Effect of marination with broccoli (Brassica oleracea var. italica) juice and soy sauce on physicochemical, structural and oxidative properties of beef steak by Ashkan Jebelli Javan, Fatemeh Mirhaj, Nasim Khorshidian, Mehrdad Mohammadi

Get full text

Nano-technological advancements in multimodal diagnosis and treatment by Dinesh Bhatia, Tania Acharjee, Shruti Shukla, Monika Bhatia

“…Beyond imaging, NPs offer a “one-two punch” in the treatment of complicated disorders by enabling photothermal (PTT), photodynamic (PDT), and multimodal therapies (MMT), as well as nano drug delivery systems (NDDS). This nanotechnology-based technique personalizes medicines for diseases such as tuberculosis (TB) and cardiovascular disease (CVD), focusing on damaged tissues to improve therapeutic response. …”
Get full text

Clinical, Socioeconomic, and Psychosocial Factors Associated with Blood Pressure Control and Adherence: Results from a Multidisciplinary Cardiovascular National Program Providing U... by Daniela Sandoval, Carolina Nazzal, Tomás Romero

“…Limited information exists on blood pressure (BP) control factors and adherence to antihypertensive drug therapy (Rx) in developing countries. Methods. …”
Get full text

Lack of Effect of H2-Receptor Antagonists and Antacids on the Gastric and Duodenal Gastrin-, Somatostatin- and Serotonin-Producing Cells in Patients with Acid Peptic Disorders by WR Yacoub, ABR Thomson, P Hooper, LD Jewell

“…Biopsies obtained on different occasions over time indicated that in patients on enprostil (a synthetic E2 prostaglandin), there was a trend towards increasing cell counts, suggesting that the serum gastrin-lowering effect of this drug may result from inhibition of gastrin release. …”
Get full text

Metabolic stability and its role in the discovery of new chemical entities by Słoczyńska Karolina, Gunia-Krzyżak Agnieszka, Koczurkiewicz Paulina, Wójcik-Pszczoła Katarzyna, Żelaszczyk Dorota, Popiół Justyna, Pękala Elżbieta

“…Determination of metabolic profiles of new chemical entities is a key step in the process of drug discovery, since it influences pharmacokinetic characteristics of therapeutic compounds. …”
Get full text

Trends in Stroke Prevention between 2014 and 2018 in Hospitalized Atrial Fibrillation Patients by B. Bielecka, I. Gorczyca, O. Jelonek, B. Wożakowska-Kapłon

“…In the study group of 4027 patients with AF, to prevent thromboembolic complications, OACs were used in 3680 patients (91.4%), an antiplatelet drug(s) was used in 124 patients (3.1%), and 223 patients (5.5%) did not undergo any thromboembolic event prevention. …”
Get full text

Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer Therapy by Wu Y, Liu Y, Wu H, Tong M, Du L, Ren S, Che Y

“…Specifically, UTMD improves drug transfer efficiency and destroys tumor neovascularization while reducing toxic side effects on the body during tumor treatment. …”
Get full text

Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia by Yeswanth Ranganathan, Saayaa Nazar, Ravi Shankar Krishnan, Yuvaraj Dinakarkumar, Vijayalakshmi Varadarajan, Lenita Sebastian, Brindha Rethinam

“…The study highlights the impact of personalized medicine, drug discovery, and repurposing through bioinformatics. …”
Get full text

Metformin Facilitates Osteoblastic Differentiation and M2 Macrophage Polarization by PI3K/AKT/mTOR Pathway in Human Umbilical Cord Mesenchymal Stem Cells by Min Shen, Huihui Yu, Yunfeng Jin, Jiahang Mo, Jingni Sui, Xiaohan Qian, Tong Chen

“…Metformin, a glucose-lowering drug, exerts powerful impact on metabolic signaling. …”
Get full text

Commercial classification of conventional polypropylene and polyester meshes for groin hernia repair: A descriptive study by Can Deniz Deveci, Stina Öberg, Jacob Rosenberg

“…MATERIALS AND METHODS: We included Food and Drug Administration (FDA)-approved conventional non-coated flat meshes made of polypropylene or polyester. …”
Get full text

Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties by Md. Sharif Hasan, Narhari Das, Zobaer Al Mahmud, S. M. Abdur Rahman

