Performance of Quantum Annealing Machine Learning Classification Models on ADMET Datasets by Hadi Salloum, Kamil Sabbagh, Vladislav Savchuk, Ruslan Lukin, Osama Orabi, Marat Isangulov, Manuel Mazzara

“…This work focuses on experimentally evaluating quantum annealing machine learning (QAML) classification methods, specifically Quantum Support Vector Machines (QSVM) and QBoost, on ADMET datasets—one of the most important datasets in the drug discovery domain. We compare QAML with classical machine learning to evaluate their relative performance. …”
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A Combined Computational and Experimental Study on Nanoparticle Transport and Partitioning in the Human Trachea and Upper Bronchial Airways by Jiawei Ma, Wei-Chung Su, Yi Chen, Yidan Shang, Jingliang Dong, Jiyuan Tu, Lin Tian

“…Abstract In the past few decades, the transport and deposition of aerosol in the human respiratory tract has been a crucial area of research, resulting in the identification of the toxicity pathways of inhaled pollutants and facilitating the design of efficient drug delivery systems for targeted treatment. Owing to the complexity of the tracheobronchial tree, experimental studies in vivo/in vitro have been extremely limited; hence, detailed data on the airflow and particle dynamics have been obtained predominantly through computational investigations. …”
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Development and Validation of an RP-HPLC Method for CB13 Evaluation in Several PLGA Nanoparticle Systems by J. Álvarez-Fuentes, L. Martín-Banderas, I. Muñoz-Rubio, M. A. Holgado, M. Fernández-Arévalo

“…The developed method was applied to the analysis of CB13 in nanoparticles samples obtained by three different procedures (SEV, FF, and NPP) in terms of encapsulation efficiency and drug release. Nanoparticles size and size distribution were also evaluated founding that NPP method presented the most lowest particle sizes with narrow-size distribution (≈320 nm) and slightly negative zeta potential (≈−25 mV) which presumes a suitable procedure for the synthesis of PLGA-CB13 nanoparticles for oral administration.…”
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Oral Administration of Semicarbazide Limits Weight Gain together with Inhibition of Fat Deposition and of Primary Amine Oxidase Activity in Adipose Tissue by Josep Mercader, Zsuzsa Iffiú-Soltész, Sandy Bour, Christian Carpéné

“…Although semicarbazide is currently considered as a food contaminant with deleterious effects, the SSAO inhibition it induces appears as a novel concept to modulate adipose tissue development, which is promising for antiobesity drug discovery.…”
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Anti-Tumor Effects of <i>Vespa bicolor</i> Venom on Liver Cancer: In Vitro and In Vivo Studies by Yong-Hua Wu, Feng Xiong, Zheng-Wen Ou, Jing-An Wang, Jing Cui, Lin Jiang, Wen-Jian Lan

“…Initial studies have shown the strong potential of VBV as an anti-liver-tumor drug, highlighting its unique clinical value.…”
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Effects of proton pump inhibitors and histamine-2 receptor antagonists on response to fidaxomicin or vancomycin in patients with Clostridium difficile-associated diarrhoea by Thomas Louie, Karl Weiss, Mark A Miller, Kathleen Mullane, Derrick W Crook, Sherwood L Gorbach

“…Treatment group was the single significant predictor of recurrence; the probability of recurrence after fidaxomicin therapy was half that following vancomycin therapy.Conclusions Acid-suppressing drugs, used by nearly two-thirds of inpatients with CDAD, did not worsen clinical response or recurrence when used concurrently with fidaxomicin or vancomycin. …”
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Characterizing temporal and global host innate immune responses against SARS-CoV-1 and -2 infection in pathologically relevant human lung epithelial cells. by Vivian Y Tat, Aleksandra K Drelich, Pinghan Huang, Kamil Khanipov, Jason C Hsu, Steven G Widen, Chien-Te Kent Tseng, George Golovko

“…., bone marrow stromal cell antigen 2 (BST2), Z-DNA Binding Protein 1 (ZBP1), C-X-C Motif Chemokine Ligand 11 (CXCL11), and Interferon Induced Transmembrane Protein 1 (IFITM1), were identified as potential drug targets against β-CoVs. Our findings suggest that these genes affect both pathogens directly and indirectly through the innate immune response, making them potential targets for host-directed antivirals. …”
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Remimazolam for procedural sedation in gastrointestinal endoscopy: real-life, single center observational study by Conigliaro Rita, Pigò Flavia, Caiazzo Anna, Grande Giuseppe, Russo Salvatore, Cocca Silvia, Lupo Marinella, Marocchi Margherita, Marsico Maria, Sculli Simone, Bertani Helga

“…Abstract Background and aim Remimazolam has proved to be a very promising sedative drug in randomized clinical trials for usage in a wide spectrum of patients, including critically ill ones. …”
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Aprepitant in a Multimodal Approach for Prevention of Postoperative Nausea and Vomiting in High-Risk Patients: Is There Such a Thing as “Too Many Modalities”? by John J. Hache, Manuel C. Vallejo, Jonathan H. Waters, Brian A. Williams

“…When using regression modeling and comparing patients who received one or two vs. three or four mechanistically unique antiemetics (added to preoperative aprepitant), while adjusting for surgical case duration, the three or four additional antiemetic group showed more PONV/PDNV (Odds Ratio 3.73, 95% CI 1.3-10.9, p = 0.016) than did the one or two additional drug group. There were no other predictors of PONV/PDNV (transabdominal surgery, four vs. three Apfel risk factors) in these patients. …”
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The good, the bad, and the ugly: Compliance of e-pharmacies serving India and Kenya with regulatory requirements and best practices. by Gautam Satheesh, Sammy Masibo, Sasi Kumar Tiruttani, Irene Khayoni, Benjamin Palafox, Devaki Nambiar, Jaison Joseph, Emmanuel Kweyu, Abdul Salam, Francis Wafula, Catherine Goodman

