Improvement of Blood Plasmalogens and Clinical Symptoms in Parkinson’s Disease by Oral Administration of Ether Phospholipids: A Preliminary Report by Shiro Mawatari, Shinji Ohara, Yoshihide Taniwaki, Yoshio Tsuboi, Toru Maruyama, Takehiko Fujino

“…L-DOPA (1,3,4-dihydroxyalanine) is the most effective drug in the symptomatic treatment of PD. Nonmotor symptoms in PD include sleep problems, depression, and dementia, which are not adequately controlled with dopaminergic therapy. …”
Get full text

Antimicrobial Activity of Aspergillus sp. from the Amazon Biome: Isolation of Kojic Acid by Josy Caldas Rodrigues, Weison Lima da Silva, David Ribeiro da Silva, Carolina Rabelo Maia, Clarice Virginia Santos Goiabeira, Haile Dean Figueiredo Chagas, Gigliola Mayara Ayres D’Elia, Gleica Soyan Barbosa Alves, Viviane Zahner, Cecilia Veronica Nunez, Ormezinda Celeste Cristo Fernandes

“…., with antibacterial activity and moderate toxicity at the concentrations tested, is a promising prototype of an alternative active principle of an antimicrobial drug.…”
Get full text

Domperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a “Black Box” Warning: A Canadian Tertiary Care Center Study by Nauzer Forbes, Mohan Cooray, Raed Al-Dabbagh, Yuhong Yuan, Frances Tse, Louis W. C. Liu, Ted Xenodemetropoulos

“…Use of domperidone as the sole GI drug predicted nonapproved indications (OR = 2.51, 95% CI 1.38–4.55, p=0.002). …”
Get full text

Hepatoprotective potential of Chrysin in a rat model of isoniazid- and rifampicin-induced hepatic injury: suppression of matrix metalloproteinase and transforming growth factor β by Deepa Mandlik, Akhilesh Tokey, Rohit Lokhande, Yash Dagadu, Heena Choudhary, Satish Mandlik

“…The scope of the research was to show that CHY protects the rat liver against damage caused by the drugs isoniazid (INH) and rifampicin (RFM). Results Rats were divided into 6 groups, each of which had six rats. …”
Get full text

A Cost-Effective and Robust Cell-Based Bioassay Method for Evaluating the Bioactivity of Trastuzumab-like Antibodies by Pooja Bharali, Subhash Chand, Harish Chander

“…The biological activity of trastuzumab was determined using the inhibition of proliferation (IOP) assay on the SKBR3, which was optimized based on the parameters of cell seeding density, drug dilution range, and incubation time, and it was further validated as per the compendial guidelines and found valid for the parameters of specificity, accuracy (% relative bias = 0.0067%), precision (repeatability: % GCV = 1.21%), linearity (R2 = 0.99), and range (50% to 200%). …”
Get full text

Essential oils from Amorpha fruticosa against hepatocellular carcinoma based on network pharmacology by Yixian Liu, Xiaojun Zhang, Jiacong Hao, Ying Zhao, Min Zou, Huiping Chen, Jintao Zhang

“…The detected components of AFLEO and AFFEO were performed ADME screening to examine their drug-likeness. Then a PPI network, compound-target network, compound-target-pathway network, gene ontology, and KEGG enrichment for HCC were applied to identify the targets and pathways for AFLEO and AFFEO against HCC. …”
Get full text

Investigating the Expression of c-Myc and BIRC5 in TRAIL and PBOX-15 treated Metastatic Prostate Cancer Cells by Corinne Kai Leng Chew, Hannah O'Toole, Daniela M Zisterer, Seema M. Nathwani, Jade K. Pollock

“…A novel microtubule-targeting agent, PBOX-15 is known to exhibit anti-tumour activity in cancer cell lines including those with multi-drug resistance. Previous studies demonstrated that PBOX-15 is capable in sensitising cancer cells to TRAIL-mediated cell death by upregulation of death receptors and downregulation of related oncogenes. …”
Get full text

Effects of removing reimbursement restrictions on targeted therapy accessibility for non-small cell lung cancer treatment in Taiwan: an interrupted time series study by Jason C Hsu, Chen-Fang Wei, Szu-Chun Yang

“…Removing reimbursement restrictions can significantly increase the level and the speed of drug accessibility.…”
Get full text

Antibacterial Effect of Sea Buckthorn ( Hippophae rhamnoides L.) Fruit Extract on Radish Seeds Prior to Sprouting by Katarzyna Rajkowska, Emilia Rykała, Agata Czyżowska

“…The efficacy of 15-min seed treatment and 3-h soaking in the extract solution was evaluated in comparison to the treatment with 20,000 mg/L calcium hypochlorite, recommended by the U.S. Food and Drug Administration. The effect of the sea buckthorn fruit extract on radish seed germination capacity and the profile of phenolic compounds in the extract were also determined. …”
Get full text

Status of zoonotic disease research in refugees, asylum seekers and internally displaced people, globally: A scoping review of forty clinically important zoonotic pathogens. by Regina Oakley, Nadja Hedrich, Alexandra Walker, Habtamu Merha Dinkita, Rea Tschopp, Charles Abongomera, Daniel H Paris

