Comparative Efficacy of Antihypertensive Agents in Flow-Mediated Vasodilation of Patients with Hypertension: Network Meta-Analysis of Randomized Controlled Trial by Hong Ding, Shu Liu, Ke-Xin Zhao, Jie Pu, Ya-Fei Xie, Xiao-Wei Zhang

“…There were no significant differences between antihypertensive drug-based monotherapies.…”
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Hiper IgE dengan Nekrolisis Epidermal Toksik by Adrian Ramdhany, Raveinal Raveinal

“…Akibatnya, istilah-istilah seperti ‘staphylococcal-induced toxic epidermal necrolysis’ dan ‘drug-induced scalded skin syndrome’ menang selama beberapa dekade, tetapi sekarang dipisahkan karena terapi dan prognosisnya berbeda. …”
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Safety, Tolerability, and Pharmacokinetics of NIM‐1324 an Oral LANCL2 Agonist in a Randomized, Double‐Blind, Placebo‐Controlled Phase I Clinical Trial by Andrew Leber, Raquel Hontecillas, Nuria Tubau‐Juni, Josep Bassaganya‐Riera

“…ABSTRACT NIM‐1324 is an oral investigational new drug for autoimmune disease that targets the Lanthionine Synthetase C‐like 2 (LANCL2) pathway. …”
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The effect of gnrh and simultaneous gnrh and pgf2α treatment of dairy cows with ovarian cysts by Hüseyin Erdem, Tevfik Tekeli, Mehmet Uçar, Mustafa Yenice

“…It was found that simultaneous GnRH and PGF2α treatment had no effect lo alter the effects of each drug. In addition to these, determining the plasma progesteron levels was found useful for evaluation of the effectiveness ot the treatment.…”
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Molecular Characterization and Antibacterial Potential of Endophytic Fungal Isolates from Selected Mangroves along the Coastline of Kenya by Teresia Nyambura Wacira, Huxley Mae Makonde, Carren Moraa Bosire, Cromwell Mwiti Kibiti

“…Scientists have been striving to find novel bioactive compounds and drugs to overcome these obstacles. This study aimed to characterize mangrove endophytic fungi and evaluate their antibacterial activity. …”
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Identification of Potential Biomarkers for Coronary Artery Disease Based on Cuproptosis by Bohong Zhang, Mingliang He

“…Finally, 13 potential therapeutic drugs targeting 2 marker genes (S100A12 and F5) were identified using the Drug Gene Interaction Database (DGIdb). …”
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Anti-cancer activity of synthetic gefitinib-1,2,3-triazole derivatives against Hela cells via induction of apoptosis by Zhihong Hu, Xixi Hou, Yongjing Ren, Ziyuan Wu, Dong Yan, Hong Chen, Lan Wang

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Curcumin as a potential inhibitor of TGFβ3 computational insights for breast cancer therapy by Ali G. Alkhathami, Mohammad Y. Alshahrani, Saad Ali Alshehri, Nazim Nasir, Shadma Wahab

“…The curcumin has low Molecular Weight 368.130 (MW) and follows Lipinski Rule, Pfizer Rule, GSK Rule, Golden Triangle, BMS Rule, zero PAINS alert and Acute Toxicity Rule with zero alert. Any drug-like contender must follow these qualities. …”
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Antiallergic Effect of the Alpha-Cyclodextrin Moringin Complex in Rat Basophilic Leukaemia (RBL-2H3) Cell Line by Ebtisam Yousef A. Alnakeeb, Ahmad Faizal Abdull Razis, Kim Wei Chan, Chau Ling Tham, Yee Han Chan, Anwar Salm Kalifa Kafo, Nuzul Noorahya Jambari, Patrick Rollin, Florence Djedaini-Pilard

“…Thus, α-CD/MG can potentially be developed as an antiallergic drug as it has the ability to inhibit allergic responses in the late and early stages.…”
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Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2pos Breast Cancer by Nirmala Ghimirey, Chase Steele, Brian J. Czerniecki, Gary K. Koski, Loral E. Showalter

“…To explore the possibility of combining targeted drugs with Th1-polarizing vaccines, we undertook a study to examine the impact of combining Th1 cytokines with the relatively broad-spectrum receptor tyrosine kinase antagonist, sunitinib. …”
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Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff by Eva-Maria Maintz, Mahbub Hassan, M. Mamun Huda, Debashis Ghosh, Md. Shakhawat Hossain, Abdul Alim, Axel Kroeger, Byron Arana, Dinesh Mondal

