Pharmacological insights and therapeutic advances of mangiferin against various pathological conditions in liver diseases by Tanvir Zaman Shoyshob, Sumaya Akter, Muhammad Ramiz Uddin, Mithila Farjana, Akhi Moni, Wonhyo Seo, Md. Golzar Hossain, Md Jamal Uddin

“…Therefore, mangiferin could be considered a multitarget therapeutic and promising drug candidate for the treatment of hepatic diseases, although a detailed mechanistic explanation needs to be provided. …”
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Epidemiology and associated factors of genital warts among patients in Iran: A cross-sectional study highlighting the impact of education and sexual behavior by Hossein Faramarzi, Hasti Jofreyi, Nahid Heydari Marandi, Mehdi Ghahartars, Nasrin Aliabadi

“…Moreover, 98 (14.4 %) and participants who confirmed eGW suffer from addiction and 2 (0.3 %) from drug Injection. In addition, 528 (77.8 %) had unprotected sex, 298 (43.9 %) had multiple sexual partners, and 35 (5.1 %) participants had homosexual sex. …”
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Effects of Baicalin on Gout Based on Network Pharmacology, Molecular Docking, and in vitro Experiments by Liu C, Liu W, Lu H, Fan Y, Wang A

“…The gout-related targets were retrieved from the DrugBank, TTD, and Genecards databases. Then, the potential targets and signaling pathways were acquired via protein–protein interaction (PPI), as well as the Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. …”
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How the Suboxone Education Programme presented as a solution to risks in the Canadian opioid crisis: a critical discourse analysis by Quinn Grundy, Fiona Webster, Daniel Z Buchman, Sheryl Spithoff, Ross E G Upshur, Abhimanyu Sud, Matthew Strang

“…Discursive themes were identified through iterative and duplicate analyses using a semistructured data extraction instrument.Results Documents characterised the Programme as addressing iatrogenic risks from overprescribing opioid analgesics, environmental risks from a toxic street drug supply and pharmacological risks relating to the dominant therapeutic alternative of methadone. …”
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Neonatal Intensive Care Unit Apocalypse—Rise of the World Health Organization Priority Pathogens by Apurva Kawdiya, Swati Bhalse, Gaurav Mogra, Kewal K Arora

“…Conclusion: Burden of drug-resistant organisms in NICU is increasing at an alarming rate. …”
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Representing and Quantifying Conformational Changes of Kinases and Phosphatases Using the TSR-Based Algorithm by Tarikul I. Milon, Krishna Rauniyar, Sara Furman, Khairum H. Orthi, Yingchun Wang, Vijay Raghavan, Wu Xu

“…Protein kinases and phosphatases are key signaling proteins and are important drug targets. An explosion in the number of publicly available 3D structures of proteins has been seen in recent years. …”
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Biological properties of Moringa oleifera: A systematic review of the last decade [version 2; peer review: 2 approved, 1 approved with reservations] by Andrea Catalina Gómez, Javier Andrés Soto, C. A. Zuniga-Gonzalez, Karen Shirley Molina, Andrea Natalia Barreto, Maryeli Vásquez

“…Background The growing incidence of chronic diseases such as cancer and the emergence of drug-resistant microorganisms constitute one of the greatest health challenges of the 21st century. …”
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Clinical application of oral Chinese Patent Medicines in ophthalmology: a scoping review protocol by Wei Zhou, Kai Xu, Ziyang Huang, Xiaoyu Li, Xing Liao, Lina Liang, Yamin Li, Qianqian Zuo

“…However, comprehensive evidence for using CPMs in ophthalmology is lacking.Aim We will apply the methodology of scoping review to systematically search and sort out the available evidence on oral CPMs for the treatment of eye diseases, identify the distribution of evidence in this field and provide a basis for clinical practice and medical decisions.Methods The scoping review will be implemented in the following seven steps: (1) defining the research question; (2) searching National Essential Medicines List (2018 edition), National Basic Medical Insurance, Work Injury Insurance and Maternity Insurance Drug Catalog (2020 edition) and Chinese Pharmacopoeia (2020 edition) for oral CPMs for the treatment of eye diseases; (3) searching Embase, Web of Science, PubMed, Cochrane Library, Chongqing VIP Chinese Scientific Journals Database, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database and Wanfang Database for relevant literature published from inception to December 2021; (4) developing eligibility criteria; (5) screening the studies based on inclusion criteria; (6) extracting relevant data and lastly, (7) collating, summarising and reporting the results.Ethics and dissemination Since the scoping review aims at collecting data from publicly available publications, this study does not require ethical approval. …”
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Immunoglobulin Gamma-Like Therapeutic Bispecific Antibody Formats for Tumor Therapy by Shixue Chen, Lingling Li, Fan Zhang, Yu Wang, Yi Hu, Lei Zhao

“…Bispecific antibodies (BsAbs) are a sort of dual functional proteins with specific binding to two distinct targets, which have become a focus of interest in antibody engineering and drug development research and have a promising future for wide applications in cancer immunotherapy and autoimmune disease. …”
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Effects of gestational and lactational exposure to ethanol on body and bone growth of rat offspring by Natalia Viana Tamiasso, Fabiana Rocha Araújo, Natália de Melo Ocarino, Amanda Maria Sena Reis, Athelson Stefanon Bittencourt, Rogéria Serakides