“…Vaccination/prophylaxis drug administration, surveillance/screening and improved hygiene/sanitation were the most commonly discussed preventative measures.…”
Get full text

Co-occurring factors associated with suicidal ideation among individuals with parole involvement: A classification and regression tree analysis by Leah MCCOY, Javier F. BOYAS, Sung Seek MOON, Michael A. ROBINSON, Onick LEWIS, Amy E. COX

“…Methods: Pooled data from the National Survey on Drug Use and Health were analyzed through a CART analysis to uncover co-occurring interactions associated with suicidal ideation among a national sample of individuals with parole involvement (N=1,725). …”
Get full text

A Comparative Study to Determine the Efficacy of Atosiban versus Nifedipine in Management of Preterm Labour by Vidya Gaikwad, Jay Patel, Suhas Gaikwad

“…Conclusion: Both Atosiban and Nifedipine were effective in managing PTL, with each drug offering distinct advantages depending on the clinical scenario. …”
Get full text

YAP1 as a Novel Negative Biomarker of Immune Checkpoint Inhibitors for EGFR-Mutant Non-Small-Cell Lung Cancer by Ling-Chen Li, Xie-Wan Chen, Ling Fang, Chun-Li Jian, Yong-Xin Yu, Xing-Yun Liao, Jian-Guo Sun

“…However, its application to epidermal growth factor receptor (EGFR)-mutant NSCLC patients is confronted with drug resistance. This study aimed to clarify the potential role of Yes1-associated transcriptional regulator (YAP1) in ICIs treatment for EGFR-mutant NSCLC population. …”
Get full text

Silver Nanoparticles Conjugate Attenuates Highly Active Antiretroviral Therapy-Induced Hippocampal Nissl Substance and Cognitive Deficits in Diabetic Rats by Sodiq Kolawole Lawal, Samuel Oluwaseun Olojede, Ayobami Dare, Oluwaseun Samuel Faborode, Edwin Coleridge S. Naidu, Carmen Olivia Rennie, Onyemaechi Okpara Azu

“…However, the safety of drugs loaded with silver nanoparticles has been debatable. …”
Get full text

Development and validation of a new reverse-phase high-performance liquid chromatography (RP-HPLC) method for the quantifications of tolperisone loaded in liposomes by Rawan N. AlKaraki, Rula R. Haddadin, Shahed K. Tarawneh, Marwa A.M. Alimari, Rehan M. Alkasasbeh, Tebat Al-ferdous E. Shamaileh, Mustafa S. Almohtaseb, Malek G. Hajaya

“…The validated RP-HPLC method was used to demonstrate the suitability of liposomes as a carrier for TOL by evaluating its entrapment efficiency (14.76 %), along with achieving a slower drug in-vitro cumulative percentage release in the targeted media (compared to free TOL solution) from the liposomes.…”
Get full text

Development and validation of a recurrence risk prediction model for elderly schizophrenia patients by Biqi Zu, Chunying Pan, Ting Wang, Hongliang Huo, Wentao Li, Libin An, Juan Yin, Yulan Wu, Meiling Tang, Dandan Li, Xin Wu, Ziwei Xie

“…Lasso-Logistic regression analysis identified Medication status, Premorbid personality, Exercise frequency, Drug adverse reactions, Family care, Social support, and Life events as predictors of ESCZP recurrence. …”
Get full text

Hymecromone Efficacy in the Treatment of Biliary Pancreatitis by A. V. Okhlobystin, M. A. Tatarkina, O. Z. Okhlobystina, S. A. Budzinskiy, P. V. Pavlov, L. A. Labut

“…An analysis of the efficacy and safety of the studied drug was performed on the 21st day of treatment based on the results of laboratory tests, abdominal ultrasound, cholecystography and endosonography of the pancreatobiliary zone, quality-of-life assessment according to the SF-36 questionnaire, the frequency and severity of adverse effects (AE).Results. …”
Get full text

Fenofibrate Enhances the In Vitro Differentiation of Foxp3+ Regulatory T Cells in Mice by Zhou Zhou, Ying Liang, Yanxiang Gao, Wei Kong, Juan Feng, Xian Wang

“…Some reports suggested an anti-inflammatory and anti-autoimmune potential for fenofibrate, a hypolipidemic drug used worldwide, whose lipid effects are mediated by the activation of peroxisome proliferator-activated receptor 𝛼 (PPAR𝛼). …”
Get full text

Identification of CβS and ODC antimony resistance markers in anthroponotic cutaneous leishmaniasis field isolates by gene expression profiling by Farzaneh Zarrinkar, Iraj Sharifi, Razieh Tavakoli Oliaee, Ali Afgar, Elaheh Molaakbari, Mehdi Bamorovat, Zahra Babaei, Ebrahim Eskandari, Ehsan Salarkia, Marzieh Asadi

“…The findings showed that CβS and ODC are directly linked with the resistance to L. tropica. Alternative drugs or combination therapy and monitoring drug resistance to prevent the spread of resistant isolates are proper strategies to control the disease.…”
Get full text

Profiling Proteins in the Hypothalamus and Hippocampus of a Rat Model of Premenstrual Syndrome Irritability by Mingqi Qiao, Peng Sun, Yang Wang, Sheng Wei, Xia Wei, Chunhong Song, Fushun Wang, Jibiao Wu

Get full text