Antiviral activity of natural compounds extracted from Mediterranean medicinal plants against SARS-CoV-2 by Stephanie Ghio, Jean-Pierre Brincat, Yuksel Cetin, Frederick Lia

“… Spices and Mediterranean medicinal plants provide a rich resource for novel antiviral drug development. The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic with devastating outcomes, and hence, there is a global need to search for small-molecule inhibitors that can act against this viral pathogen. …”
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Natural bioactive compounds form herbal medicine in Alzheimer’s disease: from the perspective of GSK-3β by Mei Wang, Wendi Huang, Juan Huang, Juan Huang, Yong Luo, Yong Luo, Nanqu Huang, Nanqu Huang

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A Systematic Literature Review and Indirect Treatment Comparison of Efficacy of Repository Corticotropin Injection versus Synthetic Adrenocorticotropic Hormone for Infantile Spasms by Michael S. Duchowny, Ishveen Chopra, John Niewoehner, George J. Wan, Beth Devine

“…RCI is a naturally-sourced complex mixture of purified ACTH analogs and other pituitary peptides approved by the United States Food and Drug Administration as a monotherapy for the treatment of infantile spasms. …”
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Cost-Effectiveness and Budget Impact of Emerging Minimally Invasive Surgical Treatments for Benign Prostatic Hyperplasia by Bilal Chughtai, Sirikan Rojanasarot, Kurt Neeser, Dmitry Gultyaev, Stacey L. Amorosi, Neal D. Shore

“…Procedural, adverse event, retreatment, follow-up, and medication costs were based on 2019 Medicare payment rates and Medicare Part D drug spending. One-way and probabilistic sensitivity analyses (PSAs) were performed. …”
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Computational and In silico study of novel fungicides against combating root rot, gray mold, fusarium wilt, and cereal rust. by Mollah Naimuzzaman, Md Mahabub Hasan, Ajoy Kumer, Abu Yousuf Hossin, Mohammad Harun-Ur-Rashid, Swapan Kumar Roy, Abu Noman Faruq Ahmmed, Jamal Uddin

“…Finally, Difenoconazole (L03) has been considered as the most promising antifungal drug evaluated from the studies.…”
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Perception of Toxic Habits in Adolescents in Educational Units of the Ambato Canton by Carlos Alejandro Troya Altamirano, Eduardo Leonel Alvarado Pico, Andrea Gabriela Suárez López

“…There is a need to continue providing knowledge and delve into the effects and risks of alcohol, tobacco and drug consumption and the need to adopt healthy lifestyle habits. …”
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Andrographolide prevents acute hyperammonemia-induced motor dysfunction in rats. Evidences for its mechanism of action by Arghya Mukherjee, Santosh Singh

“…Conclusion: Our study showed AGP could be a potential natural anti-hyperammonemic drug as it has prevented the development of acute hyperammonemic encaphalopathy in rats by suppressing NMDAR-nNOS-cGMP cascade and oxidative stress in cerebral cortex and cerebellum.…”
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Magnetic resonance imaging in primates. The example of the mouse lemur (Microcebus murinus): From detection of pathological aging to therapeutic evaluations by Nelly Joseph-Mathurin, Olene Dorieux, Audrey Kraska, Anne Bertrand, Mathieu Santin, Nadine El Tannir El Tayara, Marc Dhenain

“…Complementary models such as non-human primates are phylogenetically close to humans and thus more predictive of drug efficiency in humans. Mouse lemur (Microcebus murinus) is a small primate (about 12cm, 100g) described as a useful model of cerebral aging and as a potential model of AD. …”
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A Stability-Indicating HPLC-DAD Method for Determination of Stiripentol: Development, Validation, Kinetics, Structure Elucidation and Application to Commercial Dosage Form by Hany W. Darwish, Ali S. Abdelhameed, Mohamed I. Attia, Ahmed H. Bakheit, Nasr Y. Khalil, Abdulrahman A. Al-Majed

“…Stiripentol degraded only under acidic conditions, forming a single degradation product which was well resolved from the pure drug with significantly different retention time values. …”
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Healthcare resource utilization and costs in immunodeficient patients receiving subcutaneous Ig: Real-world evidence from France. by Guillaume Lefèvre, Isabelle Borget, Cinira Lefèvre, Chahrazed Maherzi, Arnaud Nucit, Mouna Hennaoui, Aurélie Schmidt, Hannah Lennon, Benjamin Grenier, Florent Daydé, Nizar Mahlaoui

“…<h4>Methods</h4>This retrospective study of Ig-naïve patients with PID or SID newly receiving a SCIg between 2016 and 2018, extracted from the French National Healthcare reimbursement database (SNDS), analyzed the SCIg-related HCRU and reimbursed costs generated from in-hospital (hospitalizations and SCIg doses) or at-home (nurse visits [NV] and pump provider visits [PPV], drug doses) SCIg administration.<h4>Results</h4>Overall, 2,012 patients (PID:534; SID:1,478) were analyzed. …”
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Propofol Ameliorates Microglia Activation by Targeting MicroRNA-221/222-IRF2 Axis by Xi Xiao, Yuanyuan Hou, Wei Yu, Sihua Qi

“…Propofol is a widely used intravenous anesthetic drug with potential neuroprotective effect in diverse diseases of neuronal injuries such as traumatic brain injury and ischemic stroke. …”
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Explication of Pharmacological Proficiency of Phytoconstituents from Adansonia digitata Bark: An In Vitro and In Silico Approaches by Sangavi P., Gowtham Kumar S., Nachammai KT., Chandrabose Selvaraj, Langeswaran K.