“… Introduction: Ethanol is the most widely consumed drug in the world. When this consumption occurs by pregnant women, the harmful effects extend to the fetus. …”
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Cutting-edge: bionanomaterial solutions in the battle against Severe Acute Respiratory Syndrome Coronavirus 2 by U. Saeed, R. Uppal, M. H. Najmi, I. Fazal, A. A. Khan, Z. Z. Piracha, M. R. Uppal, H. N. Ijaz, D. U. Ozsahin, B. Uzun, I. Ozsahin

“…Their functionalization via a kaleidoscope of functional groups or in concert with antiviral drug combinations augments their prowess. These microscopic champions effectively hinder viral ingress into host cells and orchestrate the controlled release of antiviral agents, casting a profound influence on the course of viral infections. …”
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Anti-inflammatory effect of Plantago asiatica crude extract in rat gout arthritis model by Bingjun Qian, Jun Hu, Li Dai, Yue Zhou, Haixia Xu

“…PAE treatment significantly reversed patho- genic joint space narrowing and swelling, reversed the MSU-induced changes in inflammatory factors, and in general imparted effects very similar to those seen with colchicine (COL; known non-steroidal anti-inflammatory drug for clinical treatment of GA). Collectively, these findings provide experimental evidence supporting the potential applicability of PAE to treat gouty arthritis.…”
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Opioid-related harms and experiences of care among people in justice settings in New South Wales, Australia: evidence from the National Ambulance Surveillance System by Naomi Beard, Michael McGrath, Harry M. X. Lai, James Wilson, Anthony Hew, Amaya Muñoz Labiano, Dan I. Lubman, Rowan P. Ogeil

“…Abstract Background People in justice settings experience higher rates of psychiatric morbidity, including alcohol and drug use disorders, compared with the general population. …”
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Prevalence, Awareness, Treatment, and Control of Hypertension among Saudi Adult Population: A National Survey by Abdalla A. Saeed, Nasser A. Al-Hamdan, Ahmed A. Bahnassy, Abdelshakour M. Abdalla, Mostafa A. F. Abbas, Lamiaa Z. Abuzaid

“…Awareness was significantly associated with gender, age, geographical location, occupation, and comorbidity. Applying drug treatment was significantly more among older patients, but control was significantly higher among younger patients and patients with higher level of physical activity. …”
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Serum Vascular Endothelial Growth Factor Levels before and after Intravitreous Ranibizumab Injection for Retinopathy of Prematurity by Xuting Chen, Lin Zhou, Qi Zhang, Yu Xu, Peiquan Zhao, Hongping Xia

“…Intravitreal injection of ranibizumab (IVR), an antivascular endothelial growth factor (VEGF) drug, showed significant benefit for ROP. However, there are concerns about systemic complications of anti-VEGF therapy in preterm infants. …”
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Betaine enhances SCAPs chondrogenic differentiation and promotes cartilage repair in TMJOA through WDR81 by Meiyue Wang, Zejie Wu, Xiaoyu Zheng, Yishu Huang, Yizhou Jin, Jiaxin Song, Wanzhen Lei, Hua Liu, Riyue Yu, Haoqing Yang, Runtao Gao

“…WDR81 may serve as the potential drug target through mitophagy.…”
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Structural basis of Spliced Leader RNA recognition by the Trypanosoma brucei cap-binding complex by Harald Bernhard, Hana Petržílková, Barbora Popelářová, Kamil Ziemkiewicz, Karolina Bartosik, Marcin Warmiński, Laura Tengo, Henri Gröger, Luciano G. Dolce, Cameron D. Mackereth, Ronald Micura, Jacek Jemielity, Eva Kowalinski

“…Moreover, the observed structural similarities and differences between TbCBC and the mammalian cap-binding complex will be crucial for considering the potential of TbCBC as a target for anti-trypanosomatid drug development.…”
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Therapeutic Anticoagulation with Argatroban and Heparins Reduces Granulocyte Migration: Possible Impact on ECLS-Therapy? by Andre Bredthauer, Manuel Kopfmueller, Michael Gruber, Sophie-Marie Pfaehler, Karla Lehle, Walter Petermichl, Timo Seyfried, Diane Bitzinger, Andreas Redel

“…Blood samples from 30 healthy volunteers were investigated, whereby PMNs were isolated by density gradient centrifugation and incubated with 0.8 μg/mL of argatroban, 1.0 U/mL of low-molecular-weight heparin (LMWH), 1.0 U/mL of unfractionated heparin (UFH), or without drug (control). A collagen-cell mixture was prepared and filled into 3D μ-slide chemotaxis chambers (IBIDI® GmbH, Germany). …”
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Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model by Yoshiaki Katsuda, Yusuke Kemmochi, Mimi Maki, Ryuhei Sano, Yasufumi Toriniwa, Yukihito Ishii, Katsuhiro Miyajima, Kochi Kakimoto, Takeshi Ohta

“…In conclusion, the SDT fatty rat is useful in investigations to elucidate the pathogenesis of human diabetic nephropathy and in new drug discovery.…”
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Microwave coprocessing of modafinil with Gelucire®: Thermal and compression characteristics by Derar Omari, Assayed Sallam, Iyad Rashid, Shereen M. Assaf, Faisal Akayleh, Khaldoun A. Al-Sou′od

“… Introduction: Modafinil, a wakefulness-promoting agent, is primarily used to treat excessive daytime sleepiness associated with narcolepsy and fatigue. As a BCS class II drug, modafinil exhibits low solubility and high permeability, with its crystalline structure significantly impacting dissolution, bioavailability, and compressibility. …”
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