“…Politicalcommitment for ambisome is strong; the general hospital infrastructure favours implementation but further strengthening is required, particularly for drug storage below 25°C (refrigerators), back-up energy (fuel for generators), and supplies for ambisome administration (like 5% dextrose solution). …”
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The Anti-proliferative Effect of a Novel Glutaminase Inhibitor IN-3 on Prostate Cancer Cells by Ummuhan DEMIR, Ayse Busranur CELIK

“…Further studies are warranted to elucidate its drug potential in prostate cancer.…”
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Antimicrobial resistance characterization of Staphylococcus aureus from different animal food origins in Jimma, South Western Ethiopia by Diriba Taddese, Mukarim Abdurahaman, Motuma Debelo, Eshetu Shumi, Gelana Urgessa, Dase Kefyalew, Moa Melaku, Tadele Kebeta, Gazali Abafaji

“…Nearly a quarter (24.4%) of the 41 Staphylococcus aureus isolates exhibited multi-drug resistance, highlighting the significant prevalence of this concerning trait. …”
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Upregulation of CD19 by low‐dose chidamide promotes CAR T cells functionality in B-cell non-Hodgkin lymphoma by Ying Ni, Qun Zhang, Xiaochen Tang, Xiuchun Li, Shiguang Ye, Yan Lu, Aibin Liang, Ping Li

“…Therefore, it is of great importance to overcome the drug resistance of CD19 CAR T cells after B-NHL treatment and reduce the recurrence rate of CD19 CAR T cells after B-NHL treatment. …”
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Interaction of α-Cembrenediol with Human Serum Albumin Based on Spectroscopic and Computational Analyses by Xian-Kun Su, Zhen-Chun Sun, Chang-You Zhao, Hui Yang, Tian-Ming Zhao, Chao Ma, Guo-Fei Zhu

“…However, knowledge of the absorption, transport, and release of α-cembrenediol in drug metabolism within the body is currently limited. …”
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Lidocaine Versus Ketamine Pretreatment on Propofol Injection Pain by Amir Murad Khudadad Boujan, Nashmeel fazeel Kareem, Amanj A. Marouf, Saman Abdullah Ahmed Fahmi, Salah Qadir Mahmood

“…Propofol is commonly used intravenous anesthesia induction drug but it causes ache upon use, many methods with different results, have been suggested to prevent this pain, the current research was concluded in order to investigate the impact of lidocaine, ketamine in reducing the ache on giving intravenous propofol. …”
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AI-enhanced 3D-QSAR screening of fragment-based novel designed molecules targeting Phalaris minor ACCase by Bikash Kumar Rajak, Priyanka Rani, Durg Vijay Singh, Nitesh Singh

“…Using small molecule databases such as ZINC, CHEMBL, and DrugBank, an initial screening based on structural similarity to known ACCase inhibitors is performed. …”
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Costs of home-delivered antiretroviral therapy refills for persons living with HIV: Evidence from a pilot randomized controlled trial in KwaZulu-Natal, South Africa. by Ashley S Tseng, Ruanne V Barnabas, Alastair van Heerden, Xolani Ntinga, Maitreyi Sahu

“…Personnel costs were the largest cost for home-delivered refills while ART drug costs were the largest cost of clinic-based refills. …”
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The first clinical case of the left-ventricular electrode implantation with active fixation for the purpose of cardiac resynchronization therapy in Ukraine by V.V. Boiko, S.V. Rybchynskyi, D.O. Lopin, D.E. Volkov

“…Standard therapy includes long-term medications, such as angiotensin-converting-enzyme inhibitor or angiotensin-II-receptor antagonists, beta-blockers, treatment of concomitant cardiac pathology, but drug therapy is not always effective, even with regular use of drugs in the correct dosages. …”
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Development of a Novel Prognostic Model for Lung Adenocarcinoma Utilizing Pyroptosis-Associated LncRNAs by Hong-Yan Bai, Tian-Tian Li, Li-Na Sun, Jing-Hong Zhang, Xiu-He Kang, Yi-Qing Qu

“…Difficulty in early diagnosis and strong drug resistance have always been difficulties in the treatment of lung cancer, so the prognosis of lung cancer has always been the focus of scientific researchers. …”
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