Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in the Treatment of HIV-Infected Patients: Experience with the First 100 Patients from Qatar by Hussam Al Soub, A. Latif M. Al-khal, Deema Alsoub, Waleed Awouda

“…Among treatment-experienced patients, the most common reasons for switch to EVG/COBI/FTC/TAF were safety concerns, followed by regimen simplification and adverse drug reaction of the previous regimen (40%, 14%, and 13%, respectively). …”
Get full text

Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners by Katarzyna Popiolek-Barczyk, Anna Piotrowska, Wioletta Makuch, Joanna Mika

“…Biphalin may be a putative drug for future pain therapy, especially for the treatment of neuropathic pain, when the lower analgesic effects of morphine are correlated with profound microglial cell activation.…”
Get full text

On-Time Appointment Keeping and Associated Factors among Human Immunodeficiency Virus-Positive Adult Patients Accessing Antiretroviral Therapy at Health Centers in East Gojjam Zone... by Mengistie Kassahun Tariku, Abebe Habtamu Belete, Daniel Tarekegn Worede, Sewnet Wongiel Misikir

“…Being >24 years old (adjusted odds ratio (AOR) = 2.13; 95% confidence interval (CI) = 1.54–4.25), being unmarried (AOR = 0.59; 95% CI = 0.45–0.82), taking a drug regimen of tenofovir + lamivudine (3TC) + efavirenz (EFV) (AOR = 2.11; 95% CI = 1.84–3.62), taking ART ≥12 months (AOR = 4.32; 95% CI = 2.22–8.40), having a mobile (AOR = 2.22; 95% CI = 1.44–3.64), and getting adherence support (AOR = 1.83; 95% CI = 1.16; 95% 1.16–3.50) were significant factors. …”
Get full text

The antifungal peptide AnAFP from Aspergillus niger promotes nutrient mobilization through autophagic recycling during asexual development by Stephan Starke, Laura Velleman, Birgit Dobbert, Luis Seibert, Jordi Witte, Sascha Jung, Vera Meyer

“…Antifungal peptides are promising drug candidates to fight fungal infections in the clinics and agriculture. …”
Get full text

SCO and BRICS in an emerging multipolar world order by D. V. Malyshev

“…The author emphasizes that in addition to addressing traditional challenges, the SCO member states are actively cooperating in countering new threats, such as separatism, drug trafficking, terrorism, and Islamic extremism. …”
Get full text

Induction of cell cycle arrest via the p21, p27–cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol by Huang Zhiwei, Wang Lianqiu, Chen Lifeng, Zhang Yifei, Shi Ping

“…This suggests that clioquinol may have a therapeutic potential as an anticancer drug for certain malignances.…”
Get full text

The Cost of Health Care for AIDS Patients in Saskatchewan by Kevin P Browne, Steve D Shafran, John M Conly

“…The average medical/surgical and drug costs per patient day in hospital were greater for aids patients than for the average medical/surgical patient in the authors’ institution.…”
Get full text

Factors Leading To Early Versus Late Presentation In Patients With Neck Masses by Ansa Umara Akram, Sadia Chaudhry, Nighat Qamar, Amna Kausar, Amna Javaid, Adia Bushra Piracha

“…Conclusion: The majority of patients who were drug and alcohol addicts were presented late with advanced disease. …”
Get full text

Chemotherapy-related side effects in childhood cancer in Hiwa Hospital Sulaimani city/Kurdistan region, Iraq by Awayi Ghazy Abdulkareem, Zhian Salah Ramzi, Jamal Ahmad Rashid, Heshu Sulaiman Rahman

“…Cancer cells tend to grow fast, and chemo drugs kill fast-growing cells. However, since such drugs move to almost all part of the body, they might have an influence on healthy cells which are normal and grow fast. …”
Get full text

Cochlear Organ Dissection, Immunostaining, and Confocal Imaging in Mice by Chenyu Chen, Binjun Chen, Xiaoqing Qian, Haojie Sun, Xiao Fu, Dongdong Ren

“…Damage to these structures due to noise exposure, drug toxicity, aging, or environmental factors can lead to hearing loss and other disorders. …”
Get full text

Efficacy and safety of a generic remifentanil formulation versus fentanyl and Ultiva during general anaesthesia: A phase III, prospective, multi-centric, observer-blind, randomised... by Indrani Hemantkumar, Ashok Kumar Swain, Manjaree Mishra, Swati Singh, Challakere Lakshminarain Gurudatt, Janampet Bekkam Giridhar

