Best Evidence Summary for the Improvement and Management of Disorders of Consciousness in Patients With Severe Brain Injury by Miaoyuan Lin, Qiongna Lu, Sheng Yu, Wenjuan Lin

“…The 26 best pieces of evidence were recommended by inducting and integrating the evidence from these articles, covering the following seven aspects: consciousness assessment, multidisciplinary team, intervention in facilitating arousal, sensory stimulation programs, drug administration, rehabilitation program, and prevention of complications. …”
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Dysbiosis of infant gut microbiota is related to the altered fatty acid composition of human milk from mothers with gestational diabetes mellitus: a prospective cohort study by Kelei Li, Jin Jin, Zhizuo Liu, Chuanjing Chen, Ludi Huang, Yongye Sun

“…The mothers received guidance on diet and exercise but not drug therapy. All infants were exclusively breastfed. …”
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To Bind or to Let Loose: Effectiveness of Sodium Polystyrene Sulfonate in Decreasing Serum Potassium by Shaifali Sandal, Hatim Karachiwala, John Noviasky, Dongliang Wang, William C. Elliott, David F. Lehmann

“…Patients who received any other form of potassium-altering drug or treatment were excluded. Results. The administration of sodium polystyrene sulfonate reduced serum potassium by 16.7% (P<0.001) as compared to the baseline serum potassium over a period of 24 hours. …”
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Anionic liposomes prepared without organic solvents for effective siRNA delivery by Xiu Han, Yan Lu, Zhaoluo Xu, Yanan Chu, Xueping Ma, Haiping Wu, Bingjie Zou, Guohua Zhou

“…Therefore, anionic liposomes prepared with glycerol will be a safe and effective delivery platform for siRNA and even other nucleic acid drugs.…”
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Serological diagnosis of soil-transmitted helminth (Ascaris, Trichuris and hookworm) infections: A scoping review. by Sara Roose, Fiona Vande Velde, Johnny Vlaminck, Peter Geldhof, Bruno Levecke

“…Serological assays offer a potential solution for integrated diagnosis of NTDs, particularly for those requiring mass drug administration (MDA) as primary control and elimination strategy. …”
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Evaluation of reporting trends in the MAUDE Database: 1991 to 2022 by Meital Mishali, Nadav Sheffer, Oren Mishali, Maya Negev

“…Adverse event reporting for medical devices is critical for risk mitigation. The Food and Drug Administration's (FDA) Manufacturer and User Facility Device Experience (MAUDE) database serves as a key tool for post-market surveillance, receiving reports from various sources. …”
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Attitudes and Practices Surrounding Opioid Prescriptions following Open Reduction Internal Fixation of Distal Radius and Ankle Fractures: A Survey of the Canadian Orthopaedic Assoc... by Jihad A. Abouali, Evan D. Curd, Xin Y. Mei, Ujash Sheth, Moin Khan, Darren de SA, Vehniah K. Tjong, Jesleen Rana

“…A 40-item survey was developed focusing on four themes: respondent demographics, opioid-prescribing practice, patients with substance use disorders, and drug diversion. The survey was distributed among members of the Canadian Orthopaedic Association. …”
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High Throughput Approaches to Unravel the Mechanism of Action of a New Vanadium-Based Compound against Trypanosoma cruzi by M. Florencia Mosquillo, Pablo Smircich, Analía Lima, Sergio A. Gehrke, Gonzalo Scalese, Ignacio Machado, Dinorah Gambino, Beatriz Garat, Leticia Pérez-Díaz

“…In this work, we study a new prospective antitrypanosomal drug based on vanadium, here named VIVO(5Brsal)(aminophen). …”
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Zonisamide Enhances Motor Effects of Levodopa, Not of Apomorphine, in a Rat Model of Parkinson’s Disease by Haruo Nishijima, Yasuo Miki, Shinya Ueno, Masahiko Tomiyama

“…Zonisamide is a relatively recent drug for Parkinson’s disease. Multiple hypotheses have been proposed to explain the antiparkinsonian effects of zonisamide. …”
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Tomographic Aspects of Advanced Active Pulmonary Tuberculosis and Evaluation of Sequelae following Treatment by Rafael Barcelos Capone, Domenico Capone, Thiago Mafort, Roberto Mogami, Rosana de Souza Rodrigues, Miriam Menna Barreto, Rogerio Rufino

