Automated Zebrafish Spine Scoring System Based on Instance Segmentation by Wen-Hsin Chen, Tien-Ying Kuo, Yu-Jen Wei, Cheng-Jung Ho, Ming-der Lin, Huan Chen, Wen-Ying Lin

“…In studying new medicines for osteoporosis, researchers use zebrafish as animal subjects to test drugs and observe the growth situation of their vertebrae in the spine to confirm the efficacy of new medicines. …”
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Awareness of Contraindications Among Cancer Patients in Riyadh, Saudi Arabia: A Cross-Sectional Study by Mansour Almuqbil, Rama Abdulhamid Mohammed Alobaid, Amouna Abdulrahim Mazal Alhamad, Noor Hussam Eddin, Nora Al Yahya, Walaa F. Alsanie, Abdulhakeem S. Alamri, Majid Alhomrani, Amal F. Alshammary, Rafiulla Gilkaramenthi, Syed Mohammed Basheeruddin Asdaq

“…Results Nationality, co-morbidities, and cancer duration were significant predictors of awareness regarding contraindicated drugs. Saudi patients were more likely to be aware of contraindicated medications ( P = 0.010), and those without chronic diseases were 15 times more likely to know about drug contraindications (OR = 15.076, 95% CI: 3.442-66.042). …”
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PMMB COVID-19 Bulletin: Spain (18th April 2020) by Hooi-Leng Ser, Vengadesh Letchumanan, Jodi Woan-Fei Law, Loh Teng-Hern Tan, Nurul-Syakima Ab Mutalib, Learn-Han Lee

“…The Spanish government has taken counter-measures for the management of COVID-19, consisting of the announcement of “state-of-emergency” and subsequent extension to control movements, setting up research grants to expedite drug and vaccine development in addition to introduction of the use of artificial intelligence as an official channel to provide advice and enquires about COVID-19. …”
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Self-assessment of Readiness and Equipment of Dental Clinics for Managing Medical Emergencies in the Republic of Croatia by Bruno Špiljak, Maja Firić, Miroslav Sikora, Vlaho Brailo

“…Adrenaline was the most available drug (98.7%), while other drugs were less common. …”
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Combinatorial protective effect of Cinnamomum verum and Stingless Bee Honey against oxidative stress in isoproterenol-induced cardiotoxicity in Wistar rats by Arul Mozhi Padmanabhan, Victor Arokia Doss

“…In a 7-day controlled study, rats were randomly assigned into seven treatment groups, receiving either saline (Group I), isoproterenol (ISO) (Group II) or ISO combined with drug interventions of Losartan (Group III), CV (Group IV) and SBH (Group V) along with several combined regimens (Group VI & VII). …”
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Inhibition of Horseradish Peroxidase Activity by Boroxine Derivative, Dipotassium-trioxohydroxytetrafluorotriborate K2[B3O3F4OH] by Jelena Ostojic, Safija Herenda, Semira Galijasevic, Borivoj Galic, Mladen Milos

“…Thus, the inhibition of HRP activity by dipotassium-trioxohydroxytetrafluorotriborate K2[B3O3F4OH] was investigated for possible explanation of previously observed antitumour activities of this promising drug. HRP activity was studied under steady-state kinetic conditions by a spectrophotometric method. …”
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Influence of <i>Eimeria</i> spp. and <i>Clostridium perfringens</i> Infection on Growth Performance and Toltrazuril Residues in Chickens by Konrad Pietruk, Jacek Karamon, Piotr Jedziniak, Stanisław Tokarzewski, Małgorzata Olejnik

“…This research contributes to optimizing drug use and residue management in poultry production.…”
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Synergism of d-limonene and temozolomide on migratory and apoptotic behaviors of human glioblastoma cell lines by Megha Gautam, Reema Gabrani

“…The treatment of GBM remains challenging primarily due to the drug resistance to the current standard therapeutic option, temozolomide (TMZ). …”
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The On-Freezing Phenomenon: Cognitive and Behavioral Aspects by Rita Moretti, Paola Torre, Rodolfo M. Antonello, Francesca Esposito, Giuseppe Bellini

“…Differently, the on-freezing phenomenon seems to be related to a neural disruption of the frontal-parietal-basal ganglia-pontine projections; clinically, it does not respond to therapy modifications or to different drug titration. In a group of patients with on-freezing, we have detected an alteration of focusing attention, an impairment of set-shifting, in addition to poor abstract reasoning and a reduction of planning. …”
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β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia by Kristoffer L. Egerod, Chunyu Jin, Pia Steen Petersen, Nils Wierup, Frank Sundler, Birgitte Holst, Thue W. Schwartz

