Pleiotropic effects of niacin: Current possibilities for its clinical use by Zeman Miroslav, Vecka Marek, Perlík František, Staňková Barbora, Hromádka Robert, Tvrzická Eva, Širc Jakub, Hrib Jakub, Žák Aleš

“…Niacin was the first hypolipidemic drug to significantly reduce both major cardiovascular events and mortality in patients with cardiovascular disease. …”
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Emerging biotechnologies for engineering liver organoids by Junqi Zhao, Yue Zhi, Haozhen Ren, Jinglin Wang, Yuanjin Zhao

“…Further, we introduce the applications of liver organoids in disease modeling, drug screening and regenerative medicine. Lastly, we overview the current obstacles and forward-looking perspectives on the future of engineered liver organoids. …”
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The effect of malotilate, a derivative of malotilate and a flavenoid on eicosanoid production in inflammatory bowel disease in rats by A. P. M. van Dijk, J. H. P. Wilson, F. J. Zijlstra

“…Acetic acid induced colitis in rats was used to investigate the effects of malotilate, a drug which has been shown to inhibit 5-1ipoxygenase in human macrophages, the malotilate derivate ZY16268 and the flavenoid ZY16369 on the eicosanoid production and the colonic morphology in inflammatory bowel disease. …”
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Facial Edema Evaluation Using Digital Image Processing by A. E. Villafuerte-Nuñez, A. C. Téllez-Anguiano, O. Hernández-Díaz, R. Rodríguez-Vera, J. A. Gutiérrez-Gnecchi, J. L. Salazar-Martínez

“…The main objective of the facial edema evaluation is providing the needed information to determine the effectiveness of the anti-inflammatory drugs in development. This paper presents a system that measures the four main variables present in facial edemas: trismus, blush (coloration), temperature, and inflammation. …”
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Gastrointestinal Parasites With Their Risk Factors in Tharu Indigenous People in Southern Nepal: A Cross‐Sectional Study by Pinki Kumari Chaudhary, Tirth Raj Ghimire

“…Occupation, animal husbandry, parasitologic knowledge, drinking water sources, pork‐feeding habit, diarrheal or stomachache symptoms, and drug‐consuming history were associated with one or more GI parasitosis (p < 0.05). …”
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Targeted therapy for cisplatin‐resistant lung cancer via aptamer‐guided nano‐zinc carriers containing USP14 siRNA by Xinmin Zhao, Xianghua Wu, Huijie Wang, Songtao Lai, Jialei Wang

“…These results indicate that aptamer‐guided nano‐zinc carriers may be a potent carrier for the precise treatment of drug‐resistant tumors.…”
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A computational tool to infer enzyme activity using post-translational modification profiling data by Dehui Kong, Aijun Zhang, Ling Li, Zuo-Fei Yuan, Yingxue Fu, Long Wu, Ashutosh Mishra, Anthony A. High, Junmin Peng, Xusheng Wang

“…Collectively, JUMPsem provides an improved tool for inferring protein enzyme activities, potentially facilitating targeted drug development.…”
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Gastrointestinal side effects in hepatocellular carcinoma patients receiving transarterial chemoembolization: a meta-analysis of 81 studies and 9495 patients by Nathalie Arendt, Maria Kopsida, Jaafar Khaled, Markus Sjöblom, Femke Heindryckx

“…Studies not involving cTACE or drug-eluting bead TACE (DEB-TACE), non-HCC studies, meta-analyses or systematic reviews, and inaccessible publications were excluded. …”
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COFcap2, a recyclable tandem catalysis reactor for nitrogen fixation and conversion to chiral amines by Qianqian Zhu, Peijie Dong, Jiangyue Yu, Zhifang Wang, Ting Wang, Shan Qiao, Jinjin Liu, Shubo Geng, Yunlong Zheng, Peng Cheng, Michael J. Zaworotko, Zhenjie Zhang, Yao Chen

“…The amines, including drug product intermediates and active pharmaceutical ingredient, are prepared in >99% enantiomeric excess under ambient conditions in water. …”
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Multisite Infection with Mycobacterium abscessus after Replacement of Breast Implants and Gluteal Lipofilling by Eva Rüegg, Alexandre Cheretakis, Ali Modarressi, Stephan Harbarth, Brigitte Pittet-Cuénod

“…Adequate antibiotic treatment was stopped after seven days for drug-related hepatitis. At entrance, gluteal puncture for bacterial analysis was performed. …”
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Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro by Rudolfová Petra, Hanušová Veronika, Skálová Lenka, Bártíková Hana, Matoušková Petra, Boušová Iva

