Point Mutations in the folP Gene Partly Explain Sulfonamide Resistance of Streptococcus mutans by W. Buwembo, S. Aery, C. M. Rwenyonyi, G. Swedberg, F. Kironde

“…Cotrimoxazole inhibits dhfr and dhps and reportedly selects for drug resistance in pathogens. Here, Streptococcus mutans isolates were obtained from saliva of HIV/AIDS patients taking cotrimoxazole prophylaxis in Uganda. …”
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Home management of malaria among caregivers of under-five children in Owo, Ondo State, Nigeria by Liasu Adeagbo Ahmed, Olubankole Akinboboye, Olayinka Stephen Ilesanmi, David Akintayo Oguntuase

“…Most of the caregivers bought antifever drugs from patent medicine shops and only 11.9 % of them got a prescription drug from pharmacies. …”
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Wnt/β-catenin signalling underpins juvenile Fasciola hepatica growth and development. by Rebecca Armstrong, Nikki J Marks, Timothy G Geary, John Harrington, Paul M Selzer, Aaron G Maule

“…The putative pharmacological inhibition of Wnt/β-catenin signalling using commercially available inhibitors phenocopied RNAi results and provides impetus for drug repurposing. Taken together, these data functionally and chemically validate the targeting of Wnt signalling as a novel strategy to undermine the pathogenicity of juvenile F. hepatica.…”
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Current Status and Future Directions of Artificial Intelligence in Post-Traumatic Stress Disorder: A Literature Measurement Analysis by Ruoyu Wan, Ruohong Wan, Qing Xie, Anshu Hu, Wei Xie, Junjie Chen, Yuhan Liu

“…This study aims to explore the current state of research and the applicability of artificial intelligence (AI) at various stages of post-traumatic stress disorder (PTSD), including prevention, diagnosis, treatment, patient self-management, and drug development. We conducted a bibliometric analysis using software tools such as Bibliometrix (version 4.1), VOSviewer (version 1.6.19), and CiteSpace (version 6.3.R1) on the relevant literature from the Web of Science Core Collection (WoSCC). …”
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Efficacy of parenteral pantoprazole in patients with acute ulcerative gastroduodenal bleeding at high risk of relapse by S. G. Shapovalyants, S. A. Chernyakevich, A. I. Mikhalev, O. I. Yudin, I. V. Babkova, G. N. Storozhuk, Ye. K. Mayat, P. L. Chernyakevich

“…Injection of sunpraz with subsequent oral intake of the drug in combination to endoscopic hemostasis and antihelicobacter treatment is an effictive method of treatment of AUGDB at high risk of relapses.…”
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Identification of Ferroptosis-Associated Long Noncoding RNA Prognostic Model and Tumor Immune Microenvironment in Thyroid Cancer by Yongjian Lin, Fu Gan, Xiaoyu He, Huachu Deng, Yong Li

“…Ferroptosis is a form of cell death distinct from apoptosis, which involves antitumor drug-related research. Long noncoding RNAs (lncRNAs) could affect cancer prognosis by regulating the ferroptosis; thus, ferroptosis-associated lncRNAs are emerging as prospective biomarkers for cancer therapy and prognosis. …”
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Serum Matrix Metalloproteinase-3 in Comparison with Acute Phase Proteins as a Marker of Disease Activity and Radiographic Damage in Early Rheumatoid Arthritis by Mahmood M. T. M. Ally, Bridget Hodkinson, Pieter W. A. Meyer, Eustasius Musenge, Mohammed Tikly, Ronald Anderson

“…MMP-3 was measured by ELISA in serum samples of 128 disease-modifying, drug-naïve patients and analysed in relation to shared epitope genotype, a range of circulating chemokines/cytokines, acute phase reactants, autoantibodies, cartilage oligomeric protein (COMP), and the simplified disease activity index (SDAI). …”
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Quantification of Escherichia coli Transfer from Plastic Mulch to Field-grown Tomatoes and Bell Peppers by Autumn R. Burnett, Faith Critzer, Timothy Coolong

“…In the United States, the Food and Drug Administration (USFDA) prohibits the distribution of fruit that is dropped from the plant and contacts the ground during harvest. …”
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Diagnosis of Coxiella burnetii endocarditis by using nanopore targeted sequencing: a case report by Xinsheng Yan, Qimei Wei, Tingting Liu, Dong Wang, Zhenlu Zhang

“…Although clinical suspicion of infective endocarditis was raised, since echocardiogram did not reveal any vegetations and blood cultures were negative, the etiology remained unclear and empirical drug therapy was used. The patient exhibited a severe inflammatory reaction after aortic valve replacement. …”
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Mechanistic insights into epithelial-mesenchymal transition mediated cisplatin resistance in ovarian cancer by Taha Umair Wani, Hyun-Yi Kim, Geum-Hwa Lee, Young Je Lim, Han-Jung Chae, Ji-Ye Kim, Hyonok Yoon