“…This study aimed to compare the efficacy and safety of a generic remifentanil (test drug) with fentanyl and Ultiva (innovator formulation) during general anaesthesia in the Indian population. …”
Get full text

Isolation and In Silico Anti-COVID-19 Main Protease (Mpro) Activities of Flavonoids and a Sesquiterpene Lactone from Artemisia sublessingiana by Roza I. Jalmakhanbetova, Yerlan M. Suleimen, Masayoshi Oyama, Eslam B. Elkaeed, Ibrahim. H. Eissa, Raigul N. Suleimen, Ahmed M. Metwaly, Margarita Yu. Ishmuratova

“…The emergence of the COVID-19 pandemic declared the huge need of humanity for new and effective antiviral drugs. The reported antimicrobial activities of Artemisia sublessingiana encouraged us to investigate the ethanol extract of its aerial parts which led to the isolation of six flavonoids and a sesquiterpenoid. …”
Get full text

Exploring the Interactions Between Caffeic Acid and Human Serum Albumin Using Spectroscopic and Molecular Docking Techniques by Ali Jahanban-Esfahlan, Leila Roufegarinejad, Mahnaz Tabibiazar, José M. Lorenzo, Ryszard Amarowicz

Get full text

POTENCY OF SOURSOP LEAF EXTRACT AND CURCUMIN WITH MAGNETIC AND MUCUS-PENETRATING NANOPARTICLE AS COLORECTAL CANCER ALTERNATIVE THERAPY by Faiza Rahma Ebnudesita, Ayik Rochyatul Jannah, Savira Butsainah Dienanta, Reny I'tishom

“…Curcumin also plays a role in the inhibition of nuclear factor κ-light-chain-enhancer of activated B (NF-κB) cells, thus inhibits carcinogenesis. For drug delivery, magnetic nanoparticles and mucus-penetrating nanoparticles could be used. …”
Get full text

On-site quantitative detection of fentanyl in heroin by machine learning-enabled SERS on super absorbing metasurfaces by Yingkun Zhu, Haomin Song, Ruiying Liu, Yunyun Mu, Murali Gedda, Abdullah N. Alodhay, Lei Ying, Qiaoqiang Gan

“…Abstract The global surge in opioid misuse, particularly fentanyl, presents a formidable public health challenge, highlighted by increasing drug-related mortalities. Our study introduces a novel approach for on-site quantitative detection of fentanyl in heroin, employing machine learning-enabled surface-enhanced Raman spectroscopy (SERS) on superabsorbing metasurfaces. …”
Get full text

Rat Hippocampal Neural Stem Cell Modulation Using PDGF, VEGF, PDGF/VEGF, and BDNF by Neus Gomila Pelegri, Catherine A. Gorrie, Jerran Santos

Get full text

Evaluation of Ethnopharmacological and Antioxidant Potential of Zanthoxylum armatum DC. by Rabia Kanwal, Muhammad Arshad, Yamin Bibi, Saira Asif, Sunbal Khalil Chaudhari

“…Further in vitro and in vivo research should be performed, so this plant can be further utilized in drug development.…”
Get full text

Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 Pathway by Ximei Shen, Beibei Fan, Xin Hu, Liufen Luo, Yuanli Yan, Liyong Yang

“…Metformin, a widely used antidiabetic drug, has been shown to have anti-inflammatory properties; nevertheless, its influence on β-cell meta-inflammation remains unclear. …”
Get full text

Defaulting from antiretroviral therapy and associated factors among HIV/AIDS patients in public hospitals of Eastern Zone, Tigray, Ethiopia, 2020: a cross-sectional study by Tsegu Hailu Gebru, Haftea Hagos Mekonen

“…Furthermore, participants with high pill burden, drug toxicity, mental instability, and poor ART adherence were more likely to default from the treatment. …”
Get full text

Development and Validation of a Specific Stability Indicating High Performance Liquid Chromatographic Methods for Related Compounds and Assay of Solifenacin Succinate by B. V. Rami Reddy, B. Srinivasa Reddy, N. V. V. S. S. Raman, K. Subhash Reddy, C. Rambabu

“…In the developed HPLC method the resolution between solifenacin succinate and its closely eluting impurity, that is, solifenacin N-oxide was found to be greater than 3.0. The drug was subjected to stress conditions such as hydrolysis, oxidation, photolysis, and thermal degradation. …”
Get full text