Review: performance of jujube and its extracts in cancer: therapeutic, toxicity-reducing and potentiating effects by Boyun Gou, Guoqing Chen, Shicong Huang, Na Ning, Qian Gu, Shuai Duan, Yuhua Du, Yi Nan, Ling Yuan

“…With the development of the pharmaceutical industry, there is a gradual desire to develop low-toxicity and effective anticancer drugs from traditional Chinese herbs. Due to its “homology of medicine and food,” jujube is one of the traditional Chinese herbs that is extensively used in China. …”
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One Health, One Hive: A scoping review of honey bees, climate change, pollutants, and antimicrobial resistance. by Etienne J de Jongh, Sherilee L Harper, Shelby S Yamamoto, Carlee J Wright, Craig W Wilkinson, Soumyaditya Ghosh, Simon J G Otto

“…These articles predominantly investigated hive immunocompetence and multi-drug resistance transporter downregulation (n = 11/22), susceptibility to pests (n = 16/22), especially American foulbrood (n = 9/22), and hive product augmentation (n = 3/22). …”
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Expanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry by Yutian Gan, Steffen Lippold, John Stobaugh, Christian Schöneich, Feng Yang

“…Therefore, it is important to identify and quantify glycans during drug development. Glycosylation is a highly complex post-translational modification (PTM) due to its structural heterogeneity, i.e. glycosylation site occupancy, glycan compositions, modifications, and isomers. …”
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Antibacterial and Antioxidant Activities of Triterpenoids and Cyclic 1,7-Diarylheptanoids from the Stem Bark of Myrica salicifolia: A Combined Experimental and Computational Study by Abraham Dilnesa Gashaw, Kibrom Gebreheiwot Bedane, Taye B. Demissie, Japheth O. Ombito, Estifanos Ele Yaya, Mekonnen Abebayehu Desta

“…The lowest binding affinity for compound 7 was found to be −7.26 to −10.35 kcal/mol against PqsA protein of P. aeruginosa, pyruvate kinase (PK) enzyme of S. aureus, LuxS protein of S. pyogenes, and DNA gyrase B of E. coli, which showed better binding affinity compared to the standard drug ampicillin (−7.36 to −8.03 kcal/mol) and ciprofloxacin (−6.19 to −6.83 kcal/mol). …”
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Silver <i>N</i>-Heterocyclic Carbene (NHC) Complexes as Antimicrobial and/or Anticancer Agents by Jessica Ceramella, Alessia Catalano, Annaluisa Mariconda, Assunta D’Amato, Saveria Aquila, Carmela Saturnino, Camillo Rosano, Maria Stefania Sinicropi, Pasquale Longo

“…Numerous Ag(I)-NHC complexes have revealed high antibacterial and/or anticancer properties, even higher than those of reference drugs. Herein, we summarize the most recent studies while also discussing the proposed mechanism of action and offering an interesting remark about the research in this field. …”
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Association of Phthalate Exposure with Thyroid Function and Thyroid Homeostasis Parameters in Type 2 Diabetes by Yi Chen, Wen Zhang, JingSi Chen, Ningjian Wang, Chi Chen, Yuying Wang, Heng Wan, Bo Chen, Yingli Lu

“…We aimed to evaluate the relationship of phthalate metabolites with thyroid function and thyroid homeostasis parameters in type 2 diabetes and to explore whether thyroid autoimmunity status and metformin, the most common antidiabetic drug, may influence such associations. Methods. Concurrent urine and blood samples were collected from 639 participants with type 2 diabetes in the METAL (Environmental Pollutant Exposure and Metabolic Diseases in Shanghai) study. …”
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Black Garlic Supplementation and Glomerular Protection in Hyperuricemic Rats: A Study on Kidney Health Prevention by Wahyudin Wahyudin, Fajar Wahyu Pribadi, Gita Nawangtantrini, Muhammad Riski Fatah, Zainuddin Zainuddin

“…The sample consisted of 30 male Sprague-Dawley rats divided into 5 groups: disease control, drug control (allopurinol), and 3 black garlic dose groups (240 mg/day, 480 mg/day, and 960 mg/day). …”
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The First Autopsy Case of Fatal Acute Cardiac Failure after Administration of Carfilzomib in a Patient with Multiple Myeloma by Teruhito Takakuwa, Ippei Otomaru, Taku Araki, Akiko Miura, Yotaro Fujitani, Yasuhide Mochizuki, Yoshimi Miyagi, Hideto Senzaki, Ryosuke Yamamura

“…Pathological findings of hypersensitivity myocarditis, a drug-induced cardiomyopathy, appeared to agree with this case except for absence of an eosinophilic infiltration of the myocardium. …”
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Two-photon NAD(P)H-FLIM reveals unperturbed energy metabolism of Ascaris suum larvae, in contrast to host macrophages upon artemisinin derivatives exposure by Zaneta D. Musimbi, Arkadi Kundik, Jürgen Krücken, Anja E. Hauser, Sebastian Rausch, Peter H. Seeberger, Raluca Niesner, Ruth Leben, Susanne Hartmann

