Association of direct oral anticoagulant-proton pump inhibitor cotherapy with adverse outcomes: protocol for a population-based cohort study by Lehana Thabane, Lawrence Mbuagbaw, Michael Paterson, Laura Targownik, Mei Wang, Anne Holbrook, Deborah Siegal

“…Our objective is to explore the risk of clinically relevant events, including bleeding, thromboembolic events and death, in patients prescribed DOACs while taking PPIs versus no PPI.Methods and analysis The protocol describes a retrospective cohort study of all Ontario residents aged 66 years or older with atrial fibrillation and at least one pharmacy dispensation for a DOAC identified using linked administrative healthcare databases covering 2009–2020. Ontario drug benefit dispensation records will be used to ascertain PPI exposure during DOAC therapy. …”
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Evolution of artificial intelligence in healthcare: a 30-year bibliometric study by Yaojue Xie, Yuansheng Zhai, Yuansheng Zhai, Guihua Lu, Guihua Lu

“…Notably, the rapid expansion of emerging topics such as COVID-19 and new drug discovery in recent years is noteworthy. Furthermore, the top five most cited papers in 2023 were all pertinent to the theme of ChatGPT.ConclusionThis study reveals a sustained explosive growth trend in AI technologies within the healthcare sector in recent years, with increasingly profound applications in medicine. …”
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The Impact of <i>Lactobacillus reuteri</i> on Oral and Systemic Health: A Comprehensive Review of Recent Research by Zihui Liu, Qing Cao, Wenqing Wang, Bowen Wang, Yilun Yang, Cory J. Xian, Tiejun Li, Yuankun Zhai

“…Future research should focus on revealing the specific pathways of action of <i>Lactobacillus reuteri</i>, screening for the most beneficial strains, determining the most effective drug delivery strategies, developing oral and systemic health products based on <i>Lactobacillus reuteri</i>, and ensuring their safety in clinical applications.…”
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Development and Characterisation of a Novel NF-κB Reporter Cell Line for Investigation of Neuroinflammation by Marie-Theres Zeuner, Thomas Vallance, Sakthivel Vaiyapuri, Graeme S. Cottrell, Darius Widera

“…Reporter cell lines are a valuable state-of-the art tool for comparative analysis of in vitro drug screening. However, a reporter cell line for the investigation of NF-κB-driven neuroinflammation has not been available. …”
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Potential Piperolactam A Isolated From Piper betle as Natural Inhibitors of Brucella Species Aminoacyl‐tRNA Synthetase for Livestock Infections: In Silico Approach by Diding Latipudin, Sefren Geiner Tumilaar, Yoga Ramdani, Dudi Dudi, Dikdik Kurnia

“…The urgency of discovering new drug candidates to combat Brucella’s infection necessitates the exploration of novel alternative agents with unique protein targets. …”
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Molecular imprinted polymer-based potentiometric approach for the determination of carvedilol and ivabradine hydrochloride in dosage form, spiked human plasma and in presence of th... by Nermine V. Fares, Haitham A. El Fiky, Dina A. Ahmed, Maha F. Abd El Ghany, Amr M. Badawey, Mahmoud A. Tantawy

“…Precipitation polymerization was used to create molecular imprinted polymers (MIPs) for each drug. MIPs’ graved cavities serve as artificial host-tailored receptors that are able to recognize and bind to individual drugs. …”
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Beliefs and outlook toward medications in Indian patients with very early rheumatoid arthritis: Cross sectional survey by Sakir Ahmed, Arup Mahapatra, Basanta Kumar Behera, Prasanta Padhan

“…Introduction: Beliefs toward medicine influences drug compliance in rheumatoid arthritis (RA). Studies on attitudes toward medicine are available for established RA, where the disease itself could have altered the beliefs. …”
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Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial by Kathryn S. Merriam, Kristina A. Leake, Mollie Elliot, Michelle L. Matthews, Rebecca S. Usadi, Bradley S. Hurst

“…Vaginal progesterone gel is reduced in women after intercourse which may decrease drug efficacy during luteal phase support. Because men absorb low levels of progesterone during intercourse, exposure could cause adverse effects such as decreased libido. …”
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Histopathological and Immunohistochemical Evaluation of Methotrexate-Induced Gonadal Damage in Rats: Role of SCF, mTOR, and SIRT-1 by Kübra Tuğçe KALKAN, Betül YALÇIN, Özge CENGİZ MAT, Arzu Hanım YAY

“…Objective: Methotrexate (MTX) is a highly effective chemotherapy for cancer. This drug has a gonadotoxic effect, mainly in the testes and ovaries. …”
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Costs of Potential Medication Wastage Due to Switching Treatment Among People With Multiple Sclerosis by Darin T. Okuda, Achal Patel, Robert Schuldt, Ibraheem Abioye, Nicole G. Bonine

