Protein structure and interactions elucidated with in-cell NMR for different cell cycle phases and in 3D human tissue models by Jan Rynes, Eva Istvankova, Michaela Dzurov Krafcikova, Enrico Luchinat, Letizia Barbieri, Lucia Banci, Kristyna Kamarytova, Tomas Loja, Bohumil Fafilek, Gustavo Rico-Llanos, Pavel Krejci, Libor Macurek, Silvie Foldynova-Trantirkova, Lukas Trantirek

“…The described approach opens avenues for investigating how protein structure or drug recognition responds to cell-cell communication or changes in intracellular space composition during transitions among cell cycle phases.…”
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Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment by Alberto N. Peón, Yadira Ledesma-Soto, Jonadab E. Olguín, Marcel Bautista-Donis, Edda Sciutto, Luis I. Terrazas

“…A negative correlation between the geographical distribution of autoimmune diseases and helminth infections has been largely associated in the last few years with a possible role for such type of parasites in the regulation of inflammatory diseases, suggesting new pathways for drug development. However, few helminth-derived immunomodulators have been tested in experimental autoimmune encephalomyelitis (EAE), an animal model of the human disease multiple sclerosis (MS). …”
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Stent Fracture after Everolimus-Eluting Stent Implantation by Ali S. Almasood, Xavier Freixa, Sohail Q. Khan, Peter H. Seidelin, Vladimír Džavík

“…Compared with bare-metal stents, drug-eluting stents (DES) have greatly reduced the risk of in-stent restenosis (ISR) by inhibiting neointimal growth. …”
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Does Faeces Excreted by Moxidectin-Treated Sheep Impact Coprophagous Insects and the Activity of Soil Microbiota in Subtropical Pastures? by Susana Gilaverte Hentz, Felix Guillermo Reyes Reyes, Glaciela Kaschuk, Leandro Bittencourt de Oliveira, Maria Angela Machado Fernandes, Alda Lúcia Gomes Monteiro

“…However, adding MOX to faeces from drug-free sheep had a negative impact on soil microbial activity and biomass.…”
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Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells by Anine Crous, Elvin Chizenga, Natasha Hodgkinson, Heidi Abrahamse

“…Scientific studies have shown that subset of cells within a tumour, known as cancer stem cells (CSCs), are responsible for tumourigenesis, metastasis, drug resistance, and recurrences. CSCs have characteristic features of enhanced self-renewal, proliferation, and limited but multidirectional differentiation capacity. …”
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Detection of Complement C1q B Chain Overexpression and Its Latent Molecular Mechanisms in Cervical Cancer Tissues Using Multiple Methods by Si-Tong Lin, Zi-Qian Liang, Xiao-Yu Chen, Xin-Qing Ye, Yu-Yan Pang, Jia-Yuan Luo, Jun-Hong Chen, Yi-Wu Dang, Gang Chen

“…A relationship was predicted between C1QB expression and drug sensitivity to cisplatin, paclitaxel, and docetaxel. …”
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The Global Challenge of <i>Campylobacter</i>: Antimicrobial Resistance and Emerging Intervention Strategies by Zubeiru Bukari, Toyin Emmanuel, Jude Woodward, Richard Ferguson, Martha Ezughara, Nikhil Darga, Bruno Silvester Lopes

“…Resistance to fluoroquinolones, macrolides, and tetracyclines complicates treatment and increases the risk of severe infections. Drug-resistant <i>Campylobacter</i> is transmitted to humans via contaminated food, water, and direct contact with animals, highlighting its zoonotic potential. …”
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Deep brain stimulation of the anterior cingulate cortex reduces opioid addiction in preclinical studies by Mahdi Fatemizadeh, Esmail Riahi, Gholamreza Hassanzadeh, Anahita Torkaman-Boutorabi, Forough Radfar, Maryam Farahmandfar

“…Abstract Substance Use Disorder (SUD) is a medical condition where an individual compulsively misuses drugs or alcohol despite knowing the negative consequences. …”
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Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases by Nausicaa Clemente, Davide Raineri, Giuseppe Cappellano, Elena Boggio, Francesco Favero, Maria Felicia Soluri, Chiara Dianzani, Cristoforo Comi, Umberto Dianzani, Annalisa Chiocchetti

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Early and Midterm Outcomes of Percutaneous Arteriovenous Fistula Creation by Ahmed Kamel Abdel Aal, Juri Bassuner, Husameddin El Khudari, Reema F. Alrasheed, Shahroz Aziz, Mohamed Shahin, Ammar Almehmi, Bridget Kowalczyk

