Impact of Out-of-pocket Costs on Varenicline Utilization and Persistence by Aaron Galaznik, Katherine Cappell, Leslie Montejano, Geoffrey Makinson, Kelly H. Zou, Gregory Lenhart

“…The main outcome measures were utilization (defined as presence of a drug claim) and persistence (according to days’ supply and number of days to discontinuation). …”
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Azole Antifungal Consumption in Community Pharmacy Sales in Mainland Portugal: Trend Analysis from 2014 to 2023 by Sofia Moura, Paulo Duarte, Ana Sofia Oliveira, José Martinez-de-Oliveira, Ana Palmeira-de-Oliveira, Joana Rolo

“…<b>Background/Objectives</b>: Excessive or inadequate use of antimicrobial drugs may lead to the emergence of resistant strains. …”
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Effect of Electric Fields on the Mechanical Mechanism of Regorafenib–VEGFR2 Interaction to Enhance Inhibition of Hepatocellular Carcinoma by Yichen Tian, Fenghui Liao, Heng Sun, Yongrong Lei, Yuna Fu, Feng Xia, Jianhua Wang

“…The interaction between molecular targeted therapy drugs and target proteins is crucial with regard to the drugs’ anti-tumor effects. …”
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Norcantharidin induces G2/M arrest and apoptosis via activation of ERK and JNK, but not p38 signaling in human renal cell carcinoma ACHN cells by Huang Shuaishuai, Tuergong Gulimire, Zhu Hangjie, Wang Xue, Weng Guobin, Ren Yu

“…This study provided evidence that NCTD is a promising therapeutic drug for the treatment of RCC.…”
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Rectus Abdominis Muscle Endometriosis: A Unique Case Report with a Literature Review by Marijana Turčić, Koviljka Matušan Ilijaš, Koraljka Rajković Molek, Petra Valković Zujić

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Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-te... by Alan B. Dogan, Spencer R. Marsh, Rachel J. Tschetter, Claire E. Beard, Md R. Amin, L. Jane Jourdan, Robert G. Gourdie

“…Abstract Extracellular vesicles (EVs) are widely investigated for their implications in cell-cell signaling, immune modulation, disease pathogenesis, cancer, regenerative medicine, and as a potential drug delivery vector. However, maintaining integrity and bioactivity of EVs between Good Manufacturing Practice separation/filtration and end-user application remains a consistent bottleneck towards commercialization. …”
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Assessment of typing methods, virulence genes profile and antimicrobial susceptibility for clinical isolates of Proteus mirabilis by Lamiaa A. Salama, Hazem Hamed Saleh, Shaymaa H. Abdel-Rhman, Rasha Barwa, Ramadan Hassan

“…A total of 73.33% of isolates were classified as multi drug resistance (MDR) and 78.3% of isolates were distributed in several antibiotypes with MAR index over 0.2. …”
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Current Status, Challenges, Policies, and Bioethics of Biobanks by Byunghak Kang, Jaesun Park, Sangyun Cho, Meehee Lee, Namhee Kim, Haesook Min, Sooyoun Lee, Ok Park, Bokghee Han

“…The main aim of the biobank is to store and to maintain biomaterials for studying chronic disease, identifying risk factors of specific diseases, and applying personalized drug therapies. This report provides a review of biobanks, including Korean biobanks and an analysis of sample volumes, regulations, policies, and ethical issues of the biobank. …”
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Hepatoprotective Effects of Crude Stem Bark Extracts and Solvent Fractions of Cordia africana against Acetaminophen-Induced Liver Injury in Rats by Gudeta Duga Geresu, Shemsu Umer, Mahlet Arayaselassie, Genet Ashebir, Eyasu Makonnen

“…Administration of the standard drug, silymarin 100 mg/kg, extracts at doses of 100, 200, and 400 mg/kg and fractions at the dose of 400 mg/kg reversed the serum levels of all parameters to normal. …”
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Targeted next-generation sequencing for antimicrobial resistance detection in ventilator-associated pneumonia by Yuting Li, Yanfang Jiang, Hao Liu, Yao Fu, Junying Lu, Hongyan Li, Lulu Sheng, Dejian Gu, Dong Zhang

