Antifungal and Antibacterial Activity of Aqueous and Ethanolic Extracts of Different <i>Rosa rugosa</i> Parts by Žaneta Maželienė, Jolita Kirvaitienė, Kamilė Kaklauskienė, Rasa Volskienė, Asta Aleksandravičienė

“…With the rising incidence of drug-resistant pathogens, focus should be placed on biologically active compounds derived from plant species used in herbal medicine, as these compounds may provide a new source of antifungal and antibacterial activities. …”
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Successful Percutaneous Coronary Intervention Using Intravascular Ultrasound-Guided Rewiring Technique in a Case of Spontaneous Coronary Artery Dissection Involving Left Main Bifur... by Yohei Numasawa, Souichi Yokokura, Yasuhiro Hitomi, Shohei Imaeda, Makoto Tanaka, Ryota Tabei, Masaki Kodaira

“…We then reinserted another guide wire using an IVUS-guided rewiring technique from the true lumen of the LMT to the distal LAD. Finally, a drug-eluting stent was deployed to cover the dissected segment, and final coronary angiography revealed acceptable results with a patent left circumflex artery. …”
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Epigenetic Properties of Compounds Contained in Functional Foods Against Cancer by Giulia Casari, Brenda Romaldi, Andrea Scirè, Cristina Minnelli, Daniela Marzioni, Gianna Ferretti, Tatiana Armeni

“…The goal is to identify new therapeutic epigenetic targets for drug development, whether as stand-alone treatments or in combination with conventional antitumor approaches.…”
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Expression and clinical significance of disulfidptosis-related LncRNA in gastric cancer by CHU Yudan, SUN Haidong, CUI Ran, ZHENG Hong

“…DRG-RS model was significantly correlated with tumor-related signaling pathways, clinical characteristics and drug sensitivity of gastric cancer patients. LncRNA-SNHG4 expression was significantly increased in gastric cancer. …”
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Comparison of target concentration of propofol during three phases of live donor liver transplant surgery using a target-controlled infusion of propofol total intravenous anaesthes... by Neha Garg, Yatin Kalra, Shivali Panwar, Mahesh K. Arora, Udit Dhingra

“…Background and Aims: Three phases (dissection, anhepatic, and neohepatic) exist for propofol pharmacokinetics during liver transplantation (LT), resulting in varying cardiac output, volume of distribution, and drug metabolism. The primary objective was to compare the mean target concentration of propofol required to maintain the bispectral index (BIS) between 40 and 60 during three phases of LT by using a target-controlled infusion of total intravenous anaesthesia (TCI-TIVA). …”
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Machine Learning Enabled Prediction of Biologically Relevant Gene Expression Using CT‐Based Radiomic Features in Non‐Small Cell Lung Cancer by Shrey S. Sukhadia, Christoph Sadée, Olivier Gevaert, Shivashankar H. Nagaraj

“…These genes have recognized implications in a variety of biological pathways and mechanisms of drug resistance pertinent to NSCLC. Conclusion The successful integration of heterogeneous radiogenomic datasets underscores the potential of imaging biomarkers in uncovering NSCLC biological processes through gene expression profiles.…”
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Exploratory study on the efficacy of topical pan-JAK inhibitor in ocular and skin GVHD in a sclerodermatous GVHD mouse model by Shinri Sato, Yoko Ogawa, Kazuki Asai, Eisuke Shimizu, Shota Shimizu, Hiroko Taniguchi, Takahiro Okazaki, Shigeto Shimmura, Kazuno Negishi, Masatoshi Hirayama

“…Abstract Systemic administration of Janus kinase (JAK) inhibitors is effective in treating chronic graft-versus-host disease (cGVHD) but is associated with side effects. Topical drug administration effectively minimizes side effects. …”
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Seizure-Related Injuries among People with Epilepsy at the Outpatient Department of the University of Gondar Hospital, Northwest Ethiopia: Cross-Sectional Institutional-Based Study by Berhanu Boru Bifftu, Bewket Tadesse Tiruneh, Mengistu Mekonnen Kelkay, Nestanet Habte Bayu, Abebe Woldesellassie Tewolde, Wubet Worku Takele, Mehammed Adem Getnet, Abere Woretaw Azagew

“…The characteristics of epilepsy such as the episodic nature of impairment of consciousness and motor control, psychomotor comorbidity, seizure frequency, and side effects of antiepileptic drugs impact negatively on the physical safety of the patients. …”
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Functional Disorders of the Biliary Tract and Cholelithiasis: Analysis of a Possible Relationship by Yu. O. Shulpekova, I. R. Popova, V. M. Nechaev

“…The biliary tract-selective antispasmodic hymecromone has shown high effectiveness in relieving biliary pain, which also has a moderate choleretic effect and the ability to prevent the crystallization of cholesterol in bile and can be used both for functional diseases and for cholelithiasis. The domestic drug hymecromone “Odecromone” entered the pharmaceutical market.   …”
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Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis by Nese Caglayan, Banu Sancak, Zeynep Kanlidere, Tanil Kocagoz, Tanil Kocagoz

