Albuminuria Is Associated with Left Ventricular Hypertrophy in Patients with Early Diabetic Kidney Disease by Nan Wu, Weiwei Zhao, Kuanping Ye, Yintao Li, Min He, Bin Lu, Renming Hu

“…Multivariate linear regression analysis demonstrated that albuminuria status (no, micro-, and macroalbuminuria; P<0.001), age (P<0.001), systolic blood pressure (P=0.0578), and the use of ACEI/ARB drug (P<0.001) were independently associated with LVMI. …”
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Impact of prolonged one or more natural menstrual cycles on the outcomes of ovulation induction intrauterine artificial insemination pregnancy: a single-centre, retrospective study... by Shuai Zhang, Han-Han Tang, Ming-Lian Zhou

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Pattern of Bacterial Pathogens and Their Susceptibility Isolated from Surgical Site Infections at Selected Referral Hospitals, Addis Ababa, Ethiopia by Walelign Dessie, Gebru Mulugeta, Surafael Fentaw, Amete Mihret, Mulu Hassen, Engida Abebe

“…To determine bacterial pathogens and drug susceptibility isolated from surgical site infections at St. …”
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MicroRNA-155 modulates methotrexate-induced spatial memory impairment by disruption of the blood-brain barrier integrity by Yu-Chieh Chen, Li-Tung Huang, Hong-Ren Yu, Jiunn-Ming Sheen

“…Aim: Methotrexate (MTX) is a commonly used chemotherapy drug, yet its late neurotoxic side effects are gaining attention. …”
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Efficacy of Anti-Cancer Immune Responses Elicited Using Tumor-Targeted IL-2 Cytokine and Its Derivatives in Combined Preclinical Therapies by Sahar Balkhi, Giorgia Bilato, Andrea De Lerma Barbaro, Paola Orecchia, Alessandro Poggi, Lorenzo Mortara

“…Innovative IL-2-based immunotherapeutic approaches include immunotoxins, such as antibody–drug conjugates, immunocytokines, and antibody–cytokine fusion proteins that enhance tumor-specific delivery. …”
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Methylcobalamin protects against liver failure via engaging gasdermin E by Wanfeng Xu, Yun Wang, Shuang Cui, Qiuling Zheng, Yanghao Lin, Qingqing Cui, Yuxin Xie, Yuming Zeng, Chuan Zhang, Yujie Li, Xin Jin, Minna Qin, Huiyong Sun, Haiping Hao, Lijuan Cao

“…In summary, our study discovers MeCbl as a specific GSDME inhibitor that is promisingly to be developed as an effective drug against cholestatic liver failure, and other GSDME triggered sterile inflammation and/or organ failure.…”
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Single-Round Patterned DNA Library Microarray Aptamer Lead Identification by Jennifer A. Martin, Peter A. Mirau, Yaroslav Chushak, Jorge L. Chávez, Rajesh R. Naik, Joshua A. Hagen, Nancy Kelley-Loughnane

“…The DNA library was specifically designed to increase the probability of binding by enhancing structural complexity in a sequence-space confined environment, much like generating lead compounds in a combinatorial drug screening library. The sequence demonstrating the highest fluorescence intensity upon target addition was confirmed to bind the target molecule thrombin with specificity by surface plasmon resonance, and a novel imino proton NMR/2D NOESY combination was used to screen the structure for G-quartet formation. …”
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Investigation of Crinum solapurense leaves extract for antidiabetic activity and histopathological evaluation in an in-vivo experimental model by Sunayana Mali, Gaurav Jain, Jyotiram Sawale, Audumbar Mali

“…Results: After inducing diabetes in rats by using dexamethasone, various groups of rats were treated with distilled water, a standard antidiabetic drug used as a Glibenclamide (GLC), and lower, medium, and higher doses of C. solapurense leaf extracts like 100.00 mg/kg, 200.00 mg/kg &amp; 400.00 mg/kg respectively. …”
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Inhibitory Effect of Lactobacillus delbrueckii subsp. bulgaricus KSFY07 on Kappa-Carrageenan-Induced Thrombosis in Mice and the Regulation of Oxidative Damage by Pan Wang, Fang Tan, Jianfei Mu, Hongjiang Chen, Xin Zhao, Yanan Xu

“…These results indicate that LDSB-KSFY07 was able to inhibit mouse thrombosis and reduce liver oxidative stress damage in thrombus mice and show that high concentrations of LDSB-KSFY07 provided a better response similar to that of the drug heparin.…”
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Pharmacological Treatment of Presbyopia Using Pilocarpine 1.25% Eye Drops by Seyed Abolghasem Mousavi, Zhale Rajavi, Hamideh Sabbaghi, Saeid Abdi, Nafeeseh Montazerin, Bahareh Kheiri, Azadeh Haseli- Monfared, Kourosh Sheibani, Hemn Baghban Jaldian

