Effectiveness of an HIV peer support precision matching platform: a randomized controlled trial protocol by Xin Xie, Shuyu Han, Yangfeng Wu, Tao Huang, Junyi Duan, Dongmei Li, Shuyu Chen, Bo Zhou, Jiangping Zhang, Lili Zhang

“…The intervention group (n = 70) will have access to all 12 features of Aspark, including precise volunteer matching, health management tools, drug interaction queries, and medication reminders. …”
Get full text

Promoting physical activity in vulnerable adults ‘at risk’ of homelessness: a randomised controlled trial protocol by Sarah E Jackson, Lee Smith, Charlotte Stringer, Mike Loosemore, Eloise Moller, Guillermo Felipe López-Sánchez, Joseph Firth, James Johnstone, Brendon Stubbs, Davy Vancampfort

“…The secondary outcomes will include change in fitness assessments and mental health parameters. Changes in drug use and alcohol dependency will also be explored.Ethics and dissemination Ethical approval to process and analyse data and disseminate findings was obtained through the Anglia Ruskin University Department of Sport and Exercise Sciences Research Ethics Committee. …”
Get full text

Metformin and Probiotics Interplay in Amelioration of Ethanol-Induced Oxidative Stress and Inflammatory Response in an In Vitro and In Vivo Model of Hepatic Injury by Farhin Patel, Kirti Parwani, Dhara Patel, Palash Mandal

“…Despite rigorous research, there is still no Food and Drug Administration (FDA) approved therapies for any stage of alcoholic liver disease (ALD). …”
Get full text

Platelet Rich Plasma in the Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw: Personal Experience and Review of the Literature by F. Longo, A. Guida, C. Aversa, E. Pavone, G. Di Costanzo, L. Ramaglia, F. Ionna

“…Bisphosphonates (BPs) are a class of synthetic drugs commonly used to treat bone metastasis and various bone diseases that cause osseous fragility (such as osteoporosis). …”
Get full text

Phage display as a tool for identifying HIV-1 broadly neutralizing antibodies by A. N. Chikaev, A. P. Rudometov, Yu. A. Merkulyeva, L. I. Karpenko

“…Combinatorial biology methods offer a good solution for targeting interactions of specific molecules by a high-throughput screening and are widely used for drug development, diagnostics, identification of novel monoclonal antibodies, search for linear peptide mimetics of discontinuous epitopes for the development of immunogens or vaccine components. …”
Get full text

A case report: interstitial pneumonia following treatment of gastric cancer with sintilimab in combination with S-1 by Pei Zhu, Qingming Sun, Sheng Xu, Wanhui Dong

“…Severe interstitial pneumonia can lead to death. Antitumor drugs can induce interstitial pneumonia. Sintilimab is an immune checkpoint inhibitor, a recombinant fully human immunoglobulin G-type programmed death protein-1 monoclonal antibody inhibitor. …”
Get full text

Adsorption characteristics of metronidazole on CoZr-LDH and its GO nanocomposite: Experimental and theoretical study by Edris Jamshidi, Fateme Fathabadi, Faranak Manteghi, Rahime Eshaghimalekshah

“…In the adsorption process of metronidazole using both the CoZr-LDH and CoZr-LDH/GO nanocomposite as adsorbents, parameters such as initial solution pH, adsorbent dose, initial drug concentration, and contact time were optimized to obtain the maximum adsorption capacity. …”
Get full text

Phylogenetic analysis and protective effects of thymol and its chromatographic fractions from a novel wild mushroom in combating oxidative stress by M. Subbulakshmi, Sugapriya Dhanasekaran, S. Abirami, M. Kannan, R. Palaniappan, Divya Venugopal

“…The application of thymol natural products from novel mushroom SMK-1 as nutrition supplements could inhibit oxidative stress triggered by numerous pathologies that may pave the way to develop a new therapeutic natural drug.…”
Get full text

Recent Trends in the Development and Application of Nano-Antioxidants for Skin-Related Disease by Yi Xue, Tao Wang, Ji-Peng Liu, Qi Chen, Xiao-Long Dai, Min Su, Yu-Hang Cheng, Cheng-Chao Chu, Yun-Qing Ren

“…Additionally, we summarize the prospects and potential future directions for nano-antioxidant drugs in treating skin-related diseases.…”
Get full text

Anti-breast cancer activity of some novel quinoline derivatives by Ghorab Mostafa M., Alsaid Mansour S.

