Oligonucleotides as a Novel Therapeutic Approach: An Innovative Area for Drug Delivery in Neurological Disorders by Yasir Qasim Almajidi, Rana Kadum Muslim, Yaseen T. khalf

Get full text

Chromosomal genome assembly resolves drug resistance loci in the parasitic nematode Teladorsagia circumcincta. by Jennifer McIntyre, Alison Morrison, Kirsty Maitland, Duncan Berger, Daniel R G Price, Sam Dougan, Dionysis Grigoriadis, Alan Tracey, Nancy Holroyd, Katie Bull, Hannah Rose Vineer, Mike J Glover, Eric R Morgan, Alasdair J Nisbet, Tom N McNeilly, Yvonne Bartley, Neil Sargison, Dave Bartley, Matt Berriman, James A Cotton, Eileen Devaney, Roz Laing, Stephen R Doyle

“…The parasitic nematode Teladorsagia circumcincta is one of the most important pathogens of sheep and goats in temperate climates worldwide and can rapidly evolve resistance to drugs used to control it. To understand the genetics of drug resistance, we have generated a highly contiguous genome assembly for the UK T. circumcincta isolate, MTci2. …”
Get full text

Cutaneous adverse drug reaction associated with topical use of benzyl benzoate in a dog by Fabiana Wurster Strey, Marinara Macelai Leite, Jéssica Vargas, Bruno Leite Anjos

“…ABSTRACT: Cutaneous adverse drug reactions (CADR) are unexpected dermatological reactions caused by medications. …”
Get full text

Optimisation and In Vivo Evaluation of Pectin Based Drug Delivery System Containing Curcumin for Colon by Kishor Butte, Munira Momin, Hemant Deshmukh

“…The higher incidences of side effects of existing drugs have shifted researchers and clinicians to explore the dietary phytoconstituents for its therapeutic potentials. …”
Get full text

A systematic review of the cost-effectiveness of anti-VEGF drugs for the treatment of diabetic retinopathy by Robert Hodgson, Matthew Walton, Helen Fulbright, Laura Bojke, Ruth Walker, Alexis Llewellyn, Sofia Dias, Lesley Stewart, David Steel, John Lawrenson, Tunde Peto, Mark Simmonds

“…Anti-vascular endothelial growth factor drugs represent a treatment option for people with diabetic retinopathy and are routinely used to treat various other eye conditions. …”
Get full text

Geospatial mapping of drug-resistant tuberculosis prevalence in Africa at national and sub-national levels by Alemneh Mekuriaw Liyew, Archie C.A. Clements, Fasil Wagnew, Beth Gilmour, Kefyalew Addis Alene

Subjects: “…Drug-resistant tuberculosis…”
Get full text

Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks by Elena Díaz-Santiago, Aurelio A. Moya-García, Jesús Pérez-García, Raquel Yahyaoui, Raquel Yahyaoui, Christine Orengo, Florencio Pazos, James R. Perkins, James R. Perkins, James R. Perkins, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea

Subjects: “…drug effects…”
Get full text

Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient by Serena Patel, Michel H. Mendler, Mark A. Valasek, Shirley M. Tsunoda

“…Drug-induced liver injury (DILI) has not been previously reported as a complication of treatment with everolimus. …”
Get full text

Exploring Fragment Adding Strategies to Enhance Molecule Pretraining in AI-Driven Drug Discovery by Zhaoxu Meng, Cheng Chen, Xuan Zhang, Wei Zhao, Xuefeng Cui

Subjects: Get full text

Current Challenges and Potential Solutions for Targeted Drug Delivery (TDD) in Cancer Pain Management by Chung M, Kalia H, Schatman ME, Robinson CL

Get full text

Electrochemical Analysis of Antichemotherapeutic Drug Zanosar in Pharmaceutical and Biological Samples by Differential Pulse Polarography by Chennupalle Nageswara Reddy, Puthalapattu ReddyPrasad, NeelamYughandhar Sreedhar

“…A simple DPP technique was proposed for the direct quantitative determination of anticancer drug zanosar in pharmaceutical formulation and spiked human urine samples for the first time. …”
Get full text

Drug-Induced Liver Injury Caused by Adalimumab: A Case Report and Review of the Bibliography by Bernardo Frider, Andres Bruno, Marcelo Ponte, Marcelo Amante

“…The most serious adverse drug reaction of adalimumab (ADR) is tuberculosis reactivation. …”
Get full text

Influence of injection technique, drug formulation and tumor microenvironment on intratumoral immunotherapy delivery and efficacy by Patrick Hwu, Ravi Murthy, Aung Naing, Sapna P. Patel, Simon Young, Alda Tam, Nina M. Muñoz, Malea Williams, Katherine Dixon, Crystal Dupuis, Amanda McWatters, Rony Avritscher, Soraya Zorro Manrique, Kevin McHugh, David Leach, Jeffrey D. Hartgerink, Punit Prakash, Rahul A. Sheth

“…However, we have previously shown that off-target delivery is a substantial problem during intratumoral injections; this can lead to diminished drug efficacy and systemic toxicities. We have identified three variables that influence intratumoral drug delivery: injection technique, drug formulation and tumor microenvironment. …”
Get full text

Role of drug-induced sleep endoscopy in evaluation of positional vs non-positional OSA by Ming-Chin Lan, Stanley Yung-Chuan Liu, Ming-Ying Lan, Yun-Chen Huang, Tung-Tsun Huang, Yen-Bin Hsu

“…Methods A cross-sectional study of 230 consecutive patients with OSA undergoing DISE (Drug-induced Sleep Endoscopy) was carried out at a tertiary academic medical center. …”
Get full text

Treatment completion of drug-resistant tuberculosis in Ethiopia: A perspective from healthcare users. by Ahmed Reshid Tusho, Sheila Theresa Mokoboto-Zwane

“…Drug-resistant tuberculosis remains a persistent public health threat. …”
Get full text

Surgical Cryoablation of Drug Resistant Ventricular Tachycardia and Aneurysmectomy of Postinfarction Left Ventricular Aneurysm by Marek Pojar, Jan Harrer, Nedal Omran, Martin Vobornik

Get full text

The role of complement in tumor immune tolerance and drug resistance: a double-edged sword by Ronghui Yang, Di Fu, Di Fu, Aijun Liao

Subjects: Get full text

Pharmacological and Pharmacodynamic Implications of Nonsteroidal Anti-Inflammatory Drug Therapy in Elderly Arthritic Patients by W Watson Buchanan

“…There is growing evidence chat elderly patients may be more likely to develop adverse drug reactions to nonsteroidal anti-inflammatory drug/analgesic therapy. …”
Get full text

Machine Learning-Assisted Drug Repurposing Framework for Discovery of Aurora Kinase B Inhibitors by George Nicolae Daniel Ion, George Mihai Nitulescu, Dragos Paul Mihai

Subjects: Get full text

A model of competing saturable kinetic processes with application to thepharmacokinetics of the anticancer drug paclitaxel by Rebeccah E. Marsh, Jack A. Tuszyński, Michael Sawyer, Kenneth J. E. Vos

“…A saturable multi-compartment pharmacokinetic model for the anti-cancer drug paclitaxel is proposed based on a meta-analysis of pharmacokinetic data published over the last two decades. …”
Get full text