Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE Bacteria Staphylococcus aureus and Pseudomonas aeruginosa by Bridget Kamurai, Molly Mombeshora, Stanley Mukanganyama

“…However, de novo synthesis of antibiotics is expensive and time-consuming since the development of a new drug has to go through several clinical trials. Repurposing of old drugs for the treatment of antimicrobial resistant pathogens has been explored as an alternative strategy in the field of antimicrobial drug discovery. …”
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Alcohol and Drug Use During Adolescence: Problems and Solutions that Youth Professionals Need to Know by Kate Fogarty, Mark A. Brennan

“…In addition, the public needs to know that community and youth programs are useful deterrents to drug and alcohol abuse. Community and youth activities can provide opportunities for children and youth to engage in constructive activities and encourage norms that discourage drug/alcohol experimentation. …”
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Deep Drug–Target Binding Affinity Prediction Base on Multiple Feature Extraction and Fusion by Zepeng Li, Yuni Zeng, Mingfeng Jiang, Bo Wei

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Severe Cutaneous Adverse Drug Reactions at a Tertiary Care Center in Saudi Arabia by Mohammed I. AlJasser

“…Severe cutaneous adverse drug reactions (SCARs), although rare, are known to be associated with significant morbidity and mortality. …”
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Multiple programmed cell death patterns predict the prognosis and drug sensitivity in gastric cancer by Qiying Song, Shihe Liu, Di Wu, Aizhen Cai

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Recommendations for the treatment of multiple sclerosis with disease-modifying drugs during the COVID-19 pandemic by R. Kizlaitienė, N. Giedraitienė, I. Sereikė, J. Liutkienė, L. Leščinskienė, G. Kaubrys

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Identification of new ClpC1-NTD binders for Mycobacterium tuberculosis drug development by Katharina Weinhäupl, Louis Meuret, Sandy Desrat, Fanny Roussy, Nelly Morellet, Sandra Beaupierre, Catherine Guillou, Carine van Heijenoort, Olga Abian, Sonia Vega, Ian Wolf, Tatos Akopian, Olga Krandor, Eric Rubin, Adrian Velazquez-Campoy, Diego Gauto, Hugo Fraga

“…Abstract MtbClpC1 is a promising drug target against tuberculosis. Recent studies have shown that several natural product antibiotics targeting the unfoldase N-terminal domain can impair MtbClpC1 function resulting in cell death. …”
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Factors Associated with Spontaneous Clearance of Hepatitis C Virus among Illicit Drug Users by Jason Grebely, Jesse D Raffa, Calvin Lai, Mel Krajden, Brian Conway, Mark W Tyndall

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Assessment of Patients Adherence to Oral Regimen of Drug-Resistant   Tuberculosis among Iraqi Patients by Noor Alaa Jasim, Manal Khalid Abdulridha, Ahmed Asmar Mankhy, Ahmed Hadi Tarish

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Human Brain Organoid: A Versatile Tool for Modeling Neurodegeneration Diseases and for Drug Screening by Cuili Ma, Hwanwook Seong, Xiaowei Li, Xiao Yu, Shunliang Xu, Yujing Li

“…Most of these human organoids have been employed for in vitro biomedical study and drug screening. However, the efficiency and quality of the organoids in recapitulating the development of human organs have been hindered by engineering and conceptual challenges. …”
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The role of lipids and lipids lowering drugs in human papillomavirus (HPV) and HPV-associated cancers by Ehsan Shabani, Aida Hasanzadi, Omer Qutaiba B. Allela, Radhwan Abdul Kareem, Riyad E. Abed, Ali M. Ali Al-Nuaimi, Zainab H. Athab, Shiva Khodarahmi

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Proteomic Characterization of Liver Cancer Cells Treated with Clinical Targeted Drugs for Hepatocellular Carcinoma by Hezhou Long, Jiafu Zhou, Changxia Zhou, Shuyu Xie, Jingling Wang, Minjia Tan, Junyu Xu

Subjects: “…hepatocellular carcinoma-targeted drugs…”
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A Machine Learning Algorithm to Predict Medical Device Recall by the Food and Drug Administration by Victor Barbosa Slivinskis, Isabela Agi Maluli, Joshua Seth Broder

“…While the United States Food and Drug Administration (FDA) employs an adverse event reporting program (MedWatch) and database (MAUDE), other data sources and methods might have utility to identify potentially dangerous medical devices. …”
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A review of drug knowledge discovery using BioNLP and tensor or matrix decomposition by Mina Gachloo, Yuxing Wang, Jingbo Xia

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Drug-induced autoimmune-like hepatitis: A disproportionality analysis based on the FAERS database. by Wangyu Ye, Yuan Ding, Meng Li, Zhihua Tian, Shaoli Wang, Zhen Liu

“…While the association between certain drugs and DI-ALH has been documented, a comprehensive analysis of drug-related signals in a large, real-world pharmacovigilance database is lacking. …”
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The differentiation state of small intestinal organoid models influences prediction of drug-induced toxicity by Jessica A. Klein, Julia D. Heidmann, Tomomi Kiyota, Aaron Fullerton, Kimberly A. Homan, Julia Y. Co

“…Drug-induced intestinal toxicity (GIT) is a frequent dose-limiting adverse event that can impact patient compliance and treatment outcomes. …”
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Drug-Induced Hematological Cytopenia in Kidney Transplantation and the Challenges It Poses for Kidney Transplant Physicians by Muhammad Abdul Mabood Khalil, Muhammad Ashhad Ullah Khalil, Taqi F. Taufeeq Khan, Jackson Tan

“…Drug-induced hematological cytopenia is common in kidney transplantation. …”
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3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment by Aida Rodriguez-Garcia, Jacqueline Oliva-Ramirez, Claudia Bautista-Flores, Samira Hosseini

“…Organ-on-chip devices, including in vitro modelling of 3D organoids, 3D microfabrication, and 3D bioprinted platforms, play an essential role in drug discovery, testing, and assessment. In this article, a thorough review is provided of the latest advancements in the area of organ-on-chip devices targeting liver, kidney, lung, gut, heart, skin, and brain mimicry devices for drug discovery, development, and/or assessment. …”
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Corrigendum: Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery by Fanda Meng, Xinyu Qiao, Chenglong Xin, Xiaoli Ju, Meilin He

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<i>H. pylori</i> eradication therapy for patients receiving nonsteroid antiinflammatory drugs by V. T. Ivashkin, T. L. Lapina

“…To demonstrate value of H. pylori eradication therapy in patients for prophylaxis and treatment of nonsteroid antiinflammatory drugs (NSAID)- induced gastropathies.Key points. …”
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