Hubungan Tingkat Pengetahuan dan Sikap dengan Penggunaan Antibiotik Tanpa Resep Dokter by Hasnal Laily Yarza, Yanwirasti ., Lili Irawati

“…Now many antibiotics are used without doctors prescription, whereas antibiotics must be used with doctors prescription and bought in drug strore. Use antibiotics without doctors prescription will be impact resistence. …”
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L-Dopa Pharmacokinetic Profile with Effervescent Melevodopa/Carbidopa versus Standard-Release Levodopa/Carbidopa Tablets in Parkinson’s Disease: A Randomised Study by Fabrizio Stocchi, Laura Vacca, Paola Grassini, Stephen Pawsey, Holly Whale, Stefano Marconi, Margherita Torti

“…V1512 provides a more reliable L-dopa pharmacokinetic profile versus standard-release L-dopa/carbidopa, with less drug accumulation and less variability. This trial is registered with ClinicalTrials.gov NCT00491998.…”
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Delirium management and current practice among Intensive Care Units Doctors, Khartoum [version 3; peer review: 1 approved, 2 approved with reservations] by Mudawi Mohammed Ahmed Abdallah, Sheema Hamid Seidna Hamid, Hana Eltayeb Salih Elamin, Ghada Omer Hamad Abd El-Raheem

“…Haloperidol was the most commonly used drug (83.3%). A total of 40.3% of doctors did not stop delirium medication on ICU discharge. …”
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Deep Venous Thrombosis in Patients with Erythema Nodosum Leprosum in the Use of Thalidomide and Systemic Corticosteroid in Reference Service in Belo Horizonte, Minas Gerais by Luiz Alberto Bomjardim Pôrto, Maria Aparecida de Faria Grossi, Edilamar Silva de Alecrim, Marcus Henrique de Souza Brito Xavier, Frederico Paiva e Silva, Amalia Sathler Pires, Fabianny Sanglard da Silva, Sandra Lyon

“…ASA 100mg/day as prophylaxis for DVT in case of this drug association in ENL is recommended. Conclusion. …”
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Safety of Levodopa-Carbidopa Intestinal Gel Treatment in Patients with Advanced Parkinson’s Disease Receiving ≥2000 mg Daily Dose of Levodopa by Cindy Zadikoff, Werner Poewe, James T. Boyd, Lars Bergmann, Horia Ijacu, Pavnit Kukreja, Weining Z. Robieson, Janet Benesh, Angelo Antonini

“…LCIG safety (adverse effects (AEs)/adverse drug reactions (ADRs)) and efficacy (modified Unified Parkinson’s Disease Rating Scale (UPDRS) part IV item 32 and 39 scores for “On” time with dyskinesia and “Off” time) were assessed in patients who received ≥2000 mg/day vs <2000 mg/day LCIG. …”
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Computational Study of the Phytochemical Constituents from Uncaria tomentosa Stem Bark against SARS-CoV-2 Omicron Spike Protein by Oscar Herrera-Calderon, Abdulrahman M. Saleh, Andres F. Yepes-Perez, Nada H. Aljarba, Saad Alkahtani, Gaber El-Saber Batiha, Renan Dilton Hañari-Quispe, Haydee Chavez, Josefa Bertha Pari-Olarte, Eddie Loyola-Gonzales, José Santiago Almeida-Galindo, José Francisco Kong-Chirinos, Taoufiq Benali

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Uji Efek Antibakteri Ekstrak Etanol Kulit Batang Salam {Syzigium polyanthum (Wight) Walp} terhadap Staphylococcus aureus dan Escherichia coli secara Invitro by Ikhsan Amanda Putra, Erly ., Machdawaty Masri

“…The parts of the plant that can be used as drug are bark. From the research that has been conducted has proven that Salam leaves has an antibacterial effect. …”
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Selected Abstracts of the 8th World Summit on Pediatrics; Madrid (Spain); October 3-6, 2024 by --- Various Authors

“…WHEN A FUNCTIONAL NEUROLOGIC DIS­ORDER OVERLAPS WITH AN UNCOMMON ADVERSE DRUG REACTION: A CHALLENGING DIAGNOSIS • M. Proserpio, S. …”
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Case report: Personalized management of treatment resistance in advanced NSCLC patients with mutated epidermal growth factor receptor: special examples and literature review by Jun Wang, Jun Wang, Xiaojing Li, Shuang Dong, Sheng Hu, Fengming Ran, Yu Qian

“…The first subclass involves the acquisition of target mutations that lead to changes in the kinase domain, thereby hindering drug binding. The second mechanism, known as bypass resistance, entails tumor clones utilizing alternative signaling pathways for proliferation. …”
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Restriction of mitochondrial oxidation of glutamine or fatty acids enhances intracellular growth of Mycobacterium abscessus in macrophages by Ho Won Kim, Ji Won Lee, Hoe Sun Yoon, Hwan-Woo Park, Young Ik Lee, Sung Ki Lee, Jake Whang, Jong-Seok Kim

“…By manipulating host mitochondrial metabolism, we identify a potential host-directed therapeutic strategy against Mab, offering a promising alternative to conventional treatments beleaguered by drug resistance. This study underscores the importance of exploring metabolic interventions to combat Mab infection, paving the way for innovative approaches in the fight against this formidable pathogen.…”
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Investigation of Scutellaria Barbata’s immunological mechanism against thyroid cancer using network pharmacology and experimental validation by Gen Ouyang, Yuangui Zhu, Zhehao Ouyang

