In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species by M. Karkhane Yousefi, M. Seyed Hashtroudi, A. Mashinchian Moradi, A.R. Ghasempour

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Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma by Erin E. Crotty, Aimee A. Sato, Aimee A. Sato, Mohamed S. Abdelbaki

“…This review highlights current approaches for the clinical implementation of MEK and RAF kinase inhibitors for pLGG, focusing on the practical aspects of drug administration, toxicity management, response monitoring, and distribution to patients experiencing geographic or financial barriers to care. …”
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Enhanced precise therapy of ROS-sensitive dual-layer shell nanoparticles loading quercetin on DSS-induced ulcerative colitis mice by Yang Bai, Danling Jiang, Boda Wu, Jiao Peng, Ji Wang, Yuhui Chen, Xi Li

“…Therefore, Que@Gel-DA NPs, a ROS-sensitive nano-drug delivery system, represent a novel therapeutic approach for the clinical intervention of UC.…”
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The Effect of Nintedanib in Post-COVID-19 Lung Fibrosis: An Observational Study by Narongkorn Saiphoklang, Pimchanok Patanayindee, Pitchayapa Ruchiwit

“…However, this antifibrotic drug improved SpO2/FiO2 ratio in our patients. Further randomized controlled trials are needed to determine the efficacy of nintedanib for treatment of patients with post-COVID-19 lung fibrosis. …”
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The changing landscape of antimicrobial resistance and use in South Africa: The need for access to new antibiotics: A position paper by H Finlayson, V Chibabhai, P Jeena, S Kolman, W Lowman, T C Manzini, T Nana, J Nuttall, A Parker, P Skosana, V Ueckermann, A Wise

“…There is a need for improved access to new antibiotics to treat infections caused by drug-resistant organisms in order to limit side-effects and improve patient outcomes of currently available antibiotics. …”
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Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis by Fenli Shao, Qianqian Liu, Yuyu Zhu, Zhidan Fan, Wenjun Chen, Shijia Liu, Xiaohui Li, Wenjie Guo, Gen-Sheng Feng, Haiguo Yu, Qiang Xu, Yang Sun

“…These findings suggest that blockade of chondrogenesis by sonidegib would be a drug repurposing strategy for AS treatment.…”
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Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells by Stefanie Hoyer, Kerstin F. Gerer, Isabell A. Pfeiffer, Sabrina Prommersberger, Sandra Höfflin, Tanushree Jaitly, Luca Beltrame, Duccio Cavalieri, Gerold Schuler, Julio Vera, Niels Schaft, Jan Dörrie

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Factors associated with early-onset androgenetic alopecia: A scoping review. by Li-Ping Liu, Mary Adumo Wariboko, Xiao Hu, Zi-Han Wang, Qian Wu, Yu-Mei Li

“…Men with early-onset AGA may have reduced treatment efficacy with drug like rosuvastatin, metformin or lisinopril for dyslipidemia, prediabetes, or hypertension. …”
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Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models by Alexander J. Szalai, Mark A. McCrory, Dongqi Xing, Fadi G. Hage, Andrew Miller, Suzanne Oparil, Yiu-Fai Chen, Michelle Mazzone, Richard Early, Scott P. Henry, Thomas A. Zanardi, Mark J. Graham, Rosanne M. Crooke

“…However, no CRP specific drug is currently available so such a prospective study cannot be performed. …”
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Effect of Antifungal-Treated Host Macrophages on Candida glabrata by Hong-Bin Li, Na Li, Shu-Ran Wen, Ming-Yue Qiang, Zheng-Hui Yang, Tian-Xiang Dong, Yu-Ye Li, Yi-Qun Kuang

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Injection of Lidocaine Alone versus Lidocaine plus Dexmedetomidine in Impacted Third Molar Extraction Surgery, a Double-Blind Randomized Control Trial for Postoperative Pain Evalua... by Javad Alizargar, Milad Etemadi Sh, Nasser Kaviani, Shu-Fang Vivienne Wu, Keyvan Jafarzadeh, Parisa Ranjbarian, Nan-Chen Hsieh

