Controversies in the management of anti-TNF therapy in patients with Crohn’s disease: a Delphi consensus by Ignacio Marin-Jimenez, Guillermo Bastida, Daniel Carpio, Fernando Muñoz, Yago González-Lama, Elena Ricart, Daniel Ceballos, Daniel Ginard, Luis Menchen

“…Background Despite research, there are still controversial areas in the management of Crohn’s disease (CD).Objective To establish practical recommendations on using anti-tumour necrosis factor (TNF) drugs in patients with moderate-to-severe CD.Methods Clinical controversies in the management of CD using anti-TNF therapies were identified. …”
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Immunoinformatic strategy for developing multi-epitope subunit vaccine against Helicobacter pylori. by Md Nahian, Md Rasel Khan, Fabiha Rahman, Hossain Mohammed Reza, Imren Bayil, Tanjum Ahmed Nodee, Tabassum Basher, Mostafizur Rahaman Sany, Rabeya Najnin Munmun, S M Ariful Habib, Lincon Mazumder, Mrityunjoy Acharjee

“…The extremophilic characteristics of this bacterium make it resistant to current drug treatments, and there are no licensed vaccines available against H. pylori. …”
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Evaluation of Biophysical Interaction between Newly Synthesized Pyrazoline Pyridazine Derivative and Bovine Serum Albumin by Spectroscopic and Molecular Docking Studies by Abdulrahman A. Al-Mehizia, Ahmed H. Bakheit, Seema Zargar, Mashooq A. Bhat, Majid Mohammed Asmari, Tanveer A. Wani

“…The quenching of BSA fluorescence by using investigational drug 5d was the basic principle for the methodology. …”
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Antecedents and service contact in an observational study of 242 suicide deaths in middle-aged men in England, Scotland and Wales, 2017 by Nav Kapur, Saied Ibrahim, Jane Graney

“…We found a complex pattern of stresses and recent adversity before suicide including economic adversity (139, 57%), physical ill-health (125, 52%), self-harm (106, 44%), alcohol and/or drug misuse (119, 49%), and bereavement (82, 34%; including by suicide, 14, 6%). …”
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Sex differences in prevalence and clinical correlates of subclinical hypothyroidism in Chinese patients with first-episode untreated major depressive disorder by Junqiang Cui, Yujia Weng, XiaoE Lang, Fangfang Shangguan, Xiang-Yang Zhang

“…Methods A total of 1706 first-episode drug naïve Chinese patients with MDD were recruited. …”
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In Vitro Dissolution Profile of Dapagliflozin: Development, Method Validation, and Analysis of Commercial Tablets by Rafaela Zielinski Cavalheiro de Meira, Aline Biggi Maciel, Fabio Seigi Murakami, Paulo Renato de Oliveira, Larissa Sakis Bernardi

“…Dapagliflozin was the first of its class (inhibitors of sodium-glucose cotransporter) to be approved in Europe, USA, and Brazil. As the drug was recently approved, there is the need for research on analytical methods, including dissolution studies for the quality evaluation and assurance of tablets. …”
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DETECTION OF PANTON-VALENTINE LEUKOCIDIN (PVL) GENE AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) IN DIABETIC ULCER PATIENTS by Prisma Anjarlena, Suliati, Wisnu Istanto, Retno Sasongkowati

“…Nevertheless, misapplication of antibiotics might lead to drug resistance or MRSA. Panton-Valentine Leukocidin (PVL) is a crucial factor of S. aureus pathogenicity. …”
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Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid by Elizabeth Henao, Ezequiel Delgado, Héctor Contreras, Germán Quintana

“…Therefore, the method of gel preparation employed had a major influence on the size and pore distribution, parameters which in turn influence encapsulation and drug delivery in these systems.…”
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Antimicrobial Usage in Smallholder Poultry Production in Nigeria by Oladeji Bamidele, Tunde A. Amole, Oluwafikayo A. Oyewale, Olayinka O. Bamidele, Abdulmojeed Yakubu, Uduak E. Ogundu, Folasade O. Ajayi, Waheed A. Hassan

“…Therefore, this study investigated the use of antimicrobials among smallholder poultry farmers in Nigeria, and compared the prevalence of antimicrobial drug use against the practice of ethnoveterinary medicine (EVM). …”
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A Comprehensive Analysis for the Heterogeneous Effects on Driver Injury Severity in Single-Vehicle Passenger Car and SUV Rollover Crashes by Huiying Wen, Zuogan Tang, Yuchen Zeng, Kexiong Zhang

