Charge heterogeneity of therapeutic monoclonal antibodies by different cIEF systems: views on the current situation by Alessandro Ascione, Marcello Belfiore, Jaana Vesterinen, Mihaela Buda, Wolf Holtkamp, Francesca Luciani

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Comparison of Real-world Outcomes Between Patients Treated with Tapentadol ER or Oxycodone CR by Mike Durkin, Jacqueline Pesa, Jessica Lopatto, Rachel Halpern, Damon Van Voorhis, Stephanie Korrer

“…Patients had continuous health plan enrollment for 6 months before and after the index date, ≥ 90 days supply of opioid therapy, and no index drug claims in the preindex period. Patients were propensity score matched in a 1:2 ratio (tapentadol ER : oxycodone CR). …”
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Determination of Tetracycline in Pharmaceutical Preparation by Molecular and Atomic Absorption Spectrophotometry and High Performance Liquid Chromatography via Complex Formation wi... by Ahlam Jameel Abdulghani, Hadi Hassan Jasim, Abbas Shebeeb Hassan

“…UV-visible and atomic spectrophotometry and HPLC techniques were applied for the determination of tetracycline (TC) in pharmaceutical preparations via complexation of the drug with Au(III) and Hg(II) ions in solutions. The mole ratio of TC to metal ions was 1 : 1. …”
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Unusual presentation of anomalous origin of the right pulmonary artery from the ascending aorta: case report by Mohamed Elhudairy, Naif Alkhushi, Osman Al-Radi, Khadijah Maghrabi, Gaser Abdelmohsen

“…Despite initial management with prostaglandin E1 (PGE1) infusion, discontinuation of the drug led to clinical deterioration characterized by severe metabolic acidosis and low cardiac output syndrome. …”
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Effect of a Topical Combination of Latanoprost and Pranoprofen on Intraocular Pressure and the Ocular Surface in Open-Angle Glaucoma Patients by Simin Zhu, Dabo Wang, Jing Han

“…A prospective study was performed to observe the effects of nonsteroidal anti-inflammatory drug (NSAID) eyedrops on intraocular pressure (IOP) and the ocular surface in primary open-angle glaucoma (POAG) patients treated with 0.005% latanoprost eyedrops. …”
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New Insights on Biosynthesis of Nanoparticles Using Plants Emphasizing the Use of Alfalfa (Medicago sativa L.) by Inese Kokina, Ilona Plaksenkova, Lauris Jankovskis, Marija Jermaļonoka, Renata Galek

“…Plant biomolecules determine the antibacterial and anticancer properties of NPs, as well as increasing the use of NPs in biomedicine, for better drug transport, therefore medicinal plants or sea plants are mostly used for biosynthesis. …”
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Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry by Charlotte Förster, André Eichert, Dominik Oberthür, Christian Betzel, Reinhard Geßner, Andreas Nitsche, Jens P. Fürste

“…LNA-modified nucleic acids provide thus structural and functional features that may be successfully exploited for future application in biotechnology and drug discovery.…”
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Osthole regulates N6‐methyladenosine‐modified TGM2 to inhibit the progression of rheumatoid arthritis and associated interstitial lung disease by Xian Lin, Jian Chen, Cheng Tao, Lianxiang Luo, Juan He, Qingwen Wang

“…Taken together, our work emphasized OS as an effective drug candidate and TGM2 as a promising target for RA and RA‐ILD treatment.…”
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Role of prescribed medication in the development of iron deficiency anaemia in adults—a case–control study by Orouba Almilaji, Jonathon Snook, Kiran Prabhu, Elizabeth Williams, Frazer Warricker

“…IDA was not associated with long-term exposure to any of the other three drug classes. In contrast to the relationship with PPIs, the association with OACs was primarily in the IDA sub-group with haemorrhagic lesions.Conclusion Long-term exposure to PPIs and OACs are independently associated with the risk of developing IDA. …”
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Stimuli-responsive hydrogel dressing for wound healing by Wei Zhang, Jun Hu, Hao Wu, Xiufei Lin, Limei Cai

“…The wound microenvironment is collectively regulated by internal biomolecules, external drugs, and external sanitation. Traditional wound dressings (powders, bandages, sponges, etc.) often have poor therapeutic effects during wound healing and repair processes because they cannot respond to the dynamic wound microenvironment changes over the long-term. …”
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Assessing chemical exposure risk in breastfeeding infants: An explainable machine learning model for human milk transfer prediction by Xiaojie Huang, Jiajia Chen, Peineng Liu

