Proton pump inhibitors enhance chemosensitivity, promote apoptosis, and suppress migration of breast cancer cells by Ihraiz Worood G., Ahram Mamoun, Bardaweel Sanaa K.

“…Proton pump inhibitors (PPIs) are one of the most commonly prescribed drugs for the treatment of acid-related conditions. …”
Get full text

Cystic Echinococcosis/Hydatid Cyst Coinfection with HIV: A Report from Shiraz, Iran by Yosef Sharifi, Seyed Mahmoud Sadjjadi, Hamed Nikoupour Dailami, Seyed Hamed Jafari, Mohammad Hossein Anbardar, Mohammad Bagher Khosravi

“…Our observations show that huge, large, and high-pressure cysts with hundreds of daughter cysts are difficult to be completely removed, and drug treatment has not been able to reduce their size. …”
Get full text

Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair by Shishi Tao, Yue Pu, Eun Ju Yang, Guowen Ren, Changxiang Shi, Li-Jie Chen, Liang Chen, Joong Sup Shim

“…The findings of this study suggest that the GSK3β and HRR pathways are potential drug targets in lung cancer patients with FHIT loss.…”
Get full text

Perspectives of healthcare providers and persons with type 2 diabetes mellitus on improving glycaemic control in Kinshasa, Democratic Republic of the Congo: a qualitative study by Joel M Francis, Olufemi Babatunde Omole, Jean-Pierre Fina Lubaki

“…This is achieved through training of healthcare providers, equipping healthcare structures and organising a reliable drug delivery system. Healthcare providers must also act to ensure that patients get adequate support from their surroundings and the community by providing adequate information about diabetes. …”
Get full text

Additive Effects of Glutathione in Improving Antibiotic Efficacy in HIV–<i>M.tb</i> Co-Infection in the Central Nervous System: A Systematic Review by Leena Nabipur, Michael Mouawad, Vishwanath Venketaraman

“…Current treatments face challenges such as drug resistance, immune reconstitution inflammatory syndrome (IRIS), and persistent inflammation. …”
Get full text

Mesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling by Seyed Ali Sajadian, Nadia Esfandiari, Adrián Rojas, Salar Hemmati, Abolghasem Jouyban, Gonzalo Aguila, Chandrasekhar Garlapati

Get full text

Use of Magnetic Nanoparticles as Targeted Therapy: Theranostic Approach to Treat and Diagnose Cancer by Arif Malik, Tariq Tahir Butt, Sara Zahid, Fatima Zahid, Sulayman Waquar, Mahmood Rasool, Mahmood Husain Qazi, Aamer Mahmood Qazi

“…In practice, magnetic nanoparticles- (MNPs-) based systems following the application of Fe3O4 bound antitumor drug have shown an enhanced therapeutic index in comparison with conventional chemotherapy ensuring the significant decline in nanosystems’ toxicity. …”
Get full text

Gd3+-Doped Magnetic Nanoparticles for Biomedical Applications by A. P. Budnyk, T. A. Lastovina, A. L. Bugaev, V. A. Polyakov, K. S. Vetlitsyna-Novikova, M. A. Sirota, K. G. Abdulvakhidov, A. G. Fedorenko, E. O. Podlesnaya, A. V. Soldatov

“…Magnetic nanoparticles (MNPs) made of iron oxides with cubic symmetry (Fe3O4, γ-Fe2O3) are demanded objects for multipurpose in biomedical applications as contrast agents for magnetic resonance imaging, magnetically driven carriers for drug delivery, and heaters in hyperthermia cancer treatment. …”
Get full text

Antiulcer Effect of Genus Symphytum L. and Portulaca oleracea L. as Investigated on Experimental Animals by El-Sayed H. Bakr, Amal Al-Ghamdi, Reham Al-Amri, Muna Al-Otaibi, Nada Al-Saad, Ghala Al-Matrafi, Ziad T. Kishmira, Firas Azzeh, Areej A. Almuraee

“…Peptic ulcer disease (PUD) occurs when open sores, or ulcers, form in the stomach or first part of the small intestine caused by bacterial infection (H. pylori) and/or nonsteroidal anti-inflammatory drug (NSAID) use. This study was conducted to evaluate the antiulcer effect of some plants including genus Symphytum L., and Portulaca oleracea L. on aspirin-induced acute gastric ulcer in rats. …”
Get full text

Case report: Tongue metastasis as an initial sign of clear cell renal cell carcinoma and its prognosis by Shuo Liu, Hongyun Liu, Bowen Weng, Sichuan Hou