“…In tail-flick test, at both doses of 25 and 50 mg/kg, the copper, cobalt, silver, and zinc complexes showed higher antinociceptive activity after 90 minutes than the parent drug naproxen. In elevated plus maze (EPM) model the cobalt and zinc complexes of naproxen showed significant anxiolytic effects in dose dependent manner, while the copper, cobalt, and zinc complexes showed significant CNS depressant and hypoglycemic activity. …”
Get full text

Studies on Dissipations and Residues of Indoxacarb under Different Field and Environmental Conditions by Ying-Hong Li, Xiang-Yun Wang, Wei Hua, Hu Zhang

Get full text

A Novel Nitrite Reductase from <i>Acinetobacter haemolyticus</i> for Efficient Degradation of Nitrite by Xiao-Yan Yin, Emmanuel Mintah Bonku, Jian-Feng Yuan, Zhong-Hua Yang

Get full text

Quality by Design (QbD) Assisted Fabrication of Fast Dissolving Buccal Film for Clonidine Hydrochloride: Exploring the Quality Attributes by Pankaj V. Dangre, Ram D. Phad, Sanjay J. Surana, Shailesh S. Chalikwar

“…The optimized formulation (F6) showed fast drug dissolution (>90%) within 8 min, and solid state characterization by DSC, XRD revealed excellent film characteristics. …”
Get full text

Follow-up Care among Medicaid Patients with Schizophrenia treated with Antipsychotics in the Inpatient Setting by Amanda M. Farr, David M. Smith, Jacqueline A. Pesa, Zhun Cao

“…**Methods:** Adults administered oral or long-acting injectable antipsychotic medication during a hospitalization for schizophrenia were identified in the linked MarketScan® Hospital Drug and Multi-State Medicaid Databases. Psychiatric-related follow-up outpatient visits within 30 days of discharge were identified from Medicaid claims based on Healthcare Effectiveness Data and Information Set specifications. …”
Get full text

Cationic Polymers Inhibit the Conductance of Lysenin Channels by Daniel Fologea, Eric Krueger, Steve Rossland, Sheenah Bryant, Wylie Foss, Tyler Clark

“…These findings reveal key structural characteristics which may provide insight into lysenin’s functionality while opening innovative approaches for the development of applications such as transient cell permeabilization and advanced drug delivery systems.…”
Get full text

Chemical profiling, in-vitro and in silico α-glucosidase inhibition, antioxidant and antibacterial activities of Hypotrachyna cirrhata (Fr.) Hale ex Sipman by Deepa Karki, Anuraj Phunyal, Tika Ram Lamichhane, Asmita Rayamajhi, Asmita Sapkota, Hari Nyaupane, Suraj Shrestha, Achyut Adhikari

“…Natural products are essential in drug development, with increasing interest in lichen-derived compounds for their therapeutic potential. …”
Get full text

Multiple machine learning-based integrations of multi-omics data to identify molecular subtypes and construct a prognostic model for HNSCC by Xiaoqin Luo, Chao Li, Gang Qin

“…Abstract Background Immunotherapy has introduced new breakthroughs in improving the survival of head and neck squamous cell carcinoma (HNSCC) patients, yet drug resistance remains a critical challenge. Developing personalized treatment strategies based on the molecular heterogeneity of HNSCC is essential to enhance therapeutic efficacy and prognosis. …”
Get full text

The Effect of the Thai Herbal Suksaiyad Formula on Platelet Aggregation in Healthy Volunteers: A Quasi-experimental, Single-dose Study by Titchaphorn Palo, Nalinthika Nathananwanit, Pravit Akarasereenont, Suksalin Booranasubkajorn

“…Conclusion: Caution is advised when using SSF in patients with blood disorders. Potential herb-drug interactions between SSF and drugs that impact platelet aggregation, such as aspirin, should be closely monitored. …”
Get full text

Diethylene glycol monoethyl ether-mediated nanostructured lipid carriers enhance trans-ferulic acid delivery by Caco-2 cells superior to solid lipid nanoparticles by Zhang Hongyu, Guo Jingwen, Wang Zhi, Wang Na, Feng Nianping, Zhang Yongtai

“…This work confirms that NLCs have better properties than SLNs in terms of increasing drug transport by Caco-2 cells. This helps to comprehend the approach by which NLC-mediated oral bioavailability of trans-ferulic acid is better than that mediated by SLNs, as shown in our previous report.…”
Get full text