“…Currently, there are two Food and Drug Administration (FDA) approved systems, namely WavelinQ and Ellipsys. …”
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Comparative analysis of Oreochromis niloticus responses to Chlorella vulgaris and Lactobacillus-fermented Azolla economic feed supplements in biofloc and green systems: An in silic... by Ahmed M. Aboseif, Nasser S. Flefil, Mostafa K.S. Taha, Asmaa Negm El-Dein, Mingchun Ren, Hualiang Liang, Abd-Ellatif M. Hussian

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Research Progress of Fuzheng Jiedu Huayu Method in Reducing Toxicity and Enhancing Efficacy of Immunotherapy by Yufan CHEN, Sicong LI, Yiyuan CUI, Li FENG

“…However, primary or secondary drug resistance in tumors severely limits the survival benefits for patients. …”
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Identification of Two Flavonoids as New and Safe Inhibitors of Kynurenine Aminotransferase II via Computational and In Vitro Study by Redouane Rebai, Luc Jasmin, Abdennacer Boudah

“…<b>Methods:</b> Virtual screening, MM/GBSA, and molecular dynamics simulations were conducted to identify the top drug candidates, followed by kinetic measurements and in vitro cytotoxicity evaluation. …”
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High-Yield Generation of Glucose-Responsive Pseudoislets From Murine Insulinoma Cells for Studies and Longitudinal Monitoring of Graft Survival by Grisell C. Gonzalez, Chris M. Li, Ilaria Pasolini, Sophia I. Pete, Connor Verheyen, Sofia M. Vignolo, Teresa De Toni, Aaron A. Stock, Alice A. Tomei

“…Overall, this platform provides an accessible protocol for generating high yields of 3D pseudoislets and non-invasive longitudinal monitoring of graft survival in different models offer advantages over primary islets for optimization and mechanistic studies of β cell biology, drug discovery, T1D pathogenesis and prevention, and β cell transplantation.…”
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Flavor release from traditional dry-cured pork during oral processing by Xing Tian, Zongjun Li, Ke Li, Zhongqin Wu, Rui Ren, Haodong Wang, Chaoqun Zeng

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K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma. by Joanne Van Der Velden, Grace Sum, Donna Barker, Emmanuel Koumoundouros, Garry Barcham, Heike Wulff, Neil Castle, Peter Bradding, Kenneth Snibson

“…A separate sheep group received no allergen challenges or drug treatment. In the vehicle-control group, twelve weeks of allergen challenges resulted in a 60±19% increase in resting airway resistance, and this was completely attenuated by treatment with Senicapoc (0.25±12%; n = 10, P = 0.0147). …”
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Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry for Identification of In Vitro and In Vivo Metabolites of Bornyl Gallate in Rats by Wei Lan, Liujiao Bian, Xinfeng Zhao, Pu Jia, Xue Meng, Yizhen Wu, Shixiang Wang, Sha Liao, Jie Yu, Xiaohui Zheng

“…Bornyl gallate (BG) is a potential drug candidate synthesized by the reaction of two natural products, gallic acid and borneol. …”
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MCL Plays an Anti-Inflammatory Role in Mycobacterium tuberculosis-Induced Immune Response by Inhibiting NF-κB and NLRP3 Inflammasome Activation by Qingwen Zhang, Xinru Jiang, Weigang He, Kailin Wei, Jinxia Sun, Xiangyang Qin, Yuejuan Zheng, Xin Jiang

“…Therefore, MCL may represent as a potential drug candidate in the adjuvant treatment of TB by regulating host immune response.…”
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Quality by Design-Based Methodology for Development of Titanate Nanotubes Specified for Pharmaceutical Applications Based on Risk Assessment and Artificial Neural Network Modeling by Ranim Saker, Géza Regdon, Krisztina Ludasi, Tamás Sovány

“…Methods: In the present work, a risk assessment-based procedure was developed and completed using ANN-based modeling to enable the design and fabrication of titanate nanotube-based drug delivery systems with desired properties, based on the critical analysis and evaluation of data collected from published articles regarding titanate nanotube preparation using the hydrothermal treatment method. …”
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Penetration of linezolid and tedizolid in cerebrospinal fluid of mouse and impact of blood–brain barrier disruption by Marin Lahouati, Mélanie Oudart, Philippe Alzieu, Candice Chapouly, Antoine Petitcollin, Fabien Xuereb

“…Pharmacokinetic parameters were calculated using a non‐compartmental approach based on the free drug concentration. The penetration ratio from the plasma into the CSF was calculated by the AUC0‐8h (Area Under Curve) ratio (AUC0‐8hCSF/AUC0‐8hplasma). …”
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