Effects of acepromazine, xylazine and propofol on spinal reflexes in healthy dogs by Ali Sheykhbahaedinzade, Ali Asghar Sarchahi, Hossein Kazemi Mehrjerdi

“…Among the drugs, acepromazine has the least effects compared to other drugs, making it a suitable choice for sedation.…”
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Therapeutic Effect of Stem Cells on Male Infertility in a Rat Model: Histological, Molecular, Biochemical, and Functional Study by Sally S. Mohammed, Mona F. Mansour, Noha A. Salem

“…Methotrexate (MTX) is a folic acid antagonist, widely used as a chemotherapeutic and immunosuppressive drug, but it is toxic to reproductive systems. In recent years, the era of stem cell applications becomes a promising point as a possible therapeutic agent in male infertility. …”
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Data Mining Models in Prediction of Vancomycin-Intermediate <i>Staphylococcus aureus</i> in Methicillin-Resistant <i>S. aureus</i> (MRSA) Bacteremia Patients in a Clinical Care Set... by Wei-Chuan Chen, Jiun-Ling Wang, Chi-Chuan Chang, Yusen Eason Lin

“…Vancomycin-intermediate <i>Staphylococcus aureus</i> (VISA) is a multi-drug-resistant pathogen of significant clinical concern. …”
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Effect of combined therapy by pinaverium bromide and itopride hydrochloride on clinical semiology and quality of life of patients with combination of constipation variant of irrita... by O. V. Krapivnaya, S. A. Alekseyenko

“…Application of the combined therapy including spasmolytic drug pinaverium bromide and prokinetic agent itopride hydrochloride for patients combination of IBS-C and PDS significantly increased efficacy of relief of clinical symptoms of combined disease and improved quality of life of patients.…”
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Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With Zr-Labeled Reporter Nanoparticles by Govindarajan Srimathveeravalli PhD, Dalya Abdel-Atti BS, Carlos Pérez-Medina PhD, Haruyuki Takaki MD, PhD, Stephen B. Solomon MD, Willem J. M. Mulder PhD, Thomas Reiner PhD

“…Reversible electroporation–related vascular effects seem to play an important role in nanoparticle delivery to tumors and drug uptake can be quantified with 89 Zr-NRep.…”
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Synergistic activity of Pitstop-2 and 1,6-hexanediol in aggressive human lung cancer cells by Sílvio Terra Stefanello, Caren Rigon Mizdal, Aline Franzen da Silva, Luca Matteo Todesca, Félix Alexandre Antunes Soares, Victor Shahin

“…Moreover, motility assays show that the compounds combination significantly impedes the motility of all cells. Drug safety and tolerability assessments were validated using the in vivo model organism Caenorhabditis elegans, where fairly high doses showed negligible impact on survival, development, or behavioral parameters. …”
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A Comprehensive Study of the Relationship between the Production of β-Lactamase Enzymes and Iron/Siderophore Uptake Regulatory Genes in Clinical Isolates of Acinetobacter baumannii... by Mahyar Porbaran, Hamed Tahmasebi, MohammadReza Arabestani

“…Based on our knowledge from this study, the association between β-lactamase production and IUS genes in A. baumannii plays an essential role in the emergence of drug-resistant strains.…”
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Towards the Application of Atorvastatin to Intensify Proapoptotic Potential of Conventional Antileukemic Agents In Vitro by Jolanta D. Żołnierczyk, Arleta Kaźmierczuk, Paweł Hikisz, Barbara Cebula-Obrzut, Ewa Wawrzyniak, Jerzy Z. Błoński, Małgorzata Misiewicz, Paweł Robak, Piotr Smolewski, Zofia M. Kiliańska

“…However, their usage alone in clinical practice may be limited due to possible side effects of high doses of these drugs. On the other hand, combined treatment of leukemia with statins and the conventional chemotherapeutics is questionable because of unknown influence of the first on the standard treatment results. …”
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Trends in prescribing sodium‐glucose cotransporter 2 inhibitors for individuals with type 2 diabetes with and without cardiovascular‐renal disease in South Korea, 2015–2021 by Kyoung Hwa Ha, Soyoung Shin, EunJi Na, Dae Jung Kim

“…ABSTRACT Background This study evaluates shifts in oral glucose‐lowering drug prescription patterns and the adoption of sodium‐glucose cotransporter 2 inhibitors (SGLT2is) in South Korea. …”
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Characterization of Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Hospitalized Patients in Palestine by Regeen Handal, Lulu Qunibi, Ibrahim Sahouri, Maha Juhari, Rula Dawodi, Hiyam Marzouqa, Musa Hindiyeh

