99mTc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as an auspicious tumour targeting by Adli A. Selim, Tamer M. Sakr, Basma M. Essa, Galal H. Sayed, Kurls E. Anwer

“…Gold nanoparticles (AuNPs) offer precise cancer treatment through targeted delivery, boasting high drug-loading capacity and low toxicity. This study aimed to develop and evaluate 99mTc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as a tumor-targeting agent. …”
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Caffeoylquinic Acid Derivatives Extract of Erigeron multiradiatus Alleviated Acute Myocardial Ischemia Reperfusion Injury in Rats through Inhibiting NF-KappaB and JNK Activations by Zhifeng Zhang, Yuan Liu, Xuecong Ren, Hua Zhou, Kaishun Wang, Hao Zhang, Pei Luo

“…Thus, caffeoylquinic acids might be the active compounds in E. multiradiatus on myocardial ischemia and be a potential natural drug for treating myocardial I/R injury.…”
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Metastatic brain tumors: from development to cutting‐edge treatment by Guilong Tanzhu, Liu Chen, Jiaoyang Ning, Wenxiang Xue, Ce Wang, Gang Xiao, Jie Yang, Rongrong Zhou

“…Moreover, preclinical agents often need to cross the blood–brain barrier to achieve high intracranial concentrations, including small‐molecule inhibitors, nanoparticles, and peptide drugs. Addressing BM is imperative.…”
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Liver cirrhosis epidemiology in Chelyabinsk region in 2006-2015 by A. I. Dolgushina, Ye. R. Olevskaya, A. N. Tarasov, M. S. Kazakova, A. Yu. Markina

“…However objectively restrictions in utilization of the available range of treatment-and-prophylactic actions for treatment of LC in the outcome of viral hepatitis (in drug addicts, alcoholic or asocial patients) due to their low treatment compliance.…”
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Peptide Antigen Modifications Influence the On-Target and Off-Target Antibody Response for an Influenza Subunit Vaccine by Megan C. Schulte, Adam C. Boll, Agustin T. Barcellona, Elida A. Lopez, Adam G. Schrum, Bret D. Ulery

“…Background/Objectives: Peptide amphiphile micelles (PAMs) are an exciting nanotechnology currently being studied for a variety of biomedical applications, especially for drug delivery. Specifically, PAMs can enhance in vivo trafficking, cell-targeting, and cell interactions/internalization. …”
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Collapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathy by Thaíza Passaglia Bernardes, Thalita Alvarenga Ferradosa Paula, Gabriel Teixeira Montezuma Sales, Patrícia Varela Calais, Renato Demarchi Foresto, Luiz Antonio Moura, Marcelino de Souza Durão Junior, João Bosco Pesquero, Gianna Mastroianni Kirsztajn

“…Treatment can be challenging in such a context, as no antiviral drug is efficient and immunosuppression has no discernable benefit, although steroid use was efficient in treating renal manifestations in this case.…”
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Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS by Federica Pilotto, Paulien Hermine Smeele, Olivier Scheidegger, Rim Diab, Martina Schobesberger, Julieth Andrea Sierra-Delgado, Smita Saxena

“…Nevertheless, to date, no cure or effective therapy is available, and thus attempts to find a potential drug target, have received increasing attention. …”
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Occurrence, Antimicrobial Resistance, and Virulence Profiles of Salmonella Serovars Isolated from Wild Reptiles in South Africa by Lungile N. Mlangeni, Tsepo Ramatla, Kgaugelo E. Lekota, Cormac Price, Oriel Thekisoe, Che Weldon

“…Effective antibiotic treatment appears promising for infection, given the minimal drug resistance observed in reptile Salmonella serovars in the current study.…”
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NEIL3 Mediates Lung Cancer Progression and Modulates PI3K/AKT/mTOR Signaling: A Potential Therapeutic Target by Hongbo Huang, Qingwang Hua

“…Tumor Immune Dysfunction and Exclusion (TIDE) as well as Genomics of Drug Sensitivity in Cancer (GDSC) was used for immunotherapeutic and chemotherapeutic sensitivity analyses. …”
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Biosynthesis of ZnO nanoparticles using banana peel pectin for antibacterial and photocatalytic applications by Kazi Suraiya Islam, Md. Hasnain Mustak, Md. Khalid Hossain Shishir, Md. Minnatul Karim, Gazi Md. Arifuzzaman Khan

“…Moreover, the p-ZnO NPs exhibited a significant bactericidal effect against drug-resistant gram-positive Staphylococcus aureus but were ineffective against gram-negative Escherichia coli.…”
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Incorporation of recombinant proteins into extracellular vesicles by Lactococcus cremoris by Tina Vida Plavec, Kristina Žagar Soderžnik, Giulia Della Pelle, Špela Zupančič, Robert Vidmar, Aleš Berlec

“…EVs have diagnostic potential, as they play a role in intercellular interspecies communication, and could be applied in drug delivery. In contrast to mammalian cell-derived EVs, the study of EVs from bacteria, particularly Gram-positive bacteria, received less research attention. …”
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Predictive Factors for a Long Hospital Stay in Patients Undergoing Laparoscopic Cholecystectomy by Wasana Ko-iam, Trichak Sandhu, Sahattaya Paiboonworachat, Paisal Pongchairerks, Anon Chotirosniramit, Narain Chotirosniramit, Kamtone Chandacham, Tidarat Jirapongcharoenlap, Sunhawit Junrungsee

