Epidemiological Analysis of a <i>K. pneumoniae</i> NDM Outbreak in a Temporary Ward for Patients with Primary COVID-19 Infection by Agata Pruss, Klaudia Miładowska, Helena Masiuk, Paweł Kwiatkowski, Joanna Jursa-Kulesza, Bartosz Wojciuk, Stefania Giedrys-Kalemba, Barbara Dołęgowska

“…Twenty-eight <i>K. pneumoniae</i> strains were analyzed from patients with primary COVID-19 infection. The drug susceptibility of the strains was determined by the diffusion–circulation method and E-test. …”
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Tuberculosis treatment outcomes and associated factors among patients treated at Bosaso TB Hospital, Bosaso, Somalia: A five-year retrospective study. by Saaid Said Jama, Mohamed Mohamud Abdi

“…Therefore, we recommend strengthening the TB care system, conducting regular supportive supervision for TB facilities, implementing strategies to encourage drug adherence, strengthening mechanisms to minimize the anti-TB treatment default rate, improving counseling services, and giving more attention to the vulnerable age groups and HIV-positive patients.…”
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Phenols from Vaccinium dunalianum Wight: Secondary Mass Spectrometry Fragmentation and Neuroprotective Effect by ZHOU Tang, WANG Ji, QIAO Wenhao, LIN Zhiqi, ZHU Hongbo, CHANG Yue, HU Weiyan, ZHANG Rongping, CHEN Xinglong

“…The neuroprotective effect was stronger than that of the positive drug epigallocatechin gallate. The above findings indicated that V. dunalianum buds was rich in phenolic compounds with obvious neuroprotective effects, which would expand the health functions of V. dunalianum buds as green health foods.…”
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A Retrospective Claims Data Analysis on the Burden of COVID-19-Related Hospitalization in Adults at High Risk for Severe Disease Progression in Germany by Timotheus Stremel, Svitlana Schnaidt, Nicole Bihrer, Emma Fröling, Christian Jacob, Agnes Kisser

“…Nirmatrelvir/ritonavir (NMV/r) is an antiviral drug aiming to prevent severe disease courses. Our study aimed to assess the resource utilization and costs of adults hospitalized for COVID-19 at high risk for severe disease progression. …”
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Continued high rates of antibiotic prescribing to adults with respiratory tract infection: survey of 568 UK general practices by Paul Little, Lucy Yardley, Martin C Gulliford, Judith Charlton, Lisa McDermott, Michael V Moore, Mark Ashworth, Tjeerd van Staa, Alex Dregan, Gerard McCann

“…Objectives Overutilisation of antibiotics may contribute to the emergence of antimicrobial drug resistance, a growing international concern. …”
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Molecular Mechanisms and Therapeutic Prospects of Immunotherapy and Targeted Therapy in Primary Central Nervous System Lymphoma by Lin Zhong MM, Anqing Lu MB, Xiyue Lu MM, Xiaoyin Liu MD, Lujia Cao MM, Shihong Zhu MM, SiJun Diao MM, Xu Cheng MM, Hongwei Wu MB, Jing Chen MD

“…However, some patients still experience disease recurrence or develop drug resistance. With a deeper understanding of the pathophysiology of PCNSL, various therapies, including CD20 monoclonal antibodies, Bruton's tyrosine kinase (BTK) inhibitors, immunomodulatory drugs, immune checkpoint inhibitors, phosphoinositide 3-kinase (PI3 K)/mammalian target of rapamycin(mTOR) inhibitors, and chimeric antigen receptor (CAR) -T cells are increasingly being applied and have demonstrated considerable efficacy. …”
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Cytopenia among CML Patients on Imatinib in Kenya: Types, Grades, and Time Course by Angela McLigeyo, Jamilla Rajab, Mohammed Ezzi, Peter Oyiro, Yatich Bett, Andrew Odhiambo, Matilda Ong’ondi, Sitna Mwanzi, Mercy Gatua, NAOthieno- Abinya

“…Patients on imatinib treatment may develop cytopenia due to drug toxicity. This study aimed to determine the types, grades, and time course of cytopenia in CML patients on imatinib at a Nairobi hospital. …”
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Identification and Validation of the Pyroptosis-Related Hub Gene Signature and the Associated Regulation Axis in Diabetic Keratopathy by Yi Cui, Li Wang, Wentao Liang, Li Huang, Shuting Zhuang, Hong Shi, Nuo Xu, Jianzhang Hu

“…An integrated bioinformatics pipeline, including differentially expressed gene (DEG) identification, enrichment analysis, protein-protein interaction (PPI) network, coexpression, drug prediction, and immune deconvolution analyses, identified hub genes and key drivers in DK pathogenesis. …”
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Analysis of differentially expressed genes in hypertension and hypertensive cerebral hemorrhage via RNA-sequencing by Hongwu Qi, Min Qiao, Yansong Liu, Weijun Zeng, Lizhao Zhang, Hongjun Guo

