Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy by Aziza Rashed Al-Rafiah, Khlood Mohammed Mehdar

“…Sodium valproate (SVP) is a commonly used antiepileptic drug (AED); however, it has toxic effects. Lutein (L), a carotenoid, has potent antioxidant and anti-inflammatory properties. …”
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Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels by Jorge Sánchez, Andres Sánchez, Ricardo Cardona

“…Chronic spontaneous urticaria (CSU) is a heterogeneous disease with some frequent comorbidities like autoimmune diseases, drug reactions, and inducible urticaria. IgE antibodies against thyroid peroxidase (anti-TPO IgE) could be associated with some of these clinical characteristics. …”
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Hepatoma-Targeted Radionuclide Immune Albumin Nanospheres: 131I-antiAFPMcAb-GCV-BSA-NPs by Mei Lin, Junxing Huang, Dongsheng Zhang, Xingmao Jiang, Jia Zhang, Hong Yu, Yanhong Xiao, Yujuan Shi, Ting Guo

“…Compared to 131I alone, 131I-antiAFPMcAb-GCV-BSA-NPs were much more easily taken in and retained by hepatoma tissue, with a much higher T/NT. Due to good drug-loading, high encapsulation ratio, and highly selective affinity for AFP-positive tumors, the 131I-antiAFPMcAb-GCV-BSA-NPs are promising for further effective radiation-gene therapy of hepatoma.…”
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Impact of Clazosentan on Vasospasm Reduction and Functional Recovery after Aneurysmal Subarachnoid Hemorrhage by Sosho KAJIWARA, Takayuki KAWANO, Yu HASEGAWA, Yukihiko NAKAMURA, Kiyohiko SAKATA, Jin KIKUCHI, Masaru HIROHATA, Motohiro MORIOKA

“…However, with the approval of clazosentan in January 2022, it has been used as a first-choice drug more frequently. Despite this shift, limited evidence exists regarding the use of clazosentan as the first choice for DCI prevention. …”
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Integrating post-validation surveillance of lymphatic filariasis with the WHO STEPwise approach to non-communicable disease risk factor surveillance in Niue, a study protocol. by Adam T Craig, Harriet Lawford, Grizelda Mokoia, Minerva Ikimau, Peter Fetaui, Tonia Marqardt, Colleen L Lau

“…After extensive efforts involving multiple rounds of Mass Drug Administration, Niue was validated by the World Health Organization (WHO) as having e4liminated LF as a public health problem in 2016. …”
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New Prospects of Cytoprotection in the Treatment and Prevention of Gastric and Intestinal Diseases (Resolution of an Expert Council and Literature Review) by A. I. Martynov, A. A. Sheptulin, I. V. Mayev, A. N. Kazyulin, A. Ye. Karateev, A. V. Melekhov, L. K. Pal’gova, K. L. Raikhel’son

“…Rebamipid is a highly effective drug positively affecting various cytoprotection links, thus being suitable for the treatment and prevention of erosive and ulcerative lesions of the gastrointestinal tract, as well as gastroenterological diseases of various etiologies.Conflict of interest: The Expert Council meeting was supported by the Alium company.…”
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Overuse Injury, Substance Use, and Resilience in Collegiate Female Athlete by Chelsea L Martin, Ellen Shanley, Chris Harnish, Amy M Knab, Shefali Christopher, Srikant Vallabhajosula, Garrett S Bullock

“… # Results IP for pain was 45.0% (95% CI: 38.2-51.9); Overuse injury 52.0% (45.1-58.9); Alcohol use 35.1% (28.6-41.6); Electronic cigarette use 19.5% (14.6-24.9); Cigarette use 2.8% (6-5.1); and Drug use 3.3% (0.9-5.8). No significant differences were found between resilience groups for the Oslo Sports Trauma Research Center Overuse Injury Questionnaire (OSTRC) variables (Pain: p=0.102; Overuse injury: p=0.331; Substantial overuse injury: p=0.084; Not playing: p=0.058), alcohol (p=0.723), or combined substance use (p=0.069)…”
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Based on network pharmacology and molecular docking to study the mechanisms of active ingredients of ginseng in the treatment of atopic dermatitis by BU Jialiang, SHEN Lin, MENG Yuan, PIAO Yingshi

“…[Methods] The databases of OMIM, TTD, CTD, GEO and GeneCards were used to screen the homologous targets and disease targets of active ingredients in ginseng. Then the ″drug-component-target″ network was constructed, and the potential and core targets of ginseng for the treatment of atopic dermatitis were screened. …”
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Three-Year Point Prevalence Survey of Antimicrobial Use in a Chinese University Hospital by Fa-Hong Jing, Qiang Wang, Tian-Jiao He, Na Xin, Yao-Wei Wang, Yang Han, Xin Wang, Zhuo Li

“…Data including basic patient information, antimicrobial drugs, quality evaluation of antimicrobial drug prescription, and the risk factors of nosocomial infection were collected from doctor network workstation. …”
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Immunocompatibility of Bacteriophages as Nanomedicines by Tranum Kaur, Nafiseh Nafissi, Olla Wasfi, Katlyn Sheldon, Shawn Wettig, Roderick Slavcev