“…Only 16% (India) and 42% (Kenya) provided complete drug information. On average, websites serving Kenya met 8.9 of the 12 (74%) Kenyan regulatory requirements, while those serving India met 7.5 of the 14 (54%) 'proposed requirements'. …”
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Efficacy and Safety of Bicyclol Treatment for Non-Alcoholic Fatty Liver Disease: Results of a Cohort Study by I. Yu. Pirogova, S. V. Yakovleva, T. V. Neuymina, S. P. Sinitsyn, V. S. Chulkov, T. N. Shamaeva

“…No significant changes were found in the group without drug therapy.Conclusions.  Bicyclol therapy in NAFLD is accompanied by positive dynamics of inflammation activity markers, insulin resistance and lipid spectrum, which suggests a positive dynamics of the stages of liver fibrosis and steatosis.…”
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Vitamin B6 Deficiency Induces Autism-Like Behaviors in Rats by Regulating mTOR-Mediated Autophagy in the Hippocampus by Lijuan Chen, Jing Li, Xinglian Liu, Zhiwei Zhao, Yan Jin, Yikun Fu, Aiqin Zhou, Chengqun Wang, Yan Zhou

“…In order to conduct rescue experiments, the inhibition of mammalian target of rapamycin (mTOR) or the activation of GABA was achieved by drug administration to the offspring rats with VB6 deficiency. …”
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Laser-Induced Thermal Therapy in the Management of Low-Grade Gliomas: A Narrative Review by Ibrahim Omar hamed Dalabeh, Hossam Salameh, Yasmin Dahabreh, Abdallah Ali suleiman Al-Zayadneh, Mehreen Amir, Ayman Haitham Khaled, Malak A. Hassan, Azad Jehad Makableh, Mohammad Omar hamed Dalabeh

“…Results: LITT, a minimally invasive technique, offers targeted tumor ablation with the added benefit of disrupting the blood-brain barrier to enhance drug delivery. Studies have shown that LITT can effectively reduce tumor size and improve survival rates in patients with both primary and recurrent gliomas. …”
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A simulation study to quantitatively assess the performance of electronic prescribing systems in English NHS Hospital Trusts by Stephanie Klein, Athanasios Tsanas, Jamie Coleman, Rebecca Osselton, Jude Heed, Ann Slee, Neil Watson

“…Anyone who routinely prescribes medication could benefit from digitally assisted automated checks to identify whether a prescription should potentially not be allowed (e.g. drug allergy). National Health Service (NHS) Trusts have implemented a range of EP systems; however, their performance has not hitherto been evaluated. …”
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Hemodynamic Effects of Methamphetamine and General Anesthesia by Keyvan M. Safdari, Curtis Converse, Fanglong Dong, Nickolas Alan MacDougall, Kevin Hyer, Alec Runyon, Haley Ahlering, Mark E. Comunale

“…Patients who present to the operating room with a positive urine drug screen for amphetamines within 2 days of surgery are at increased risk of hemodynamic instability. …”
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Clinical Outcomes from Unselected “Real-World” Patients with Long Coronary Lesion Receiving 40 mm Biodegradable Polymer Coated Sirolimus-Eluting Stent by Anurag Polavarapu, Raghava Sarma Polavarapu, Jayesh Prajapati, Kamlesh Thakkar, Asif Raheem, Tamanpreet Mayall, Ashok Thakkar

“…Long lesions being implanted with drug-eluting stents (DES) are associated with relatively high restenosis rates and higher incidences of adverse events. …”
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Isolation and Antibiotic Sensitivity Testing of Pseudomonas aeruginosa Isolates from Patients with Chronic Suppurative Otitis Media in Baghdad by Fatima Rheem Wadi, Maryam Kareem Ali

“…Pseudomonas aeruginosa represents the most implicated bacterial pathogen associated with this infection. colistin is the most effective antibiotic and can be considered as the drug of choice against  P. aeruginosa. …”
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Intravenous immunoglobulin in the management of idiopathic inflammatory myositis: A single centre retrospective review by Jeet Hemantkumar Patel, Lalit Duggal, Ved Chaturvedi, Neeraj Jain, Gurbir Bhandari, Mayank Gupta

“…Conclusion: IVIG is often the drug of choice for patients with infections in IIM in the Indian setting. …”
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Metformin dosage and galectin-3 levels: insights from PCOS patients preparing for IVF by Valentina N. Nikolić, Milan Stefanović, Milan Stefanović, Dejan Mitić, Dejan Mitić, Slavica Sunarić, Vladana Stojiljkovic, Hristina Trajković, Aleksandra Ignjatović, Dragana Stokanović

“…Notably, the correlation between galectin-3 levels and metformin concentration was either absent or weak after adjusting for the daily dose, indicating that treatment duration and dosage, rather than absolute drug levels, may more critically influence galectin-3. …”
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Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin by Yulia N. Nosova, Ilia V. Zenin, Varvara P. Maximova, Ekaterina M. Zhidkova, Kirill I. Kirsanov, Ekaterina A. Lesovaya, Anna A. Lobas, Mikhail V. Gorshkov, Olga N. Kovaleva, Elena R. Milaeva, Markus Galanski, Bernhard K. Keppler, Alexey A. Nazarov

“…We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. …”
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