Integrating multiomics analysis and machine learning to refine the molecular subtyping and prognostic analysis of stomach adenocarcinoma by Miaodong Wang, Qin He, Zeshan Chen, Yijue Qin

“…The prognostic relationship between CMLS and STAD was assessed using Kaplan-Meier curves, and the independent prognostic value of CMLS was determined by univariate and multivariate regression analyses. we also evaluated the immune characteristics, immunotherapy response, and drug sensitivity of different CMLS groups. The results of the multiomics analysis classified STAD into three subtypes, with CS1 resulting in the best survival outcome. …”
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Forecasting Asparaginase Need and Cost for Childhood Cancer Using ACCESS FORxECAST by Terence M. Hughes, Nitin Shrivastava, Lewis B. Silverman, A. Lindsay Frazier, Sumit Gupta, Avram Denburg

“…Short shelf lives, intermittent availability, and concern for substandard formulations in LMICs have created a need for proactive ASN demand estimates.METHODSWe adapted FORxECAST, a pediatric cancer drug forecasting model, to focus on ASN for pediatric ALL. …”
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Young adults’ cigarillo risk perceptions, attention to warning labels and perceptions of proposed pictorial warnings: a focus group study by Michelle Jeong, Olivia A Wackowski, Stefanie K Gratale, Andrew A Strasser, Cristine D Delnevo, Zeinab Safi, Anupreet Sidhu

“…Objective Although cigars pose similar health risks to cigarettes, they are not uniformly required to carry a warning label on their packaging in the USA. The US Food and Drug Administration’s 2016 deeming rule established a cigar warning requirement, but it was challenged in federal court for failing to document warning effects on prevention/cessation, thus necessitating an evidentiary base for such requirements. …”
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Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives by Virendra Kumar Yadav, Seshathiri Dhanasekaran, Nisha Choudhary, Deepak Nathiya, Vishal Thakur, Rachna Gupta, Sheersha Pramanik, Pankaj Kumar, Nishant Gupta, Ashish Patel

“…Nanomedicine utilizes nanoparticles for targeted drug delivery, leveraging their small size and high surface area to volume ratio to cross the blood-brain barrier and deliver therapeutic agents directly to affected brain regions. …”
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Comparison of the effectiveness of temporomandibular joint osteoarthritis treatment with corticosteroids, hyaluronic acid, and platelet-rich plasma mono-therapy by I. A. Shynchukovskyi, O. H. Tereshchuk

“…Today, intra-articular injections are often used for treatment, so it is necessary to study the effectiveness of drug administration on the course of the disease. …”
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Adherence to Dihydroartemisinin-Piperaquine Treatment among Patients with Uncomplicated Malaria in Northern Ghana by Abraham Rexford Oduro, Samuel Chatio, Paula Beeri, Thomas Anyorigiya, Rita Baiden, Philip Adongo, Patricia Akweongo

“…Follow-up visits were made on days 3 and 28 after diagnosis to collect data on adherence, drug safety and therapeutic effectiveness. During follow-up visits, in-depth interviews were conducted and the blister packs directly observed for the number of tablets remaining. …”
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Relationship between body mass index and clinical events in patients with atrial fibrillation undergoing percutaneous coronary intervention. by Tatsuro Yamazaki, Hideki Kitahara, Daichi Yamashita, Takanori Sato, Sakuramaru Suzuki, Takashi Hiraga, Tadahiro Matsumoto, Takahiro Kobayashi, Yuji Ohno, Junya Harada, Kenichi Fukushima, Tatsuhiko Asano, Naoki Ishio, Raita Uchiyama, Hirofumi Miyahara, Shinichi Okino, Masanori Sano, Nehiro Kuriyama, Masashi Yamamoto, Naoya Sakamoto, Junji Kanda, Yoshio Kobayashi

“…AF patients who underwent PCI with drug-eluting stents for CAD were retrospectively and prospectively included. …”
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Effectiveness of Propofol versus Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Ear, Nose, and Throat Surgery in Tikur Anbessa Specialized Hospital and Yekati... by Abere Tilahun Bantie, Wosenyeleh Admasu, Sintayehu Mulugeta, Abera Regassa Bacha, Desalegn Getnet Demsie

“…However, the comparative effectiveness of the two drugs has not been assessed. The aim of this study was to compare the effectiveness of propofol and dexamethasone for prevention of PONV in ear, nose, and throat surgery. …”
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Prevalence of TB-related symptoms and self-reported disability among adult TB survivors by A.K. McDonald, D. Nakkonde, P. Kaggwa, S. Zalwango, A. Joseph, E. Buregyeya, J.N. Sekandi

“…METHODS: Between January 2022 and October 2023, we conducted a study of adults who completed treatment for drug-susceptible TB in Kampala, Uganda. We collected data on demographics, TB-related symptoms, HIV status, and disability measured using the World Health Organization Disability Assessment Schedule (WHODAS 2.0). …”
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Expert consensus guidelines on management and best practices for tumor-infiltrating lymphocyte cell therapy by Sarah Nikiforow, John Haanen, Omid Hamid, Igor Puzanov, Rodabe Amaria, Amod Sarnaik, Marcus O Butler, Michael R Bishop, Allison Betof Warner, Adam J Schoenfeld, Krishna Komanduri