“…In the TCMSP database, the active components and potential targets of SBH were screened to construct a drug-component-target-disease network. TC targets were then filtered, and common targets were selected to build a protein-protein interaction network. …”
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Glycemic Profile and Clinical Treatment in Patients with Diabetes Mellitus-Tuberculosis: An Update Scoping Review by Rissaadah S, Nursiswati N, Pahria T

“…Severe hyperglycemia in patients with DM-TB is associated with an increased risk of TB treatment failure, a long recovery time, and the likelihood of developing multi-drug-resistant tuberculosis (MDR-TB). In addition, patients with DM-TB who did not start TB treatment were more likely to have poorer glycemic control than patients with DM-TB who underwent active TB treatment.Conclusion: Patients with DM-TB, such as MDR-TB, are at a higher risk of poor glycemic control, treatment failure, and clinical severity. …”
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Safety and Efficacy of Cryoballoon Ablation of Atrial Fibrillation in relation to the Patients’ Age: Results from a Large Real-World Multicenter Observational Project by Luigi Sciarra, Saverio Iacopino, Giuseppe Arena, Claudio Tondo, Paolo Pieragnoli, Giulio Molon, Massimiliano Manfrin, Antonio Curnis, Antonio Dello Russo, Giovanni Rovaris, Giuseppe Stabile, Leonardo Calò, Gabriele Boscolo, Roberto Verlato

“…Methods. 2,534 patients underwent pulmonary vein isolation (PVI) by way of CBA for paroxysmal or persistent drug-resistant and symptomatic AF. The population was divided into age quartiles for evaluation, including (1) <53 years, (2) ≥53 and <61 years, (3) ≥61 and <67 years, and (4) ≥67 years. …”
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Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential by Mi-bo Tang, Yi-xuan Liu, Zheng-wei Hu, Hai-yang Luo, Shuo Zhang, Chang-he Shi, Yu-ming Xu, Yu-ming Xu, Yu-ming Xu

“…Importantly, we discuss some compounds or drug-targeting strategies that have been studied to ameliorate the pathology of these neurological diseases and introduce the possible mechanistic pathways. …”
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<i>Lilium candidum</i> Extract Loaded in Alginate Hydrogel Beads for Chronic Wound Healing by Ioana Bâldea, Maria-Loredana Soran, Adina Stegarescu, Ocsana Opriș, Irina Kacso, Septimiu Tripon, Alexandra Adascalitei, Iulian George Fericel, Roxana Decea, Ildiko Lung

“…Smart wound dressings that provide a controlled drug release can significantly improve the healing process. …”
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Phosphodiesterase 10A Is a Mediator of Osteogenic Differentiation and Mechanotransduction in Bone Marrow-Derived Mesenchymal Stromal Cells by Sigrid Müller-Deubert, Carolin Ege, Melanie Krug, Jutta Meißner-Weigl, Maximilian Rudert, Oliver Bischof, Franz Jakob, Regina Ebert

“…While applying mechanical strain via cyclic stretching of hMSCs led to an upregulation of PDE10A gene expression, inhibition of PDE10A using the drug papaverine repressed expression of mechanoresponsive genes. …”
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An Evaluation of the Antibacterial Properties of Tormentic Acid Congener and Extracts From Callistemon viminalis on Selected ESKAPE Pathogens and Effects on Biofilm Formation by Tafadzwa Chipenzi, Genuine Baloyi, Tatenda Mudondo, Simbarashe Sithole, Godloves Fru Chi, Stanley Mukanganyama

“…The antibacterial effects were determined by the microbroth dilution method, and ciprofloxacin was used as the standard antibacterial drug. Biofilm formation and detachment assays were performed using crystal violet staining. …”
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Cost-effectiveness of the Floodlight MS app in Austria. Unlocking the mystery of costs and outcomes of a digital health application for patients with multiple sclerosis by Evelyn Walter, Matthäus Traunfellner, Franz Meyer, Christian Enzinger, Michael Guger, Christian Bsteh, Patrick Altmann, Harald Hegen, Christoph Goger, Veronika Mikl

“…The analysis included treatment-naive individuals and those already on drug therapy, modelling the app's role in early detection of disease progression and relapses to improve quality-of-life. …”
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Comparable Enhanced Prothrombogenesis in Simple Central Obesity and Metabolic Syndrome by Noor Shafina Mohd Nor, Hanis Saimin, Thuhairah Rahman, Suraya Abdul Razak, Nadzimah Mohd Nasir, Zaliha Ismail, Hapizah Mohd Nawawi

“…A cross-sectional study involving 503 drug naive subjects (163 males, aged 30–65 years old (mean age ± SD = 47.4 ± 8.3 years)) divided into MS, COB and NC groups. …”
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ISU201 Enhances the Resolution of Airway Inflammation in a Mouse Model of an Acute Exacerbation of Asthma by Yuka Hiroshima, Linda Garthwaite, Kenneth Hsu, Hyouna Yoo, Sang-Ho Park, Carolyn L. Geczy, Rakesh K. Kumar, Cristan Herbert

“…Using a murine model of an acute exacerbation of asthma, we assessed the ability of ISU201, a novel protein drug, to suppress the inflammatory response when administered after induction of an exacerbation. …”
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