“…**Objectives:** To estimate the cost associated with potential medication wastage (PMW) in a subcohort of PwMS receiving oral or self-injectable US Food and Drug Administration–approved DMTs who switched DMTs in a calendar year in the United States. …”
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Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids by Poje Goran, Šakić Davor, Marinović Marina, You Jiangyang, Tarpley Michael, Williams Kevin P., Golub Nikolina, Dernovšek Jaka, Tomašič Tihomir, Bešić Erim, Rajić Zrinka

“…The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. …”
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Sex, Prescribing Practices and Guideline Recommended, Blood Pressure, and LDL Cholesterol Targets at Baseline in the BARI 2D Trial by Michelle F. Magee, Jacqueline E. Tamis-Holland, Jiang Lu, Vera A. Bittner, Maria Mori Brooks, Neuza Lopes, Alice K. Jacobs, BARI 2D Study Group

“…Our findings suggest that there may be sex differences in response to drug therapies used to treat diabetes, hypertension, and hyperlipidemia.…”
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Molecular investigation on active compounds in papaya leaves (Carica papaya Linn) as anti-malaria using network pharmacology, molecular docking, clustering-based analysis and molec... by Arwansyah Arwansyah, Sitti Rahmawati, Siti Nuryanti, Yenni Yusuf, Hartono, Abdur Rahman Arif

“…However, limited access to healthcare services in remote areas and the emergence of resistance to antimalarial drugs pose significant challenges to malaria elimination efforts in Indonesia. …”
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Prevalence of Provocative Seizures in Persons with Epilepsy: A Longitudinal Study at Khon Kaen University Hospital, Thailand by Nutthaya Vongkasamchai, Sunee Lertsinudom, Acharawan Topark-Ngarm, Udomlack Peansukwech, Kittisak Sawanyawisuth, Somsak Tiamkao, Integrated Epilepsy Research Group

“…The patients who aged 15 years or over, who had been treated at least 3 months with at least one antiepileptic drug, and who were followed up for at least one year were included. …”
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Functional-proteomics-based investigation of the cellular response to farnesyltransferase inhibition in lung cancer by Yanbo Pan, Olena Berkovska, Soumitra Marathe, Georgios Mermelekas, Greta Gudoityte, Amare D. Wolide, Taner Arslan, Brinton Seashore-Ludlow, Janne Lehtiö, Lukas M. Orre

“…Additionally, we identified a synergistic drug combination involving tipifarnib and a ferroptosis inducer and discovered PTP4A1 as a regulator of interferon signaling. …”
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Perspectives of substance use disorder counselors on the benefits and drawbacks of medications for opioid use disorder by Nicholas C. Cardamone, Rebecca E. Stewart, Kyle M. Kampman, Steven C. Marcus

“…The most frequently reported advantage across all three types of MOUD was their ability to reduce cravings and illicit drug use. The most frequently reported disadvantage related to the potential for some types of MOUD to develop long-term medication dependence. …”
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Correction of cellular and humoral links immunity in piglets under the weaning condition by Nataliia Ohorodnyk, Vitalii Tkachuk, Nataliia Motko, Andriy Boyko, Serhii Pavkovych

“…The observed immunomodulatory effect of the tested drug is attributed to the synergistic combination of fat-soluble vitamins, mineral elements, and arginine in its composition, which effectively prevented the development of stress-induced immunodeficiency in piglets following weaning…”
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Where are the data linking infant outcomes, breastfeeding and medicine exposure? A systematic scoping review. by Sue Jordan, Sophia Komninou, Sandra Lopez Leon

“…Eleven papers reported analyses from ten established databases with information on maternal prescription or non-prescription drugs, breastfeeding and infant outcomes. Twenty-four cohort studies were also identified. …”
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Cervical Bone Graft Candida albicans Osteomyelitis: Management Strategies for an Uncommon Infection by Carlo Brembilla, Luigi Andrea Lanterna, Andrea Risso, Giuseppe Bonaldi, Paolo Gritti, Bruno Resmini, Andrea Viscone

“…The factors contributing to its emergence include a growing population of immunosuppressed patients, invasive surgeries, broad-spectrum antibiotics, injection drug users, and alcohol abuse. The diagnosis requires a high degree of suspicion. …”
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Total Flavonoids Content in the Raw Material and Aqueous Extractives from Bauhinia monandra Kurz (Caesalpiniaceae) by Ana Josane Dantas Fernandes, Magda Rhayanny Assunção Ferreira, Karina Perrelli Randau, Tatiane Pereira de Souza, Luiz Alberto Lira Soares

“…The aim of this work was to evaluate the spectrophotometric methodology for determining the total flavonoid content (TFC) in herbal drug and derived products from Bauhinia monandra Kurz. …”
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