Bovine mycoplasmosis occurrence on livestock farms in the Russian Federation for 2015–2018 by Mohammad Abed Alhussen, A. A. Nesterov, V. V. Kirpichenko, S. P. Yatsentyuk, A. V. Sprygin, O. P. Byadovskaya, A. V. Kononov

Get full text

Advances in Deep Brain Imaging with Quantum Dots: Structural, Functional, and Disease-Specific Roles by Tenesha Connor, Hemal Weerasinghe, Justin Lathia, Clemens Burda, Murat Yildirim

“…Their stability enables long-term, targeted drug delivery and photodynamic therapy, presenting potential therapeutic applications in treating brain tumors, Alzheimer’s disease, and traumatic brain injury. …”
Get full text

Community-based participatory process evaluation based on the Reach, Quality Control, Fidelity, Satisfaction, and Management (RQFSM) model in Nevada: A study protocol by Asma Awan, Manoj Sharma

“…Furthermore, it is anticipated that the necessity to integrate services like mental health, drug addiction treatment, pharmacies, disability assistance, and health care for older individuals would be acknowledged. …”
Get full text

The The Evaluation of Clove oil Concentration on Physicochemical and Antimicrobial Activity in the Laponite Gel Delivery System by Dian Eka Ermawati, Susanti Putriana, Tri Setyowati, Tabita Putri Kuntari, Fitri Salsabila, M. Nur Dewi Kartikasari

“…Clove oil as an antimicrobial topical requires a drug delivery system that is easy and comfortable to apply. …”
Get full text

cGAS-STING targeting offers therapy choice in lung diseases by Yu Wang, Xuan Zhang, Weixue Wang, Yi Zhang, Joshua S. Fleishman, Hongquan Wang

Get full text

Nuclear DNA Content and Chromatin Pattern of Rat Rhabdomyosarcoma Cell Sublines with Different Metastatic Potentials by Jean Dufer, Marie-France Poupon, Sonia Yatouji

“…Image cytometry of metastatic tumor cells give rise to variable results, partly because of a heterogeneous origin of cells, or potential drug effects. The aim of this work was to characterize nuclear changes observed in metastatic cell clones issued in vitro from the same parental cell population The nuclear phenotypes of 6 cell sublines isolated from a rat rhabdomyosarcoma cell line and differing in their metastatic ability were evaluated by image cytometry on Feulgen‐stained preparations. …”
Get full text

A Case Report of Acute Esotropia in a Young Woman following Heroin Withdrawal by Bethel Shiferaw, Ebisa Bekele, Sara Syed, Lu Fan, Nirav Patel, Samia Qazi, Nicolas Biro

“…Evaluating acute esotropia requires detailed information of medical history with an emphasis on drug use. Conclusion. Acute onset esotropia with double vision can be caused by abrupt withdrawal of opiates. …”
Get full text

TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses by Gilmara Barros de Lima, Everton Nencioni, Fábio Thimoteo, Camila Perea, Rafaela Fuzaro Alves Pinto, Sergio Daishi Sasaki

“…Beyond infectious diseases, TMPRSS2 has also been linked to some cancers, suggesting it could be a valuable target for drug development. This review provides a summary of TMPRSS2 inhibitors currently under study, with some already in clinical trials to test their effectiveness against viral infections. …”
Get full text

Effects of Cytochrome P450 Inhibitors on Itraconazole and Fluconazole Induced Cytotoxicity in Hepatocytes by Nhareet Somchit, Chong Sock Ngee, Azhar Yaakob, Zuraini Ahmad, Zainul Amiruddin Zakaria

“…Differences of the effects of SKF 525A on the cytotoxicity induced by itraconazole and fluconazole may be due to the differences on the metabolism of each antifungal drug in vivo.…”
Get full text

Crystallographic and computational characterization and in silico target fishing of six aromatic and aliphatic sulfonamide derivatives by Anh Van Nguyen, Anh Thi Ngoc Vu, Andrey N. Utenyshev, Valeriy Tkachev, Nadezhda Polyanskaya, Dmitriy Shchevnikov, Magrarita Vasil’eva, Hieu Tran-Trung, Xuan Ha Nguyen, Olga V. Kovalchukova

“…Consequently, these compounds may serve as promising lead-like molecules for drug development targeting protozoan infections.…”
Get full text