“…Overall, two-photon NAD(P)H-FLIM proved to be a powerful tool for studying specific metabolic pathways in Ascaris larvae and host macrophages, offering valuable insights into the metabolic mechanisms of drug action on both parasite and host.…”
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Adding Water to the Mill: Olmesartan-Induced Collagenous Sprue—A Case Report and Brief Literature Review by Claudine Desruisseaux, Michaël Bensoussan, Etienne Désilets, Hanh-Khiem Tran, Robert Arcand, Germain Poirier, Andrew Wisniewski, Thibaut Manière

“…We report a unique case of olmesartan-induced collagenous sprue in a 79-year-old man that showed complete histological and clinical remission with the sole withdrawal of the incriminating drug. The literature on this topic is briefly reviewed.…”
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo... by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…Methods Our trial is a Phase 2 randomized study of immunotherapy drug pembrolizumab given in combination with azacitidine (HMA). …”
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CT-sensitized nanoprobe for effective early diagnosis and treatment of pulmonary fibrosis by Jiwei Hou, Qijian Ji, Tianyu Tang, Yonger Xue, Lin Gao, Li Dai, Jinbing Xie

“…This approach led to significant accumulation of the CT sensitizer iodide in fibrotic lung tissues, resulting in enhanced CT imaging for the detection of fibroblastic foci and enabling early diagnosis of PF. Moreover, a dual-drug combination of oltipraz and rosiglitazone was co-loaded into the nanoparticles for the treatment of early-diagnosed PF. …”
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A generative deep neural network for pan-digestive tract cancer survival analysis by Lekai Xu, Tianjun Lan, Yiqian Huang, Liansheng Wang, Junqi Lin, Xinpeng Song, Hui Tang, Haotian Cao, Hua Chai

“…Conclusions The experiment indicate that GDEC outperforms better than other deep-learning-based methods, and the interpretable algorithm can select biologically significant genes and potential drugs for DTC treatment.…”
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46,XY Disorder of Sex Development Caused by 17α-Hydroxylase/17,20-Lyase Deficiency due to Homozygous Mutation of CYP17A1 Gene: Consequences of Late Diagnosis by Giampaolo Papi, Rosa Maria Paragliola, Paola Concolino, Carlo Di Donato, Alfredo Pontecorvi, Salvatore Maria Corsello

“…Hydrocortisone and ethinyl-estradiol supplementation therapy led to incomplete withdrawal of antihypertensive drug and breast development progression to Tanner stage B2 and slight height increase, respectively. …”
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Development and Validation of New High Performance Liquid Chromatography Analytical Technique For Separation of Diclofenac Sodium and Lidocaine Hydrochloride From Ampoule Injection by Mohammed Ali Salih, Dlivan Fattah Aziz, Salar Ibrahim Ali

“…Finally, the both drugs were isolated and resolute with selective and stable characteristics by the proposed technique. …”
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Natural antifibrosis potential of anthocyanin in Ipomoea batatas against Transforming Growth Factor beta Type II receptor by in silico ADMET and molecular docking study by Evi Lusiana, Ernawati Sinaga, Zen Hafy, Debby Handayati Harahap, Ramzi Amin, Irsan Saleh

“…Analysis of protein–ligand interactions demonstrates that anthocyanins bind to amino acid residues in the target protein’s active site, and these anthocyanins have higher binding energy than the reference drug. I. batatas, one of the traditional medicinal plants containing anthocyanins, has the potential to generate effective therapeutic approaches for the treatment of fibrosis. …”
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A scoping review of conventional and laser acupuncture as a modality of treatment for migraine by Chizoba ANYIMUKWU, Vinayak K. NAHAR, Sunita KAPUR, Manoj SHARMA

“…It has a promising role as an adjuvant to conventional drug therapy. More randomized controlled trials for efficacy and effectiveness testing are needed.…”

SARS-CoV-2 Oral Vaccine Design Based on Nanoparticle Encapsulation with a Combination of Chitosan and Alginate by Ni Putu Fiona Cista Dewi, Ni Luh Dian Saptari Amelia Putri, I Wayan Ari Sudarma, Sang Ayu Putu Chika Iswari Anjani, Gusti Nyoman Oka Saputra, Sagung Chandra Yowani

“…The combination of chitosan and alginate can protect the drug from gastrointestinal disturbances. Our research aims to nanoencapsulate the intravenous vaccine "Inavac" using chitosan and alginate polymers into a vaccine that can be consumed orally. …”
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Left Atrial Appendage Occlusion in High Bleeding Risk Patients by Pierluigi Merella, Giovanni Lorenzoni, Alessandro P. Delitala, Filomena Sechi, Federica Decandia, Graziana Viola, Paola Berne, Gianluca Deiana, Patrizio Mazzone, Gavino Casu

“…At discharge, 32/68 patients were on dual antiplatelet therapy (APT), 34/68 were without any antithrombotic therapy or with a single antiplatelet drug, and 2/68 were on anticoagulant therapy. At three-month follow-up visit, 73.6% of the patients did not receive dual APT, of whom 14.7% had no thrombotic therapy and 58.9% were on single antiplatelet therapy. …”
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Telephone consultations with otolaryngology – head and neck surgery reduced emergency visits and specialty consultations in northern Alberta by Peter George Jaminal Tian, Dean Eurich, Hadi Seikaly, Douglas Boisvert, John Montpetit, Jeffrey Harris

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