“…Forty patients undergoing mandibular third molar extraction entered the study and were randomly allocated to the control and interventional groups. 0.15 ml of dexmedetomidine was added to each lidocaine cartridge and the drug concentration was adjusted to 15 μg for the intervention group while only lidocaine was used in the control group. …”
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The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts by Rafaela Torres Portugal Leite, Sarah de Oliveira Nogueira, João Paulo Rodrigues do Nascimento, Laisa Soares de Lima, Taís Bastos da Nóbrega, Mariana da Silva Virgínio, Lucas Monte da Costa Moreno, Bruno Henrique Barbosa Sampaio, Fábio Gomes de Matos e Souza

“…Substance abuse may precede the onset of BD and cannabis is the most common illicit drug used. The main goal of this study is to review the association of cannabis use as a risk factor for early onset of BD and for suicide attempts. …”
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(−)-Epigallocatechin-3-Gallate and Quercetin Inhibit Quiescin Sulfhydryl Oxidase 1 Secretion from Hepatocellular Carcinoma Cells by Lumin Yang, Yuying Fang, Yufeng He, Jinsong Zhang

“…The first-line therapeutic drug sorafenib offers only a moderate improvement in patients’ conditions. …”
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Mechanisms of multidrug resistance caused by an Ipi1 mutation in the fungal pathogen Candida glabrata by Taiga Miyazaki, Shintaro Shimamura, Yohsuke Nagayoshi, Hironobu Nakayama, Akihiro Morita, Yutaka Tanaka, Yasuhiko Matsumoto, Tatsuo Inamine, Hiroshi Nishikawa, Nana Nakada, Makoto Sumiyoshi, Tatsuro Hirayama, Shigeru Kohno, Hiroshi Mukae

“…Exposure of C. glabrata cells to micafungin (an echinocandin) leads to the isolation of a mutant exhibiting resistance to echinocandin and azole antifungals. The drug-resistant phenotype is due to a non-synonymous mutation (R70H) in gene IPI1, which is involved in pre-rRNA processing. …”
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The mystery of methylene blue and its role in managing post-cardiac surgery vasoplegic shock by Mohamed Elbayomi, Oliver Dewald, Presheet Pathare, Markus Kondruweit, Rene Tandler, Michael Weyand, Christian Heim

“…Pharmacy records identified 84 patients (group 1, MB group) who received methylene blue and 116 patients (group 2, Control group) who didn’t receive the drug. This single-center retrospective cohort study’s primary outcome was in-hospital mortality. …”
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Men’s Experiences of Psychological and Other Forms of Abuse in Intimate Relationships: A Qualitative Study by Gloria Macassa, Frida Stål, Michelle Rydback, Joan Pliakas, Daniel Winsjansen, Anne-sofie Hiswåls, Joaquim Soares

“…In some instances, it affected their health behavior, as they reverted to alcohol and drug use to cope with the abuse. Moreover, the interviewees felt lonely and unwilling to disclose their suffering because of fear of what family, friends, society, and professionals across different services would think of them. …”
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Rapid Improvement in Neck Disability, Mobility, and Sleep Quality with Chronic Neck Pain Treated by Fu’s Subcutaneous Needling: A Randomized Control Study by Ching-Hsuan Huang, Lung-Hung Tsai, Mao-Feng Sun, Zhonghua Fu, Jian Sun, Li-Wei Chou

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Therapeutic effects of NAC and CoQ10 on aluminium phosphide poisoning as an adjuvant therapy: A Pilot study by Maii Farag Henaidy, Maha Ghanem, Shehata Farag Shehata, Amal M. Shouair, Reda R. Mabrouk

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Delirium in geriatric patients with hip fracture by A. Konkayev, N. Bekmagambetova, M. Konkayeva, M. Šerpytis, D. Gineitytė-Ozolince, J. Šipylaitė, D. Jatužis

“…Delirium occurs in up to 87% of the intensive care unit (ICU) patients and is associated with numerous poor outcomes. The drug most commonly used to treat delirium is haloperidol, a centrally acting dopamine antagonist. …”
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Identification of hub genes, non-coding RNAs and pathways in Renal cell carcinoma (RCC): A comprehensive in silico study by Ahmad Golestanifar, Hengameh Khedri, Parisa Noorabadi, Mohammadreza Saberiyan

“…We constructed a competitive endogenous RNA (ceRNA) network involving lncRNAs, circRNAs, and miRNAs, suggesting complex regulatory interactions that drive KIRC pathogenesis.Additionally, the study examined drug sensitivity associated with the expression of hub genes, revealing the potential for personalized treatments. …”
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