“…The corresponding 2-cyano-3-(4-hydroxy-3-methoxyphenyl)-N-(quinolin-3-yl) acrylamide (15), 3-oxo-N-(quinolin-3-yl)-3H-benzol[f] chromene-2-carboxamide (27), 2-cyano-3-(4-fluorophenyl-N-(quinolin-3-yl) acrylamide (7), 2-cyano-5-(4-(dimethyl-amino) phenyl)-N-(quinolin-3-yl) penta-2,4-dienamide (19) exhibited higher activity compared to doxorubicin (with IC50 value of 47.9 μmol L−1) as a reference drug, with IC50 values of 29.8, 39.0, 40.0, 40.4 μmol L−1, resp. …”
Get full text

Noninvasive in vivo imaging of macrophages: understanding tumor microenvironments and delivery of therapeutics by Prakash Gangadaran, Akanksha Onkar, Ramya Lakshmi Rajendran, Anshika Goenka, Ji Min Oh, Fatima Khan, ArulJothi Kandasamy Nagarajan, Sathish Muthu, Anand Krishnan, Chae Moon Hong, Byeong-Cheol Ahn

“…Notably, macrophages have also been harnessed to deliver drugs. Noninvasive in vivo molecular imaging of macrophages is crucial for investigating intricate cellular processes, comprehending the underlying mechanisms of diseases, tracking cells and EVs’ migration, and devising macrophage-dependent drug-delivery systems in living organisms. …”
Get full text

Effects of Curcumin on Iron Overload in Rats by Gülüzar Özbolat, Arash Alizadeh Yegani

“… Background: Iron overload, common in patients with hematological disorders, is a key target in drug development. This study investigated the effects of curcumin on iron overload in rats. …”
Get full text

Tapentadol Prolonged Release for Severe Chronic Osteoarthritis Pain in the Elderly—A Subgroup Analysis of Routine Clinical Practice Data by Andreas Schwittay, Melanie Sohns, Birgit Heckes, Christian Elling

“…Only 8.4% of the elderly experienced adverse drug reactions, most frequently nausea (2.7% of patients) and dizziness (1.5%). …”
Get full text

Effectiveness of case management interventions for frequent users of healthcare services: a scoping review by Catherine Hudon, Maud-Christine Chouinard, Isabelle Dufour, Mireille Lambert, Cynthia Krieg

“…Patient outcomes such as drug and alcohol use, health locus of control, patient satisfaction and psychological functioning were evaluated in 3 studies, but no change was reported.Conclusions Many studies suggest that CM could reduce emergency department visits and hospitalisations as well as cost. …”
Get full text

Danshen-Honghua Ameliorates Stress-Induced Menopausal Depression in Rats by Simeng Gu, Yao Ma, Kemin Ge, Ruifang Nie, Erxi Wu, Yang Li

“…The rats in the last two groups were treated with stresses together with intragastric drug administration for three weeks after the surgery. …”
Get full text

Phenolic Compounds from Ocimum basilicum Revealed as Antibacterial by Experimental and Computational Screening-Based Studies against Oral Infections by Salsabila Aqila Putri, Euis Julaeha, Natsuko Kagawa, Dikdik Kurnia

“…The pharmacokinetics were predicted by ADMET analysis, and methyl caffeate (4) showed the best potential as a drug compound. The conclusion is that phenolic compounds isolated from O. basilicum have potential as natural antibacterials. …”
Get full text

Design, Molecular Docking, Synthesis, Characterization and Preliminary Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Cyclin-Dependent Kinase 2 Inhibitors by Yousef Sabah Ali, Monther Faisal Mahdi, Basma Monjid Abd Razik, Talal Aburjai

“…Furthermore, these compounds underwent physicochemical, drug-like, and toxicological predictions. The molecular docking investigation shows that 1,3,4-oxadiazole derivatives bind strongly to the CDK-2 protein's active binding site. …”
Get full text

Zinc Monotherapy as an Alternative Treatment Option for Decompensated Liver Disease due to Wilson Disease? by Hansa Haftu, Mohammed Mustefa, Teklu Gebrehiwot

“…Although zinc is of low toxicity and low cost for treatment of Wilson disease, it has been limited to the adjunctive as a single maintenance drug or for asymptomatic patients. The use of zinc monotherapy in patients suffering from a severe liver disease was not well studied. …”
Get full text

Isolation and identification of Starmerella davenportii strain Do18 and its application in black tea beverage fermentation by Chuanhai Tu, Wenxiu Hu, Sijie Tang, Ling Meng, Zhihai Huang, Xiao Xu, Xiudong Xia, Fidelis Azi, Mingsheng Dong

Get full text

Lebanese Cannabis sativa L. extract protects from cisplatin-induced nephrotoxicity in mice by inhibiting podocytes apoptosis by Alia Khalil, Sahar Al Toufaily, Wassim Shebaby, Marissa El Hage, Dima Mroue, Wissam Faour, Mohamad Mroueh

“…Abstract Background Cisplatin is an anti-cancer drug used to treat a plethora of solid tumors. However, it is associated with dose dependent nephrotoxicity limiting its use as anticancer agent. …”
Get full text