Screening and Characterizing Tyrosinase Inhibitors from Salvia miltiorrhiza and Carthamus tinctorius by Spectrum-Effect Relationship Analysis and Molecular Docking by Ya-Li Wang, Guang Hu, Qian Zhang, Yu-Xiu Yang, Qiao-Qiao Li, Yuan-Jia Hu, Hua Chen, Feng-Qing Yang

“…Tyrosinase (TYR) is a rate-limiting enzyme in the synthesis of melanin, while direct TYR inhibitors are a class of important clinical antimelanoma drugs. This study established a spectrum-effect relationship analysis method and high-performance liquid chromatography-mass spectrometry (LC-MS) analysis method to screen and identify the active ingredients that inhibited TYR in Salvia miltiorrhiza–Carthamus tinctorius (Danshen–Honghua, DH) herbal pair. …”
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Efficacy and safety of Saireito (TJ-114) in patients with atrial fibrillation undergoing catheter ablation procedures: A randomized pilot study. by Tetsuma Kawaji, Satoshi Shizuta, Hidenori Yaku, Kazuhisa Kaneda, Fumiya Yoneda, Shushi Nishiwaki, Munekazu Tanaka, Takanori Aizawa, Shun Hojo, Kenji Nakatsuma, Masashi Kato, Takafumi Yokomatsu, Shinji Miki, Koh Ono, Takeshi Kimura

“…<h4>Results</h4>Three (6.0%) out of 50 patients treated with Saireito discontinued the drug because of adverse symptoms. The Saireito group was associated with a numerically lower number of episodes of frequent atrial tachyarrhythmias than the control group (3.1 versus 5.2 times, P = 0.17). …”
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Dramatic response of advanced pulmonary sarcomatoid carcinoma to tislelizumab combined with anlotinib: a case report by Ranran Li, Xiliang Di, Yuan Li, Hao Li, Chonghua Liu

“…Radiotherapy was performed for the brain and skull metastases, followed by treatment with tislelizumab combined with anlotinib, a programmed cell death protein 1 (PD-1) inhibitor with anti angiogenic drug, respectfully. The patient initially received nine cycles of treatment with tislelizumab and anlotinib, resulting in a significant shrinkage of the lung tumor. …”
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Advancements in cellular immunotherapy: overcoming resistance in lung and colorectal cancer by Lijuan Qin, Yuan Li, Juan Liu, Xiaoqin An

“…The review also explores cutting-edge strategies aimed at overcoming resistance, including combination therapies, gene editing technologies, and nanotechnology for targeted drug delivery. By discussing the molecular, cellular, and microenvironmental factors contributing to resistance, we aim to provide a comprehensive overview of how these challenges can be overcome, paving the way for more effective, personalized immunotherapies in lung and colorectal cancer treatment.…”
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Ranolazine Induced Bradycardia, Renal Failure, and Hyperkalemia: A BRASH Syndrome Variant by Syed Arsalan Akhter Zaidi, Danial Shaikh, Muhammad Saad, Timothy J. Vittorio

“…Ranolazine is a well-known antianginal drug, that was first licensed for use in the United States in 2006. …”
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Influence of Electrostatic Interactions on the Self-Assembly of Charged Peptides by Xue Sun, Bolan Wu, Na Li, Bo Liu, Shijun Li, Liang Ma, Hangyu Zhang

“…Peptides can be designed to self-assemble into predefined supramolecular nanostructures, which are then employed as biomaterials in a range of applications, including tissue engineering, drug delivery, and vaccination. However, current self-assembling peptide (SAP) hydrogels exhibit inadequate self-healing capacities and necessitate the use of sophisticated printing apparatus, rendering them unsuitable for 3D printing under physiological conditions. …”
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Puerarin Promotes the Migration and Differentiation of Myoblasts by Activating the FAK and PI3K/AKT Signaling Pathways by Xiaofeng Fang, Hangjia Xu, Zhaoxin Fan, Hongge Yang, Yan Huang, Lin Xu, Yiwei Rong, Wei Ma, Liubao Pei, Hongsheng Liang

“…Taken together, our data indicate that puerarin facilitated myogenesis by promoting migration and differentiation, which suggests puerarin as a new candidate drug for the treatment of muscle loss diseases.…”
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Chemical Constituents of the Bark of Zanthoxylum gilletii (Rutaceae) and Their In Vitro Antiplasmodial and Molecular Docking Studies by Liliane Clotilde Dzouemo, Gervais Mouthé Happi, Sikiru Akinyeye Ahmed, Willifred Dongmo Tekapi Tsopgni, Michael Nde Akuma, Shina Salau, Emmanuel Ngeufa Happi, Jean Duplex Wansi

“…The present study provides further information to enrich the chemistry of Z. gilletii and its qualification as an important source for good candidates in new antiplasmodial drug development.…”
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The effect of the nisin-based pharmaceutical formulation used in the treatment plan for cows with subclinical mastitis on the milk microbiota by M. N. Isakova, Ya. Yu. Lysova