Särndal Approach and Separate Type Quantile Robust Regression Type Mean Estimators for Nonsensitive and Sensitive Variables in Stratified Random Sampling by Usman Shahzad, Ishfaq Ahmad, Nadia H. Al-Noor, Soofia Iftikhar, A. H. Abd Ellah, Troon J. Benedict

“…The issues of a population related to these themes (for example homeless and nonregular workers, heavy drinkers, assault and rape unfortunate casualties, and drug users) contain estimation errors ascribable to nonresponses as well as untruthful revealing. …”
Get full text

Fungi in the Gut Microbiota: Interactions, Homeostasis, and Host Physiology by Hao-Yu Liu, Shicheng Li, Kennedy Jerry Ogamune, Abdelkareem A. Ahmed, In Ho Kim, Yunzeng Zhang, Demin Cai

“…Meanwhile, the composition of the mycobiota is influenced by multiple factors, with diet, nutrition, drug use (e.g., antimicrobials), and physical condition standing as primary drivers. …”
Get full text

The rational use of glucocorticoids may reduce the risk of readmission in menopausal women with knee osteoarthritis: results from a five-year longitudinal study by Huang Xi, Hao Huiqin, Liu Hongqi, Zhang Ruqi, Zhang Junfeng

“…Compared to patients who have not used the drug, the risk of early readmission in patients who have used GCs was reduced by 96% (HR = 0.04, 95%CI: 0.006 ~ 0.284, $$\:P<0.001$$ ). …”
Get full text

Detection and Structural Characterization of Nucleophiles Trapped Reactive Metabolites of Limonin Using Liquid Chromatography-Mass Spectrometry by Yujie Deng, Yudong Fu, Shumin Xu, Ping Wang, Nailong Yang, Chengqian Li, Qing Yu

“…Recent studies demonstrated that LIM has great potential for inhibiting the activity of drug-metabolizing enzymes. However, the mechanisms of LIM-induced enzyme inactivation processes remain unexplored. …”
Get full text

Elucidation of the Inhibitory Effect of Phytochemicals with Kir6.2 Wild-Type and Mutant Models Associated in Type-1 Diabetes through Molecular Docking Approach by Manaswini Jagadeb, V Badireenath Konkimalla, Surya Narayan Rath, Rohit Pritam Das

“…But, there is still a gap in deciding on the choice of a drug, especially when the target is mutated. Mutations in the KCNJ11 gene, encoding the kir6.2 channel, are reported to be associated with congenital hyperinsulinism, having a major impact in causing type 1 diabetes, and due to the lack of its 3D structure, an attempt has been made to predict the structure of kir6.2, applying fold recognition methods. …”
Get full text

Crushed Capsicum chacoense Hunz Fruits: A Food Native Resource of Paraguay with Antioxidant and Anthelmintic Activity by Eva Coronel, Laura Mereles, Silvia Caballero, Nelson Alvarenga

“…The drugs used for treating these diseases are few, and the emergence of resistance is a risk. …”
Get full text

The incidence of eating disorders in the UK in 2000–2009: findings from the General Practice Research Database by Irene Petersen, Nadia Micali, Janet L Treasure, Katrina W Hagberg

Get full text

Clinical, Epidemiological and Therapeutic Characteristics of Patients Admitted for a Bronchial Asthma Attack by Juan Carlos Yanes Macías, Juan Camilo Díaz Ceballos, Mercedes Fonseca Hernández, Ileana García Rodríguez, Caridad Llul Tombo, Daimy Tio González

“…The variables were analyzed: age, sex, skin color, classification of the asthmatic disease, severity of the crisis on admission, and form of drug distribution. Descriptive statistics procedures were applied, such as the determination of the frequency of occurrence and the percentages. …”
Get full text

An Aptamer Sensor Based on Alendronic Acid-Modified Upconversion Nanoparticles Combined with Magnetic Separation for Rapid and Sensitive Detection of Thiamethoxam by Qian Huang, Lu Han, Hui Ma, Weijie Lan, Kang Tu, Jing Peng, Jing Su, Leiqing Pan

Get full text

Density functional theory and molecular dynamics simulation-based bioprospection of Agathosma betulina essential oil metabolites against protein tyrosine phosphatase 1B for interve... by Oluwaseye Adedirin, Rukayat A. Abdulsalam, Khadeejah O. Nasir-Naeem, Ayenitaju A. Oke, Akolade O. Jubril, Saheed Sabiu

“…The compounds showed favorable drug-like properties complying with Lipinski's rules. …”
Get full text