Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applications by Asmae Hbika, Ayoub Farihi, Mohammed Benali, Fatima-Zahrae Ed-darraz, Abdelhamid Bouyanzer, Mohammed F. Hawwal, Ramzi A. Mothana, Elkhadir Gharibi

“…ADME modeling indicating that 8-methoxyflavone, a major component in the dichloromethane extract, is a promising candidate for drug development targeting the central nervous system.…”
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Use of Graph Database for the Integration of Heterogeneous Biological Data by Byoung-Ha Yoon, Seon-Kyu Kim, Seon-Young Kim

“…We collected various biological data (protein-protein interaction, drug-target, gene-disease, etc.) from several existing sources, removed duplicate and redundant data, and finally constructed a graph database containing 114,550 nodes and 82,674,321 relationships. …”
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Neuroprotective effects of curculigoside against Alzheimer’s disease via regulation oxidative stress mediated mitochondrial dysfunction in L-Glu-exposed HT22 cells and APP/PS1 mice... by Wenqi Wang, Yidi Qu, Siyu Li, Jinyu Chu, Hongxin Yang, Lirong Teng, Di Wang

“…CCG has a prominent neuroprotective effect on regulate the AMPK/Nrf2-mediated mitochondrial dysfunction in cells APP/PS1 mice support CCG is a potentially potent drug for AD treatment and merits further investigation.…”
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Aaron Temkin Beck (born July 18, 1921-) Biography by K. Fatih Yavuz, M. Hakan Türkçapar

“…Since 1959 he has directed funded research investigations of the psychopathology of depression, suicide, anxiety disorders, panic disorders, alcoholism, drug abuse, personality disorders, and schizophrenia and of cognitive therapy of these disorders. …”
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Janus kinase inhibitors in rheumatoid arthritis-associated interstitial lung disease: where do we stand and what may be the future? by Beatrice Maranini, Roberta Foti, Moustapha Taha, Veronica Venturelli, Andrea Lo Monaco, Marcello Govoni

“…The objective of this narrative review is to summarize the current evidence of the efficacy and safety of JAKis in RA-ILD management, investigating a possible emerging role for this drug class in such subset of patients. Results. …”
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Extensive In Silico Analysis of ATL1 Gene : Discovered Five Mutations That May Cause Hereditary Spastic Paraplegia Type 3A by Mujahed I. Mustafa, Naseem S. Murshed, Abdelrahman H. Abdelmoneim, Miyssa I. Abdelmageed, Nafisa M. Elfadol, Abdelrafie M. Makhawi

“…In this study, the impact of nsSNPs in the ATL1 gene was investigated by various in silico tools that revealed five nsSNPs (V67F, T120I, R217Q, R495W, and G504E) are deleterious SNPs, which have a functional impact on ATL1 protein and, therefore, can be used as genomic biomarkers specifically before 4 years of age; also, it may play a key role in pharmacogenomics by evaluating drug response for this disabling disease.…”
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Levetiracetam Ameliorates L-DOPA-Induced Dyskinesia in Hemiparkinsonian Rats Inducing Critical Molecular Changes in the Striatum by Huan Du, Shuke Nie, Guiqin Chen, Kai Ma, Yan Xu, Zhentao Zhang, Stella M. Papa, Xuebing Cao

“…Levetiracetam, a new antiepileptic drug, has been shown to reduce LID, but the mechanisms underlying its effects are unknown. …”
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The Gut Microbiome Regulates the Psychomotor Effects and Context-Dependent Rewarding Responses to Cocaine in Germ-Free and Antibiotic-Treated Animal Models by Andrew D. Winters, Dina M. Francescutti, David J. Kracht, Diptaraj S. Chaudhari, Branislava Zagorac, Mariana Angoa-Perez

“…Cocaine use disorder remains a major global health concern, with growing evidence that the gut microbiome modulates drug-related behaviors. This study examines the microbiome’s role in cocaine-induced psychomotor activation and context-dependent reward responses using germ-free (GF) and antibiotic-treated (ABX) models. …”
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Gene Expression Profiling of the Sciatic Nerve in Streptozotocin-Induced Diabetic Rats with Peripheral Neuropathy by Yiji Tu, Zenggan Chen, Feng Zhang, Zhenglin Di, Junhui Zhang, Li Cai

“…DEGs from the 3 most highly connected clusters in the protein-protein interaction network were enriched for biological processes or pathways such as “cell division,” “cell cycle,” “protein phosphorylation,” “chemokine signaling pathway,” “neuropeptide signaling pathway,” “response to drug,” “cellular response to insulin stimulus,” “PPAR signaling pathway,” and “glycerophospholipid metabolism.” …”
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Toll-like receptors in atopic dermatitis: pathogenesis and therapeutic implications by Ahmad Vafaeian, Fateme Rajabi, Nima Rezaei