“…Due to the growing threat of antimicrobial resistance, the search and development of new drugs to treat infectious mammary gland diseases of high yielding cows is an urgent task. …”
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Functional Role of P-Glycoprotein and Binding Protein Effect on the Placental Transfer of Lopinavir/Ritonavir in the Ex Vivo Human Perfusion Model by Pierre-Francois Ceccaldi, Laurent Gavard, Laurent Mandelbrot, Elisabeth Rey, Robert Farinotti, Jean-Marc Treluyer, Sophie Gil

“…Even at high albumin concentrations, inhibition of placental P-glycoprotein increased placental transfer of lopinavir, suggesting that this efflux pump actively reduces placental transfer of the drug. This mechanism may play a role in fetal exposure to maternal antiretroviral therapy.…”
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Gambaran Pemeriksaan Kadar SGOT, SGPT, Ureum dan Kreatinin Pasien Covid-19 dengan dan tanpa Komorbid by Rachmi Fadillah, Ellyza Nasrul, Tuty Prihandani

“…Coronavirus disease (COVID-19) causes damage through mechanisms: cytotoxic to the bile duct, liver and renal tubular epithelial cells; severe inflammatory response due to excessive pro-inflammatory cytokines (cytokine storm); tissue anoxia; and drug-induced liver and kidney damage. AST and ALT enzymes are used to determine liver damage, while kidney damage is examined from increased urea and creatinine levels. …”
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Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W. I. Cox, Mattia Chiesa, Yuri D’Alessandra, Michela Garofalo, Caroline H. Topham, Gianpiero Di Leva

“…Together, these findings highlight the potential of multi-CDK inhibition by dinaciclib as an alternative option to CDK4/6 specific inhibition, frequently associated with drug resistance in patients.…”
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Understanding the mechanism underlying the green synthesis of metallic nanoparticles using plant extract(s) with special reference to Silver, Gold, Copper and Zinc oxide nanopartic... by Kangkan Deka, Renaldy Donlang Nongbet, Karan Das, Pranjal Saikia, Simran Kaur, Abhijita Talukder, Bhargab Thakuria

“…These nanoparticles find utility in biomedical research, drug delivery, catalysis, sensing, and environmental clean-up. …”
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The Effectiveness of Ebselen in Facial Nerve Crush Injury: An Experimental Study by Lütfü Şeneldir, Veysel Alparslan Gölcük, Gökçe Tanyeri Toker, Ayşegül Verim, Pembegül Güneş

“…Background: Ebselen is a neuroprotective drug that protects cellular components from oxidative damage by modulating enzymatic cofactors, metalloproteins, gene expression, antioxidant-anti-inflammatory effects, and immunological systems. …”
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Mutant Prevention Concentration of Ciprofloxacin against Klebsiella pneumoniae Clinical Isolates: An Ideal Prognosticator in Treating Multidrug-Resistant Strains by B. Aditi Priyadarshini, Krishnan Mahalakshmi, Venkatesan Naveen Kumar

“…Estimation of the MPC in the case of multidrug-resistant isolates in the clinical setup may help in treating these drug-resistant strains.…”
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A Case of Influenza B and Mycoplasma pneumoniae Coinfection in an Adult by Taro Shinozaki, Kotaro Sasahara, Eri Iwami, Aoi Kuroda, Tatsu Matsuzaki, Takahiro Nakajima, Takeshi Terashima

“…Initially, the patient was diagnosed with influenza B infection associated with lobar pneumonia and treated with an anti-influenza virus drug and sulbactam/ampicillin. The patient’s fever persisted, and her respiratory condition worsened. …”
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Assessment of microbial diversity and antimicrobial resistance in raw camel milk: Genomic and phenotypic analysis of Kharai and Kutchi breeds of Gujarat, India by Hetvi J. Adhyaru, Devangi B. Mangroliya, Jayesh H. Kabariya, Vimal M. Ramani

“…Through phenotypic antimicrobial resistance analysis using the disc diffusion method, a significant number of multidrug-resistant (MDR) and extensively drug-resistant (XDR) bacterial isolates were identified. …”
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Correlating NAD(P)H lifetime shifts to tamoxifen resistance in breast cancer cells: A metabolic screening study with time-resolved flow cytometry by Samantha Valentino, Karla Ortega-Sandoval, Kevin D. Houston, Jessica P. Houston

“…This work is impacting because it establishes an early step toward developing a reliable screening technology in which large cell censuses can be differentiated for drug sensitivity in a label-free fashion.…”
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Current Concepts on Antiplatelet Therapy: Focus on the Novel Thienopyridine and Non-Thienopyridine Agents by L. Testa, G. G. L. Biondi Zoccai, M. Valgimigli, R. A. Latini, S. Pizzocri, S. Lanotte, M. L. Laudisa, N. Brambilla, M. R. Ward, G. A. Figtree, F. Bedogni, R. Bhindi

“…Thienopyridines are a class of drug targeting the platelet adenosine diphosphate (ADP) 2 receptor. …”
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Gastric Dilation due to a Neuroleptic Agent in an Elderly Patient: A Case Report by V. Parent, L. Popitean, A. Loctin, A. Camus, P. Manckoundia

“…This report underlines all of the necessary precautions and surveillance around drug prescription, especially in elderly persons.…”
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