“…Estimation of cell infiltration, drug prediction, and real-time qPCR (RT-qPCR) validation were performed. …”
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Isolation, Characterization and Genetic Diversity of Aspergillus flavus in Animal Feed by Dina Al-Shinawy, Reda E.M. Moghaieb, Sara B. Awaly, Gihan El-Moghazy, Dalia S. Ahmed

“…The data showed that all samples except one (S1) contained total aflatoxin levels below 20 μg/ kg, considered safe for animal consumption according to the European Union (EU), United States Food and Drug Administration (US FDA), and World Health Organization (WHO) guidelines. …”
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Epsin3 promotes non-small cell lung cancer progression via modulating EGFR stability by Huiling Su, Jie Shen, Chenzi Gao, Yue Zhao, Wanyu Deng, Bo Qin, Xin Zhang, Juan Lai, Qian Wang, Jie Dou, Min Guo

“…Targeting EPN3 could offer a novel therapeutic strategy to overcome drug resistance in EGFR-driven NSCLC.…”
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Comparison between the HLA-B∗58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions by Niwat Saksit, Nontaya Nakkam, Parinya Konyoung, Usanee Khunarkornsiri, Wongwiwat Tassaneeyakul, Pansu Chumworathayi, Sirimas Kanjanawart, Chonlaphat Sukasem, Alisara Sangviroon, Oranuch Pattanacheewapull, Wichittra Tassaneeyakul

“…Severe cutaneous adverse drug reactions (SCARs) are life-threatening reactions. …”
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Effects of Dual Peroxisome Proliferator-Activated Receptors α and γ Activation in Two Rat Models of Neuropathic Pain by Mohammad Alsalem, Mansour Haddad, Sara A. Aldossary, Heba Kalbouneh, Belal Azab, Aala Dweik, Amer Imraish, Khalid El-Salem

“…Antinociceptive effects of tesaglitazar were determined 6 hours after drug administration. Cobalt influx assays in cultured dorsal root ganglia (DRG) neurons were used to study the effects of tesaglitazar preincubation on capsaicin-evoked cobalt influx. …”
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From guideline to practice: three years of ICH S11 insights and recommendations by Diana Tavares, Hsiao-Tzu Chien, Hsiao-Tzu Chien, Maria Elzbieta Sheean, Peter Theunissen, Peter Theunissen, Peter van Meer, Peter van Meer, Peter van Meer, Karen Van Malderen

“…The WoE approach in ICH S11 ensures that relevant safety information is generated to support paediatric drug development while balancing the principles of non-clinical replacement, reduction and refinement (the 3Rs).…”
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Weizmannia coagulans: an ideal probiotic for gut health by Shiqi Zhang, Pinglan Li, Suwon Lee, Yu Wang, Chunming Tan, Nan Shang

“…W. coagulans has been generally recognized as safe (GRAS) by the US Food and Drug Administration (FDA), thus it is an ideal probiotic for improving gut health. …”
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A deep learning analysis for dual healthcare system users and risk of opioid use disorder by Ying Yin, Elizabeth Workman, Phillip Ma, Yan Cheng, Yijun Shao, Joseph L. Goulet, Friedhelm Sandbrink, Cynthia Brandt, Christopher Spevak, Jacob T. Kean, William Becker, Alexander Libin, Nawar Shara, Helen M. Sheriff, Jorie Butler, Rajeev M. Agrawal, Joel Kupersmith, Qing Zeng-Trietler

“…Interestingly, a history of other drug use interacted negatively with dual-system use regarding OUD risk. …”
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Derivation and Identification of Motor Neurons from Human Urine-Derived Induced Pluripotent Stem Cells by Huan Yi, Bingbing Xie, Ben Liu, Xuan Wang, Li Xu, Jia Liu, Min Li, Xiufeng Zhong, Fuhua Peng

“…Induced pluripotent stem cells (iPSCs) have provided new opportunities for motor neuron disease (MND) modeling, drug screening, and cellular therapeutic development. …”
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fragSMILES as a chemical string notation for advanced fragment and chirality representation by Fabrizio Mastrolorito, Fulvio Ciriaco, Maria Vittoria Togo, Nicola Gambacorta, Daniela Trisciuzzi, Cosimo Damiano Altomare, Nicola Amoroso, Francesca Grisoni, Orazio Nicolotti

“…Abstract Generative models have revolutionized de novo drug design, allowing to produce molecules on-demand with desired physicochemical and pharmacological properties. …”
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NLRP3 is a BMI-independent mediator of stable COPD by Yonca Gungor, Selin Ercan, Saliha Selin Özuygur Ermiş, Yiğit Kozalı, Gizem Kursunluoglu, Ceyda Sahan, Aylin Ozgen Alpaydin, Hulya Ayar Kayali

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Learning “How to Learn”: Super Declarative Motor Learning Is Impaired in Parkinson’s Disease by Lucio Marinelli, Carlo Trompetto, Stefania Canneva, Laura Mori, Flavio Nobili, Francesco Fattapposta, Antonio Currà, Giovanni Abbruzzese, Maria Felice Ghilardi

“…The aim of this study is to investigate the retention and anterograde interference using a declarative sequence learning task in drug-naive patients in the disease’s early stages. …”
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