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Development of Modified-Release Diclofenac Sodium Capsules Using Blends of Pectin-Clay Multiparticulate Hybrid Systems as Release Retardants by Ofosua Adi-Dako, Frederick William Akuffo Owusu, Isaac Yaw Attah, Doris Kumadoh, Prince George Acquah Jnr, Issaka Nelson, Nii Odartey Hutton-Mills, Karen Yaa Yeboaa Obese, Joseph Adusei Sarkodie, Benoit Banga N’guessan, Awo Afi Kwapong, Christina Osei-Asare, Emmanuel Adase, Mary-Ann Archer

“…The diclofenac content, uniformity of the weight of capsules, in vitro drug release, and the kinetics and mechanism of release of diclofenac from the hybrid systems were also investigated using mathematical models. …”
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Small Extracellular Vesicles from Inflamed Adipose Derived Stromal Cells Enhance the NF-κB-Dependent Inflammatory/Catabolic Environment of Osteoarthritis by Carola Cavallo, Giulia Merli, Nicoletta Zini, Stefania D’Adamo, Luca Cattini, Michele Guescini, Brunella Grigolo, Alessandro Di Martino, Spartaco Santi, Rosa Maria Borzì, Giuseppe Filardo

“…In the perspective of developing a cell-free advanced therapy medicinal product, a focus has been recently addressed to the ADSC secretome that lends itself to an allogeneic use and can be further dissected for the selective purification of small extracellular vesicles (sEVs). sEVs can act as “biological drug carriers” to transfer information that mirror the pathophysiology of the providing cells. …”
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A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy by Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle, Jay M. Short

“…Initial attempts to develop EpCAM-specific T-cell engagers were unsuccessful due to severe cytokine release effects, as well as serious on-target, off-tumor drug-related toxicities. We developed novel, conditionally active biological (CAB) bispecific antibodies that bind to both EpCAM and CD3 in an acidic tumor microenvironment. …”
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Routine Multimodal Antiemesis Including Low-Dose Perphenazine in an Ambulatory Surgery Unit of a University Hospital: A 10-Year History by Brian A. Williams, Michael L. Kentor, Susan J. Skledar, Steven L. Orebaugh, Manuel C. Vallejo

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The Experience of Survivors of Firearm Suicide Attempts: A Retrospective Case Series by Jeffrey R. Savarino, MD, MPH, Emily Rubin, MD, JD, Peter T. Masiakos, MD, MS, Rachel McLellan, BA, Myron L. Rolle, MD, MSc, Pranav Nanda, MD, Christopher J. Stapleton, MD, Chana A. Sacks, MD, MPH

“…Nineteen (56%) patients were acutely intoxicated with alcohol upon hospitalization and 17 (50%) patients had a positive urine drug screen. Acute stressors involving interpersonal relationships (53%), work/school (32%), and legal disputes (18%), among others, were documented in 82% of patients. …”
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Actively protective combinatorial analysis: A scalable novel method for detecting variants that contribute to reduced disease prevalence in high-risk individuals by J Sardell, S Das, K Taylor, C Stubberfield, A Malinowski, M Strivens, S Gardner

“…These protective signatures can potentially be used to identify novel drug targets, pharmacogenomic and/or therapeutic mRNA opportunities and to better stratify patients by overall disease risk and mechanistic subtype.We describe the method and illustrate how it offers increased power for detecting disease-associated genetic variants relative to traditional methods. …”
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In-vitro acaricidal activity of peganum harmala and glaucium flavum alkaloid against rhipicephalus sp. of dog by Rosa Kebbi, Omar Besseboua, Mohamed Nait-Mouloud, Abdelhanine Ayad

“…<b>Aim: </b>The major problem of drug intended for tick control is resistance developed to application doses on the hosts. …”
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Effects of Pioglitazone on Nonalcoholic Fatty Liver Disease in the Absence of Constitutive Androstane Receptor Expression by Hwa Young Ahn, Hwan Hee Kim, Ji-Yeon Hwang, Changhun Park, Bo Youn Cho, Young Joo Park

“…Pioglitazone, which was developed as an antidiabetic drug, is known to improve NALFD. Pioglitazone is metabolized by multiple cytochrome P450 (CYP) enzymes, which are regulated by the xenobiotic receptor constitutive androstane receptor (CAR). …”
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The SEPALLATA-like gene HrSEP1 in Hippophae rhamnoides regulates flower development by interacting with other MADS-box subfamily genes by Di Cong, Xue Zhao, Xue Zhao, Chang Ni, Mengru Li, Luwen Han, Jianlin Cheng, Hongzhang Liu, Huijing Liu, Dan Yao, Shuying Liu, Guoshuang Chen

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Qingfei Tongluo Mixture Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis through mTOR-Dependent Autophagy in Rats by Shuyu Ge, Zhenghong Guo, Ting Xiao, Pingping Sun, Bo Yang, Yin Ying

“…After induction modeling and drug intervention, blood samples and lung tissue were collected for further detection. …”
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