“…Filamentous phages also can and have been formulated as targeted drug-delivery nanomedicines, and phage may also serve as promising alternatives/complements to antibiotics. …”
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An unbiased cell morphology-based screen for new, biologically active small molecules. by Masahiro Tanaka, Raynard Bateman, Daniel Rauh, Eugeni Vaisberg, Shyam Ramachandani, Chao Zhang, Kirk C Hansen, Alma L Burlingame, Jay K Trautman, Kevan M Shokat, Cynthia L Adams

“…Morphology-based screening of diverse cancer cell types has provided a method for discovering potent new small-molecule probes for cell biological studies and anticancer drug candidates.…”
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The AhR pathway regulation in phthalates-induced cancer promotion, progression and metastasis: a scoping review by Mostafa Akbariani, Mahmoud Omidi, Zohreh Shahabi, Hamed Haghi-Aminjan, Amir Shadboorestan

“…Specifically, DEHP activated AhR, leading to elevated expression of EMT markers, increased cancer stem cell populations, and enhanced drug metabolism and resistance. Other phthalates, such as Butyl Benzyl Phthalate (BBP), also activated AhR-mediated pathways, promoting angiogenesis and metastasis. …”
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Synthesis, Structural Characterization, and Preclinical Efficacy of a Novel Paclitaxel-Loaded Alginate Nanoparticle for Breast Cancer Treatment by Ahmed A. Markeb, Nagwa A. El-Maali, Douaa M. Sayed, Amany Osama, Mohamed A. Y. Abdel-Malek, Amen H. Zaki, Mostafa E. A. Elwanis, James J. Driscoll

“…PTX was combined with ALG in a nanoparticle as a drug delivery system designed to improve breast cancer tumor cell killing. …”
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Liraglutide Attenuates Hepatic Oxidative Stress, Inflammation, and Apoptosis in Streptozotocin-Induced Diabetic Mice by Modulating the Wnt/β-Catenin Signaling Pathway by Jie Yu, Yuan Zhao, Lingling Xu, Wei Li, Huabing Zhang, Fan Ping, Yuxiu Li

“…Interestingly, liraglutide monotherapy showed better efficacy in ameliorating liver injury in T1DM mice than insulin monotherapy, similar to the combined drug therapy. Furthermore, the expression of Wnt/β-catenin signaling pathway-associated molecules was upregulated in the liver of mice treated with liraglutide or insulin. …”
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The effect of Shirodhara on essential hypertension: Systematic review and meta-analysis by Meenakshi Khapre, Dhanlika Dhanlika, Sriloy Mohanty, Amrita Mehndiratta

“…The percentage of relief in clinical symptoms was notably higher in the Shirodhara and Ayurveda groups than in the Ayurvedic drug group. Shirodhara lowered diastolic blood pressure significantly, but it has low clinical value. …”
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Opioidergic tuning of social attachment: reciprocal relationship between social deprivation and opioid abuse by Julia A. Galiza Soares, Samantha N. Sutley-Koury, Matthew B. Pomrenze, Matthew B. Pomrenze, Jason M. Tucciarone

“…This disruption in social functioning further promotes addiction, creating a cycle in which increasing isolation drives drug use. Social factors also appear to impact susceptibility and progression of opioid dependence. …”
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The Inhibitory Effect of Validamycin A on Aspergillus flavus by Napasawan Plabutong, Supanuch Ekronarongchai, Nattarika Niwetbowornchai, Steven W. Edwards, Sita Virakul, Direkrit Chiewchengchol, Arsa Thammahong

“…The FICI of validamycin A and amphotericin B of these clinical isolates was about 0.25–0.28 with synergistic effects. No drug cytotoxicity was observed in human bronchial epithelial cells treated with validamycin A using LDH-cytotoxicity assays. …”
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Differentiation value of miR-26b for major depressive disorder, schizophrenia, generalized anxiety disorder by Lingming Kong, Xiaoli Zhu, Liyi Zhang, Shengdong Chen

“…Introduction: First episode and drug naive schizophrenia (SZ) patients comorbid with major depressive episode and generalized anxiety disorder (GAD) comorbid with major depressive disorder (MDD) are common in clinical practice, overlapping symptomatology during first presentation of MDD, SZ and GAD challenged the diagnostic process. …”
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Protective activity of propofol, Diprivan® and intralipid against active oxygen species by M. Mathy-Hartert, G. Deby-Dupont, P. Hans, C. Deby, M. Lamy

“…By HPLC, we demonstrated that PPF was not incorporated into the cells. The drug thus acted by scavenging the active oxygen species released in the extracellular medium. …”
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Primary multiple synchronous tumors: soft tissue sarcoma of the retroperitoneal space and metastatic prostate cancer by O. A. Mailyan, K. Yu. Kanukoev, P. G. Berezin, K. M. Nyushko, V. A. Gorbach

“…However, given the high detectability of prostate cancer, primary patients are currently receiving radical treatment, and if metastatic prostate cancer is detected, they are receiving drug treatment, which improves the survival and quality of life of patients. …”
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