Sicca Symptoms in Parkinson’s Disease: Association with Other Nonmotor Symptoms and Health-Related Quality of Life by Tino Prell, Denise Schaller, Caroline Perner, Otto W. Witte, Julian Grosskreutz

“…Overall, 75% of the subjects took at least one drug that can cause sicca symptoms (anti-PD medication, antidepressant drugs, antihypertensive drugs, antipsychotic drugs, antimuscarinic drugs, and analgesic drugs). …”
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Diagnostic Performance between Histidine-Rich Protein 2 (HRP-2), a Rapid Malaria Diagnostic Test and Microscopic-Based Staining Techniques for Diagnosis of Malaria by Jean Baptiste Niyibizi, Emmanuel Kamana Gatera

“…The patients included in the study did not receive any antimalarial drug. The mean age of the study participants was 31.6 ± 12.4 with the majority of participants being between 25 and 44 years and the minority being above 65 years. …”
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Effect and safety of ethanolamine oleate in sclerotherapy in patients with difficult-to-resect venous malformations: A multicenter, single-arm study. by Mine Ozaki, Tadashi Nomura, Keigo Osuga, Masakazu Kurita, Ayato Hayashi, Shunsuke Yuzuriha, Noriko Aramaki-Hattori, Makoto Hikosaka, Taiki Nozaki, Michio Ozeki, Junko Ochi, Shimpei Akiyama, Yasumasa Kakei, Keiko Miyakoda, Naoko Kashiwagi, Takahiro Yasuda, Yuki Iwashina, Tsuyoshi Kaneko, Kiyoko Kamibeppu, Takafumi Soejima, Kiyonori Harii

“…Hemoglobinuria was observed in 23 patients (52%), a known drug-related adverse event. Prompt initiation of haptoglobin therapy led to full recovery within a month for these patients.…”
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Potentiation of Doxorubicin Cytotoxicity Utilizing Clarithromycin Loaded-PEGylated Liposomes by Islam Alfreahat MS, Hamdi Nsairat PhD, Ibrahim Deeb Aldeeb PhD, Ali Al-Samydai PhD, Walhan Alshaer PhD

“…Background Doxorubicin (DOX) is a potent chemotherapeutic agent for breast cancer, but its effectiveness is often diminished by resistance mechanisms, particularly through p-glycoprotein (P-gp) mediated drug efflux. Clarithromycin (CAM), a macrolide antibiotic, inhibits multiple metabolic pathways including CYP3A and P-gp, potentially countering DOX resistance. …”
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The Major Prognostic Features of Nuclear Receptor NR5A2 in Infiltrating Ductal Breast Carcinomas by Li-Yun Chang, Li-Yu D. Liu, Don A. Roth, Wen-Hung Kuo, Hsiao-Lin Hwa, King-Jen Chang, Fon-Jou Hsieh

“…NR5A2 may be a potential drug target for treating a subset of breast cancer tumors across breast cancer subtypes, especially ER(−) breast tumors. …”
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Genomics Analysis of Metabolic Pathways of Human Stem Cell-Derived Microglia-Like Cells and the Integrated Cortical Spheroids by Julie Bejoy, Xuegang Yuan, Liqing Song, Thien Hua, Richard Jeske, Sébastien Sart, Qing-Xiang Amy Sang, Yan Li

“…This analysis indicates that physiological 3-D microenvironment may reshape the immunity of in vitro cortical spheroids and better recapitulate in vivo brain tissue function for disease modeling and drug screening.…”
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Artesunate, EDTA, and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella by Yajun Zhai, Peiyi Liu, Xueqin Hu, Changjian Fan, Xiaodie Cui, Qibiao He, Dandan He, Xiaoyuan Ma, Gongzheng Hu

“…Collectively, our work opens new avenues toward the potentiation of COL and reveals an alternative drug combination strategy to overcome COL-resistant bacterial infections.…”
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KaRhab: an international online registry for cardiac rhabdomyomas by Vera-Maria Herrmann, Maria Arelin, Caroline G. Bergner, Julia Herrmann, Paula Janz, Henriette Kiep, Annika Mueller, Steffen Syrbe, Robert Wagner, Bardo Wannenmacher, Nadine Wolf, Michael Weidenbach, Vincent Strehlow

“…Conclusion In the view of the heterogeneity of treatment methods, a systematic overview of cardiac RHM is all the more important, especially as specific drug treatment options now exist. The registry should not just provide a comprehensive and informative overview of causes, time course, symptoms and therapeutic options of cardiac RHM but also facilitate information sharing among clinicians and researchers and serve as a basis for future clinical and pharmacological studies.…”
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Peripheral tryptophan-kynurenine pathway dysfunction in first-episode schizophrenia by Mian Li, Yue Wu, Yan Xu, Xin Huang, Kerun Gao, Nannan Hu, Shuangyue Zhu, Chengpeng Wang, Sugai Liang

“…This study included 38 drug-naive patients with FES and 43 healthy controls (HCs). …”
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New Insights Into Hepatic Impairment (HI) Trials by Sebastian Haertter, Maximilian Lobmeyer, Brian C. Ferslew, Pallabi Mitra, Thomas Arnhold

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DockCADD: A streamlined in silico pipeline for the identification of potent ribosomal S6 Kinase 2 (RSK2) inhibitors by El Mehdi Karim, Meriem Khedraoui, Abdelkbir Errougui, Yasir S. Raouf, Abdelouahid Samadi, Samir Chtita

