RF-PSSM: A Combination of Rotation Forest Algorithm and Position-Specific Scoring Matrix for Improved Prediction of Protein-Protein Interactions Between Hepatitis C Virus and Human by Xin Liu, Yaping Lu, Liang Wang, Wei Geng, Xinyi Shi, Xiao Zhang

“…The identification of hepatitis C virus (HCV) virus-human protein interactions will not only help us understand the molecular mechanisms of related diseases but also be conductive to discovering new drug targets. An increasing number of clinically and experimentally validated interactions between HCV and human proteins have been documented in public databases, facilitating studies based on computational methods. …”
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Solvent‐Based and Matrix‐Matched Calibration Methods on Analysis of Ceftiofur Residues in Milk and Pharmaceutical Samples Using a Novel HPLC Method by Saniye Özcan, Serkan Levent, Nafiz Öncü Can

“…Ceftiofur (CEF) is a leading drug used in dairy industry for pulmonary infections. …”
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The inhibitory effect of anti-allergic agent suplatast tosilate (IPD–1151T) on methacholine- and allergen-induced bronchoconstriction in sensitized mice by Kazuhito Asano, Tetsuya Mizutani, Toshikazu Shimane, Masataka Hisano, Tadashi Hisamitsu, Harumi Suzaki

“…Bronchoconstriction was measured 24 h after the final drug administration. IPD-1151T inhibited both antigen- and MCh-mediated bronchoconstriction in actively sensitized mice. …”
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Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat by Caroline E. Rasmussen, Jette Nowak, Julie M. Larsen, Emma Moore, David Bell, Kai Chiu Liu, Nanna Skall Sorensen, Wendela A. Kappers, Thomas Krogh-Meibom, Hanne Offenberg

“…Conducting long-term toxicity studies in animals using human proteins can be complicated by anti-drug antibody (ADA) development. To evaluate long-term safety of N8-GP, 26- and 52-week toxicity studies were conducted in immune-deficient rats dosed intravenously every fourth day with 0, 50, 150, 500, or 1200 IU/kg N8-GP. …”
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Efficiency and Safety of Prolonged Levosimendan Infusion in Patients with Acute Heart Failure by Georgios Aidonidis, Ioannis Kanonidis, Vasileios Koutsimanis, Till Neumann, Raimund Erbel, Georgios Sakadamis

“…Levosimendan is an inotropic drug with unique pharmacological advantages in patients with acute heart failure. …”
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Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xeno... by Sonali P. Barwe, Anilkumar Gopalakrisnapillai, Nitin Mahajan, Todd E. Druley, E. Anders Kolb, Erin L. Crowgey

“…The presence of gene fusions representing the major driver mutations at similar allelic frequencies in PDX samples compared to primary samples and over multiple passages confirms the utility of PDX models for preclinical drug testing. Characterization and tracking of these novel cryptic fusions and exonal variants in PDX models is critical in assessing response to potential new therapies.…”
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Asiaticoside Suppresses Gastric Cancer Progression and Induces Endoplasmic Reticulum Stress through the miR-635/HMGA1 Axis by Chao Zhang, Xiaolin Ji, Zhenguang Chen, Zhichao Yao

“…AC suppressed gastric cancer progression and induced endoplasmic reticulum stress via the miR-635/HMGA1 axis, providing a valuable drug against gastric cancer.…”
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Hydrogels for the Application of Articular Cartilage Tissue Engineering: A Review of Hydrogels by Er-Yuan Chuang, Chih-Wei Chiang, Pei-Chun Wong, Chih-Hwa Chen

“…These gels are designed with consideration of their polymeric classification, mechanical strength, manner of biodegradation, limitations of the payload, cellular interaction, amount of cells in the 3D hydrogel, sustained release for the model drug, and the different approaches for incorporation into adjacent organs. …”
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Considerations of HLA, Renal Failure, Valproic Acid Use, and Current Treatment Guidelines in Clozapine-Induced Agranulocytosis by Melissa Sussman, Michael Epifania, Derrick Eng, Yun Jae Cho, Richard Steward

“…Clozapine, though beneficial in reducing the need for hospitalization, rehabilitation, and health care costs, is known as a drug of last resort due to its potential adverse event of clozapine-induced agranulocytosis, which holds a case fatality rate between 4.2 and 16%. …”
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First line antiepileptics and their hidden risks - a unique case report on diffuse calvarial thickening and twisted tongue linked to the use of phenytoin and sodium valproate by Sankavi Kaarthic, Selvakumar CJ