“… Purpose: To assess the efficiency and safety of pilocarpine eye drop 1.25% analogue (IRPilo) in comparison with its original brand-name drug (Vuity). Methods: In this non-randomized comparative study, 75 patients with presbyopia aged 40 to 60 years were enrolled. …”
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Comparison of Medical Treatments According to the Characteristics of Idiopathic Premature Ventricular Contractions: Beta-blockers or Calcium Channel Blockers? by Omer Faruk BAYCAN, Serdar FIDAN, Fatma Betul CELIK, Mustafa Adem TATLISU, Serhan OZYILDIRIM, Mustafa CALISKAN

“…This study investigated which drug treatment would be beneficial according to patient and electrocardiography (ECG) characteristics in patients with idiopathic PVC. …”
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Defining polypharmacy in the elderly: a systematic review protocol by Seyede Salehe Mortazavi, Mohsen Shati, Seyed Kazem Malakouti, Abasali Keshtkar, Mohsen Bazargan, Shervin Assari

“…Today, polypharmacy, a common and important problem related to drug use, occurs subsequent to this multimorbidity in the elderly in all populations. …”
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Formulation of Cefdinir Ternary Solid Dispersion and Stability Study under Harsh Conditions by Naamaa A. Naama, Ghaidaa S. Hameed, Dalya Basil Hanna, Zainab H. Mahdi

“…The capsule formulas were subjected to pre-formulation and capsule evaluation tests, which included weight variation, drug content, disintegration time, and In-vitro dissolution tests. …”
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Microwave-assisted synthesis and swelling behavior of poly lactic acid (PLA) grafted Cordia dichotoma gum-based hydrogels by Jyoti Sinha, Abubakar Hamisu Mijinyawa, Faisal Islam Chowdhury, Muhd Zu Azhan Yahya, Pramod Kumar Singh, Geeta Durga

“…The swelling of CDG-g-PLA in water was measured and found to be significantly lower than CDG, making them novel candidates for drug-delivery and sustainable food packaging applications.…”
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Observation of symptomatic thromboembolic events in endoscopic retrograde cholangiopancreatography patients with interruption of antithrombotic therapies by Jinqing Wu, Jinqing Wu, Jianglong Hong, Hao Ding, Qiao Mei

“…The symptomatic TE event rate in subjects on any antithrombotic drug was 1.46% with an odds ratio (OR) of 5.267 (n = 689, 95% CI 1.79–15.46, p = 0.002), compared with those not treated with antithrombotic drugs (n = 1,793). …”
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Partial Block by Riluzole of Muscle Sodium Channels in Myotubes from Amyotrophic Lateral Sclerosis Patients by Cristina Deflorio, Emanuela Onesti, Clotilde Lauro, Giorgio Tartaglia, Aldo Giovannelli, Cristina Limatola, Maurizio Inghilleri, Francesca Grassi

“…Riluzole, the only approved drug for ALS treatment, blocks voltage-gated Na+ channels, but its effects on muscle Na+ channels and fibrillations are yet poorly characterized. …”
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6-thioguanine inhibits EV71 replication by reducing BIRC3-mediated autophagy by Qiao You, Jing Wu, Ruining Lyu, Yurong Cai, Na Jiang, Ye Liu, Fang Zhang, Yating He, Deyan Chen, Zhiwei Wu

“…Our previous studies had identified the 6-thioguanine (6-TG), an FDA-approved anticancer drug, as a potential antiviral agent, but its anti-EV71 activity is largely unknown, therefore, we aim to explore the antiviral effect of 6-TG on EV71. …”
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Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors by Dandan Yuan, Yali Gao, Lin Xia, Han Liu, Xingye Wu, Xueyan Ding, Yudan Huang, Changchun Deng, Jin Li, Wenqi Dai, Jieqing Liu, Junjie Ma

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Deciphering the potential of plant metabolites as insecticides against melon fly (Zeugodacus cucurbitae): Exposing control alternatives to assure food security by Zinat Jahan Chowdhury, Anik Banik, Tanjin Barketullah Robin, Mohammed Rashed Chowdhury

“…However, as this study was conducted solely through computational methods, we recommend subsequent in vitro and field trials for the future drug development.…”
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Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study by Kaylie I. Kirkwood-Donelson, Alan K. Jarmusch, Carl D. Bortner, Bruce Alex Merrick, Birandra K. Sinha

“…IntroductionOvarian cancer has been difficult to cure due to acquired or intrinsic resistance and therefore, newer or more effective drugs/approaches are needed for a successful treatment in the clinic. …”
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