“…Unfortunately, treatment was discontinued due to adverse drug reactions, and the patient was transitioned to palliative care. …”
Get full text

The Expression Regulation and Cancer-Promoting Roles of RACGAP1 by Jiacheng Lin, Yuhao Zhu, Zhaoping Lin, Jindong Yu, Xiaobing Lin, Weiyuan Lai, Beibei Tong, Liyan Xu, Enmin Li, Lin Long

“…In addition, studies have revealed that RACGAP1 can be a biomarker for prognosis, and its role in reducing doxorubicin sensitivity poses difficulties for treatment, while the current drug targets mainly focus on its downstream molecule. …”
Get full text

Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease by Tomonori Sugita, Katsushi Amano, Masanori Nakano, Noriko Masubuchi, Masahiro Sugihara, Tomokazu Matsuura

Get full text

The role of size in PEGylated liposomal doxorubicin biodistribution and anti‐tumour activity by Saba Dadpour, Amin Mehrabian, Mahdieh Arabsalmani, Elaheh Mirhadi, Anis Askarizadeh, Mohammad Mashreghi, Mahmoud Reza Jaafari

“…Abstract The size of nanoliposome‐encapsulated drugs significantly affects their therapeutic efficacy, biodistribution, targeting ability, and toxicity profile for the cancer treatment. …”
Get full text

An annotated high-content fluorescence microscopy dataset with EGFP-Galectin-3-stained cells and manually labelled outlineszenodo by Salma Kazemi Rashed, Malou Arvidsson, Rafsan Ahmed, Sonja Aits

“…In the context of microscopy-based high-throughput drug and genomic screening and even in smaller scale microscopy experiments, the objects that most often need to be detected are cells. …”
Get full text

The potential utility of phage therapy in the treatment of periprosthetic infection caused by multidrug-resistant pathogens: a review by Taalaibek U. Sheraliev, Alexander G. Samokhin, Baikozho R. Tashtanov, Andrey A. Korytkin, Vitaliy V. Pavlov

“…Its combination with antibiotics seems to be the most promising, as it can significantly increase the effectiveness of therapy for infections caused by multidrug-resistant pathogens due to the synergy of these drug classes.…”
Get full text

Application and progress of 3D printed biomaterials in osteoporosis by Chenxu Wang, Chenxu Wang, Aiguo Liu, Aiguo Liu, Ziwen Zhao, Ting Ying, Shuang Deng, Zhen Jian, Xu Zhang, Chengqing Yi, Dejian Li

“…Conventional treatments, such as pharmaceutical drugs and hormone replacement therapy, often yield suboptimal results and are frequently associated with side effects. …”
Get full text

Synthesis, Characterization, and Biological Evaluation of Gabapentinoid Hybrids with Isoindole-1,3(2H)-Dione Moiety as Potential Antioxidant, Antimicrobial, and Anticancer Agents by Mirna Jabbour, Mohammad Ammar Al-Khayat, Mahmoud Al-Ktaifani

“…All compounds showed antibacterial activity against Escherichia coli and Staphylococcus aureus related to concentration, while parent drugs did not exhibit any antibacterial effect. Compounds 1 and 2 showed a good zone of inhibition against E. coli at micromolar concentrations, and they are more effective than Gentamicin Sulfate. …”
Get full text

Ranolazine Improves Glycemic Variability and Endothelial Function in Patients with Diabetes and Chronic Coronary Syndromes: Results from an Experimental Study by Annunziata Nusca, Federico Bernardini, Fabio Mangiacapra, Ernesto Maddaloni, Rosetta Melfi, Elisabetta Ricottini, Francesco Piccirillo, Silvia Manfrini, Gian Paolo Ussia, Francesco Grigioni

“…Ranolazine is a second-line drug for the management of chronic coronary syndromes (CCS). …”
Get full text

Structural, Electronic, Elastic, Mechanical, and Opto-Electronic Properties for ZnAg2SnS4 and ZnAg2Sn0.93Fe0.07S4 Photocatalyst Effort on Wastewater Treatment through the First Pri... by Mohammad Jahidul Islam, Md. Sabbir Hasan Sohag, Unesco Chakma, Ajoy Kumer, Md. Monsur Alam, Mohammed Nazrul Islam Khan

Get full text

Integrated people-centered eye care: A scoping review on engaging communities in eye care in low- and middle-income settings. by Ling Lee, Elise Moo, Tiffany Angelopoulos, Aryati Yashadhana

“…A variety of community actors were engaged in implementation, in four main domains of eye care: health promotion and education; drug and supplement distribution and immunization campaigns; surveillance, screening and detection activities; and referral and pathway navigation. …”
Get full text