“…Based on the encouraging efficacy, tolerable safety profile, and advancements in a central manufacturing process, lifileucel is now the first US Food and Drug Administration (FDA)-approved TIL cell therapy product. …”
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Bacterial Profile of External Ocular Infections, Its Associated Factors, and Antimicrobial Susceptibility Pattern among Patients Attending Karamara Hospital, Jigjiga, Eastern Ethio... by Tigist Abebe, Zelalem Teklemariam, Tadesse Shume, Surafel Mekuria, Kedir Urgesa, Fitsum Weldegebreal

“…Antibiotics that were susceptible to the specific bacteria should be used as a drug of choice and using soap for washing the face is advisable to protect against external ocular infection.…”
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The Safety and Efficacy of Lansoprazole plus Metoclopramide among Neonates with Gastroesophageal Reflux Disease Resistant to Conservative Therapy and Monotherapy: A Clinical Trial by Peymaneh Alizadeh Taheri, Elahe Validad, Kambiz Eftekhari

“…The response rate of “lansoprazole plus metoclopramide” was significantly higher than “ranitidine plus metoclopramide” (7.44±3.86 score vs. 9.3±4.57 score, p=0.018) after one week and (2.41±3.06 score vs. 4.5±4.12 score, p=0.003) after one month (primary outcome). There were no drug adverse effects in either group during intervention (secondary outcome). …”
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Pharmacokinetics of pradofloxacin, florfenicol, and tulathromycin and response to treatment of steers experimentally infected with Mannheimia hemolytica by Derek M. Foster, Jennifer L. Halleran, Megan E. Jacob, Stephanie Hempstead, Luke B. Borst, Tatiane T. Negrao Watanabe, Hiroko Enomoto, Mark G. Papich

“…Pharmacokinetic data of these drugs is relatively limited in diseased animals. …”
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Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway by Lili Wu, Chunfeng Liang, Xuemei Huang, Xiujun Deng, Jiming Jiang, Zuojie Luo

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Attitudes to Medication after Kidney Transplantation and Their Association with Medication Adherence and Graft Survival: A 2-Year Follow-Up Study by Mirjam Tielen, Job van Exel, Mirjam Laging, Denise K. Beck, Roshni Khemai, Teun van Gelder, Michiel G. H. Betjes, Willem Weimar, Emma K. Massey

“…Moreover, the intrapatient variability in the pharmacokinetics of tacrolimus was calculated, which measures stability of drug intake. Data on graft survival was retrieved from patient records up to 2 years after transplantation. …”
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Determinants of Deescalation Failure in Critically Ill Patients with Sepsis: A Prospective Cohort Study by Nawal Salahuddin, Lama Amer, Mini Joseph, Alya El Hazmi, Hassan Hawa, Khalid Maghrabi

“…Current deescalation practices reflect physician reluctance when dealing with complicated, sicker patients or with drug-resistance or fungal sepsis. Integrating an antibiotic stewardship program may increase physician confidence and provide support towards increasing deescalation rates.…”
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Efficacy of Osthole in Management of Hypoperfused Retina by Ran Du, Zhao-yang Meng, Jia-lin Wang, Yan-ling Wang

“…Four rats in each group were sacrificed every 5 days after drug administration, and histopathology along with morphology of retina were observed. …”
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Isolation and Evaluation of Clinically Important Acinetobacter Baumannii From Intensive Care Unit Samples by Mohamed Mowfik Sehree, Hanaa N. Abdullah, Amani M. Jasim

“…The current findings suggest that automated Vitek 2 system is the most common method to accurately detect the isolates and evaluate multi-drug resistant A. baumannii among patients. …”
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Akkermansia muciniphila Mediated the Preventive Effect of Disulfiram on Acute Liver Injury via PI3K/Akt Pathway by Ruonan Zhang, Xuewei Sun, Han Lu, Xinrui Zhang, Mingyan Zhang, Xuewen Ji, Xinyi Yu, Chengliang Tang, Zihan Wu, Yinghua Mao, Jin Zhu, Minjun Ji, Zhan Yang

“…Disulfiram (DSF) is a multitarget drug that has been proven to play a role in a variety of liver diseases and can affect intestinal flora, but whether it can alleviate ALI is not clear. …”
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Risk of Gastrointestinal Bleeding with Rivaroxaban: A Comparative Study with Warfarin by Muhammed Sherid, Samian Sulaiman, Salih Samo, Husein Husein, Ruth Tupper, Charles Spurr, Humberto Sifuentes, Subbaramiah Sridhar

“…The risk factors for GI bleeding with rivaroxaban were the first 40 days of taking the drug, concomitant dual antiplatelet agents, and prior GI bleeding.…”
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