“…Future directions include CRISPR-based gene editing to understand TLR functions, development of specific TLR modulators for targeted therapy, and machine learning applications to predict drug responses and identify novel ligands. Patient heterogeneity, including the presence or absence of polymorphisms, variations in TLR expression levels, and differences in immune responses, underscores the need for personalized therapeutic approaches.…”
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In vitro effects of ascorbic acid on viability and metabolism of patients’ osteosarcoma stem cells by Jovičić Marijana Šimić, Pušić Maja, Antunović Maja, Ledinski Maja, Librenjak Lucija, Kolundžić Robert, Ribičić Tomislav, Trkulja Vladimir, Urlić Inga

“…OS cancer stem cells (OS-CSC) are taught to have the ability to self-renew and develop mechanisms of anticancer drug resistance, and this is why it is difficult to eradicate them. …”
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Antibacterial Potential of Crude Extracts from <i>Cylindrospermum alatosporum</i> NR125682 and <i>Loriellopsis cavernicola</i> NR117881 by Albert Olufemi Ikhane, Foluso Oluwagbemiga Osunsanmi, Rebamang Anthony Mosa, Andrew Rowland Opoku

“…The mechanism of action of the extracts including membrane damage, efflux pump, β-lactamase activity, DNA degradation, and extract–drug interaction was investigated using standard procedures. …”
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Oleraceins from Portulaca oleracea leaves: Quali-quantitative determination and antioxidant potential by Ciro Cannavacciuolo, Assunta Napolitano, Verena M. Dirsch, Elke H. Heiss, Milena Masullo, Sonia Piacente

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Use of amantadine in traumatic brain injury: an updated meta-analysis of randomized controlled trials by João Félix, Luísa Araújo, Antônio Henriques, Ana Pereira, Saul Carneiro

“…However, the efficacy of this drug in TBI patients remains poorly defined.MethodsWe performed a systematic review and meta-analysis of randomized trials (RCTs) evaluating the effects of amantadine in TBI patients. …”
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Exosome-Associated Gene Signature for Predicting the Prognosis of Ovarian Cancer Patients by Zihan Zhu, Rui Geng, Yixin Zhang, Jinhui Liu, Jianling Bai

“…The connections between the exosome-related gene risk score (ERGRS) and clinical features, immune infiltration, immune checkpoint-related genes, copy number variation, and drug sensitivity were explored. We also assessed the function of the ERGRS to forecast immunotherapeutic efficacy by immunophenoscore (IPS). …”
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General practice database on mortality in adults on methylphenidate: cohort study by Bruno Stricker, Katia Verhamme, Kiki Cheung

“…Objectives Methylphenidate is a ‘prescription only’ drug against attention disorders which is increasingly used by adults. …”
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Free Radical Scavenging, Anti-Infectious, and Toxicity Activities from Stenochlaena palustris (Burm.f.) Bedd. Extracts by Rudi Hendra, Rohimatul Khodijah, Muhammad Almurdani, Yuli Haryani, Ari Satia Nugraha, Neni Frimayanti, Hilwan Yuda Teruna, Rizky Abdulah

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A scoping review and prevalence analysis of soil-transmitted helminth infections in Honduras. by Ana Lourdes Sanchez, José Antonio Gabrie, María Mercedes Rueda, Rosa Elena Mejia, Maria Elena Bottazzi, Maritza Canales

“…<h4>Conclusions</h4>This is the first study to provide a comprehensive historic review of STH research activity and prevalence in Honduras, revealing important knowledge gaps related to infection risk factors, disease burden, and anti-parasitic drug efficacy, among others. Our decade-long prevalence analysis reveals geographical differences in STH prevalence and these findings suggest that differential intervention strategies might be necessary in Honduras for the control of these infections.…”
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4D-Printed Magnetic Responsive Bilayer Hydrogel by Yangyang Li, Yuanyi Li, Jiawei Cao, Peng Luo, Jianpeng Liu, Lina Ma, Guo-Lin Gao, Zaixing Jiang

“…Despite its widespread application in targeted drug delivery, soft robotics, and smart screens, magnetic hydrogel still faces challenges from lagging mechanical performance to sluggish response times. …”
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Mechanisms of Herbal Nephroprotection in diabetes mellitus by Dorin Dragoș, Maria Mirabela Manea, Delia Timofte, Dorin Ionescu

“…Despite the multilayered complexity of the mechanisms involved in the pathogenesis of DN, the conventional treatment is limited to just a few drug classes fraught with the risk of adverse events, including the progression of renal dysfunction. …”
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