“…It is concluded that GPR39 functions in a β-cell protective manner and it is suggested that it is involved in some of the beneficial, β-cell protective effects observed for Zn++ and that GPR39 may be a target for antidiabetic drug intervention.…”
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Two Sudden and Unexpected Deaths of Patients with Schizophrenia Associated with Intramuscular Injections of Antipsychotics and Practice Guidelines to Limit the Use of High Doses of... by Nasratullah Wahidi, Katie M. Johnson, Allen Brenzel, Jose de Leon

“…These two sudden deaths were probable adverse drug reactions (ADRs) following intramuscular (IM) antipsychotics. …”
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Monoclonal Antibodies in Prevention and Early Treatment of COVID-19 in Lung Transplant Recipients: A Systematic Review and Perspective on the Role of Monoclonal Antibodies in the F... by David A. Van Eijndhoven, Robin Vos, Robin Vos, Saskia Bos, Saskia Bos

“…A systematic search of PubMed/MEDLINE, Embase and Cochrane was conducted for studies reporting clinical outcomes of adult LTR or solid organ transplant recipients (SOTR) including LTR with drug-specific outcomes. Twelve studies were included. …”
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A mechanism-informed deep neural network enables prioritization of regulators that drive cell state transitions by Xi Xi, Jiaqi Li, Jinmeng Jia, Qiuchen Meng, Chen Li, Xiaowo Wang, Lei Wei, Xuegong Zhang

“…Some regulators reveal potential new therapeutic targets, drug repurposing possibilities, and putative causal single nucleotide polymorphisms. …”
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Hydroxychloroquine and Fabry Disease: Three Case Reports Examining an Unexpected Pathologic Link and a Review of the Literature by Rouhin Sen, Kathleen Borghoff, Kirk W. Foster, Stanley J. Radio, Alan Erickson, Michelene Hearth-Holmes

“…Our case reports are unique in that they explore the rare and sometimes overlooked effects of this drug on multiple organ systems, specifically the kidney, cardiac muscle, and skeletal muscle. …”
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Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19 by Hilmi Farhan Ramadhani, Annisa Annisa, Aryo Tedjo, Dimas R. Noor, Wisnu Ananta Kusuma

“…These proteins can be a potential target either as biomarkers or targets in drug discovery. Therefore, we combined enrichment analysis of these proteins to identify biological knowledge related to hyperinflammation. …”
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Machine learning analysis of the relationships between traumatic childbirth experience with positive and negative fertility motivations in Iran in a community-based sample by Mahdieh Arian, Talat Khadivzadeh, Mahla Shafeei, Sedigheh Abdollahpour

“…Elastic network modeling predicts using RMSE, MAE and R-squared that religious beliefs, married duration, and women’s education have the greatest increasing effect on positive fertility motivation. Drug addiction, traumatic childbirth, and abortion history have the greatest effect on increasing negative fertility motivation. …”
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Rising Healthcare Costs and Utilization among Young Adults with Cirrhosis in Ontario: A Population-Based Study by Jeffrey B. Ames, Maya Djerboua, Norah A. Terrault, Christopher M. Booth, Jennifer A. Flemming

“…On a per-patient basis, annual costs were the highest for cirrhosis ($6,581/year) compared to IBD ($5,260/year), and asthma ($2,934/year) driven by acute care in cirrhosis and asthma, and drug costs in IBD. Annual costs were four-fold higher in patients with decompensated versus compensated cirrhosis ($20,651/year vs. $5,280/year). …”
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Telaprevir in treatment of chronic hepatitis C: safety issues by T. M. Ignatova

“…Tactics of early diagnostics, monitoring and active treatment of AE, and drug interactions prophylaxes increase safety and efficacy of treatment.…”
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The effect of carbonyl cyanide m-chlorophenyl-hydrazine on antibiotic susceptibility in MDR Enterobacteriaceae isolates in Babylon, Iraq by Hadeel Qasim Jebur, Alaa H. Al-Charrakh

“…Abstract Background: One of the efflux pump inhibitors is carbonyl cyanide 3-chlorophenylhydrazone (CCCP) that has often been found to increase the susceptibility of a number of multi-drug resistant (MDR) MDR bacteria, isolated from human clinical specimens. …”
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Generative AI, IoT, and blockchain in healthcare: application, issues, and solutions by Tehseen Mazhar, Sunawar khan, Tariq Shahzad, Muhammad Amir khan, Mamoon M. Saeed, Joseph Bamidele Awotunde, Habib Hamam

“…Generative AI has additionally enhanced medical research and drug development, cutting the time and expense of introducing new medicines. …”
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