“…Vancomycin-resistant enterococci (VRE) evades vancomycin by replacing D-Ala-D-Ala in their cell wall precursors with D-Ala-D-Lac, reducing the drug’s effectiveness. However, how PBPs-which typically use D-Ala-D-Ala as a substrate-adapt to recognize D-Ala-D-Lac remains unclear. …”
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Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress through Regulation of CHOP and JNK in Bone Marrow Mesenchymal Stem Cells from Patients with Systemic Lupus Erythemato... by Genkai Guo, Yan Meng, Wei Tan, Yunfei Xia, Chun Cheng, Xiaolan Chen, Zhifeng Gu

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Acidic Microenvironment Enhances Cisplatin Resistance in Bladder Cancer via Bcl-2 and XIAP by Kaede Hiruma, Vladimir Bilim, Akira Kazama, Yuko Shirono, Masaki Murata, Yoshihiko Tomita

“…Cisplatin (CDDP) remains a key drug for patients with advanced bladder cancer (BC), despite the emergence of new therapeutic agents; thus, the identification of factors contributing to CDDP treatment resistance is crucial. …”
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Application of Chain Nursing Process in the Nursing of Elderly Inpatients with Implantable Venous Infusion Port by Juan Hu, Li Zhou, Juanying Ding

“…The catheter-related indicators and incidence rates of adverse events (drug extravasation, local hematoma, infusion port blockage, catheter-related infection) were compared between the two groups of patients. …”
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The “L-Sandwich” Strategy for True Coronary Bifurcation Lesions: A Randomized Clinical Trial by Quan Guo, Liang Peng, Lixin Rao, Cao Ma, Kang Zhao, Zhenzhou Zhao, Haiyu Tang, Muwei Li

“…This study explored the efficacy of the “L-sandwich” strategy, which involves the implantation of stents in the main vessel (MV) and shaft of the side branch (SB) with a drug-coated balloon (DCB) applied to the SB ostium, for coronary true bifurcation lesions. …”
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Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate by Halyna M. Kuznietsova, Maryna S. Yena, Iryna P. Kotlyar, Olexandr V. Ogloblya, Volodymyr K. Rybalchenko

“…The anti-inflammatory effects of MI-1 (2.7 mg/kg daily) compared to reference drug Prednisolone (0.7 mg/kg daily) after 14-day usage were evaluated on macro- and light microscopy levels and expressed in 21-grade scale. …”
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Characterization of ZnO nanoparticles synthesized using probiotic Lactiplantibacillus plantarum GP258 by Prashantkumar Siddappa Chakra, Aishwarya Banakar, Shriram Narayan Puranik, Vishwas Kaveeshwar, C. R. Ravikumar, Devaraja Gayathri

“…Additionally, the NPs were photocatalytically and electrochemically analyzed, indicating their potential use in cancer research as well as in coating and drug delivery applications.…”
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Essential oils modulate virulence phenotypes in a multidrug-resistant pyomelanogenic Pseudomonas aeruginosa clinical isolate by Jayalekshmi Haripriyan, Christy Rose Binu, Nitasha D Menon, Muralidharan Vanuopadath, Malavika B. Hari, N Namitha, Kesiya Binoy, Anil Kumar, Bipin G. Nair, Victor Nizet, Geetha B. Kumar

“…Additionally, garlic potentiates drug sensitivity, suggesting its promising therapeutic use in combating pyomelanogenic MDR infections.…”
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NADPH Oxidase Inhibitor Apocynin Attenuates PCB153-Induced Thyroid Injury in Rats by Ablikim Abliz, Chen Chen, Wenhong Deng, Weixing Wang, Rongze Sun

“…In order to clarify the hypotheses that NADPH oxidase (NOX) and subsequent NF-κB pathway may play roles in thyroid dysfunction, sixty Sprague-Dawley rats were randomly divided into four groups: control group, PCB153 treated (PCB) group, received apocynin with PCB153 treatment (APO + PCB) group, and drug control (APO) group. Serum thyroid hormone levels were evaluated. …”
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Uncovering antidepressant prescription patterns: a three-year analysis of outpatient trends by Hossein Karami, Reza Mehrizi, Mohammad Effatpanah, Azamsadat Rivandi, Rajabali Daroudi, Nezam Armand, Leila Ghamkhar

“…Results SSRIs were the most commonly prescribed class, accounting for 63.71% of prescriptions, with sertraline being the most common drug (24.65%). Females accounted for 66.11% of the patient population. …”
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Dual Role of Bacteria in Carcinoma: Stimulation and Inhibition by Suad A Al-Hilu, Wisam H Al-Shujairi

“…Also, bacteria can be used as vectors for drug, gene, or therapy, and this is a great step to treat cancer. …”
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