“…These included patients with cirrhosis, patients with a history of previous acute cholecystitis, cholangitis, or pancreatitis, patients on anticoagulation with warfarin, patients with standard-pressure pneumoperitoneum, patients who had been given metoclopramide as an intraoperative antiemetic drug, patients who had been using abdominal drain, patients who had numeric rating scale for pain > 3, patients with an oral analgesia requirement > 2 doses, complications, and private ward admission. …”
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Apoptosis-Inducing Factor, Protein Expression, and Apoptosis Changes with Glutamine in Podocytes Cells Exposed with Cisplatin by Imam Susilo, Himmayatussorofil Maulida, Lindawati Alimsardjono, Dyah Fauziah, Herinda Pertiwi

“…Cisplatin is a well-known chemotherapeutic drug. It is one of the most effective anticancer agents and is widely used for the treatment of several types of tumors. …”
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Comparison of Clinical Efficacy of Intravenous Acetaminophen with Intravenous Morphine in Acute Renal Colic: A Randomized, Double-Blind, Controlled Trial by Kambiz Masoumi, Arash Forouzan, Ali Asgari Darian, Maryam Feli, Hassan Barzegari, Ali Khavanin

“…The VAS reduction at primary endpoint (30 min after drug administration) was significantly higher in the acetaminophen group than in the morphine group (P=0.0001). …”
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Astrocytic HIV-1 Nef Expression Decreases Glutamate Transporter Expression in the Nucleus Accumbens and Increases Cocaine-Seeking Behavior in Rats by Jessalyn Pla-Tenorio, Bethzaly Velazquez-Perez, Yainira Mendez-Borrero, Myrella L. Cruz, Marian T. Sepulveda-Orengo, Richard J. Noel

“…This study investigates the relationship among Nef, glutamate homeostasis, and cocaine in the nucleus accumbens (NAc), a critical brain region associated with drug motivation and reward. Methods: Male and female Sprague Dawley rats were used to compare the effects of astrocytic Nef and cocaine by molecular analysis of glutamate transporters, GLT-1 and the cysteine glutamate exchanger (xCT), in the NAc. …”
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Immunological Changes in Peripheral Blood of Ankylosing Spondylitis Patients during Anti-TNF-α Therapy and Their Correlations with Treatment Outcomes by Rongjuan Chen, Hongyan Qian, Xiaoqing Yuan, Shiju Chen, Yuan Liu, Bin Wang, Guixiu Shi

“…Tumor necrosis factor-α (TNF-α) inhibitors are the main types of biological conventional synthetic disease-modifying antirheumatic drugs and have efficacy in treating ankylosing spondylitis (AS) which is not sensitive for nonsteroidal anti-inflammatory drug. …”
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Surface Modification with NGF-Loaded Chitosan/Heparin Nanoparticles for Improving Biocompatibility of Cardiovascular Stent by Haixin Song, Tao Wu, Xiaotian Yang, Yangzheng Li, Ye Ye, Bo Li, Tao Liu, Shihui Liu, Jianhua Li

“…Late thrombosis and restenosis remain major challenges to the safety of drug-eluting stents. Biofunctional modification to endow the surface with selective anticoagulation and promote endothelium regeneration has become a hotpot recently. …”
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Fusarium oxysporum & Fusarium solani: Identification, Characterization, and Differentiation the Fungal Phenolic Profiles by HPLC and the Fungal Lipid Profiles by GC-MS by Nashwa M. Shalapy, Wenyi Kang

“…These displayed data illustrated conclusively that Fusarium oxysporum had a wide medicinal effectiveness as antioxidant, anticancer, anti-inflammation, and cardioprotective action due to its plentiful content from valuable phenols, flavonoids, and fatty acids in comparison with F. solani, as it may be elected as an alternative natural drug for some pharmaceutical applications.…”
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Inhibitory Effects of Polaprezine on the Inflammatory Response to Helicobacter pylori by Osamu Handa, Norimasa Yoshida, Yukiko Tanaka, Miho Ueda, Takeshi Ishikawa, Tomohisa Takagi, Naoyuki Matsumoto, Yuji Naito, Toshikazu Yoshikawa

“…To clarify the efficacy of polaprezinc, a chelate compound consisting of zinc and L-carnosine, against H pylori-induced inflammation including PMN infiltration, the in vitro effects of this drug on interleukin (IL)-8 production by an established gastric cancer cell line (MKN 45 cells) and on PMN-endothelial cell adhesive interactions was investigated. …”
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Clinical Specimens are the Pool of Multidrug- resistant Pseudomonas aeruginosa Harbouring oprL and toxA Virulence Genes: Findings from a Tertiary Hospital of Nepal by Yamuna Chand, Sujan Khadka, Sanjeep Sapkota, Suprina Sharma, Santosh Khanal, Alina Thapa, Binod Rayamajhee, Dhruba Kumar Khadka, Om Prakash Panta, Dipendra Shrestha, Pramod Poudel

“…The multidrug- or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa carrying some virulence genes has become a global public health threat. …”
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