“…These results have pointed out the use of DockCADD as an efficient tool for the fast and low-cost process of drug discovery; L1–L3 should be further validated experimentally for cancer therapy.…”
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Four-Year Outcomes of Left Main Percutaneous Coronary Intervention with a Bioresorbable Scaffold in the Circumflex Ostium by Andrejs Erglis, Inga Narbute, Dace Sondore, Sanda Jegere, Indulis Kumsars, Andis Dombrovskis, Karlis Grikis, Ieva Briede, Kristine Dombrovska, Karlis Trusinskis, Alona Grave, Martins Erglis, Martins Kalejs, Peteris Stradins, Uldis Strazdins

“…The study aimed to investigate the long-term outcomes of a double stent scaffold strategy in patients with left main (LM) bifurcation lesions involving the ostium of the left circumflex artery (LCX), utilizing a drug-eluting stent (DES) in the LM extending into the left anterior descending artery (LAD) and a bioresorbable vascular scaffold (BVS) in the LCX ostium. …”
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CHST1 as a prognostic-related biomarker in gastric cancer correlating with immune infiltration by Long Gui, Jin-hao Yu, Jia-nan Tan, Guang-yu Zhong, Yong-xue Wang, Lin Zhong, Jiao-jiao Su, Dong Hou, Bin Yang, Fang-hai Han, Sheng-ning Zhou

“…Furthermore, we constructed a co-expression network of CHST1 and explored its relationship with clinicopathological features, the tumor microenvironment, and immune infiltration through bioinformatics analysis. Finally, relevant drugs that inhibit CHST1 in GC were predicted using the drug susceptibility database (CellMiner) and Cancer Immunome Atlas. …”
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Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Researc... by Abhishek Abhishek, Richard D Riley, Christian D Mallen, Guruprasad P Aithal, Georgina Nakafero, Matthew J Grainge, Maarten W Taal, Tim Card, Matthew D Stevenson

“…It included adults newly diagnosed with inflammatory bowel disease and established on 5-aminosalicylic acid (5-ASA) treatment between 1 January 2007 and 31 December 2019. Drug discontinuation associated with 5-ASA nephrotoxicity defined as a prescription gap of ≥90 days with decline in kidney function was the outcome. …”
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Biocompatible and Biodegradable Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Prepared via Semicontinuous Heterophase Polymerization: Kinetics and Produc... by Henned Saade, María de Lourdes Guillén, Judith Cabello Romero, Jesús Cepeda, Anna Ilyna, Salvador Fernández, Francisco Javier Enríquez-Medrano, Raúl Guillermo López

“…Because of their biocompatibility and biodegradability as well as their extremely small size these nanoparticles could be used as vehicles for improved drug delivery in the treatment of chronic-degenerative diseases.…”
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Tarred with the same brush: An initial inquiry into courtesy stigma and problem gambling by Matthew D. Sanscartier, Jason D. Edgerton, Derek Chadee, Lance W. Roberts

“…Results: Problem gambling by a family member elicits more shame/embarrassment (M = 1.75) than using a wheelchair (M = 1.15) and having a mental illness (M = 1.22), but less shame than having a drug problem (M = 2.12) and on par with having an alcohol problem (M = 1.79, ns). …”
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Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson’s Disease Is Not Associated with Increased Body Mass Index by Sarah H. Millan, Mallory L. Hacker, Maxim Turchan, Anna L. Molinari, Amanda D. Currie, David Charles

“…Subjects were randomized to DBS plus optimal drug therapy (DBS+ODT; n=15) or ODT (n=14) and followed for 24 months. …”
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Luminescence enhancement of Y2O3:Er3+ and Y2O3:Yb3+/Er3+ sub-microcrystals by Zr4+ ions Co-doping by Zixuan Jiang, Bing Liu, Zehua Zhang, Lili Wang, Zhixu Jia, Dan Zhao

“…This research contributes to the understanding of UC luminescent properties of lanthanide (Ln3+) ions doped UC materials and their technological applications in fields such as bioimaging, drug delivery, and optical temperature sensors.…”
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Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer by Pathea Shawnae Bruno, Aneeta Arshad, Maria-Raluca Gogu, Natalie Waterman, Rylie Flack, Kimberly Dunn, Costel C. Darie, Anca-Narcisa Neagu

“…PTMs associated with cancer can be exploited to better understand the underlying molecular mechanisms of this heterogeneous and chameleonic disease, find new biomarkers of cancer progression and prognosis, personalize oncotherapies, and discover new targets for drug development.…”
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Electrocardiographic Characteristics of Breast Cancer Patients Treated with Chemotherapy by Xufei Liang, Yueying Wang, Xi Yin, Xiaohong Gong, Shuo Pan, Ziliang Chen, Xuhong Geng

“…The incidence of abnormal ECG increased from 43.75% at baseline to 65.63% at the end of chemotherapy, of which only the prevalence of fragmented QRS (fQRS) was significantly increased after the drug regimen (26.56% to 53.13%). At the end of the treatment, heart rate, P-wave dispersion, corrected QT interval, T-peak to T-end, RR, SV1, RV5, Sokolow–Lyon index (SLI), and index of cardioelectrophysiological balance deteriorated markedly (all P<0.05). …”
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