“…Additionally, the model was applied to evaluate the transfer risks of FDA-approved drugs from 2019 to 2024, identifying several with high transfer probabilities. …”
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Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein by Kazuya Kishimoto, Satoshi Kaneko, Kenji Ohmori, Tadafumi Tamura, Kazuhide Hasegawa

“…Olopatadine hydrochloride (olopatadine) is an antiallergic drug with histamine H1 receptor antagonistic activity. …”
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Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications by Ibrahim Luru Abdulai, Samuel Kojo Kwofie, Winfred Seth Gbewonyo, Daniel Boison, Joshua Buer Puplampu, Michael Buenor Adinortey

“…Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. …”
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<i>In Silico</i> PASS Predictions and Exploration of Antioxidant and Anti-inflammatory Activity of <i>Citrus Karna</i> Raf. Fruit by Prasad JAMKHANDE, Mahavir GHANTE, Rajeshwar KSHIRSAGA

“…In addition, the percentage inhibition of paw edema and swelling was observed in CKME-treated rats and mice, which is the same as that of standard drug-treated groups. The Pa value of ascorbic acid, beta-bisabolene, linalool, and naringin is more than 0.7 which shows that these phytoconstituents might contribute to the anti-inflammatory action of extract samples such as CKME. …”
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Hyperinsulinemia Induced Altered Insulin Signaling Pathway in Muscle of High Fat- and Carbohydrate-Fed Rats: Effect of Exercise by Anu Joseph, S. Parvathy, Koyikkal Karthikeya Varma

“…Thus, exercise can be considered as an excellent management approach over drug therapy for diabetes and its complications.…”
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Isolated Sporothrix schenckii Monoarthritis by Aram Barbaryan, Wissam El Atrouni, Stefania Bailuc, Matthew W. Jones, Maharshi Bhakta, Khaldoun Haj Mahmoud, Aibek E. Mirrakhimov

“…A culture of Sporothrix schenkii sensu lato is the gold standard for the diagnosis of sporotrichosis. Itraconazole is the drug of choice for osteoarticular sporotrichosis. …”
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Evaluation on Genotoxicity and Teratogenicity of Aqueous Extract from Cyclocarya paliurus Leaves by Lihong Deng, Jiandu Lei, Jing He, Jing Liu, Luying Wang, Rui Zhang, Xinhua Liu, Yun Liu

“…Iljinsk (family Cyclocaryaceae), called sweet tea tree, is a well-known edible and medicinal plant, which has been widely used in China as drug formulation for the treatment of hypertension and diabetes. …”
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Wake-up call for recovery: a paradigm shift to address the deep crisis in Israel’s public mental health services in the shadow of October 7, 2023 by Amir Krivoy, Gadi Rosenthal

“…Despite the advent of psychopharmacology, significant advancements in drug efficacy are lacking, with recovery rates stagnating or declining. …”
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Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer by Niki Tavakoli, Emma J. Fong, Abigail Coleman, Yu-Kai Huang, Mathias Bigger, Michael E. Doche, Seungil Kim, Heinz-Josef Lenz, Nicholas A. Graham, Paul Macklin, Stacey D. Finley, Shannon M. Mumenthaler

“…Abstract Cancer-associated fibroblasts (CAFs) play a key role in metabolic reprogramming and are well-established contributors to drug resistance in colorectal cancer (CRC). To exploit this metabolic crosstalk, we integrated a systems biology approach that identified key metabolic targets in a data-driven method and validated them experimentally. …”
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Synergistic Effects of Dantrolene and Nimodipine on the Phenylephrine-Induced Contraction and ACh-Induced Relaxation in Aortic Rings from Diabetic Rats by Maria J. Crespo, Marie Roman, Jonathan Matias, Myrna Morales, Hector Torres, Jose Quidgley

“…Whether diabetics with CVSP also benefit from this drug, however, is unknown. We evaluated the effects of a 30 min incubation with dantrolene (50 μM), nimodipine (50 nM), and both drugs in combination, on phenylephrine- (PHE-) induced contraction and on acetylcholine- (ACh-) induced relaxation in aortic rings from streptozotocin (STZ) diabetic rats. …”
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