“…Compared to other drug discovery sources, traditional medicine has significantly contributed to developing innovative therapeutic molecules for preventive and curative medicine. …”
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A Meta-Analysis on the Effect and Safety of LCZ696 in the Treatment of Hypertension by Li Zheng, Binbin Xia, Xuqian Zhang, Yan Zhao

“…LCZ696 can significantly reduce the blood pressure level of patients with hypertension, but it is necessary to pay attention to whether the patient will experience coughing after taking the drug.…”
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Effect of the Entorhinal Cortex on Ictal Discharges in Low-Mg2+-Induced Epileptic Hippocampal Slice Models by Ye-Jun Shi, Xin-Wei Gong, Hai-Qing Gong, Pei-Ji Liang, Pu-Ming Zhang, Qin-Chi Lu

“…The pharmacological effect of the antiepileptic drug valproate (VPA) was tested. VPA reversibly suppressed the frequency of interictal discharges but did not change the initiation site and propagation speed, and it completely blocked ictal discharges. …”
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System Pharmacological Approach to Investigate and Validate Multitargeted and Therapeutic Effect of Furocoumarins of Apium graveolens L. for Treatment of Kidney Disease by null Yasheshwar, null Gaurav, Rustam Ekkbal, Prem Gupta, Rajendra Gyawali

“…System pharmacological approaches play important roles in drug discovery and development and in biomolecular exploration to investigate the multitarget therapeutic effects of phytochemicals for the treatment of acute and chronic ailments. …”
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Targeted co-delivery nanosystem based on methotrexate, curcumin, and PAMAM dendrimer for improvement of the therapeutic efficacy in cervical cancer by Ayuob Aghanejad, Shiva Kheiriabad, Maryam Ghaffari, Simin Namvar Aghdash, Neda Ghafouri, Jafar Ezzati Nazhad Dolatabadi, Hashem Andishmand, Michael R. Hamblin

“…Abstract The simultaneous administration of multiple drugs within identical nanocarriers to cancer cells or tissues can result in the effective action of drugs at reduced concentrations. …”
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First report of MDR virulent Pseudomonas aeruginosa in apparently healthy Japanese quail (Coturnix japonica) in Bangladesh. by Alamgir Hasan, Md Tanjir Ahmmed, Bushra Benta Rahman Prapti, Aminur Rahman, Tasnim Islam, Chandra Shaker Chouhan, A K M Anisur Rahman, Mahbubul Pratik Siddique

“…All 25 P. aeruginosa isolates exhibited multi drug-resistance (MDR) patterns. Virulence gene analysis revealed the consistent presence of exoA and rhlR in all isolates, while exoS, exoY, rhlI, and rhlAB showed variable distribution. …”
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Pediatric sleep outcomes after endoscopy-directed simultaneous lingual tonsillectomy and epiglottopexy by Matthew Maksimoski, Sarah E. Maurrasse, Stephen R. Hoff, Jennifer Lavin, Taher Valika, Dana M. Thompson, Jonathan B. Ida

“…These procedures are amenable to a combination surgery in appropriately selected patients determined by sleep state endoscopy in the setting of SDB evaluated with drug-induced sleep endoscopy. Graphical abstract…”
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Antithrombotic Therapy in Patients with Acute Coronary Syndrome in the Intermountain Heart Collaborative Study by Stacey Knight, Winslow Klaskala, Scott C. Woller, Benjamin D. Horne, T. Jared Bunch, Viet T. Le, Roger M. Mills, Joseph B. Muhlestein

“…Placement of a stent increased the likelihood of DAP (bare metal: OR = 54.8, P<0.0001; drug eluting: OR = 59.4, P<0.0001). 923 had atrial fibrillation and 337 had a history of venous thromboembolism; these patients had increased use of AC (29% and 40%, resp.). …”
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Continuous Intra-Incisional Bupivacaine for Postoperative Analgesia after Hip Nailing Surgery: A Randomized Clinical Trial by Arash Farbood, Sanaz Abbasi, Naeimehossadat Asmarian, Mahsa Banifatemi, Vida Naderi-boldaji, Zeinabsadat Fattahi Saravi

“…Pain intensity (NRS), required dose of morphine, and drug-related complications within 24 hours of the intervention were assessed and compared. …”
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