“…Model estimation results show that six variables (male drivers, drivers’ age, airbag deployment, failure to drive in single lane, speed limit, and rural area) were found to produce normally distributed parameters in passenger car model, while nine parameters (male drivers, safety belt use, airbag deployment, drug or alcohol use, failure to drive in single lane, improper evasive action, vehicle model year, friday, and rural area) in SUV model were found to be normally distributed. …”
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The relative risk of fatal poisoning by methadone or buprenorphine within the wider population of England and Wales by Dave Marteau, Rebecca McDonald, Kamlesh Patel

“…Objective To examine the population-wide overdose risk emerging from the prescription of methadone and buprenorphine for opioid substitution treatment in England and Wales.Design Retrospective administrative data study.Setting National databases for England and Wales.Participants/cases Drug-related mortality data were drawn from the Office for National Statistics, and prescription data for methadone and buprenorphine were obtained from the National Health Service for the years 2007–2012. …”
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Site-specific N-glycosylation characterization and allergenicity analysis of globulin-1 S allele from wheat by Linglin Fu, Rongrong Wang, Jinru Zhou, Chong Wang, Yanbo Wang

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Comparison of Protein Acetyltransferase Action of CRTAase with the Prototypes of HAT by Prija Ponnan, Ajit Kumar, Prabhjot Singh, Prachi Gupta, Rini Joshi, Marco Gaspari, Luciano Saso, Ashok K. Prasad, Ramesh C. Rastogi, Virinder S. Parmar, Hanumantharao G. Raj

“…Our laboratory is credited for the discovery of enzymatic acetylation of protein, a phenomenon unknown till we identified an enzyme termed acetoxy drug: protein transacetylase (TAase), catalyzing the transfer of acetyl group from polyphenolic acetates to receptor proteins (RP). …”
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Preparation and Optimization of 10-Hydroxycamptothecin Nanocolloidal Particles Using Antisolvent Method Combined with High Pressure Homogenization by Bolin Lian, Yong Li, Xiuhua Zhao, Yuangang Zu, Ying Wang, Yin Zhang, Yuanyuan Li

“…The aim of this study was to prepare 10-hydroxycamptothecin nanocolloidal particles (HCPTNPs) to increase the solubility of drugs, reduce the toxicity, improve the stability of the drug, and so forth. …”
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Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM2.5, Budesonide, and Cotreated Exposures by Jarline Encarnación-Medina, Rosa I. Rodríguez-Cotto, Joseph Bloom-Oquendo, Mario G. Ortiz-Martínez, Jorge Duconge, Braulio Jiménez-Vélez

“…., particulate matter 2.5 (PM2.5)) and drug metabolites outside the cells. IL-6 secretion is related with the activation of the ABCC transporters. …”
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Temperate phage-antibiotic synergy is widespread—extending to Pseudomonas—but varies by phage, host strain, and antibiotic pairing by Rabia Fatima, Alexander P. Hynes

“…Supported by this interaction, here we explore the potential use of combined temperate phage and antibiotic against the multi-drug-resistant pathogen, Pseudomonas aeruginosa. …”
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Peroxiredoxin 5 Acts as a Negative Regulator of the Sodium-Chloride Cotransporter Involved in Alleviating Angiotensin II-Induced Hypertension by Hoon-In Choi, In Ae Jung, Soo Wan Kim

“…In conclusion, Prdx5 negatively regulates the WNK4-SPAK/OSR1-NCC signaling axis, indicating its potential as a candidate for antihypertensive drug development through NCC regulation.…”
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Platinum(II) Complexes with Tetradentate Schiff Bases as Ligands: Synthesis, Characterization and Detection of DNA Interaction by Differential Pulse Voltammetry by Lijun Li, Chao Tian, Cheng Wang, Guangyuan Wang, Lianzeng Wang, Jianlong Du

“…The sterical hindrance of antitumor drug candidates potentially makes them less susceptible to deactivation by sulphur containing proteins and helping to overcome resistance mechanisms. …”
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A Scoping Review of Eosinophilic Pneumonia and Antidepressants: An Association Not to Be Overlooked by Jaron Steiner, Leonie Steuernagel, Fotios Drakopanagiotakis, Konstantinos Bonelis, Paschalis Steiropoulos

“…Outcomes were favorable in most cases, with complete remission achieved after discontinuation of the causative drug and, in severe cases, a short course of corticosteroids. …”
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A comparison between the effect of Oral Melatonin and Hydroxyzine for preventing preoperative Anxiety in Pediatric Patients undergoing Adenotonsillectomy: A randomized, double-blin... by Sarah Omar Mousa, Amany Khairy Abo El Hussien, Gehad Hanafy Abdalgaliel

“…Background: Induction of anesthesia is one of the most anxiety-provoking factors of preoperative anxiety in children. Melatonin is a safe drug used in the management of anxiety. Hydroxyzine is a first-generation antihistaminic that crosses the blood-brain barrier, causing sedation. …”
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