“…Catechins may influence both desirable and undesirable effects of many drugs. In this study, the in vitro effect of (+)-catechin, (-)-epicatechin, (-)-epigallocatechin, (-)-epicatechin gallate, and (-)-epigallocatechin gallate (EGCG) on the efficacy of anticancer drug doxorubicin (DOX) was studied in HCT-8 cancer cells. …”
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Incidence and Predictors of Antiretroviral Treatment Modification in HIV-Infected Adults: A Brazilian Historical Cohort from 2001 to 2010 by Letícia Penna Braga, Cássia Cristina Pinto Mendicino, Edna Afonso Reis, Ricardo Andrade Carmo, Cristiane Menezes de Pádua

“…A total of 108 (45.8%) patients had their ART regimen modified at least once (incidence rate: 1.42 per 100 person-months). Adverse drug reactions were the main reason for ART modification. …”
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Screening and evaluation of novel DPP-IV inhibitory peptides in goat milk based on molecular docking and molecular dynamics simulation by Kuo Dang, Jing Lan, Yanli Wang, Daodong Pan, Lihui Du, Shikun Suo, Yali Dang, Xinchang Gao

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Optimized Naive-Bayes and Decision Tree Approaches for fMRI Smoking Cessation Classification by Amirhessam Tahmassebi, Amir H. Gandomi, Mieke H. J. Schulte, Anna E. Goudriaan, Simon Y. Foo, Anke Meyer-Baese

“…Two classes of patients were studied. One class took the drug N-acetylcysteine and the other class took a placebo. …”
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Synergistic anticancer effects of cisplatin and phenolic aglycones of the aerial part of Rumex dentatus L. in tongue squamous cell carcinoma: insights from network pharmacology and... by Amany E. Ragab, Ghada M. Al-Ashmawy, Sherin R. El Afify, Ola A. El-Feky, Amera O. Ibrahim

“…KEGG analysis indicated that the drug combination might work through pathways like PI3K-Akt signaling, microRNAs in cancer, and EGFR tyrosine kinase inhibitor resistance. …”
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Enhanced Antitumor Immune Response in 2′-5′ Oligoadenylate Synthetase-Like 1- (OASL1-) Deficient Mice upon Cisplatin Chemotherapy and Radiotherapy by Chan Kyu Sim, Jung Hoon Lee, In-Jeoung Baek, Sang-Wook Lee, Myeong Sup Lee

“…Upon treatment with the anticancer drug cisplatin, we found that Oasl1−/− mice showed enhanced resistance to injected tumors compared to untreated Oasl1−/− mice. …”
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Syntheses, Characterization, and Antimicrobial Screening of N-(benzothiazol-2-yl)benzenesulphonamide and its Cu(I), Ni(II), Mn(II), Co(II), and Zn(II) Complexes by N. L. Obasi, Okoye C. O. Benedict, P. O. Ukoha, A. O. Anaga

“…However, they were less active than the standard drugs used except Fluconazole which did not show any activity against Candida krusei (ATCC 6258) but most of the compounds synthesized were very active against it. …”
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Anti-Inflammatory therapeutic potential of Bungur (Lagerstroemia speciosa L.) leaves ethanolic extract against LPS-activated macrophage through TLR4/MD2 signaling: A computational... by Rosyadah Nuraini, Dwijayanti Dinia Rizqi, Annisa Yuslinda, Kamila Fairuz Sarah, Widyananda Muhammad Hermawan, Ulfa Siti Mariyah, Widodo Nashi

“…Identified compounds were screened in silico for drug-likeness, bioactivity, and membrane permeability. …”
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Effectiveness of a family-centered psychological intervention program based on spiritual therapy and cognitive behavioral therapy on the lifestyle of patients with type 2 diabetes by Delara Sadat Madahzad, Reza Pourhosein, Masoud Gholamali Lavasani, Gholamali Afrooz

“…Conclusion: Overall, the results of the present study showed that the family-centered psychological intervention package based on spirituality and cognitive behavioral therapy for patients with type 2 diabetes can be used as a complementary technique alongside drug therapy to improve lifestyle and treatment process of diabetic patients. …”
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Emerging PPARγ-Independent Role of PPARγ Ligands in Lung Diseases by Ajit A. Kulkarni, Collynn F. Woeller, Thomas H. Thatcher, Sesquile Ramon, Richard P. Phipps, Patricia J. Sime

“…These PPARγ-independent mechanisms are of significant interest because they suggest new therapeutic uses for currently approved drugs and because they can be used as probes to identify novel proteins and pathways involved in the pathogenesis or treatment of disease, which can then be targeted for further investigation and drug development.…”
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