“…Cross-sectional and descriptive study of 74 TB patients confirmed by sputum culture and chest computed tomography before (CT1) and 6 months after (CT2) drug therapy. Results were performed by three radiologists blinded to clinical and laboratory results. …”
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Retrospective single-center analysis of surgical treatment of patients with primary mitral insufficiency by О.A. Myshakivskyy, V.H. Аverchuk, А.V. Ratych, I.S. Protsyk, I.P. Chornenkyy, D.V. Аverchuk, T.B. Rudyk, Yu.A. Ivaniv, L.V. Povalyashko, D.S. Tymchuk, V.I. Pavliuk, L.Ya. Solovey, I.I. Кobza

“…This shows efficiency of pre-surgery drug preparation. Conclusions. The duration of the in-hospital stay depended on type of the surgery and didn’t depend on NYHA FC. …”
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Concurrent and prospective relations between aberrant stress-induced frontal alpha asymmetry and cannabis use disorder by Brandon S. Schermitzler, Julia Y. Gorday, Michael Griffin, Richard J. Macatee

“…Stress potentiation of drug use motivation is a mechanism implicated in CUD; however, little is known about the neurobiological mechanisms through which stress impacts cannabis use motivation. …”
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Cytogenetic Evolution of Human Ovarian Cell Lines Associated with Chemoresistance and Loss of Tumorigenicity by Stéphanie Struski, Martine Doco‐Fenzy, Michael Koehler, Ilse Chudoba, Francis Levy, Linda Masson, Nicole Michel, Evelyne Ulrich, Nadine Gruson, Jean Bénard, Gérard Potron, Pascale Cornillet‐Lefebvre

“…Multicolor FISH (Multiplex‐FISH and Spectral Karyotype) and conventional FISH are also used to elucidate the karyotype of parental cell line. The drug‐resistant subcell lines displayed many chromosomal abnormalities suggesting the implication of different pathways leading to a multidrug resistance phenotype. …”
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Proteomic analysis of whole blood to investigate the therapeutic effects of nervonic acid on cerebral ischemia-reperfusion injury in rats by Qingqing Li, Fengrong Zhang, Xianyu Li, Qing Wang

“…This study aimed to develop a reliable methodology for whole blood proteomics to identify early warning biomarkers and evaluate drug treatment efficacy.MethodsAfter modeling via the classic thread embolization method, whole blood samples were collected from the rats. …”
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Serotonin Syndrome after Sertraline Overdose in a Child: A Case Report by Joana Grenha, Ana Garrido, Hernani Brito, Maria José Oliveira, Fátima Santos

“…Serotonin syndrome is a potentially life-threatening drug effect. It may be misdiagnosed because it has mostly been reported in adults. …”
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Green and High Throughput Assay Using 96-Microwell Base to Determine Metformin Hydrochloride in the Tablet Dosage Form by Mohammed Alqarni, Atheer Alshehri, Bayan Almalki, Refah Althumali, Maram Alghamdi, Rawan Alqahtani, Safia G. Alotibi, Ali Alqarni, Adel H. Awad, Ibrahim A. Naguib

“…Metformin (MET) is an oral antidiabetic drug widely used as the primary treatment for type 2 diabetes mellitus (T2DM). …”
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Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus by Ping Wang, Huili Liu, Li Chen, Yingli Duan, Qunli Chen, Shoumin Xi

“…Our data suggest that the novel GKA, HMS5552, exerts antidiabetic effects on the liver and pancreas by improving GK activity and insulin resistance, which holds promise as a novel drug for the treatment of T2DM patients.…”
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Evaluation of the Cytotoxicity of Aqueous Extract and Oleo-Essential Oil of Dorema ammoniacum Plant Oleo-Gum Resin in Some Human Cancer Cell Lines by Pardis Mohammadi Pour, Spideh Bidad, Gholamreza Bahrami, Leila Hosseinzadeh, Mahdi Mojarrab, Mohammad Hosein Farzaei

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5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects by Liangliang Hu, Ting Meng, Davies Marabada, Zhichao Jin, Qing Huang, Shijie Wei, Zhizhong Wang

“…These findings not only demonstrated that 5-Fluorouracil-β-Cyclodextrin conjugates exhibits superior antitumor activity and reduced toxicity but also suggest that the linker plays a crucial role in determining both the efficacy of drug conjugates as an anticancer agent and its associated adverse effects. …”
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Clinical efficacy of Methylene Blue mediated antimicrobial Photodynamic Therapy (PDT) using 680 nm Diode Laser in patients undergoing Open Flap Debridement: An Original Research by Soundarya Singh, Manisha Rout, Mayur Kaushik, Shilpa Sharma, Aprajita Srivastava

“…Photodynamic therapy (PDT) involves the use of low-power lasers with appropriate wavelengths to kill microorganisms treated with a photosensitiser drug. PDT could be a useful adjunct to mechanical as well as antibiotics in eliminating periodontal-pathogenic bacteria. …”
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