Stability-indicating HPLC-PDA assay for simultaneous determination of paracetamol, thiamine and pyridoxal phosphate in tablet formulations by Ali Amir, Athar Muhammad Makshoof, Ahmed Mahmood, Nadeem Kashif, Murtaza Ghulam, Farooq Umar, Salman Muhammad

“…With the increased number of multi-drug formulations, there is a need to develop new methods for simultaneous determinations of drugs. …”
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Immunocytochemical and Morphometric Studies of Gastrin-, Somatostatin- and Serotonin-Producing Cells in the Stomach and Duodenum of Patients with Acid Peptic Disorders by WR Yacoub, ABR Thomson, P Hooper, LD Jewell

“…Patient age, sex, duration of symptoms, smoking habits, alcohol consumption and nonsteroidal anti-inflammatory drug use had no effect on endocrine cell densities. …”
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Monitoring Guidelines for Home and Outpatient Parenteral Antibiotic Therapy by Alain Y Martel

“…One simple guideline is the less often a drug has to be administered, the more convenient the therapy will be for the patients, facilitating a higher rate of compliance. …”
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Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model by Juan Sebastian Yakisich, Neelam Azad, Rajkumar Venkatadri, Yogesh Kulkarni, Clayton Wright, Vivek Kaushik, Anand Krishnan V. Iyer

“…LTSs generated in this manner demonstrated several traits usually associated with increased stemness such as elevated expression of the stemness-associated marker Sox2 and increased chemoresistance to conventional anticancer drugs. In addition, we report that the FDA-approved drug Digitoxin, at concentration close to its therapeutic level, decreased the viability of LTSs and downregulated Sox2 independent of the PI3K/AKT pathway. …”
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A social enterprise model for TB detection and treatment through the private sector in Pakistan by S. M. A. Zaidi, W. Z. Jamal, U. Ibrahim, S. Khowaja, A. J. Khan, J. Creswell

“…RESULTS: Overall 171,488 people were screened and 18,683 cases were notified, including 197 individuals with drug-resistant TB. Annual TB notifications in Karachi increased from 18,105 in 2014 to a maximum of 25,840 (40% increase). …”
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Iron and ferroptosis in kidney disease: molecular and metabolic mechanisms by Wenjie Wang, Jingdi Chen, Liying Zhan, Handong Zou, Lu Wang, Mengmeng Guo, Hang Gao, Jing Xu, Wei Wu

“…Over the past decade, ferroptosis’ role in mediating the development and progression of renal disorders, such as acute kidney injury (renal ischemia-reperfusion injury, drug-induced acute kidney injury, severe acute pancreatitis induced acute kidney injury and sepsis-associated acute kidney injury), chronic kidney disease (diabetic nephropathy, renal fibrosis, autosomal dominant polycystic kidney disease) and renal cell carcinoma, has come into focus. …”
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Robust and consistent bonding of polydimethylsiloxane to polystyrene cell culture plates by Marta K. Orlowska, Mary Lor, Rebecca L. Fitzsimmons, Harley Robinson, Iliana Delcheva, Daniel Williams, Craig Priest, James E. Hudson

“…This bonding process has been successfully used over the past 2 years, with hundreds of plates manufactured for drug screening applications. Others may also have similar applications where this method may facilitate the fabrication of more robust PDMS–PS devices.…”
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Comparative Analyses of Antiviral Potencies of Second-Generation Integrase Strand Transfer Inhibitors (INSTIs) and the Developmental Compound 4d Against a Panel of Integrase Quadru... by Steven J. Smith, Xue Zhi Zhao, Stephen H. Hughes, Terrence R. Burke

“…However, the delayed rollouts of these INSTIs in low- to middle-income countries during the COVID-19 pandemic combined with increased transmission of drug-resistant mutants worldwide are leading to an increase in INSTI resistance. …”
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Shenfu Injection Protects Brain Injury in Rats with Cardiac Arrest through Nogo/NgR Pathway by Haixia Deng, Zhanhong Tang, Peng Tuo, Ruihua Wu, Si Jia, Xuan Zhao, Deqing Huang, Yuguang Gao, Zhou Lan

“…After 3 hours, 24 hours, 3 days, and 7 days of drug administration, the modified Neurological Severity Score tests were performed. …”
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Antioxidants and Cognitive-Behavioral Therapy in Patients with Functional Dyspepsia by T. V. Sapozhnikova, S. A. Parfenov, T. E. Yesina, K. V. Sapozhnikov, A. N. Smirnov, A. A. Paulov, D. M. Rizakhanov, O. A. Rizakhanova

