSTN expression and clinicopathological features demonstrated superior predictive accuracy for OS. Drug sensitivity analysis suggested that high POSTN expression may be linked to resistance to multiple chemotherapeutic agents. …”
Get full text