“…BackgroundVentilator-associated pneumonia (VAP) carries a high mortality rate in the intensive care units (ICUs) due to its widespread drug resistance. Traditional microbial cultures limited by speed and sensitivity, are often unable to help clinicians make effective diagnosis and treatment. …”
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Prevalence of ESBL-Producing Enterobacter Species Resistant to Carbapenems in Iran: A Systematic Review and Meta-Analysis by Farzad Khademi, Hamid Vaez, Zohreh Neyestani, Amirhossein Sahebkar

“…However, the resistance rate to carbapenems was relatively low, and these drugs can still be considered as drugs of choice for the treatment of Enterobacter infections in Iran. …”
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Therapeutic potential of phytocompounds of Bacopa monnieri (L.) Wettst (literature review) by O.O. Nikitina, D.S. Tsyba

“…Further study of the pharmacological action of B. monnieri and the development of drug technology for solid and liquid dosage forms based on it are promising.…”
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Technical explorations for manufacturing of NiTi unibody vascular stents through metal injection molding: Materials performance, fatigue properties and biocompatibility by Dongyang Li, Junwei Wang, Changhai Du, Hao He, Zheyu He, Tun Wang, Chang Shu, Yimin Li, Jing Pan

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Enhanced Chemical Insights into Fullerene Structures via Modified Polynomials by Ali N. A. Koam, Ali Ahmad, Raed Qahiti, Muhammad Azeem, Waleed Hamali

“…This study highlights the potential for these algebraic tools to bridge the gap between theoretical models and practical applications in nanotechnology and materials science, paving the way for innovations in drug delivery, electronic devices, and catalysis.…”
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Pan-cancer analysis shows that TNFSF4 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including liver cancer by Zhaoda Deng, Lincheng Li, Zihe Meng, Guineng Zeng, Rui Cao, Rong Liu

“…TNFSF4 expression correlated with the expression of immune checkpoint genes and could influence various drug sensitivity. Vitro and vivo experiments showed that TNFSF4 could promote the development and progression of Hepatocellular Carcinoma (HCC). …”
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The Efficacy of Amniotic Membrane Stem Cell (AMSC) Metabolite Product and Vitamin E for Wrinkles, Spots, and Pores in Photoaging by Rahmadewi Rahmadewi, Retha Retha, Dyah Ayu Pitasari, Vidyani Adiningtyas Kusumastanto, Agatha Anindita Ayu Ardhaninggar, Irmadita Citrashanty, Maylita Sari, Menul Ayu Umborowati, Cita Rosita Sigit Prakoeswa

“…It is expected that a combination of amniotic membrane stem cell metabolite product (AMSC-MP) and vitamin E after fractional CO2 laser as laser-assisted drug delivery (LADD) will provide better effects in photoaging treatment as the combination reaches the target. …”
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Deoxycholic Acid as a Modifier of the Permeation of Gliclazide through the Blood Brain Barrier of a Rat by Mladena Lalić-Popović, Velibor Vasović, Boris Milijašević, Svetlana Goločorbin-Kon, Hani Al-Salami, Momir Mikov

“…Bile acids are known for their hypoglycemic effect and as promoters of drug penetration across biological membranes. Accordingly, the aim of this study is to investigate whether the bile acid (deoxycholic acid) can change the permeation of gliclazide, through the blood brain barrier of a rat model type-1 diabetes. …”
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Mesenchymal Stromal Cells Mediate Clinically Unpromising but Favourable Immune Responses in Kidney Transplant Patients by Urvashi Kaundal, Raja Ramachandran, Amit Arora, Deepesh B. Kenwar, Ratti Ram Sharma, Ritambhra Nada, Mukut Minz, Vivekanand Jha, Aruna Rakha

“…Allograft rejection postkidney transplantation (KTx) is a major clinical challenge despite increased access to a healthcare system and improvement in immunosuppressive (IS) drugs. In recent years, mesenchymal stromal cells (MSCs) have aroused considerable interest in field of transplantation due to their immunomodulatory and regenerative properties. …”
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Efficacy of single dose praziquantel against Schistosoma mansoni in East Africa: a systematic review and meta-analysis by Miseganaw Sisay, Tadesse Hailu, Destaw Damtie, Kindu Geta, Lamesgen Zelalem, Degisew Misganaw

“…Praziquantel (PZQ) is the first line drug to treat human schistosomiasis. However, there is scarcity of pooled and summarized data on PZQ efficacy to policymakers. …”
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Tumor mutational burden quantification from targeted gene panels: major advancements and challenges by Sara Gandini, Laura Fancello, Pier Giuseppe Pelicci, Luca Mazzarella

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