“…The study included 112 adult patients with functional dyspepsia receiving the antioxidant drug Cytoflavin containing succinic acid, inosine, nicotinamide and riboflavin, and cognitive behavioral therapy according to the method of Beck and Jacobson in addition to the main therapy (prokinetics, proton pump inhibitors, psychotropic drugs).Results. …”
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Mitigation of the biosafety risks of sars-cov-2 at bsl-3 laboratories by Mustafa Sencer Karagül, Orbay Sayı, Mevlüt Demirbaş, Fahriye Saraç, Mustafa Hasöksüz

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Factors Attributable to Cardiovascular Diseases in the Elderly Population of the Campo Alegre Resettlement, Tierralta, Córdoba by Carolina Castellanos Ramos, Brayan Domínguez Lozano, Daniela Jiménez Cordero, José Rocha Barraza

“…The variables studied were: age and sex, marital status, socioeconomic status, educational level, work status, household or personal income, health history and healthy lifestyle conditions such as high blood pressure, type 2 diabetes mellitus, physical activity , healthy eating and daily food ration, weight control, drug dependence, medical control and hypercholesterolemia. …”
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Characterization of Human Colorectal Cancer MDR1/P-gp Fab Antibody by Xuemei Zhang, Gary Guishan Xiao, Ying Gao

“…In this study, the peptide sized 21 kDa covering P-gp transmembrane region was first prepared for generating a novel mouse monoclonal antibody Fab fragment with biological activity against multiple drug resistance protein P-gp21 by phage display technology. …”
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Evaluation of the histopathological spectrum of skin biopsies in patients with chronic kidney disease: A single-center experience by Amany A Fathaddin

“…Acquired perforating collagenosis (APC), which was observed in 16 (36.4%) of our patients, was the most prevalent skin pathology, followed by bullous drug reactions in nine (20.5%), leukocytoclastic vasculitis (LCV) in eight (18.2%), calciphylaxis in six (13.6%), and prurigo nodularis in five (11.4%) patients. …”
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Untargeted urine metabolomics reveals dynamic metabolic differences and key biomarkers across different stages of Alzheimer’s disease by Xiaoya Feng, Shenglan Zhao

“…Pathway enrichment analysis revealed that Drug metabolism was significantly enriched across all stages, while Retinol metabolism was particularly prominent during the transition stages. …”
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Cardiovascular manifestations in COVID-19 patients by Jyotsna Maddury, Mani Krishna, Achukatla Kumar

“…Consideration for potential drug interactions should be taken when treating CVD patients with COVID-19.…”
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Robust Optimization of Alginate-Carbopol 940 Bead Formulations by J. M. López-Cacho, Pedro L. González-R, B. Talero, A. M. Rabasco, M. L. González-Rodríguez

“…Responses evaluated were related to drug release profile from beads (t50% and AUC), swelling performance, encapsulation efficiency, shape and size parameters. …”
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Two types of vidian neurectomy show efficacy in treating allergic rhinitis and vasomotor rhinitis by ShuJuan Sun, AiPing Chen, Li Shi, YuZhu Wan

“…The efficacy evaluations were used to assess patient rhinitis symptoms, quality of life and drug usage. The time points of follow-up period were preoperative, 3 months, 6 months, 1 year, 2 years, and 3 years post operation. …”
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Unveiling the omics tapestry of B-acute lymphoblastic leukemia: bridging genomics, metabolomics, and immunomics by Yin Le, Shicong Zhu, Hongling Peng, Zhihua Wang

“…While the PI3K-Akt signaling pathway and metabolic reprogramming are known to play crucial roles in B-ALL, the interactions between lipid metabolism, immune pathways, and drug resistance remain unclear. In this study, we performed multi-omics analysis on different patient cohorts (newly diagnosed, relapsed, standard-risk, and poor-risk) to investigate the molecular characteristics associated with metabolism, signaling pathways, and immune regulation in B-ALL. …”
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The prevalence and evidence-based management of needle fear in adults with chronic disease: A scoping review. by Emily Duncanson, Richard K Le Leu, Lisa Shanahan, Luke Macauley, Paul N Bennett, Rick Weichula, Stephen McDonald, Anne L J Burke, Kathryn L Collins, Anna Chur-Hansen, Shilpanjali Jesudason

“…Literature concerning dentistry, vaccination, intravenous drug users and paediatric populations were excluded.…”
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