IFN-β production induced by PRRSV is affected by GP3 quantity control and CLND4 interaction by Dexin Li, Xinyu Cui, Yingchao Li, Qin Zhang, Hongyan Gao, Youbo Li, Yanmeng Hou, Hongjie Yuan, Yihong Xiao

“…Our results indicate that sECL2 is a promising candidate drug for developing treatments to control PRRS.…”
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The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspective by Sheng Chen, Min Wang, Shuai Zhang, Xin Huang, Xinke Sui, Dou Li, Changqing Zhong, Wei Wu

“…Thus, we reviewed the clinical and pathophysiological characteristics of GARD and probe the complexity of the pathogenesis of GARD-related mucosal inflammation from the aspects of microscopic changes and specific molecular mediators. New drug therapies for the mucosal injuries in the reflux tract were also reviewed. …”
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Isoniazid and Rifampicin Produce Hepatic Fibrosis through an Oxidative Stress-Dependent Mechanism by Ayan Biswas, Suman Santra, Debasree Bishnu, Gopal Krishna Dhali, Abhijit Chowdhury, Amal Santra

“…Chronic hepatitis (CH) has emerged as a distinct outcome of drug-induced liver injury (DILI). Combination therapy of Isoniazid (INH) and Rifampicin (RMP) which is widely used for prolonged periods can cause acute hepatotoxicity and has been also incriminated in chronic DILI. …”
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Options of dyslipidemia treatment at non-alcoholic fatty liver disease by M. V. Mayevskaya, M. A. Morozova

“…Specification of efficacy and safety of application of the drug requires more large-scale clinical studies. …”
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Generation of Human-Induced Pluripotent Stem Cells by a Nonintegrating RNA Sendai Virus Vector in Feeder-Free or Xeno-Free Conditions by Chad C. MacArthur, Andrew Fontes, Namritha Ravinder, David Kuninger, Jasmeet Kaur, Matthew Bailey, Antje Taliana, Mohan C. Vemuri, Pauline T. Lieu

“…The generation of induced pluripotent stem cells (iPSCs) from somatic cells has enabled the possibility of providing unprecedented access to patient-specific iPSC cells for drug screening, disease modeling, and cell therapy applications. …”
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The Stability-Indicating Ultra High-Performance Liquid Chromatography with Diode Array Detector and Tandem Mass Spectrometry Method Applied for the Forced Degradation Study of Ritl... by Jelena Kovačić, Daniela Amidžić Klarić, Nikša Turk, Željko Krznarić, Emma Riordan, Ana Mornar

“…Background/Objectives: Janus kinase inhibitors open new horizons for small-molecule drugs in treating inflammatory bowel disease, with ritlecitinib demonstrating significant efficacy in clinical trials for ulcerative colitis and Crohn’s disease. …”
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Transforming precision medicine: The potential of the clinical artificial intelligent single‐cell framework by Christian Baumgartner, Dagmar Brislinger

“…Future applications of caiSC could include digital cell twins, offering in‐depth simulations of cellular behavior to support drug discovery and personalized treatments. Regulatory considerations are discussed, underscoring the need for SaMD/AIaMD certifications for clinical use. …”
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Atomized Neutrophil Membrane-coated MOF Nanoparticles for Direct Delivery of Dexamethasone for Severe Pneumonia by Yixiao Yang, Lizhen Yan, Han Zhang, Chuanguang Xiao, Kai Wang

“…Results: Drug release experiments revealed UiO66-Dex@NMP to exhibit favorable sustained-release properties. …”
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Sodium glucose co-transporter 2 inhibitors (SGLT2i) for pediatric kidney disease: the future is near by Gilda M. Portalatin, Irene Hong-McAtee, Irene Hong-McAtee, Anna M. Burgner, Edward R. Gould, Tracy E. Hunley, Tracy E. Hunley

“…The limited data for SGLT2i treatment in pediatric kidney disease are reviewed and highlight the need for randomized controlled trials of this drug class in pediatric kidney patients as has been done for pediatric diabetes. …”
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Q11, a CYP2E1 inhibitor, exerts anti-hepatocellular carcinoma effect by inhibiting M2 macrophage polarization by Cunzhen Zhang, Yan Fang, Mengxue Guo, Liming Tang, Yurong Xing, Jun Zhou, Yuanyuan Guo, Yuhan Gu, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao

“…Novel therapeutic strategies and drugs are urgently needed. Here, we found that CYP2E1 is upregulated in M2 macrophages. …”
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Quantitation of Phenolic Compounds Related to Antioxidant and Antiosteoporosis Activities in Ripe and Unripe Maesil (Prunus mume) by Chong Woon Cho, Young Sik Park, Xi-Tao Yan, Hyun June Kim, Young Ho Kim, Kyung Tae Kim, Chu Van Men, Jong Seong Kang

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Cardiovascular Risk Assessment among Adults in Primary Health Care Settings in Sulaimani Using WHO Risk Prediction Charts by Vian Najim Edeen, Zhian Salah Ramzi

“…Risk categories were concordant in 86.2% of the population; and when we applied single risk factor approach 51.5% would require drug treatment. The WHO/ISH risk chart is an affordable and simple tool to estimate cardiovascular disease risk. …”
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Uninvestigated Dyspepsia and Heartburn Overlap Syndrome at Industrial Hub of Eastern Siberia by V. V. Tsukanov, A. V. Vasiutin, J. L. Tonkikh, E. V. Kasparov, O. V. Smirnova

“…The risk factors of overlap syndrome were age >40 years (p = 0.002), obesity (p = 0.002), nonsteroidal anti-inflammatory drug and/or aspirin intake (p = 0.004) and tobacco smoking (p = 0.007). …”
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The challenges of using Escherichia coli as a host in recombinant insulin production by Muhammad Taher

“…The prevalence demands oral hypoglycaemic agents (OHAs) market size in Malaysia at USD282.22 million in 2025 with a CAGR of greater than 3% during forecast period (2025-2030). The drugs are mainly fall under the following segment: biguanides, alpha-glucosidase inhibitors, dopamine-d2 receptor agonists, sodium-glucose cotransport-2 (SGLT-2) inhibitor, dipeptidyl peptidase-4 (DPP-4) inhibitors, sulfonylureas, and meglitinides (Malaysia Oral Anti-Diabetic Drug Market Size | Mordor Intelligence, 2025). …”
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Phytochemical composition and antioxidant properties of Canarium odontophyllum (Sarawak Olive): A seasonal fruit from Borneo, East Malaysia by Gilbert Ringgit, Bo Eng Cheong, Muhammad Dawood Shah, Shafiquzzaman Siddiquee

“…Conclusion: The results indicate that C. odontophyllum shows a promising potential an alternative drug in pharmaceutical developments.…”
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Efficacy and safety of high-voltage versus standard-voltage pulsed radiofrequency ablation for patients with neuropathic pain: protocol for a systematic review and meta-analysis by Zheng Wang, Yitong Jia, Yanhui Ma, Tengteng Wang, Kunpeng Feng, Guang Feng, Tianlong Wang

“…The secondary outcomes will include numeric rating scale score, visual analogue scale score, time to take effect, rescue drug dosage, quality of life using the health questionnaire (SF-36) and the incidence of adverse events. …”
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The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability by Tiewei Li, Xiaojuan Li, Yichuan Feng, Geng Dong, Yuewu Wang, Junmei Yang

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Role of toxic and essential elements in sleep duration of patients with cardiovascular diseases by Namam Ali Azadi, Samaneh Nakhaee, Najmaldin Ezaldin Hassan, Borhan Mansouri, Masoumeh Ariyaee

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Highlights of 2023-Print Issue by Patient Safety Authority

“…Kathleen Walsh about the [risk of medication errors at home](https://patientsafetyj.com/article/88516) that can harm kids, families, or even their pets • Important notices about [wrong-site surgery](https://patientsafetyj.com/article/91634), [drug-eluting stents](https://patientsafetyj.com/article/91635), [diabetes and obesity medications](https://patientsafetyj.com/article/91636), and [healthcare disparities](https://patientsafetyj.com/article/91637) • A [glimpse into the future of healthcare](https://patientsafetyj.com/article/88053) with a modern Nostradamus, Dr. …”
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Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles by Jacob R. Shaw, Nicholas Caprio, Nhu Truong, Mehari Weldemariam, Anh Tran, Nageswara Pilli, Swarnima Pandey, Jace W. Jones, Maureen A. Kane, Ryan M. Pearson

“…Abstract Polymeric nanoparticles (NPs) are promising tools used for immunomodulation and drug delivery in various disease contexts. The interaction between NP surfaces and plasma-resident biomolecules results in the formation of a biomolecular corona, which varies patient-to-patient and as a function of disease state. …”
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