“…Patient had gum hypertrophy and serum phenytoin level was elevated and CT brain showed diffuse calvarial thickening, the offending drug was stopped. CASE 2: 45 year old female a case of idiopathic generalised epilepsy was started on sodium valproate for seizure control and she developed lingual dystonia during follow up. …”
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Docking to Explicate Interface between Plant-Originated Inhibitors and E6 Oncogenic Protein of Highly Threatening Human Papillomavirus 18 by Satish Kumar, Lingaraja Jena, Maheswata Sahoo, Mrunmayi Kakde, Sangeeta Daf, Ashok K. Varma

“…There is need to explore anti-cancerous drugs against this life-threatening infection. Traditionally, different natural compounds such as withaferin A, artemisinin, ursolic acid, ferulic acid, (-)-epigallocatechin-3-gallate, berberin, resveratrol, jaceosidin, curcumin, gingerol, indol-3-carbinol, and silymarin have been used as hopeful source of cancer treatment. …”
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Optogenetic regulation of endogenous gene transcription in mammals by E. S. Omelina, A. V. Pindyurin

“…An ideal system should ensure tunable and reversible spatio-temporal control over transcriptional activity of a gene of interest. Although there are drug-inducible systems for transcriptional regulation of endogenous genes, optogenetic approaches seem to be the most promising for the gene therapy applications, as they are noninvasive and do not exhibit toxicity in comparison with druginducible systems. …”
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RIOK1/2 Negatively Regulates the Antiviral Response by Targeting TBK1 in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>) by Kejun Liu, Jiayang Huang, Yuting Gui, Qian Li, Lei Zhang, Shuting Xiong

“…Comprehending the fish’s immune mechanisms, particularly the regulation of the interferon (IFN) response, is of paramount importance for future drug development and disease-resistant molecular breeding. …”
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Cannabinoid Hyperemesis Syndrome: A Case Report of Cyclic Severe Hyperemesis and Abdominal Pain with Long-Term Cannabis Use by Julia Hermes-Laufer, Lola Del Puppo, Ihsan Inan, François-Xavier Troillet, Omar Kherad

“…Recognition of this syndrome is important in order to avoid unnecessary clinical testing and to help the patients break the cycle of drug use.…”
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The Impact of T Cell Vaccination in Alleviating and Regulating Systemic Lupus Erythematosus Manifestation by Liuye Huang, Yuan Yang, Yu Kuang, Dapeng Wei, Wanyi Li, Qin Yin, Juan Pang, Zhongwei Zhang

“…In addition, the side effects and drug usage were observed during the patients’ treatment and follow-up. …”
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Improving access to pulmonary rehabilitation for patients with COPD treated for substance misuse in the London Borough of Islington by Duncan Stewart, Jane Simpson, Divya Narasimhan

“…Substance misusers with COPD have more severe symptoms and poorer health outcomes than other COPD patients, and experience inequalities in accessing PR services.This project aimed to work with a local substance misuse service to increase the referrals of patients with COPD with a history of drug and/or alcohol problems to a PR programme in the London Borough of Islington. …”
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Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents by Domenico Iacopetta, Alessia Catalano, Jessica Ceramella, Annaluisa Mariconda, Assunta D’Amato, Paola Checconi, Stefano Aquaro, Pasquale Longo, Maria Stefania Sinicropi

“…Antimicrobial resistance (AMR) is one of the major public health challenges of the twenty-first century because it represents a threat to the prevention and treatment of a growing number of bacterial, parasitic, viral, and fungal infections that are no longer treatable with the available drugs. Thus, in this review, we present a brief outline of the biological activities of CSBs as well as their complexes with metals, with a particular focus on the recent literature regarding the antimicrobial effect of these captivating derivatives.…”
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Influence of Medication on Flare Up and Infection After Elective Orthopedic Surgery in Rheumatoid Arthritis Patient – A Narrative Review by Yaldi Rosadi, Yustin Marinta, Muthiah Nur Afifah

“…The objective of our review is to assess the influence of drugs on both incidences. Literature Review: There were 13 studies included in this review. …”
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Andrographolide suppresses cervical cancer progression by targeting angiogenesis and inducing apoptosis in a CAM-PDX model by Wanwan Zou, Jun Lou, Yun Yi, Yiming Cui, Xiaoyan Chu

“…In summary, this study successfully established a reproducible CAM-PDX model for drug evaluation and highlighted the potential of AND as a promising therapeutic candidate for cervical cancer, warranting further clinical investigation. …”
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Analysis of early results of edoxaban and warfarin in the treatment of deep vein thrombosis by Abdullah Guner, Volkan Burak Taban, Muhammet Talha Ceran, Yuksel Dereli

“…Material and Methods: The results of a total of 100 patients who started drug treatment for DVT between September 2018 and March 2020 were retrospectively analysed. …”
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