“…The detection of these drug resistant pathogens is a reminder of the importance of active surveillance for resistant bacteria in order to prevent their spread in hospital settings.…”
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Matched pairs demonstrate robustness against inter-assay variability by Jochem Nelen, Horacio Pérez-Sánchez, Hans De Winter, Dries Van Rompaey

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Identification of Ethnically Specific Genetic Variations in Pan-Asian Ethnos by Jin Ok Yang, Sohyun Hwang, Woo-Yeon Kim, Seong-Jin Park, Sang Cheol Kim, Kiejung Park, Byungwook Lee

“…This study represents the first attempt to identify Asian ESNP and ECNP markers, which can be used to identify genetic differences and predict disease susceptibility and drug effectiveness in Asian ethnic populations.…”
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Assessment of IL-6 Pathway Inhibition in Gastrointestinal Behçet’s Disease from Immunological and Clinical Perspectives by Makoto Naganuma, Mitsuhiro Takeno, Aykut Ferhat Çelik, Robert Moots, Philippe Pinton, Tadakazu Hisamatsu

“…The selective inhibition of IL-6 trans-signaling may bring new impetus to the development of this drug class, particularly regarding safety. Still, the benefits of IL-6 inhibitors for patients with GIBD need to be evaluated in appropriate proof-of-concept studies. …”
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Curcumin Protects Human Umbilical Vein Endothelial Cells against H2O2-Induced Cell Injury by Jipeng Ouyang, Rong Li, Haiqin Shi, Jianping Zhong

“…As a conclusion, curcumin could mitigate H2O2-induced oxidative stress and cell death in HUVECs and may be a potential therapeutic drug for migraine.…”
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Phytochemical Study and Antibacterial and Antibiotic Modulation Activity of Punica granatum (Pomegranate) Leaves by Amine Trabelsi, Mohamed Amine El Kaibi, Aïmen Abbassi, Amira Horchani, Leila Chekir-Ghedira, Kamel Ghedira

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Inotodiol induces hepatocellular carcinoma apoptosis by activation of MAPK/ERK pathway. by Yushuang Xing, Di Jia, Xinping Zhu, Jialu Yang, Zhipeng Gao, Nana Meng, Haohao Xu, Mengxiao Wang, Shijun Chang, Mingqian Zhao, Shanbo Zhang, Zichen Mu, Qiang Tang, Weiming Zhao

“…Chemicals and chemotherapeutic agents have been experiencing problems such as side effects and drug resistance in the treatment of HCC, which cannot meet the needs of clinical treatment. …”
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Image Processing Techniques for Assessing Contractility in Isolated Adult Cardiac Myocytes by Carlos Bazan, David Torres Barba, Peter Blomgren, Paul Paolini

“…The proposed method can be utilized to evaluate changes in contractile behavior resulting from drug intervention, disease modeling, transgeneity, or other common applications to mammalian cardiocytes.…”
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Effect of 1-(phenyl)-N’-(4-methoxybenzylidene)-9H-pyrido[3,4-b] indole-3-carbohydrazide on in vitro poliovirus replication by Santos Patricia Regina, Formagio Anelise S. Nazari, Filho Benedito Prado Dias, Nakamura Celso Vataru, Sarragiotto Maria Helena, Ueda-Nakamura Tania

“…The pre-exposure and post-exposure prophylactic applications are possible situations in which an anti-PV drug might be used. Future studies are needed to elucidate the PMC mode of action and verify the feasibility of PMC use in vivo. …”
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Intravitreal Clindamycin and Dexamethasone Combined with Systemic Oral Antitoxoplasma Therapy versus Intravitreal Therapy Alone in the Management of Toxoplasma Retinochoroiditis: A... by Ashraf Bor’i, Ashraf Mahrous, Mahmoud A. Al-Aswad, Haitham Y. Al-Nashar, Waled M. Nada, Mostafa Wagih, Ahmed M. B. Awad, Wael M. El-Haig

“…Clinical outcome measures were resolution of active inflammation, changes in BCVA and CMT, adverse drug reactions, and rate of recurrence. Results. …”
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Evaluation of peptide secondary structure and intracellular uptake by introducing disubstituted amino acids into the amphipathic helical peptide C18AA by Takuma Kato, Go Ofuka, Ryota Kobayashi, Akiko Asano, Mitsunobu Doi

“…Amphipathic helical peptides are common among antimicrobial and cell membrane-permeable peptides, and amino acid substitutions within existing peptides have been an effective means of new peptide drug development. In the present study, we evaluated the effect of introducing a disubstituted amino acid (dAA), which has a stabilizing effect on the helical structure of the amphiphilic peptide C18AA, on the secondary structure of C18AA and its intracellular uptake. …”
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